公开(公告)号：US20230042914A1

公开(公告)日：2023-02-09

申请号：US17852246

申请日：2022-06-28

Applicant: The Regents of the University of Colorado, a Body Corporate

Inventor： Jan P. Kraus ,  Tomas Majtan ,  Erez Bublil

IPC: A61K38/51 ,  A61K31/205 ,  A61K47/60 ,  A61K9/00 ,  A61K45/06 ,  C12N9/88 ,  C12N9/96 ,  A61K31/198 ,  A61K31/385

Abstract: Provided herein are improved compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.

公开(公告)号：US20220265835A1

公开(公告)日：2022-08-25

申请号：US17622112

申请日：2020-06-26

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Erez Bublil ,  Frank Glavin ,  Marcia Sellos-Moura ,  Jan P. Kraus ,  Tomas Majtan ,  Randy Wanner ,  Orhan Causevic

IPC: A61K47/60 ,  A61K47/26 ,  A61K47/02 ,  A61K9/19 ,  A61P43/00

Abstract: The present disclosure provides formulations for a drug product comprising a PEGylated CBS protein having the amino acid sequence of SEQ ID NO: 1. Dosages and dosing regimens are provided for treatment of homocystinuria in a subject in need thereof. Additionally, the dosages and dosing regimens are also provided to reduce the level of homocysteine (Hcy) or increase the levels of cysteine (Cys) and/or cystathionine (Cth) in a subject in need thereof.

公开(公告)号：US10046036B2

公开(公告)日：2018-08-14

申请号：US15235355

申请日：2016-08-12

Applicant: The Regents of the University of Colorado, a Body Corporate

Inventor： Jan P Kraus ,  Tomas Majtan ,  Erez Bublil

IPC: A61K38/54 ,  A61K38/00 ,  C12N9/96 ,  C12N9/88 ,  C07H21/04 ,  C07K1/00 ,  A61K38/51 ,  A61K45/06 ,  A61K31/198 ,  A61K31/205 ,  A61K31/385 ,  A61K9/00 ,  A61K47/48

Abstract: The invention provides reagents and methods for enzyme replacement therapy using chemically modified species of human cystathionine β-synthase (CBS) to treat homocystinuria and other related diseases and disorders.

公开(公告)号：US20170224787A1

公开(公告)日：2017-08-10

申请号：US15492671

申请日：2017-04-20

Applicant: The Regents of the University of Colorado, a Body Corporate

Inventor： Jan P. Kraus ,  Tomas Majtan ,  Erez Bublil

IPC: A61K38/51 ,  C12N9/88 ,  C12N9/96 ,  A61K31/205

CPC classification number: A61K38/51 ,  A61K9/0019 ,  A61K31/198 ,  A61K31/205 ,  A61K31/385 ,  A61K45/06 ,  A61K47/48215 ,  A61K47/60 ,  A61K2300/00 ,  C12N9/88 ,  C12N9/96 ,  C12Y402/01022

Abstract: Provided herein are improved compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.

公开(公告)号：US20250041392A1

公开(公告)日：2025-02-06

申请号：US18658735

申请日：2024-05-08

Applicant: The Regents of the University of Colorado, a Body Corporate

Inventor： Jan P. Kraus ,  Tomas Majtan ,  Erez Bublil

IPC: A61K38/51 ,  A61K9/00 ,  A61K31/198 ,  A61K31/205 ,  A61K31/385 ,  A61K45/06 ,  A61K47/60 ,  C12N9/88 ,  C12N9/96

Abstract: Provided herein are improved compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.

公开(公告)号：US20240091325A1

公开(公告)日：2024-03-21

申请号：US18454701

申请日：2023-08-23

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Jan P. Kraus ,  Tomas Majtan ,  Erez Bublil

IPC: A61K38/51 ,  A61K9/00 ,  A61K31/198 ,  A61K31/205 ,  A61K31/385 ,  A61K45/06 ,  A61K47/60 ,  C12N9/88 ,  C12N9/96

CPC classification number: A61K38/51 ,  A61K9/0019 ,  A61K31/198 ,  A61K31/205 ,  A61K31/385 ,  A61K45/06 ,  A61K47/60 ,  C12N9/88 ,  C12N9/96 ,  C12Y402/01022 ,  A61K2300/00

Abstract: Provided are compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.

公开(公告)号：US20200316179A1

公开(公告)日：2020-10-08

申请号：US16910735

申请日：2020-06-24

Applicant: The Regents of the University of Colorado, a Body Corporate

Inventor： Jan P. Kraus ,  Tomas Majtan ,  Erez Bublil

IPC: A61K38/51 ,  A61K31/205 ,  A61K47/60 ,  A61K9/00 ,  A61K45/06 ,  C12N9/88 ,  C12N9/96 ,  A61K31/198 ,  A61K31/385

Abstract: Provided herein are improved compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.

公开(公告)号：US10729753B2

公开(公告)日：2020-08-04

申请号：US16243295

申请日：2019-01-09

Applicant: The Regents of the University of Colorado, a Body Corporate

Inventor： Jan P. Kraus ,  Tomas Majtan ,  Erez Bublil

IPC: A61K38/51 ,  A61K31/385 ,  A61K31/198 ,  A61K47/60 ,  C12N9/96 ,  C12N9/88 ,  A61K45/06 ,  A61K9/00 ,  A61K31/205

Abstract: Provided herein are improved compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.

公开(公告)号：US20190125845A1

公开(公告)日：2019-05-02

申请号：US16243295

申请日：2019-01-09

Applicant: The Regents of the University of Colorado, a Body Corporate

Inventor： Jan P. Kraus ,  Tomas Majtan ,  Erez Bublil

IPC: A61K38/51 ,  C12N9/96 ,  C12N9/88 ,  A61K45/06 ,  A61K9/00 ,  A61K31/205 ,  A61K31/198 ,  A61K31/385 ,  A61K47/60

Abstract: Provided herein are improved compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.