公开(公告)号：US20190071380A1

公开(公告)日：2019-03-07

申请号：US16063347

申请日：2016-12-16

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming GAO ,  Yuliang LIU ,  Qi WEI ,  Xinpeng MA ,  Gang HUANG

IPC: C07C50/32 ,  C07C311/21 ,  C07C233/33 ,  C07C225/30 ,  C07D295/116 ,  C07C233/42 ,  C07C233/91 ,  C07C311/08 ,  A61P35/00

CPC classification number: C07C50/32 ,  A61K9/0019 ,  A61K9/5123 ,  A61K9/5146 ,  A61P35/00 ,  C07C205/46 ,  C07C225/30 ,  C07C233/18 ,  C07C233/31 ,  C07C233/33 ,  C07C233/42 ,  C07C233/91 ,  C07C271/30 ,  C07C311/08 ,  C07C311/09 ,  C07C311/21 ,  C07C311/51 ,  C07C2601/14 ,  C07C2602/10 ,  C07D295/116 ,  C07D317/70

Abstract: Provided herein are naphthoquinones compounds such as those with a hydrogen bond donating group of the formula (I): wherein: R1, R2, R3, R4, R5, and n are as defined herein. Also provided herein are pharmaceutical composition of the present compounds and methods of treatment using the compounds including their use in the treatment of cancer.