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公开(公告)号：US11299512B2
公开(公告)日：2022-04-12
申请号：US16438153
申请日：2019-06-11
Inventor： Boyu Zhong , Heping Shi , Yuanwei Dai , Qi Wei , Chuo Chen , Zhijian Chen , Lijun Sun
IPC: C07H21/02 , C07H21/04 , C07H21/00 , A61K31/7084 , A61K45/06
Abstract: Disclosed are cyclic-di-nucleotide cGAMP analogs, methods of synthesizing the compounds, pharmaceutical compositions comprising the compounds thereof, and use of compounds and compositions in medical therapy.
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公开(公告)号：US11213592B2
公开(公告)日：2022-01-04
申请号：US17317864
申请日：2021-05-11
Inventor： Zhijian Chen , Heping Shi , Qi Wei , Chuo Chen , Lijun Sun , Jian Qiu , Youtong Wu
Abstract: The present disclosure relates to, among other things, antibody-drug conjugates comprising a STING agonist cyclic di-nucleotide conjugated to an antibody, preparation methods therefor, and uses therefor.
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公开(公告)号：US09783550B2
公开(公告)日：2017-10-10
申请号：US14890905
申请日：2014-05-14
Inventor： Lawrence Lum , Chuo Chen
IPC: A61K31/33 , C07D495/04 , A61K31/519 , A61K45/06 , A61N5/10
CPC classification number: C07D495/04 , A61K31/519 , A61K45/06 , A61N5/10 , A61K2300/00
Abstract: The present invention generally relates to protein signalling. In particular, compounds that inhibit the Wnt protein signalling pathway are disclosed. Such compounds may be used in the treatment of Wnt protein signalling-related diseases and conditions such as cancer, degenerative diseases, type II diabetes and osteopetrosis.
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公开(公告)号：US09045416B2
公开(公告)日：2015-06-02
申请号：US13875170
申请日：2013-05-01
Inventor： Lawrence Lum , Michael G. Roth , Baozhi Chen , Chuo Chen , Michael E. Dodge , Wei Tang
IPC: C07D209/94 , C07D239/54 , C07D401/12 , C07D401/14 , C07D403/10 , C07D209/48 , C07D413/04 , C07D417/12 , C07D471/04 , C07D519/00 , C07D401/10
CPC classification number: A61K31/519 , A61K31/502 , A61K45/06 , C07D209/48 , C07D209/94 , C07D239/54 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D413/04 , C07D417/12 , C07D471/04 , C07D519/00
Abstract: The present invention generally relates to protein signalling. In particular, compounds that inhibit the Wnt protein signalling pathway are disclosed. Such compounds may be used in the treatment of Wnt protein signalling-related diseases and conditions such as cancer, degenerative diseases, type II diabetes and osteopetrosis.
Abstract translation: 本发明一般涉及蛋白信号传导。 特别地，公开了抑制Wnt蛋白信号通路的化合物。 这些化合物可用于治疗Wnt蛋白信号传导相关疾病和病症如癌症，退行性疾病，II型糖尿病和骨细胞减少症。
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公开(公告)号：US12281078B2
公开(公告)日：2025-04-22
申请号：US18177732
申请日：2023-03-02
Inventor： Qi Wei , Heping Shi , Matt Tschantz , Jian Qiu , Youtong Wu , Huiling Tan , Lijun Sun , Chuo Chen , Zhijian Chen
IPC: C07D215/12 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.
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Patent Agency Ranking
公开(公告)号：US12065416B2
公开(公告)日：2024-08-20
申请号：US18158046
申请日：2023-01-23
Inventor： Boyu Zhong , Lijun Sun , Heping Shi , Jing Li , Chuo Chen , Zhijian Chen
IPC: C07D277/34 , A61K31/381 , A61K31/426 , A61K31/427 , A61K31/429 , A61K31/433 , A61K31/4365 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/519 , A61K39/39 , A61K45/06 , C07D277/36 , C07D277/40 , C07D403/06 , C07D417/04 , C07D417/06 , C07D417/10 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D513/04
CPC classification number: C07D277/34 , A61K31/381 , A61K31/426 , A61K31/427 , A61K31/429 , A61K31/433 , A61K31/4365 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/519 , A61K39/39 , A61K45/06 , C07D277/36 , C07D277/40 , C07D403/06 , C07D417/04 , C07D417/06 , C07D417/10 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D513/04 , A61K31/4439 , A61K2300/00 , A61K31/4709 , A61K2300/00 , A61K31/426 , A61K2300/00 , A61K31/4365 , A61K2300/00 , A61K31/429 , A61K2300/00 , A61K31/519 , A61K2300/00 , A61K31/381 , A61K2300/00 , A61K31/427 , A61K2300/00 , A61K31/433 , A61K2300/00 , A61K31/437 , A61K2300/00 , A61K31/506 , A61K2300/00
Abstract: Disclosed are novel compounds of Formula I that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.
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公开(公告)号：US11873291B2
公开(公告)日：2024-01-16
申请号：US17446951
申请日：2021-09-03
Inventor： Jian Qiu , Qi Wei , Matt Tschantz , Heping Shi , Youtong Wu , Hulling Tan , Lijun Sun , Chuo Chen , Zhijian Chen
IPC: C07D215/38 , C07D401/14 , C07D215/42 , C07D215/46 , C07D401/04 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/08 , C07D491/048 , C07F9/6503 , C07F9/6506
CPC classification number: C07D401/14 , C07D215/38 , C07D215/42 , C07D215/46 , C07D401/04 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/08 , C07D491/048 , C07F9/6506 , C07F9/65031
Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.
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公开(公告)号：US11597707B2
公开(公告)日：2023-03-07
申请号：US17191305
申请日：2021-03-03
Inventor： Boyu Zhong , Lijun Sun , Heping Shi , Jing Li , Chuo Chen , Zhijian Chen
IPC: C07D277/34 , C07D417/14 , A61K31/429 , A61K31/4365 , A61K31/4439 , A61K31/506 , A61K31/519 , A61K31/427 , C07D277/40 , A61K31/437 , A61K31/426 , A61K31/381 , A61K31/433 , A61K31/4709 , A61K39/39 , A61K45/06 , A61K31/454 , A61K31/4725 , A61K31/497 , A61K31/4985 , A61K31/501 , C07D277/36 , C07D403/06 , C07D417/04 , C07D417/06 , C07D417/10 , C07D417/12 , C07D471/04 , C07D495/04 , C07D513/04
Abstract: Disclosed are novel compounds of Formula I that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.
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公开(公告)号：US11033635B2
公开(公告)日：2021-06-15
申请号：US16933845
申请日：2020-07-20
Inventor： Zhijian Chen , Heping Shi , Qi Wei , Chuo Chen , Lijun Sun , Jian Qiu , Youtong Wu
Abstract: The present disclosure relates to, among other things, antibody-drug conjugates comprising a STING agonist cyclic di-nucleotide conjugated to an antibody, preparation methods therefor, and uses therefor.
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公开(公告)号：US10793544B2
公开(公告)日：2020-10-06
申请号：US16330050
申请日：2017-08-31
Inventor： Nageswari Yarravarapu , Chuo Chen , Lawrence Lum , Lin You , Chengwei Zhang , Xiaolei Wang , Lishu Zhang
IPC: C07D401/12 , C07D401/14 , C07D409/14 , A61K31/4192 , C07D405/14 , A61K31/506 , A61K31/4439 , A61K31/444 , A61K45/06 , C07D255/02
Abstract: The present disclosure provides compounds that may be useful for inhibiting Wnt pathway comprising compounds of the formula: (Ia) or (Ib) wherein the variables are as defined herein. In some aspects, the compounds may be used to inhibit the Wnt pathway and used to treat cancer, myocardial infarction, osteopetrosis, or used in the maturation of a precursor cell to a mature cell. Also provided herein in are pharmaceutical compositions of the compounds described herein.
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