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公开(公告)号:US6166016A
公开(公告)日:2000-12-26
申请号:US194727
申请日:1998-12-02
IPC分类号: C07D473/00 , A61K31/505 , C07D473/34 , C07D487/04 , C07D495/04 , C07C233/64 , A61K31/166 , A61K31/52
CPC分类号: C07D487/04 , C07D473/34 , C07D495/04
摘要: The invention provides amide derivatives which are useful as analgesics, anti-inflammatory agents, antimicrobial drugs, hypoglycemic agents, hypolipidemic agents, antihypertensive agents, anti-cancer agents, etc., the derivatives being represented by the formula ##STR1## wherein ring A represents a benzene ring, a naphthalene ring, a pyridine ring or a furan ring; R.sup.4 represents a heterocyclic group selected from the group consisting of a lower alkyl-substituted thieno[3,2-d]pyrimidin-4-yl group, an optionally substituted pyrazolo[1,5-a]-1,3,5-triazin-4-yl group, a pyrazolo[3,4-d]pyrimidin-4-yl group substituted at the 6-position and a purin-6-yl group substituted at the 2-position; and R.sup.5 represents a hydrogen atom or a group represented by ##STR2##
摘要翻译: PCT No.PCT / JP97 / 01875 Sec。 371日期1998年12月2日第 102(e)日期1998年12月2日PCT提交1997年6月2日PCT公布。 公开号WO97 / 46560 PCT 日期1997年11月12日本发明提供可用作止痛剂,抗炎剂,抗微生物药物,降血糖药,降血脂药,降压药,抗癌剂等的酰胺衍生物,其衍生物由下式表示:其中环 A表示苯环,萘环,吡啶环或呋喃环; R 4表示选自低级烷基取代的噻吩并[3,2-d]嘧啶-4-基,任选取代的吡唑并[1,5-a] -1,3,5-三嗪 -4-基,在6位被取代的吡唑并[3,4-d]嘧啶-4-基和在2位被取代的嘌呤-6-基; 并且R 5表示氢原子或由其表示的基团
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公开(公告)号:US5985858A
公开(公告)日:1999-11-16
申请号:US91946
申请日:1998-06-26
申请人: Kazuyoshi Miyata , Yasuhiro Sakai , Yasuo Shoji , Yoshihiko Tsuda , Yasuhide Inoue , Keigo Sato , Shinya Miki
发明人: Kazuyoshi Miyata , Yasuhiro Sakai , Yasuo Shoji , Yoshihiko Tsuda , Yasuhide Inoue , Keigo Sato , Shinya Miki
IPC分类号: C07F9/6509 , C07F9/6539 , C07F9/6553 , C07F9/6558 , C07F9/6561 , A61K31/67 , A61K31/675
CPC分类号: C07F9/650964 , C07F9/6539 , C07F9/655345 , C07F9/65583 , C07F9/65586 , C07F9/6561
摘要: A phosphonic diester derivative represented by the following formula (1): ##STR1## wherein R.sup.1 represents a cycloalkyl group; a phenyl group which may have 1 to 3 substituents selected from the group consisting of a lower alkoxy group, a lower alkyl group, a halogen atom, a halogen-substituted lower alkyl group, a lower alkanoyl group, a nitro group, a benzoyl group, a cyano group, an N-lower alkylcarbamoyl group, an N-phenyl-lower alkylcarbamoyl group, an N-(halogen-substituted phenyl)carbamoyl group and an N,N-di-lower alkylcarbamoyl group; a 1,3,4-thiadiazol-2-yl group having a halogen-substituted lower alkyl group as a substituent; a thiazolyl group; a pyridyl group which may be substituted by a halogen atom; a benzothiazol-2-yl group having 1 to 2 lower alkoxy groups on the phenyl ring; or a 4,5-dihydrothieno[3,2-e]benzothiazol-2-yl group; R.sup.2 represents a hydrogen atom or a phenyl lower alkyl group; R.sup.3 and R.sup.4 each represents a lower alkyl group; and A represents a heterocyclic ring selected from the group consisting of a pyrazine ring, a thiophene ring and a phenyl-substituted thiazole ring; the derivative being of value as an agent for treating and preventing hyperlipidemia, diabetes and cataract, or as an antitumor agent.
摘要翻译: PCT No.PCT / JP96 / 03775第 371日期:1998年6月26日 102(e)日期1998年6月26日PCT 1996年12月24日PCT公布。 公开号WO97 / 24360 PCT 日期:1997年7月10日由下式(1)表示的膦酸二酯衍生物:其中R1表示环烷基; 可以具有1〜3个选自低级烷氧基,低级烷基,卤素原子,卤素取代的低级烷基,低级烷酰基,硝基,苯甲酰基的取代基的苯基 ,氰基,N-低级烷基氨基甲酰基,N-苯基 - 低级烷基氨基甲酰基,N-(卤素取代的苯基)氨基甲酰基和N,N-二低级烷基氨基甲酰基; 具有卤素取代的低级烷基作为取代基的1,3,4-噻二唑-2-基; 噻唑基 可被卤素原子取代的吡啶基; 在苯环上具有1至2个低级烷氧基的苯并噻唑-2-基; 或4,5-二氢噻吩并[3,2-e]苯并噻唑-2-基; R2表示氢原子或苯基低级烷基; R3和R4各自表示低级烷基; A表示选自吡嗪环,噻吩环和苯基取代的噻唑环的杂环; 该衍生物作为治疗和预防高脂血症,糖尿病和白内障或作为抗肿瘤剂的药剂是有价值的。
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公开(公告)号:US5376665A
公开(公告)日:1994-12-27
申请号:US182145
申请日:1994-01-14
申请人: Kazuyoshi Miyata , Yasuo Shoji , Yoshihiko Tsuda , Kazuhiko Tsutsumi , Yasuhide Inoue , Chieko Naba , Yasuhisa Kurogi
发明人: Kazuyoshi Miyata , Yasuo Shoji , Yoshihiko Tsuda , Kazuhiko Tsutsumi , Yasuhide Inoue , Chieko Naba , Yasuhisa Kurogi
IPC分类号: A61K31/675 , C07F9/6506 , C07F9/653 , C07F9/6541 , C07F9/6561 , C07D235/04 , A61K31/415 , A61K31/44 , C07D221/04
CPC分类号: C07F9/6561 , C07F9/65068 , C07F9/65324 , C07F9/6541
摘要: The invention provides a phosphonic diester derivative of the general formula ##STR1## The phosphonic diester derivative of the invention has hypoglycemic and hypolipidemic activities, for instance, and is of value as an antidiabetic or anti-hyperlipidemic agent.
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公开(公告)号:US20090072008A1
公开(公告)日:2009-03-19
申请号:US12252258
申请日:2008-10-15
申请人: Itaru TAKEDA , Tomoyuki Kato , Yasuo Shoji
发明人: Itaru TAKEDA , Tomoyuki Kato , Yasuo Shoji
IPC分类号: B23K1/20
CPC分类号: H05K3/3426 , H01M2/1022 , H01M10/052 , H05K2201/10818 , Y02P70/613 , Y10T29/49124 , Y10T29/49149
摘要: In a lead mounting method of mounting, onto a principal surface of a printed board, a lead to be connected to a terminal, a flat lead is prepared which lead has a mounted part to be disposed on the principal surface of the printed board and a connected part to be connected to the terminal. The flat lead is bent into an L shape so that the mounted part and the connected part are perpendicular to each other to obtain an L-shaped lead. The mounted part of the L-shaped lead is connected and fixed onto the principal surface of the printed board by soldering.
摘要翻译: 在安装在印刷电路板的主表面上的引线安装方法中,要连接到端子的引线,准备一个引线,该引线具有要布置在印刷电路板的主表面上的安装部分, 连接部分要连接到终端。 扁平导线弯曲成L形,使得安装部分和连接部分彼此垂直以获得L形引线。 L形引线的安装部分通过焊接连接固定在印刷电路板的主表面上。
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公开(公告)号:US20060215376A1
公开(公告)日:2006-09-28
申请号:US11322192
申请日:2005-12-29
申请人: Itaru Takeda , Tomoyuki Kato , Yasuo Shoji
发明人: Itaru Takeda , Tomoyuki Kato , Yasuo Shoji
CPC分类号: H05K3/3426 , H01M2/1022 , H01M10/052 , H05K2201/10818 , Y02P70/613 , Y10T29/49124 , Y10T29/49149
摘要: In a lead mounting method of mounting, onto a principal surface of a printed board, a lead to be connected to a terminal, a flat lead is prepared which lead has a mounted part to be disposed on the principal surface of the printed board and a connected part to be connected to the terminal. The flat lead is bent into an L shape so that the mounted part and the connected part are perpendicular to each other to obtain an L-shaped lead. The mounted part of the L-shaped lead is connected and fixed onto the principal surface of the printed board by soldering.
摘要翻译: 在安装在印刷电路板的主表面上的引线安装方法中,要连接到端子的引线,准备一个引线,该引线具有要布置在印刷电路板的主表面上的安装部分, 连接部分要连接到终端。 扁平导线弯曲成L形,使得安装部分和连接部分彼此垂直以获得L形引线。 L形引线的安装部分通过焊接连接固定在印刷电路板的主表面上。
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公开(公告)号:US06372749B1
公开(公告)日:2002-04-16
申请号:US09700764
申请日:2000-11-20
IPC分类号: C07D48704
CPC分类号: C07D487/04
摘要: The present invention provides pyrazolo[1,5-a]pyrimidine derivatives represented by the formula (1) wherein R1 represents lower alkyl or the like; one of R2 and R3 represents hydrogen and the other represents phenyl having lower alkoxy or the like, and R4 is hydrogen, carboxyl, lower alkoxy-carbonyl or the like. The derivatives of the invention have pharmacological effects such as analgesic action, inhibitory effect on nitrogen monoxide synthetase and the like and are useful as analgesics. The derivatives of the invention are also useful as therapeutic or prophylactic agents for septicemia, endotoxin shock, chronic articular rheumatism, etc.
摘要翻译: 本发明提供由式(1)表示的吡唑并[1,5-a]嘧啶衍生物,其中R 1表示低级烷基等; R2和R3之一表示氢,另一个表示具有低级烷氧基等的苯基,R4表示氢,羧基,低级烷氧基 - 羰基等。 本发明的衍生物具有镇痛作用,对一氧化氮合成酶等的抑制作用等药理作用,可用作止痛剂。 本发明的衍生物还可用作败血症,内毒素休克,慢性关节风湿病等的治疗或预防剂。
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公开(公告)号:US5843951A
公开(公告)日:1998-12-01
申请号:US836822
申请日:1997-05-21
申请人: Makoto Inoue , Takashi Okamura , Yasuo Shoji , Kinji Hashimoto , Masayuki Ohara , Tsuneo Yasuda
发明人: Makoto Inoue , Takashi Okamura , Yasuo Shoji , Kinji Hashimoto , Masayuki Ohara , Tsuneo Yasuda
IPC分类号: C07D487/04 , C07D487/14 , A61K31/505
CPC分类号: C07D487/04 , C07D487/14
摘要: The invention provides an analgesic composition containing as an active ingredient a specific pyrimidine derivative represented by one of the follwing formulas (1) to (3): ##STR1## wherein the substituents are as defined herein. This composition exhibits potent analgesic activity and is effective for alleviating various types of pain such as postoperative pain.
摘要翻译: PCT No.PCT / JP96 / 02759 Sec。 371日期1997年5月21日 102(e)日期1997年5月21日PCT提交1996年9月24日PCT公布。 公开号WO97 / 11946 日本1997年4月3日本发明提供了含有下列式(1)〜(3)之一所表示的特定嘧啶衍生物作为活性成分的止痛剂组合物:(1)< IMAGE>(2) (3)其中取代基如本文所定义。 该组合物显示出有效的止痛活性,对于缓解各种类型的疼痛(例如术后疼痛)是有效的。
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公开(公告)号:US5480874A
公开(公告)日:1996-01-02
申请号:US318860
申请日:1995-01-12
IPC分类号: A61K31/00 , A61K31/675 , C07F9/6506 , C07F9/6541 , C07F9/6561 , C07F9/28
CPC分类号: C07F9/6561 , C07F9/6541
摘要: The invention provides a phosphonic diester derivative of the formula: ##STR1## wherein the variables are as defined in the specification. The derivative of the invention has excellent hypolipidemic and hypoglycemic activities and little side effects and hence is useful as therapeutic and prophylactic agents for hyperlipidemic diseases and diabetes and as a therapeutic agent for cataract.
摘要翻译: 本发明提供下式的膦酸二酯衍生物:其中变量如说明书中所定义。 本发明的衍生物具有优异的降血脂和降血糖活性,副作用小,因此可用作高脂血症和糖尿病的治疗和预防剂,并且作为白内障治疗剂。
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公开(公告)号:US5479419A
公开(公告)日:1995-12-26
申请号:US266771
申请日:1994-06-28
申请人: Toshimichi Naoi , Haruhiro Shiino , Yasuo Shoji
发明人: Toshimichi Naoi , Haruhiro Shiino , Yasuo Shoji
CPC分类号: H04L25/03197
摘要: An adaptive maximum likelihood sequence estimator includes a channel estimator and a Viterbi algorithm processor for estimating the maximum likelihood transmission symbol sequences. The algorithm processor includes a branch metric computer in which common components are found from regularity in computations of coded alphabets of the transmission symbols and are used for all branch metric computation to reduce the total amount of the operations. Such effective computations are implemented by either of hardware and software in accordance with the constitution of the system of the adaptive maximum likelihood sequence estimator.
摘要翻译: 自适应最大似然序列估计器包括用于估计最大似然传输符号序列的信道估计器和维特比算法处理器。 算法处理器包括分支度量计算机,其中在计算传输符号的编码字母中的规则性中找到公共组件,并且用于所有分支度量计算以减少操作的总量。 根据自适应最大似然序列估计器系统的结构,这种有效计算由硬件和软件之一来实现。
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