公开(公告)号：US20210333263A1

公开(公告)日：2021-10-28

申请号：US16333164

申请日：2017-09-12

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming GAO ,  Zhaohui WANG ,  Min LUO ,  Qi WEI ,  Gang HUANG

IPC: G01N33/50 ,  G01N33/542 ,  C09K11/07 ,  G01N21/64

Abstract: Provided herein are compounds of the formula: (I) wherein the variables are defined herein, which may be used as redox-activatable sensors. In some aspects, the compounds are fluorescence sensors which are activated by the redox state of the cell. Also provided herein are methods of using these compounds to image the cellular environment or the delivery of macromolecules to a cell.

公开(公告)号：US20190071380A1

公开(公告)日：2019-03-07

申请号：US16063347

申请日：2016-12-16

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming GAO ,  Yuliang LIU ,  Qi WEI ,  Xinpeng MA ,  Gang HUANG

IPC: C07C50/32 ,  C07C311/21 ,  C07C233/33 ,  C07C225/30 ,  C07D295/116 ,  C07C233/42 ,  C07C233/91 ,  C07C311/08 ,  A61P35/00

CPC classification number: C07C50/32 ,  A61K9/0019 ,  A61K9/5123 ,  A61K9/5146 ,  A61P35/00 ,  C07C205/46 ,  C07C225/30 ,  C07C233/18 ,  C07C233/31 ,  C07C233/33 ,  C07C233/42 ,  C07C233/91 ,  C07C271/30 ,  C07C311/08 ,  C07C311/09 ,  C07C311/21 ,  C07C311/51 ,  C07C2601/14 ,  C07C2602/10 ,  C07D295/116 ,  C07D317/70

Abstract: Provided herein are naphthoquinones compounds such as those with a hydrogen bond donating group of the formula (I): wherein: R1, R2, R3, R4, R5, and n are as defined herein. Also provided herein are pharmaceutical composition of the present compounds and methods of treatment using the compounds including their use in the treatment of cancer.