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公开(公告)号：US08951518B2
公开(公告)日：2015-02-10
申请号：US13548807
申请日：2012-07-13
申请人： Tasuku Honjo , Shiro Shibayama , Kazuhiko Takeda , Masayoshi Matsuo , Takao Yoshida , Masakazu Miyamoto
发明人： Tasuku Honjo , Shiro Shibayama , Kazuhiko Takeda , Masayoshi Matsuo , Takao Yoshida , Masakazu Miyamoto
IPC分类号： A61K39/395 , C07K16/28 , A61K39/00
CPC分类号： C07K16/2818 , A61K39/3955 , A61K2039/505 , C07K16/2803 , C07K16/2809 , C07K2317/31 , C07K2317/56 , C07K2317/73
摘要： The present invention relates to a substance specific to human PD-1 comprising a part that recognizes human PD-1, a part that recognizes a membrane protein in cell membrane of human PD-1-expressing cells, and linkers. Since the substance specific to human PD-1 selectively can recognize human PD-1 and a membrane protein on cell membrane of human PD-1-expressing cells and can transmit inhibitory signal of human PD-1, it is useful for therapy and/or prevention of diseases caused by immunopathy.
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公开(公告)号：US07273725B2
公开(公告)日：2007-09-25
申请号：US10493393
申请日：2002-10-22
申请人： Tasuku Honjo , Kei Tashiro , Jun Takahashi , Hiroki Toda
发明人： Tasuku Honjo , Kei Tashiro , Jun Takahashi , Hiroki Toda
CPC分类号： C07K16/18 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/47 , G01N33/6896 , G01N2333/47 , G01N2500/00 , G01N2500/04
摘要： The present invention relates to human, rat and mouse stem cell-derived neuron survival factor polypeptides (SDNSF), a process for producing them, cDNA encoding SDNSF, a vector comprising the cDNA, host cells transformed by the vector, an antibody against SDNSF, pharmaceutical compositions containing SDNSF or the antibody, a method of assaying SDNSF, a reagent for assaying SDNSF, and a screening method using SDNSF. The polypeptides are effective in the survival of nerve cells and, therefore, efficacious in treating injury to the central nerve system caused by brain infarction, brain hemorrhage, spinal cord injury, etc.
摘要翻译： 本发明涉及人，大鼠和小鼠干细胞来源的神经元存活因子多肽（SDNSF），其制备方法，编码SDNSF的cDNA，包含cDNA的载体，载体转化的宿主细胞，针对SDNSF的抗体， 含有SDNSF或抗体的药物组合物，测定SDNSF的方法，用于测定SDNSF的试剂和使用SDNSF的筛选方法。 这些多肽在神经细胞的存活中是有效的，因此对于脑梗塞，脑出血，脊髓损伤等引起的中枢神经系统的损伤是有效的。
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13.发明授权Polypeptide ESDN, polynucleotides encoding the polypeptide, and utility of the polypeptide 有权多肽ESDN，编码多肽的多核苷酸，以及多肽的用途公开(公告)号：US07217786B2
公开(公告)日：2007-05-15
申请号：US11055679
申请日：2005-02-11
申请人： Tasuku Honjo , Kei Tashiro , Kazuhiro Kobuke
发明人： Tasuku Honjo , Kei Tashiro , Kazuhiro Kobuke
CPC分类号： C07K16/20 , A61K38/00 , C07K14/705 , C07K16/36 , G01N2333/71 , G01N2800/323
摘要： The invention discloses a useful and novel factor (polypeptide) which plays an important role for morbid vascular smooth muscle in restenosis after percutaneous transluminal coronany angioplasty (PTCA) and arterial sclerosis in the field of cardiovascular system.
摘要翻译： 本发明公开了一种在心血管系统领域经皮冠状动脉冠状动脉成形术（PTCA）和动脉硬化后再狭窄中病态血管平滑肌发挥重要作用的有用和新的因子（多肽）。
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公开(公告)号：US20060246568A1
公开(公告)日：2006-11-02
申请号：US11484529
申请日：2006-07-11
申请人： Tasuku Honjo , Masamichi Muramatsu
发明人： Tasuku Honjo , Masamichi Muramatsu
摘要： Genes encoding novel proteins named AID (Activation-Induced cytidine Deaminase) are described. The AID proteins are structurally related to APOBEC-1, an RNA editing enzyme, and have a cytidine deaminase activity similar to APOBEC-1. The AID genes were found by preparing cDNA libraries from mouse B cell clone CH12F3-2 (which undergoes class switch recombination from IgM to IgA at an extremely high rate after activation of the cells by stimulation with cytokines), with and without stimulation with cytokines, and performing subtraction cloning using the libraries.
摘要翻译： 描述了编码命名为AID（激活诱导的胞苷脱氨酶）的新型蛋白质的基因。 AID蛋白在结构上与APOBEC-1（一种RNA编辑酶）有关，并具有类似于APOBEC-1的胞苷脱氨酶活性。 通过从小鼠B细胞克隆CH12F3-2（其通过用细胞因子刺激激活细胞后以非常高的速率以非常高的速率进行类别开关重组），通过用细胞因子刺激和非细胞因子制备cDNA文库来发现AID基因， 并使用文库进行减法克隆。
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公开(公告)号：US07083966B2
公开(公告)日：2006-08-01
申请号：US10884878
申请日：2004-07-02
申请人： Tasuku Honjo , Masamichi Muramatsu
发明人： Tasuku Honjo , Masamichi Muramatsu
摘要： Genes encoding novel proteins named AID (Activation-Induced cytidine Deaminase) are described. The AID proteins are structurally related to APOBEC-1, an RNA editing enzyme, and have a cytidine deaminase activity similar to APOBEC-1. The AID genes were found by preparing cDNA libraries from mouse B cell clone CH12F3-2 (which undergoes class switch recombination from IgM to IgA at an extremely high rate after activation of the cells by stimulation with cytokines), with and without stimulation with cytokines, and performing subtraction cloning using the libranes.
摘要翻译： 描述了编码命名为AID（激活诱导的胞苷脱氨酶）的新型蛋白质的基因。 AID蛋白在结构上与APOBEC-1（一种RNA编辑酶）有关，并具有类似于APOBEC-1的胞苷脱氨酶活性。 通过从小鼠B细胞克隆CH12F3-2（其通过用细胞因子刺激激活细胞后以非常高的速率以非常高的速率进行类别开关重组），通过用细胞因子刺激和非细胞因子制备cDNA文库来发现AID基因， 并使用这些排毒器执行减法克隆。
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公开(公告)号：US20050003488A1
公开(公告)日：2005-01-06
申请号：US10902777
申请日：2004-08-02
申请人： Tasuku Honjo , Keizo Kato , Hideaki Tada
发明人： Tasuku Honjo , Keizo Kato , Hideaki Tada
摘要： A polypeptide prepared from mouse ES cell strains by the SST method and a homologous polypeptide obtained from mouse kidney, human uterus, mouse fetus, human fetal liver and pancreas libraries; a cDNA encoding the polypeptide; a fragment selectively hybridizing with the sequence of the cDNA; a replication or expression plasmid containing the cDNA integrated thereinto; a host cell transformed with plasmid; an antibody against the polypeptide; and a pharmaceutical composition containing the polypeptide or the antibody.
摘要翻译： 通过SST方法从小鼠ES细胞株制备的多肽和从小鼠肾，人子宫，小鼠胎儿，人胎肝和胰腺文库获得的同源多肽; 编码该多肽的cDNA; 选择性地与cDNA序列杂交的片段; 包含其中整合的cDNA的复制或表达质粒; 用质粒转化的宿主细胞; 抗多肽的抗体; 和含有多肽或抗体的药物组合物。
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公开(公告)号：US09439962B2
公开(公告)日：2016-09-13
申请号：US15000869
申请日：2016-01-19
发明人： Tasuku Honjo , Nagahiro Minato , Yoshiko Iwai , Shiro Shibayama
IPC分类号： A61K39/395 , C07K16/28 , A61K31/7088 , C12Q1/02 , G01N33/50 , G01N33/574 , A61K38/21 , C07K16/18 , A61K9/00 , A61K45/06 , A61K47/26 , A61K47/02 , A61K39/00
CPC分类号： C07K16/2818 , A61K9/0019 , A61K31/7088 , A61K38/1774 , A61K38/212 , A61K39/3955 , A61K45/06 , A61K47/02 , A61K47/26 , A61K2039/505 , A61K2039/507 , C07K14/70521 , C07K16/18 , C07K16/2803 , C07K16/2827 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/73 , C07K2317/76 , C07K2319/30 , C12Q1/025 , G01N33/5011 , G01N33/574 , G01N2500/00 , Y02A50/39 , Y02A50/394 , Y02A50/463 , Y02A50/466
摘要： Compositions for cancer or infection treatment via immunopotentiation caused by inhibition of immunosuppressive signal induced by PD-1, PD-L1, or PD-L2 and therapies using them, immunopotentiative substrates included as the active ingredient, screening methods of the substrates for cancer or infection treatment, cell lines used for the screening methods, evaluation methods that selects the substrates for cancer treatment, and carcinoma cell transplanted mammals used for the evaluation methods.The compositions of the present invention that inhibits the function of PD-1, PD-L1, PD-L2 are useful for cancer or infection treatment.
摘要翻译： 抑制PD-1，PD-L1，PD-L2的功能的本发明的组合物可用于癌症或感染治疗。
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公开(公告)号：US08728474B2
公开(公告)日：2014-05-20
申请号：US12959307
申请日：2010-12-02
申请人： Tasuku Honjo , Nagahiro Minato , Yoshiko Iwai , Shiro Shibayama
发明人： Tasuku Honjo , Nagahiro Minato , Yoshiko Iwai , Shiro Shibayama
IPC分类号： A61K39/395
CPC分类号： C07K16/2818 , A61K9/0019 , A61K31/7088 , A61K38/1774 , A61K38/212 , A61K39/3955 , A61K45/06 , A61K47/02 , A61K47/26 , A61K2039/505 , A61K2039/507 , C07K14/70521 , C07K16/18 , C07K16/2803 , C07K16/2827 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/73 , C07K2317/76 , C07K2319/30 , C12Q1/025 , G01N33/5011 , G01N33/574 , G01N2500/00 , Y02A50/39 , Y02A50/394 , Y02A50/463 , Y02A50/466
摘要： Compositions for cancer or infection treatment via immunopotentiation caused by inhibition of immunosuppressive signal induced by PD-1, PD-L1, or PD-L2 and therapies using them, immunopotentiative substrates included as the active ingredient, screening methods of the substrates for cancer or infection treatment, cell lines used for the screening methods, evaluation methods that select the substrates for cancer treatment, and carcinoma cell transplanted mammals used for the evaluation methods. The compositions of the present invention that inhibits the function of PD-1, PD-L1, or PD-L2 are useful for treatment of cancer or infection.
摘要翻译： 通过由PD-1，PD-L1或PD-L2诱导的免疫抑制信号的抑制和使用它们的疗法，包括作为活性成分的免疫增强底物，用于癌症或感染的底物的筛选方法由免疫增强引起的癌症或感染治疗的组合物 治疗，用于筛选方法的细胞系，选择用于癌症治疗的底物的评价方法和用于评价方法的癌细胞移植的哺乳动物。 抑制PD-1，PD-L1或PD-L2的功能的本发明的组合物可用于治疗癌症或感染。
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公开(公告)号：US08246955B2
公开(公告)日：2012-08-21
申请号：US13169278
申请日：2011-06-27
申请人： Tasuku Honjo , Shiro Shibayama , Kazuhiko Takeda , Masayoshi Matsuo , Takao Yoshida , Masakazu Miyamoto
发明人： Tasuku Honjo , Shiro Shibayama , Kazuhiko Takeda , Masayoshi Matsuo , Takao Yoshida , Masakazu Miyamoto
IPC分类号： A61K39/395
CPC分类号： C07K16/2818 , A61K39/3955 , A61K2039/505 , C07K16/2803 , C07K16/2809 , C07K2317/31 , C07K2317/56 , C07K2317/73
摘要： The present invention relates to a substance specific to human PD-1 comprising a part that recognizes human PD-1, a part that recognizes a membrane protein in cell membrane of human PD-1-expressing cells, and linkers. Since the substance specific to human PD-1 selectively can recognize human PD-1 and a membrane protein on cell membrane of human PD-1-expressing cells and can transmit inhibitory signal of human PD-1, it is useful for therapy and/or prevention of diseases caused by immunopathy.
摘要翻译： 本发明涉及对人PD-1特异性的物质，其包含识别人PD-1的部分，识别人PD-1表达细胞的细胞膜中的膜蛋白的部分和接头。 由于对人PD-1特异性的物质可以选择性地识别人PD-1和人PD-1表达细胞的细胞膜上的膜蛋白，并且可以传递人PD-1的抑制信号，因此它可用于治疗和/或 预防免疫病引起的疾病。
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20.发明授权Method for treatment of cancer by inhibiting the immunosuppressive signal induced by PD-1 有权通过抑制PD-1诱导的免疫抑制信号治疗癌症的方法公开(公告)号：US07595048B2
公开(公告)日：2009-09-29
申请号：US10519925
申请日：2003-07-02
申请人： Tasuku Honjo , Nagahiro Minato , Yoshiko Iwai , Shiro Shibayama
发明人： Tasuku Honjo , Nagahiro Minato , Yoshiko Iwai , Shiro Shibayama
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2818 , A61K9/0019 , A61K31/7088 , A61K38/1774 , A61K38/212 , A61K39/3955 , A61K45/06 , A61K47/02 , A61K47/26 , A61K2039/505 , A61K2039/507 , C07K14/70521 , C07K16/18 , C07K16/2803 , C07K16/2827 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/73 , C07K2317/76 , C07K2319/30 , C12Q1/025 , G01N33/5011 , G01N33/574 , G01N2500/00 , Y02A50/39 , Y02A50/394 , Y02A50/463 , Y02A50/466
摘要： Compositions for cancer or infection treatment via immunopotentiation caused by inhibition of the immunosuppressive signal induced by PD-1, PD-L1, or PD-L2 and therapies using them, immunopotentiative substrates included as the active ingredient, screening methods of the substrates for cancer or infection treatment, cell lines used for the screening methods, evaluation methods that select the substrates for cancer treatment, and carcinoma cell transplanted mammals used for the evaluation methods. The compositions of the present invention that inhibit the function of PD-1, PD-L1, or PD-L2 are useful for treatment of cancer or infection.
摘要翻译： 通过由PD-1，PD-L1或PD-L2诱导的免疫抑制信号的抑制和使用它们的疗法，包括作为活性成分的免疫增强底物，用于癌症的底物的筛选方法或通过免疫增强 感染治疗，用于筛选方法的细胞系，选择用于癌症治疗的底物的评价方法和用于评价方法的癌细胞移植的哺乳动物。 抑制PD-1，PD-L1或PD-L2功能的本发明的组合物可用于治疗癌症或感染。
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