公开(公告)号：US20230081291A1

公开(公告)日：2023-03-16

申请号：US17446951

申请日：2021-09-03

Applicant: ImmuneSensor Therapeutics, Inc. ,  The Board of Regents of the University of Texas System

Inventor： Jian QIU ,  Qi WEI ,  Matt TSCHANTZ ,  Heping SHI ,  Youtong WU ,  Huiling TAN ,  Lijun SUN ,  Chuo CHEN ,  Zhijian CHEN

IPC: C07D401/14 ,  C07D401/04 ,  C07D413/14 ,  C07D403/04 ,  C07D409/14 ,  C07D417/14 ,  C07D471/08 ,  C07D405/14 ,  C07F9/6506 ,  C07F9/6503 ,  C07D215/38 ,  C07D215/42 ,  C07D215/46 ,  C07D491/048

Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

公开(公告)号：US20220105198A1

公开(公告)日：2022-04-07

申请号：US17553624

申请日：2021-12-16

Applicant: ImmuneSensor Therapeutics, Inc. ,  The Board of Regents of the University of Texas System

Inventor： Zhijian CHEN ,  Heping SHI ,  Qi WEI ,  Chuo CHEN ,  Lijun SUN ,  Jian QIU ,  Youtong WU

IPC: A61K47/68 ,  A61P35/00

Abstract: The present disclosure relates to, among other things, antibody-drug conjugates comprising a STING agonist cyclic di-nucleotide conjugated to an antibody, preparation methods therefor, and uses therefor.

公开(公告)号：US20200308216A1

公开(公告)日：2020-10-01

申请号：US16903173

申请日：2020-06-16

Applicant: The Board of Regents of the University of Texas System

Inventor： Zhijian CHEN ,  Lijun SUN ,  Jiaxi WU ,  Heping SHI ,  Chuo CHEN

IPC: C07H21/02 ,  A61K39/39 ,  C12Q1/6876 ,  C12Q1/25 ,  G01N33/573 ,  A61K31/7084 ,  G01N33/564

Abstract: Cyclic-GMP-AMP synthase (cGAS) and cyclic-GMP-AMP (cGAMP), including 2′3-cGAMP, 2′2-cGAMP, 3′2′-cGAMP and 3′3′-GAMP, are used in pharmaceutical formulations (including vaccine adjuvants), drug screens, therapies, and diagnostics.

公开(公告)号：US20200010501A1

公开(公告)日：2020-01-09

申请号：US16438153

申请日：2019-06-11

Applicant: ImmuneSensor Therapeutics, Inc. ,  The Board of Regents of the University of Texas System

Inventor： Boyu ZHONG ,  Heping SHI ,  Yuanwei DAI ,  Qi WEI ,  Chuo CHEN ,  Zhijian CHEN ,  Lijun SUN

IPC: C07H21/02 ,  C07H21/04 ,  A61K31/7084 ,  A61K45/06

Abstract: Disclosed are cyclic-di-nucleotide cGAMP analogs, methods of synthesizing the compounds, pharmaceutical compositions comprising the compounds thereof, and use of compounds and compositions in medical therapy.

公开(公告)号：US20240092760A1

公开(公告)日：2024-03-21

申请号：US18334325

申请日：2023-06-13

Applicant: IMMUNESENSOR THERAPEUTICS, INC. ,  THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Jian QIU ,  Qi WEI ,  Matt TSCHANTZ ,  Heping SHI ,  Youtong WU ,  Huiling TAN ,  Lijun SUN ,  Chuo CHEN ,  Zhijian CHEN

IPC: C07D401/14 ,  C07D215/38 ,  C07D215/42 ,  C07D215/46 ,  C07D401/04 ,  C07D403/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/08 ,  C07D491/048 ,  C07F9/6503 ,  C07F9/6506

CPC classification number: C07D401/14 ,  C07D215/38 ,  C07D215/42 ,  C07D215/46 ,  C07D401/04 ,  C07D403/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/08 ,  C07D491/048 ,  C07F9/65031 ,  C07F9/6506

Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

公开(公告)号：US20230270773A1

公开(公告)日：2023-08-31

申请号：US17768922

申请日：2020-10-14

Applicant: Immunesensor Therapeutics, Inc. ,  The Board of Regents of the University of Texas System

Inventor： Zhijian CHEN ,  Lijun SUN

IPC: A61K31/708 ,  C07K16/28 ,  A61P35/00

CPC classification number: A61K31/708 ,  A61P35/00 ,  C07K16/2818 ,  C07K16/2827

Abstract: The disclosure provides methods of treating a cancer in a patient by administering a compound (“Compound A”) having the following structure or a pharmaceutically acceptable salt thereof: at particular dosing regimens and, optionally, in combination with one or more compounds that inhibit immune checkpoint proteins.

公开(公告)号：US20220356158A1

公开(公告)日：2022-11-10

申请号：US17191305

申请日：2021-03-03

Applicant: ImmuneSensor Therapeutics, Inc. ,  The Board of Regents of the University of Texas System

Inventor： Boyu ZHONG ,  Lijun SUN ,  Heping SHI ,  Jing LI ,  Chuo CHEN ,  Zhijian CHEN

IPC: C07D277/34 ,  C07D417/14 ,  A61K31/429 ,  A61K31/4365 ,  A61K31/4439 ,  A61K31/506 ,  A61K31/519 ,  A61K31/427 ,  C07D277/40 ,  A61K31/437 ,  A61K31/426 ,  A61K31/381 ,  A61K31/433 ,  A61K31/4709 ,  A61K39/39 ,  A61K45/06 ,  A61K31/454 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/4985 ,  A61K31/501 ,  C07D277/36 ,  C07D403/06 ,  C07D417/04 ,  C07D417/06 ,  C07D417/10 ,  C07D417/12 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04

Abstract: Disclosed are novel compounds of Formula I that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

公开(公告)号：US20210290774A1

公开(公告)日：2021-09-23

申请号：US17317864

申请日：2021-05-11

Applicant: ImmuneSensor Therapeutics, Inc. ,  The Board of Regents of the University of Texas System

Inventor： Zhijian CHEN ,  Heping SHI ,  Qi WEI ,  Chuo CHEN ,  Lijun SUN ,  Jian QIU ,  Youtong WU

IPC: A61K47/68 ,  A61P35/00

Abstract: The present disclosure relates to, among other things, antibody-drug conjugates comprising a STING agonist cyclic di-nucleotide conjugated to an antibody, preparation methods therefor, and uses therefor.