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    IMMUNITY-INDUCING AGENT
    11.
    发明申请
    IMMUNITY-INDUCING AGENT 审中-公开

    公开(公告)号：US20190076492A1

    公开(公告)日：2019-03-14

    申请号：US16084100

    申请日：2017-03-27

    Applicant: TORAY INDUSTRIES, INC.

    Inventor： Takayuki FUJITA ,  Fumiyoshi OKANO

    IPC: A61K35/76 ,  A61K39/39 ,  A61P35/00 ,  C07K14/54 ,  C07K14/555 ,  C07K14/705 ,  C07K14/47

    Abstract: The present invention relates to a novel immunity-inducing agent for treatment and/or prevention of cancer. Specifically, the present invention relates to an immunity-inducing agent comprising, as an active ingredient, at least one polypeptide having immunity-inducing activity and selected from polypeptides derived from MRAP2 and modified forms thereof, or a recombinant vector comprising a polynucleotide encoding the polypeptide and capable of expressing the polypeptide in vivo, and a method for inducing immunity, comprising administering the immunity-inducing agent to a subject.

    PHARMACEUTICAL COMPOSITION FOR TREATING AND/OR PREVENTING CANCER
    12.
    发明申请
    PHARMACEUTICAL COMPOSITION FOR TREATING AND/OR PREVENTING CANCER 审中-公开

    公开(公告)号：US20180085453A1

    公开(公告)日：2018-03-29

    申请号：US15567496

    申请日：2016-04-28

    Applicant: TORAY INDUSTRIES, INC.

    Inventor： Akira KURIHARA ,  Hyongi CHON ,  Takayuki FUJITA ,  Fumiyoshi OKANO

    IPC: A61K39/395 ,  C07K4/12

    Abstract: An object of the present invention is to identify a cancer antigen protein specifically expressed on the surface of cancer cells and provide use of an antibody targeting the cancer antigen protein as a therapeutic and/or prophylactic agent for cancer. A pharmaceutical composition for treating and/or preventing cancer comprising an antibody or a fragment thereof having immunological reactivity with CSPG5 protein consisting of any one of amino acid sequences represented by SEQ ID NOs: 8, 4, 6, 10, and 12 and an amino acid sequence having an amino acid identity of 80% or more to the amino acid sequence, or a fragment thereof consisting of 7 or more consecutive amino acids, as an active ingredient.

    IMMUNE RESPONSE INDUCER
    13.
    发明申请
    IMMUNE RESPONSE INDUCER 审中-公开
    免疫反应诱发剂

    公开(公告)号：US20170035865A1

    公开(公告)日：2017-02-09

    申请号：US15299137

    申请日：2016-10-20

    Applicant: TORAY INDUSTRIES, INC.

    Inventor： Masaki ISHIBASHI ,  Fumiyoshi OKANO

    IPC: A61K39/00

    CPC classification number: A61K39/0011 ,  A61K38/208 ,  A61K38/212 ,  A61K38/215 ,  A61K2039/53 ,  A61K2300/00

    Abstract: An immunity-inducing agent comprising as an effective ingredient a specific polypeptide is disclosed. These polypeptides were isolated, by the SEREX method using a cDNA library derived from canine testis and serum from a cancer-bearing dog, as a polypeptide which binds to an antibody existing specifically in serum derived from a cancer-bearing living body. The polypeptides can induce immunity in a living body and cause regression of a tumor in a cancer-bearing living body. Therefore, these polypeptides are especially effective as a therapeutic and/or prophylactic agent for a cancer(s).

    Abstract translation: 公开了包含特定多肽作为有效成分的免疫诱导剂。 通过使用来自犬睾丸的cDNA文库和来自携带癌症的狗的血清的SEREX方法，分离这些多肽作为与存在于来自携带癌的活体的血清中特异性存在的抗体结合的多肽。 多肽可以在活体中诱导免疫，并引起携带癌的生物体中的肿瘤消退。 因此，这些多肽作为癌症的治疗和/或预防剂是特别有效的。

    PHARMACEUTICAL COMPOSITION FOR TREATMENT AND/OR PREVENTION OF CANCER
    14.
    发明申请
    PHARMACEUTICAL COMPOSITION FOR TREATMENT AND/OR PREVENTION OF CANCER 有权
    用于治疗和/或预防癌症的药物组合物

    公开(公告)号：US20160297889A1

    公开(公告)日：2016-10-13

    申请号：US14910878

    申请日：2014-08-08

    Applicant: TORAY INDUSTRIES, INC.

    Inventor： Fumiyoshi OKANO ,  Takanori SAITO ,  Yoshitaka MINAMIDA ,  Takayoshi IDO

    IPC: C07K16/30 ,  A61K39/395 ,  A61K45/06 ,  A61K47/48

    CPC classification number: C07K16/30 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6851 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/3015 ,  C07K16/3023 ,  C07K16/303 ,  C07K16/3038 ,  C07K16/3046 ,  C07K16/3053 ,  C07K16/3061 ,  C07K16/3069 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/732

    Abstract: It is intended to provide a CAPRIN-1-targeting antibody superior in antitumor activity to conventional antibodies, and use thereof as a therapeutic and/or preventive agent for a cancer. The present invention provides an antibody targeting a CAPRIN-1 polypeptide specifically expressed on the surface of cancer cells, and use of the antibody as a therapeutic and/or preventive agent for a cancer. The present invention provides an antibody which comprises a heavy chain variable region comprising complementarity-determining regions of SEQ ID NOs: 1, 2, and 3 and a light chain variable region comprising complementarity-determining regions of SEQ ID NOs: 4, 5, and 6 and has immunological reactivity with a CAPRIN-1 protein, or a fragment thereof, and a pharmaceutical composition for the treatment and/or prevention of a cancer, comprising this antibody or fragment as an active ingredient.

    Abstract translation: 旨在提供对常规抗体具有优异抗肿瘤活性的CAPRIN-1靶向抗体及其作为癌症治疗和/或预防剂的用途。 本发明提供靶向癌细胞表面特异性表达的CAPRIN-1多肽的抗体，以及该抗体作为癌症的治疗和/或预防剂的用途。 本发明提供一种抗体，其包含包含SEQ ID NO：1,2和3的互补决定区的重链可变区，以及包含SEQ ID NO：4,5和5的互补决定区的轻链可变区和 并且与CAPRIN-1蛋白质或其片段以及包含该抗体或片段作为活性成分的用于治疗和/或预防癌症的药物组合物具有免疫学反应性。

    IMMUNITY INDUCTION AGENT
    15.
    发明申请
    IMMUNITY INDUCTION AGENT 审中-公开
    免疫诱导剂

    公开(公告)号：US20160106823A1

    公开(公告)日：2016-04-21

    申请号：US14869523

    申请日：2015-09-29

    Applicant: TORAY INDUSTRIES, INC.

    Inventor： Akira KURIHARA ,  Fumiyoshi OKANO

    IPC: A61K39/00 ,  A61K39/39

    CPC classification number: A61K39/0011 ,  A61K38/20 ,  A61K38/21 ,  A61K38/44 ,  A61K39/39 ,  C12N9/0071 ,  A61K2300/00

    Abstract: Provided is a method for inducing immunity for therapy of a cancer(s). The method includes the step of administering to an individual with cancer at least one polypeptide selected from the polypeptides (a) or (b) below, and/or a recombinant vector(s) that comprise(s) a polynucleotide(s) encoding the at least one polypeptide, the recombinant vector(s) being capable of expressing the polypeptide(s) in vivo: (a) a polypeptide in any one of the amino acid sequences of SEQ ID NOs: 2, 4, 22, or 24; and (b) a polypeptide having a sequence identity of not less than 95% to the polypeptide (a). Further, an in vitro method for preparing an antigen-presenting cell is provided. The method includes the step of contacting the antigen-presenting cell with the at least one polypeptide selected from: (a) a polypeptide in any one of the amino acid sequences of SEQ ID NOs: 2, 4, 22, or 24; and (b) a polypeptide having a sequence identity of not less than 95% to the polypeptide (a).

    Abstract translation: 提供了用于诱导癌症治疗免疫的方法。 该方法包括向个体给予患有至少一种选自下述多肽（a）或（b）的多肽的个体和/或重组载体的步骤，所述重组载体包含编码 至少一种多肽，能够在体内表达多肽的重组载体：（a）SEQ ID NO：2,4,22或24的任一氨基酸序列中的多肽; 和（b）与多肽（a）具有不小于95％的序列同一性的多肽。 此外，提供了制备抗原呈递细胞的体外方法。 该方法包括使抗原呈递细胞与选自以下的至少一种多肽接触的步骤：（a）SEQ ID NO：2,4,22或24的任一氨基酸序列中的多肽; 和（b）与多肽（a）具有不小于95％的序列同一性的多肽。

    IMMUNE RESPONSE INDUCER
    20.
    发明申请
    IMMUNE RESPONSE INDUCER 审中-公开

    公开(公告)号：US20170035869A1

    公开(公告)日：2017-02-09

    申请号：US15331518

    申请日：2016-10-21

    Applicant: TORAY INDUSTRIES, INC.

    Inventor： Masaki ISHIBASHI ,  Fumiyoshi OKANO

    IPC: A61K39/00

    CPC classification number: A61K39/0011 ,  A61K38/208 ,  A61K38/212 ,  A61K38/215 ,  A61K2039/53 ,  A61K2300/00

    Abstract: An immunity-inducing agent comprising as an effective ingredient a specific polypeptide is disclosed. These polypeptides were isolated, by the SEREX method using a cDNA library derived from canine testis and serum from a cancer-bearing dog, as a polypeptide which binds to an antibody existing specifically in serum derived from a cancer-bearing living body. The polypeptides can induce immunity in a living body and cause regression of a tumor in a cancer-bearing living body. Therefore, these polypeptides are especially effective as a therapeutic and/or prophylactic agent for a cancer(s).

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