-
公开(公告)号：US09439962B2
公开(公告)日：2016-09-13
申请号：US15000869
申请日：2016-01-19
发明人： Tasuku Honjo , Nagahiro Minato , Yoshiko Iwai , Shiro Shibayama
IPC分类号： A61K39/395 , C07K16/28 , A61K31/7088 , C12Q1/02 , G01N33/50 , G01N33/574 , A61K38/21 , C07K16/18 , A61K9/00 , A61K45/06 , A61K47/26 , A61K47/02 , A61K39/00
CPC分类号： C07K16/2818 , A61K9/0019 , A61K31/7088 , A61K38/1774 , A61K38/212 , A61K39/3955 , A61K45/06 , A61K47/02 , A61K47/26 , A61K2039/505 , A61K2039/507 , C07K14/70521 , C07K16/18 , C07K16/2803 , C07K16/2827 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/73 , C07K2317/76 , C07K2319/30 , C12Q1/025 , G01N33/5011 , G01N33/574 , G01N2500/00 , Y02A50/39 , Y02A50/394 , Y02A50/463 , Y02A50/466
摘要： Compositions for cancer or infection treatment via immunopotentiation caused by inhibition of immunosuppressive signal induced by PD-1, PD-L1, or PD-L2 and therapies using them, immunopotentiative substrates included as the active ingredient, screening methods of the substrates for cancer or infection treatment, cell lines used for the screening methods, evaluation methods that selects the substrates for cancer treatment, and carcinoma cell transplanted mammals used for the evaluation methods.The compositions of the present invention that inhibits the function of PD-1, PD-L1, PD-L2 are useful for cancer or infection treatment.
摘要翻译： 抑制PD-1，PD-L1，PD-L2的功能的本发明的组合物可用于癌症或感染治疗。
-
公开(公告)号：US09393301B2
公开(公告)日：2016-07-19
申请号：US15000863
申请日：2016-01-19
发明人： Tasuku Honjo , Nagahiro Minato , Yoshiko Iwai , Shiro Shibayama
IPC分类号： A61K39/395 , C07K16/28 , A61K45/06 , A61K39/00
CPC分类号： C07K16/2818 , A61K9/0019 , A61K31/7088 , A61K38/1774 , A61K38/212 , A61K39/3955 , A61K45/06 , A61K47/02 , A61K47/26 , A61K2039/505 , A61K2039/507 , C07K14/70521 , C07K16/18 , C07K16/2803 , C07K16/2827 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/73 , C07K2317/76 , C07K2319/30 , C12Q1/025 , G01N33/5011 , G01N33/574 , G01N2500/00 , Y02A50/39 , Y02A50/394 , Y02A50/463 , Y02A50/466
摘要： Compositions for cancer or infection treatment via immunopotentiation caused by inhibition of immunosuppressive signal induced by PD-1, PD-L1, or PD-L2 and therapies using them, immunopotentiative substrates included as the active ingredient, screening methods of the substrates for cancer or infection treatment, cell lines used for the screening methods, evaluation methods that selects the substrates for cancer treatment, and carcinoma cell transplanted mammals used for the evaluation methods.The compositions of the present invention that inhibits the function of PD-1, PD-L1 PD-L2 are useful for cancer or infection treatment.
摘要翻译： 通过由PD-1，PD-L1或PD-L2诱导的免疫抑制信号的抑制和使用它们的疗法，包括作为活性成分的免疫增强底物，用于癌症或感染的底物的筛选方法由免疫增强引起的癌症或感染治疗的组合物 治疗，用于筛选方法的细胞系，选择用于癌症治疗的底物的评价方法，以及用于评价方法的癌细胞移植的哺乳动物。 抑制PD-1，PD-L1 PD-L2的功能的本发明的组合物可用于癌症或感染治疗。
-
公开(公告)号：US09073994B2
公开(公告)日：2015-07-07
申请号：US14550585
申请日：2014-11-21
发明人： Tasuku Honjo , Nagahiro Minato , Yoshiko Iwai , Shiro Shibayama
IPC分类号： C07K16/28 , A61K39/395 , A61K31/7088 , C12Q1/02 , G01N33/50 , G01N33/574 , A61K38/21 , C07K16/18 , A61K9/00 , A61K45/06 , A61K47/26 , A61K39/00
CPC分类号： C07K16/2818 , A61K9/0019 , A61K31/7088 , A61K38/1774 , A61K38/212 , A61K39/3955 , A61K45/06 , A61K47/02 , A61K47/26 , A61K2039/505 , A61K2039/507 , C07K14/70521 , C07K16/18 , C07K16/2803 , C07K16/2827 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/73 , C07K2317/76 , C07K2319/30 , C12Q1/025 , G01N33/5011 , G01N33/574 , G01N2500/00 , Y02A50/39 , Y02A50/394 , Y02A50/463 , Y02A50/466
摘要： Compositions for cancer or infection treatment via immunopotentiation caused by inhibition of immunosuppressive signal induced by PD-1, PD-L1, or PD-L2 and therapies using them, immunopotentiative substrates included as the active ingredient, screening methods of the substrates for cancer or infection treatment, cell lines used for the screening methods, evaluation methods that selects the substrates for cancer treatment, and carcinoma cell transplanted mammals used for the evaluation methods.The compositions of the present invention that inhibits the function of PD-1, PD-L1, or PD-L2 are useful for cancer or infection treatment.
-
公开(公告)号：US09067999B1
公开(公告)日：2015-06-30
申请号：US14638985
申请日：2015-03-04
发明人： Tasuku Honjo , Nagahiro Minato , Yoshiko Iwai , Shiro Shibayama
CPC分类号： C07K16/2818 , A61K9/0019 , A61K31/7088 , A61K38/1774 , A61K38/212 , A61K39/3955 , A61K45/06 , A61K47/02 , A61K47/26 , A61K2039/505 , A61K2039/507 , C07K14/70521 , C07K16/18 , C07K16/2803 , C07K16/2827 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/73 , C07K2317/76 , C07K2319/30 , C12Q1/025 , G01N33/5011 , G01N33/574 , G01N2500/00 , Y02A50/39 , Y02A50/394 , Y02A50/463 , Y02A50/466
摘要： Compositions for cancer or infection treatment via immunopotentiation caused by inhibition of immunosuppressive signal induced by PD-1, PD-L1, or PD-L2 and therapies using them, immunopotentiative substrates included as the active ingredient, screening methods of the substrates for cancer or infection treatment, cell lines used for the screening methods, evaluation methods that selects the substrates for cancer treatment, and carcinoma cell transplanted mammals used for the evaluation methods.The compositions of the present invention that inhibits the function of PD-1, PD-L1, or PD-L2 are useful for cancer or infection treatment.
摘要翻译： 通过由PD-1，PD-L1或PD-L2诱导的免疫抑制信号的抑制和使用它们的疗法，包括作为活性成分的免疫增强底物，用于癌症或感染的底物的筛选方法由免疫增强引起的癌症或感染治疗的组合物 治疗，用于筛选方法的细胞系，选择用于癌症治疗的底物的评价方法，以及用于评价方法的癌细胞移植的哺乳动物。 抑制PD-1，PD-L1或PD-L2的功能的本发明的组合物可用于癌症或感染治疗。
-
公开(公告)号：US20150093380A1
公开(公告)日：2015-04-02
申请号：US14550585
申请日：2014-11-21
发明人： Tasuku HONJO , Nagahiro Minato , Yoshiko Iwai , Shiro Shibayama
IPC分类号： C07K16/28 , A61K45/06 , A61K9/00 , A61K39/395 , A61K47/26
CPC分类号： C07K16/2818 , A61K9/0019 , A61K31/7088 , A61K38/1774 , A61K38/212 , A61K39/3955 , A61K45/06 , A61K47/02 , A61K47/26 , A61K2039/505 , A61K2039/507 , C07K14/70521 , C07K16/18 , C07K16/2803 , C07K16/2827 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/73 , C07K2317/76 , C07K2319/30 , C12Q1/025 , G01N33/5011 , G01N33/574 , G01N2500/00 , Y02A50/39 , Y02A50/394 , Y02A50/463 , Y02A50/466
摘要： Compositions for cancer or infection treatment via immunopotentiation caused by inhibition of immunosuppressive signal induced by PD-1, PD-L1, or PD-L2 and therapies using them, immunopotentiative substrates included as the active ingredient, screening methods of the substrates for cancer or infection treatment, cell lines used for the screening methods, evaluation methods that selects the substrates for cancer treatment, and carcinoma cell transplanted mammals used for the evaluation methods.The compositions of the present invention that inhibits the function of PD-1, PD-L1, or PD-L2 are useful for cancer or infection treatment.
-
公开(公告)号：US08168179B2
公开(公告)日：2012-05-01
申请号：US12538698
申请日：2009-08-10
申请人： Tasuku Honjo , Nagahiro Minato , Yoshiko Iwai , Shiro Shibayama
发明人： Tasuku Honjo , Nagahiro Minato , Yoshiko Iwai , Shiro Shibayama
IPC分类号： A61K39/395
CPC分类号： C07K16/2818 , A61K9/0019 , A61K31/7088 , A61K38/1774 , A61K38/212 , A61K39/3955 , A61K45/06 , A61K47/02 , A61K47/26 , A61K2039/505 , A61K2039/507 , C07K14/70521 , C07K16/18 , C07K16/2803 , C07K16/2827 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/73 , C07K2317/76 , C07K2319/30 , C12Q1/025 , G01N33/5011 , G01N33/574 , G01N2500/00 , Y02A50/39 , Y02A50/394 , Y02A50/463 , Y02A50/466
摘要： Compositions for cancer or infection treatment via immunopotentiation caused by inhibition of immunosuppressive signal induced by PD-1, PD-L1, or PD-L2 and therapies using them, immunopotentiative substrates included as the active ingredient, screening methods of the substrates for cancer or infection treatment, cell lines used for the screening methods, evaluation methods that select the substrates for cancer treatment, and carcinoma cell transplanted mammals used for the evaluation methods. The compositions of the present invention that inhibits the function of PD-1, PD-L1, or PD-L2 are useful for treatment of cancer or infection.
摘要翻译： 通过由PD-1，PD-L1或PD-L2诱导的免疫抑制信号的抑制和使用它们的疗法，包括作为活性成分的免疫增强底物，用于癌症或感染的底物的筛选方法由免疫增强引起的癌症或感染治疗的组合物 治疗，用于筛选方法的细胞系，选择用于癌症治疗的底物的评价方法和用于评价方法的癌细胞移植的哺乳动物。 抑制PD-1，PD-L1或PD-L2的功能的本发明的组合物可用于治疗癌症或感染。
-
公开(公告)号：US20090297518A1
公开(公告)日：2009-12-03
申请号：US12538698
申请日：2009-08-10
申请人： Tasuku Honjo , Nagahiro Minato , Yoshiko Iwai , Shiro Shibayama
发明人： Tasuku Honjo , Nagahiro Minato , Yoshiko Iwai , Shiro Shibayama
IPC分类号： A61K39/395 , A61P31/18 , A61P31/12
CPC分类号： C07K16/2818 , A61K9/0019 , A61K31/7088 , A61K38/1774 , A61K38/212 , A61K39/3955 , A61K45/06 , A61K47/02 , A61K47/26 , A61K2039/505 , A61K2039/507 , C07K14/70521 , C07K16/18 , C07K16/2803 , C07K16/2827 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/73 , C07K2317/76 , C07K2319/30 , C12Q1/025 , G01N33/5011 , G01N33/574 , G01N2500/00 , Y02A50/39 , Y02A50/394 , Y02A50/463 , Y02A50/466
摘要： Compositions for cancer or infection treatment via immunopotentiation caused by inhibition of immunosuppressive signal induced by PD-1, PD-L1, or PD-L2 and therapies using them, immunopotentiative substrates included as the active ingredient, screening methods of the substrates for cancer or infection treatment, cell lines used for the screening methods, evaluation methods that select the substrates for cancer treatment, and carcinoma cell transplanted mammals used for the evaluation methods. The compositions of the present invention that inhibits the function of PD-1, PD-L1, or PD-L2 are useful for treatment of cancer or infection.
摘要翻译： 通过由PD-1，PD-L1或PD-L2诱导的免疫抑制信号的抑制和使用它们的疗法，包括作为活性成分的免疫增强底物，用于癌症或感染的底物的筛选方法由免疫增强引起的癌症或感染治疗的组合物 治疗，用于筛选方法的细胞系，选择用于癌症治疗的底物的评价方法和用于评价方法的癌细胞移植的哺乳动物。 抑制PD-1，PD-L1或PD-L2的功能的本发明的组合物可用于治疗癌症或感染。
-
公开(公告)号：US20110081341A1
公开(公告)日：2011-04-07
申请号：US12959307
申请日：2010-12-02
申请人： Tasuku HONJO , Nagahiro Minato , Yoshiko Iwai , Shiro Shibayama
发明人： Tasuku HONJO , Nagahiro Minato , Yoshiko Iwai , Shiro Shibayama
IPC分类号： A61K39/395 , A61P31/00 , A61P35/00
CPC分类号： C07K16/2818 , A61K9/0019 , A61K31/7088 , A61K38/1774 , A61K38/212 , A61K39/3955 , A61K45/06 , A61K47/02 , A61K47/26 , A61K2039/505 , A61K2039/507 , C07K14/70521 , C07K16/18 , C07K16/2803 , C07K16/2827 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/73 , C07K2317/76 , C07K2319/30 , C12Q1/025 , G01N33/5011 , G01N33/574 , G01N2500/00 , Y02A50/39 , Y02A50/394 , Y02A50/463 , Y02A50/466
摘要： Compositions for cancer or infection treatment via immunopotentiation caused by inhibition of immunosuppressive signal induced by PD-1, PD-L1, or PD-L2 and therapies using them, immunopotentiative substrates included as the active ingredient, screening methods of the substrates for cancer or infection treatment, cell lines used for the screening methods, evaluation methods that select the substrates for cancer treatment, and carcinoma cell transplanted mammals used for the evaluation methods. The compositions of the present invention that inhibits the function of PD-1, PD-L1, or PD-L2 are useful for treatment of cancer or infection.
摘要翻译： 通过由PD-1，PD-L1或PD-L2诱导的免疫抑制信号的抑制和使用它们的疗法，包括作为活性成分的免疫增强底物，用于癌症或感染的底物的筛选方法由免疫增强引起的癌症或感染治疗的组合物 治疗，用于筛选方法的细胞系，选择用于癌症治疗的底物的评价方法和用于评价方法的癌细胞移植的哺乳动物。 抑制PD-1，PD-L1或PD-L2的功能的本发明的组合物可用于治疗癌症或感染。
-
公开(公告)号：US08728474B2
公开(公告)日：2014-05-20
申请号：US12959307
申请日：2010-12-02
申请人： Tasuku Honjo , Nagahiro Minato , Yoshiko Iwai , Shiro Shibayama
发明人： Tasuku Honjo , Nagahiro Minato , Yoshiko Iwai , Shiro Shibayama
IPC分类号： A61K39/395
CPC分类号： C07K16/2818 , A61K9/0019 , A61K31/7088 , A61K38/1774 , A61K38/212 , A61K39/3955 , A61K45/06 , A61K47/02 , A61K47/26 , A61K2039/505 , A61K2039/507 , C07K14/70521 , C07K16/18 , C07K16/2803 , C07K16/2827 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/73 , C07K2317/76 , C07K2319/30 , C12Q1/025 , G01N33/5011 , G01N33/574 , G01N2500/00 , Y02A50/39 , Y02A50/394 , Y02A50/463 , Y02A50/466
摘要： Compositions for cancer or infection treatment via immunopotentiation caused by inhibition of immunosuppressive signal induced by PD-1, PD-L1, or PD-L2 and therapies using them, immunopotentiative substrates included as the active ingredient, screening methods of the substrates for cancer or infection treatment, cell lines used for the screening methods, evaluation methods that select the substrates for cancer treatment, and carcinoma cell transplanted mammals used for the evaluation methods. The compositions of the present invention that inhibits the function of PD-1, PD-L1, or PD-L2 are useful for treatment of cancer or infection.
摘要翻译： 通过由PD-1，PD-L1或PD-L2诱导的免疫抑制信号的抑制和使用它们的疗法，包括作为活性成分的免疫增强底物，用于癌症或感染的底物的筛选方法由免疫增强引起的癌症或感染治疗的组合物 治疗，用于筛选方法的细胞系，选择用于癌症治疗的底物的评价方法和用于评价方法的癌细胞移植的哺乳动物。 抑制PD-1，PD-L1或PD-L2的功能的本发明的组合物可用于治疗癌症或感染。
-
10.发明授权Method for treatment of cancer by inhibiting the immunosuppressive signal induced by PD-1 有权通过抑制PD-1诱导的免疫抑制信号治疗癌症的方法公开(公告)号：US07595048B2
公开(公告)日：2009-09-29
申请号：US10519925
申请日：2003-07-02
申请人： Tasuku Honjo , Nagahiro Minato , Yoshiko Iwai , Shiro Shibayama
发明人： Tasuku Honjo , Nagahiro Minato , Yoshiko Iwai , Shiro Shibayama
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2818 , A61K9/0019 , A61K31/7088 , A61K38/1774 , A61K38/212 , A61K39/3955 , A61K45/06 , A61K47/02 , A61K47/26 , A61K2039/505 , A61K2039/507 , C07K14/70521 , C07K16/18 , C07K16/2803 , C07K16/2827 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/73 , C07K2317/76 , C07K2319/30 , C12Q1/025 , G01N33/5011 , G01N33/574 , G01N2500/00 , Y02A50/39 , Y02A50/394 , Y02A50/463 , Y02A50/466
摘要： Compositions for cancer or infection treatment via immunopotentiation caused by inhibition of the immunosuppressive signal induced by PD-1, PD-L1, or PD-L2 and therapies using them, immunopotentiative substrates included as the active ingredient, screening methods of the substrates for cancer or infection treatment, cell lines used for the screening methods, evaluation methods that select the substrates for cancer treatment, and carcinoma cell transplanted mammals used for the evaluation methods. The compositions of the present invention that inhibit the function of PD-1, PD-L1, or PD-L2 are useful for treatment of cancer or infection.
摘要翻译： 通过由PD-1，PD-L1或PD-L2诱导的免疫抑制信号的抑制和使用它们的疗法，包括作为活性成分的免疫增强底物，用于癌症的底物的筛选方法或通过免疫增强 感染治疗，用于筛选方法的细胞系，选择用于癌症治疗的底物的评价方法和用于评价方法的癌细胞移植的哺乳动物。 抑制PD-1，PD-L1或PD-L2功能的本发明的组合物可用于治疗癌症或感染。
-
-
-
-
-
-
-
-
-
搜索结果
12 条记录 (耗时 0.036 秒)
