LIGHT HARVESTING MULTICHROMOPHORE COMPOSITIONS AND METHODS OF USING THE SAME
    11.
    发明申请
    LIGHT HARVESTING MULTICHROMOPHORE COMPOSITIONS AND METHODS OF USING THE SAME 有权
    光收藏多色组合物及其使用方法

    公开(公告)号:US20150226746A1

    公开(公告)日:2015-08-13

    申请号:US14624466

    申请日:2015-02-17

    Abstract: Light harvesting luminescent multichromophores that are configured upon excitation to transfer energy to, and amplify the emission from, an acceptor signaling chromophore in energy-receiving proximity therewith are provided. Also provided are compositions for labelling a target. The labelling composition may include a donor light harvesting multichromophore and an acceptor signaling chromophore in energy-receiving proximity to the donor light harvesting multichromophore. Also provided is an aqueous composition for labelling a target, including: a donor light harvesting multichromophore; an acceptor signaling chromophore in energy-receiving proximity therewith; and a sensor biomolecule. Methods for using the subject compositions are also provided.

    Abstract translation: 提供了在激发下配置以将能量转移到能量接受邻近的受体信号发色团并从其扩增发射的光收集发光多色谱。 还提供了用于标记靶的组合物。 标记组合物可以包括供体光采集多色素和受体在发射能量接近供体光采集多色素的信号发生基团。 还提供了用于标记靶的水性组合物,包括:供体光收获多色素; 受体接受能量接收的信号发生器; 和传感器生物分子。 还提供了使用本发明组合物的方法。

    Methods and compositions for detection and analysis of polynucleotides using light harvesting multichromophores
    12.
    发明授权
    Methods and compositions for detection and analysis of polynucleotides using light harvesting multichromophores 有权
    使用光收获多色素探测和分析多核苷酸的方法和组合物

    公开(公告)号:US09085799B2

    公开(公告)日:2015-07-21

    申请号:US14460245

    申请日:2014-08-14

    Abstract: Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a polycationic multichromophore and a sensor polynucleotide complementary to the target polynucleotide. The sensor polynucleotide comprises a signaling chromophore to receive energy from the excited multichromophore and increase emission in the presence of the target polynucleotide. The methods can be used in multiplex form. Kits comprising reagents for performing such methods are also provided.

    Abstract translation: 提供了用于测定靶多核苷酸样品的方法,组合物和制品。 将涉及含有靶多核苷酸的样品与聚阳离子多重色素和与靶多核苷酸互补的传感器多核苷酸接触。 所述传感器多核苷酸包含用于从所述激发的多色素载体接收能量的信号发色团,并且在靶多核苷酸的存在下增加发射。 该方法可以多路复用形式使用。 还提供了包含用于执行这些方法的试剂的试剂盒。

    Methods and Compositions for Detection and Analysis of Polynucleotides Using Light Harvesting Multichromophores
    13.
    发明申请
    Methods and Compositions for Detection and Analysis of Polynucleotides Using Light Harvesting Multichromophores 有权
    使用光收获多色素检测和分析多核苷酸的方法和组合物

    公开(公告)号:US20150024504A1

    公开(公告)日:2015-01-22

    申请号:US14460245

    申请日:2014-08-14

    Abstract: Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a polycationic multichromophore and a sensor polynucleotide complementary to the target polynucleotide. The sensor polynucleotide comprises a signaling chromophore to receive energy from the excited multichromophore and increase emission in the presence of the target polynucleotide. The methods can be used in multiplex form. Kits comprising reagents for performing such methods are also provided.

    Abstract translation: 提供了用于测定靶多核苷酸样品的方法,组合物和制品。 将涉及含有靶多核苷酸的样品与聚阳离子多重色素和与靶多核苷酸互补的传感器多核苷酸接触。 所述传感器多核苷酸包含用于从所述激发的多色素载体接收能量的信号发色团,并且在靶多核苷酸的存在下增加发射。 该方法可以多路复用形式使用。 还提供了包含用于执行这些方法的试剂的试剂盒。

    Methods and Compositions for Detection and Analysis of Polynucleotides Using Light Harvesting Multichromophores
    18.
    发明申请
    Methods and Compositions for Detection and Analysis of Polynucleotides Using Light Harvesting Multichromophores 有权
    使用光收获多色素检测和分析多核苷酸的方法和组合物

    公开(公告)号:US20140141428A1

    公开(公告)日:2014-05-22

    申请号:US14086532

    申请日:2013-11-21

    Abstract: Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a polycationic multichromophore and a sensor polynucleotide complementary to the target polynucleotide. The sensor polynucleotide comprises a signaling chromophore to receive energy from the excited multichromophore and increase emission in the presence of the target polynucleotide. The methods can be used in multiplex form. Kits comprising reagents for performing such methods are also provided.

    Abstract translation: 提供了用于测定靶多核苷酸样品的方法,组合物和制品。 将涉及含有靶多核苷酸的样品与聚阳离子多重色素和与靶多核苷酸互补的传感器多核苷酸接触。 所述传感器多核苷酸包含用于从所述激发的多色素载体接收能量的信号发色团,并且在靶多核苷酸的存在下增加发射。 该方法可以多路复用形式使用。 还提供了包含用于执行这些方法的试剂的试剂盒。

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