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公开(公告)号：US07795011B2
公开(公告)日：2010-09-14
申请号：US11188000
申请日：2005-07-25
申请人： Tae-sik Park , Sung-hee Lee , Jung-ho Kang , Young-il Kim , Moon-chul Lee
发明人： Tae-sik Park , Sung-hee Lee , Jung-ho Kang , Young-il Kim , Moon-chul Lee
CPC分类号： B01L3/50273 , B01L3/502715 , B01L2200/10 , B01L2300/049 , B01L2400/049 , B01L2400/06
摘要： A bio sample processing apparatus and method using vacuum chambers in which a bio sample is injected into a first vacuum chamber connected with one end of a bio processor and, after processing, is ejected into a second vacuum chamber connected with the other end of the bio processor. The vacuum chambers and bio processor are connected with each other to form an environment with a pressure lower than atmospheric pressure, and the bio sample moves toward the second vacuum chamber due to the pressure difference created by the injection of the bio sample into the first vacuum chamber.
摘要翻译： 一种使用真空室的生物样品处理装置和方法，其中将生物样品注入与生物处理器的一端连接的第一真空室中，并且在处理之后被喷射到与生物的另一端连接的第二真空室中 处理器。 真空室和生物处理器彼此连接以形成压力低于大气压的环境，并且生物样品由于将生物样品注入第一真空产生的压差而向第二真空室移动 房间。
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12.发明申请公开(公告)号：US20050266472A1
公开(公告)日：2005-12-01
申请号：US11139571
申请日：2005-05-31
申请人： Tae-sik Park , Sung-hee Lee , Jung-ho Kang , Young-il Kim , Moon-chul Lee , Jong-hwa Won
发明人： Tae-sik Park , Sung-hee Lee , Jung-ho Kang , Young-il Kim , Moon-chul Lee , Jong-hwa Won
IPC分类号： G01N22/00 , C12M1/00 , C12N15/09 , C12Q1/68 , G01N27/00 , G01N27/02 , G01N27/22 , G01N33/487 , G01N37/00 , C12M1/34 , H01F21/02
CPC分类号： G01N27/3276
摘要： An apparatus and method for detecting bio molecule using an inductor element that can detect the bonding reaction between a sample and a biochip by measuring the change of the electrical characteristics of a circuit including the inductance device. The method includes forming a signal conversion unit with at least one inductance device, arranging a biochip in a specified area of the signal conversion unit by immobilizing capturing probe biomolecules on a substrate and measuring electric characteristics of the signal conversion unit, performing a bonding reaction between a sample (such as DNA, RNA, protein, biomolecules, etc.) to be analyzed and the biochip, and measuring the electrical characteristics of the signal conversion unit after the reaction bonding. The result of the bio molecule detection is obtained through an electrical signal, and thus the capability of detecting the bio bonding reaction can be improved in comparison to the conventional apparatus and method.
摘要翻译： 一种使用电感器元件检测生物分子的装置和方法，该电感元件可以通过测量包括电感器件的电路的电特性的变化来检测样品和生物芯片之间的结合反应。 该方法包括：形成具有至少一个电感器件的信号转换单元，通过将捕获探针生物分子固定在基片上并测量信号转换单元的电特性，将生物芯片布置在信号转换单元的指定区域中， 待分析的样品（例如DNA，RNA，蛋白质，生物分子等）和生物芯片，以及测量反应结合后的信号转换单元的电特性。 通过电信号获得生物分子检测的结果，与以往的装置和方法相比，能够提高检测生物结合反应的能力。
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公开(公告)号：US07544472B2
公开(公告)日：2009-06-09
申请号：US11325056
申请日：2006-01-03
申请人： Tae-sik Park , Young-il Kim , Jung-ho Kang
发明人： Tae-sik Park , Young-il Kim , Jung-ho Kang
CPC分类号： G01N33/542 , G01N29/036 , G01N33/54366 , G01N2291/0257
摘要： An apparatus and method for detecting biomolecular bonding are disclosed. The apparatus comprises a substrate; a rotation unit mounted on the substrate, a probe biomolecule immobilized on a surface of the rotation unit; an input port and an output port connected with the substrate. A frequency detector is connected with the output port to measure rotational frequency of the rotation unit. The presence or absence of molecular bonding is detected by measuring difference between the rotational frequencies before and after mixing the probe biomolecule with a sample biomolecule.
摘要翻译： 公开了一种用于检测生物分子结合的装置和方法。 该装置包括基板; 安装在所述基板上的旋转单元，固定在所述旋转单元的表面上的探针生物分子; 与基板连接的输入端口和输出端口。 频率检测器与输出端口连接，以测量旋转单元的旋转频率。 通过测量将探针生物分子与样品生物分子混合之前和之后的旋转频率之间的差异来检测分子键的存在或不存在。
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公开(公告)号：US20060147972A1
公开(公告)日：2006-07-06
申请号：US11325056
申请日：2006-01-03
申请人： Tae-sik Park , Young-il Kim , Jung-ho Kang
发明人： Tae-sik Park , Young-il Kim , Jung-ho Kang
CPC分类号： G01N33/542 , G01N29/036 , G01N33/54366 , G01N2291/0257
摘要： An apparatus and method for detecting biomolecular bonding are disclosed. The apparatus comprises a substrate; a rotation unit mounted on the substrate, a probe biomolecule immobilized on a surface of the rotation unit; an input port and an output port connected with the substrate. A frequency detector is connected with the output port to measure rotational frequency of the rotation unit. The presence or absence of molecular bonding is detected by measuring difference between the rotational frequencies before and after mixing the probe biomolecule with a sample biomolecule.
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15.发明授权Biomolecule bonding detection apparatus using RF wireless energy transmission and method thereof 有权使用RF无线能量传输的生物分子结合检测装置及其方法公开(公告)号：US07933720B2
公开(公告)日：2011-04-26
申请号：US11315526
申请日：2005-12-21
申请人： Tae-sik Park , Young-il Kim , Jung-ho Kang
发明人： Tae-sik Park , Young-il Kim , Jung-ho Kang
CPC分类号： G01N27/3276 , G01N33/48785
摘要： An apparatus for detecting a biomolecule bonding using a radio frequency (RF) wireless energy transmission and a method thereof are disclosed. The method includes transmitting RF energy to a sensor module having one or more probe biomolecules immobilized thereon, and determining a first energy charging time of the sensor module, the first energy charging time representing the amount of time for the sensor to be completely charged by the transmitted RF energy, prior to mixing of the one or more probe biomolecules with one or more target sample biomolecules. A second energy charging time of the sensor module is determined, the second energy charging time representing the amount of time for the sensor to be completely charged by the transmitted RF energy, following mixing of the one or more probe biomolecules with one or more target biomolecule sample. A determination of whether biomolecule bonding has occurred is based on a variation of the first and second energy charging times.
摘要翻译： 公开了一种使用射频（RF）无线能量传输检测生物分子结合的装置及其方法。 该方法包括将RF能量传送到具有固定在其上的一个或多个探针生物分子的传感器模块，以及确定传感器模块的第一能量充电时间，第一能量充电时间表示传感器完全充电的时间量 在将一种或多种探针生物分子与一种或多种靶样品生物分子混合之前，传输RF能量。 确定传感器模块的第二能量充电时间，第二能量充电时间表示在将一个或多个探针生物分子与一个或多个靶生物分子混合之后传输的RF能量完全充电的传感器的时间量 样品。 是否发生生物分子结合的确定是基于第一和第二能量充电时间的变化。
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公开(公告)号：US07815860B2
公开(公告)日：2010-10-19
申请号：US11286030
申请日：2005-11-23
申请人： Young-il Kim , Jung-ho Kang , Tae-sik Park
发明人： Young-il Kim , Jung-ho Kang , Tae-sik Park
CPC分类号： G01N27/3271
摘要： A biosensor for detecting an analyte by using a variable voltage according to infrared radiation absorption is provided. The biosensor includes an infrared absorber having a variable resistance and bioreceptors immobilized onto the infrared absorber for selectively reacting and binding with an analyte, wherein an induced voltage at the infrared absorber varies depending on whether the bioreceptor reacts and binds with the analyte.
摘要翻译： 提供了一种用于通过使用根据红外辐射吸收的可变电压来检测分析物的生物传感器。 生物传感器包括具有可变电阻的红外吸收剂和固定在红外吸收器上的生物感应器，用于选择性地与分析物反应和结合，其中红外吸收剂处的感应电压根据生物受体是否与分析物反应而结合。
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公开(公告)号：US08268552B2
公开(公告)日：2012-09-18
申请号：US11323742
申请日：2005-12-30
申请人： Tae-sik Park , Young-il Kim , Jung-ho Kang
发明人： Tae-sik Park , Young-il Kim , Jung-ho Kang
CPC分类号： G01N21/4788 , G01N21/45 , G01N33/54353 , G01N33/54366 , G01N33/6845
摘要： Disclosed is a biomolecule detector and a detection method using the same. The biomolecule detector includes a biomolecule chip having a substrate and a slit formed therein. Biomolecules are immobilized on at least a portion of the edges of the slit. A light source directs incident light toward the biomolecule chip, and a screen receives an image formed by a portion of the incident light passing through the slit. The biomolecule detector is small and portable, yet its capability for detecting a target biomolecule is quick, accurate and simple. The simple structural features of the biomolecule detector enable mass production.
摘要翻译： 公开了一种生物分子检测器及其检测方法。 生物分子检测器包括具有基板和形成在其中的狭缝的生物分子芯片。 生物分子被固定在狭缝的至少一部分边缘上。 光源将入射光引向生物分子芯片，并且屏幕接收由通过狭缝的入射光的一部分形成的图像。 生物分子检测器小巧便携，检测目标生物分子的能力快速，准确，简单。 生物分子检测器的简单结构特征使得能够批量生产。
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18.发明申请公开(公告)号：US20060148067A1
公开(公告)日：2006-07-06
申请号：US11282233
申请日：2005-11-17
申请人： Tae-sik Park , Young-il Kim , Jung-ho Kang , Nam-su Park
发明人： Tae-sik Park , Young-il Kim , Jung-ho Kang , Nam-su Park
IPC分类号： C12M1/34
CPC分类号： G01N29/022 , G01N29/2412 , G01N29/2437 , G01N2291/02466 , G01N2291/0256 , G01N2291/0423
摘要： An apparatus for detecting bio-bonding using ultrasonic waves and a method thereof are disclosed. The apparatus includes a generator for generating ultrasonic wave, a transformer, disposed in proximity to the generator, the transformer configured for vibration thereof by the generated ultrasonic wave. A probe biomolecule is immobilized on the transformer, and a metal plate is disposed in proximity to the transformer. An analyzer is configured for measuring the capacitance between the transformer and the metal plate. The bio-bonding detection apparatus conveniently determines whether bio-bonding is generated by detecting variation in capacitance or variation in a characteristic of the ultrasonic wave.
摘要翻译： 公开了一种使用超声波检测生物粘合的装置及其方法。 该装置包括用于产生超声波的发生器，设置在发电机附近的变压器，该变压器被配置为通过产生的超声波进行振动。 探针生物分子固定在变压器上，金属板设置在变压器附近。 分析器被配置为测量变压器和金属板之间的电容。 生物粘合检测装置方便地确定通过检测电容的变化或超声波的特性的变化来生成生物结合。
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公开(公告)号：US20060205060A1
公开(公告)日：2006-09-14
申请号：US11286030
申请日：2005-11-23
申请人： Young-il Kim , Jung-ho Kang , Tae-sik Park
发明人： Young-il Kim , Jung-ho Kang , Tae-sik Park
IPC分类号： C12M1/34
CPC分类号： G01N27/3271
摘要： A biosensor for detecting an analyte by using a variable voltage according to infrared radiation absorption is provided. The biosensor includes an infrared absorber having a variable resistance and bioreceptors immobilized onto the infrared absorber for selectively reacting and binding with an analyte, wherein an induced voltage at the infrared absorber varies depending on whether the bioreceptor reacts and binds with the analyte.
摘要翻译： 提供了一种用于通过使用根据红外辐射吸收的可变电压来检测分析物的生物传感器。 生物传感器包括具有可变电阻的红外吸收剂和固定在红外吸收器上的生物感应器，用于选择性地与分析物反应和结合，其中红外吸收剂处的感应电压根据生物受体是否与分析物反应而结合。
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20.发明申请Biomolecule bonding detection apparatus using wireless antenna and method thereof 审中-公开使用无线天线的生物分子接合检测装置及其方法公开(公告)号：US20060154300A1
公开(公告)日：2006-07-13
申请号：US11327032
申请日：2006-01-05
申请人： Tae-sik Park , Young-il Kim , Jung-ho Kang
发明人： Tae-sik Park , Young-il Kim , Jung-ho Kang
CPC分类号： G01N33/54373
摘要： Disclosed is a biomolecule binding detection apparatus and a method thereof, which detects biomolecule bonding by measuring change in characteristics of a test signal transmitted by an antenna on which probe biomolecules are immobilized. The biomolecule bonding detection apparatus includes a transmitting unit on which probe biomolecules are immobilized, the probe biomolecules configured for detection of specific gene information included in sample biomolecules to be analyzed, the transmitting unit further configured for signal transmission. A receiving unit is configured for detecting biomolecule bonding by comparison of selected characteristics of a test signal transmitted from the transmitting unit before and after mixing of the probe biomolecules and the sample biomolecules.
摘要翻译： 公开了一种生物分子结合检测装置及其方法，其通过测量由固定有探针生物分子的天线发射的测试信号的特性的变化来检测生物分子结合。 所述生物分子结合检测装置包括固定有探针生物分子的发送单元，所述探针生物分子被配置为检测包含在待分析的样品生物分子中的特定基因信息，所述发送单元还被配置为进行信号传输。 接收单元被配置为通过比较在探针生物分子和样品生物分子混合之前和之后从发送单元发送的测试信号的选定特征来检测生物分子结合。
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