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公开(公告)号：US20240043393A1
公开(公告)日：2024-02-08
申请号：US18158046
申请日：2023-01-23
Inventor： Boyu ZHONG , Lijun SUN , Heping SHI , Jing LI , Chuo CHEN , Zhijian CHEN
IPC: C07D277/34 , C07D417/14 , A61K31/429 , A61K31/4365 , A61K31/4439 , A61K31/506 , A61K31/519 , A61K31/427 , C07D277/40 , A61K31/437 , A61K31/426 , A61K31/381 , A61K31/433 , A61K31/4709 , A61K39/39 , A61K45/06 , A61K31/454 , A61K31/4725 , A61K31/497 , A61K31/4985 , A61K31/501 , C07D277/36 , C07D403/06 , C07D417/04 , C07D417/06 , C07D417/10 , C07D417/12 , C07D471/04 , C07D495/04 , C07D513/04
CPC classification number: C07D277/34 , C07D513/04 , A61K31/429 , A61K31/4365 , A61K31/4439 , A61K31/506 , A61K31/519 , A61K31/427 , C07D277/40 , A61K31/437 , A61K31/426 , A61K31/381 , A61K31/433 , A61K31/4709 , A61K39/39 , A61K45/06 , A61K31/454 , A61K31/4725 , A61K31/497 , A61K31/4985 , A61K31/501 , C07D277/36 , C07D403/06 , C07D417/04 , C07D417/06 , C07D417/10 , C07D417/12 , C07D471/04 , C07D495/04 , C07D417/14
Abstract: Disclosed are novel compounds of Formula I that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.
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公开(公告)号：US20230357158A1
公开(公告)日：2023-11-09
申请号：US18353718
申请日：2023-07-17
Inventor： Qi WEI , Heping SHI , Matt TSCHANTZ , Jian QIU , Youtong WU , Huiling TAN , Lijun SUN , Chuo CHEN , Zhijian CHEN
IPC: C07D215/12 , C07D417/14 , C07D413/14 , C07D405/14 , C07D401/04 , C07D401/14 , C07D409/14
CPC classification number: C07D215/12 , C07D417/14 , C07D413/14 , C07D405/14 , C07D401/04 , C07D401/14 , C07D409/14
Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.
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公开(公告)号：US20180230115A1
公开(公告)日：2018-08-16
申请号：US15953494
申请日：2018-04-15
Inventor： Boyu ZHONG , Lijun SUN , Heping SHI , Jing Li , Chuo CHEN , Zhijian CHEN
IPC: C07D277/34 , C07D417/06 , A61K31/4439 , C07D417/04 , A61K31/4725 , A61K31/497 , A61K31/506 , C07D403/06 , A61K31/501 , C07D513/04 , A61K31/429 , C07D277/36 , C07D417/12 , C07D495/04 , A61K31/4365 , C07D417/10 , A61K31/4985 , A61K31/519 , C07D417/14 , C07D471/04 , A61K31/454
CPC classification number: C07D277/34 , A61K31/381 , A61K31/426 , A61K31/427 , A61K31/429 , A61K31/433 , A61K31/4365 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/519 , A61K39/39 , A61K45/06 , C07D277/36 , C07D277/40 , C07D403/06 , C07D417/04 , C07D417/06 , C07D417/10 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D513/04 , A61K2300/00
Abstract: Disclosed are novel compounds of Formula I that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.
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公开(公告)号：US20210380695A1
公开(公告)日：2021-12-09
申请号：US17322827
申请日：2021-05-17
Inventor： Zhijian CHEN , Lijun SUN
IPC: C07K16/28 , A61K31/7084 , A61K47/68 , A61P35/00
Abstract: The disclosure provides, among other things, methods and uses for treating a disease or disorder, particularly a cancer, in a patient, comprising conjointly administering a CTLA4 inhibitor (e.g., an anti-CTLA4 antibody) and a STING agonist to the patient, wherein the CTLA4 inhibitor is administered intratumorally to the patient. The STING agonist can be administered intratumorally, orally or systemically (e.g., intravenously, intramuscularly, or subcutaneously) to the patient.
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公开(公告)号：US20210015941A1
公开(公告)日：2021-01-21
申请号：US16933845
申请日：2020-07-20
Inventor： Zhijian CHEN , Heping SHI , Qi WEI , Chuo CHEN , Lijun SUN , Jian QIU , Youtong WU
Abstract: The present disclosure relates to, among other things, antibody-drug conjugates comprising a STING agonist cyclic di-nucleotide conjugated to an antibody, preparation methods therefor, and uses therefor.
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Patent Agency Ranking
公开(公告)号：US20220340613A1
公开(公告)日：2022-10-27
申请号：US17697247
申请日：2022-03-17
Inventor： Boyu ZHONG , Heping SHI , Yuanwei DAI , Qi WEI , Chuo CHEN , Zhijian CHEN , Lijun SUN
IPC: C07H21/02 , A61K45/06 , C07H21/00 , A61K31/7084 , C07H21/04
Abstract: Disclosed are cyclic-di-nucleotide cGAMP analogs, methods of synthesizing the compounds, pharmaceutical compositions comprising the compounds thereof, and use of compounds and compositions in medical therapy.
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公开(公告)号：US20180230177A1
公开(公告)日：2018-08-16
申请号：US15953492
申请日：2018-04-15
Inventor： Boyu ZHONG , Lijun SUN , Heping SHI , Qi WEI , Yuanwei DAI , Chuo CHEN , Zhijian CHEN
IPC: C07H21/02 , A61K31/7084 , A61K45/06 , C07H21/04
CPC classification number: C07H21/02 , A61K31/7084 , A61K45/06 , C07H21/00 , C07H21/04
Abstract: Disclosed are cyclic-di-nucleotide cGAMP analogs, methods of synthesizing the compounds, pharmaceutical compositions comprising the compounds thereof, and use of compounds and compositions in medical therapy.
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公开(公告)号：US20240092760A1
公开(公告)日：2024-03-21
申请号：US18334325
申请日：2023-06-13
Inventor： Jian QIU , Qi WEI , Matt TSCHANTZ , Heping SHI , Youtong WU , Huiling TAN , Lijun SUN , Chuo CHEN , Zhijian CHEN
IPC: C07D401/14 , C07D215/38 , C07D215/42 , C07D215/46 , C07D401/04 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/08 , C07D491/048 , C07F9/6503 , C07F9/6506
CPC classification number: C07D401/14 , C07D215/38 , C07D215/42 , C07D215/46 , C07D401/04 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/08 , C07D491/048 , C07F9/65031 , C07F9/6506
Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.
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公开(公告)号：US20230270773A1
公开(公告)日：2023-08-31
申请号：US17768922
申请日：2020-10-14
Inventor： Zhijian CHEN , Lijun SUN
IPC: A61K31/708 , C07K16/28 , A61P35/00
CPC classification number: A61K31/708 , A61P35/00 , C07K16/2818 , C07K16/2827
Abstract: The disclosure provides methods of treating a cancer in a patient by administering a compound (“Compound A”) having the following structure or a pharmaceutically acceptable salt thereof: at particular dosing regimens and, optionally, in combination with one or more compounds that inhibit immune checkpoint proteins.
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公开(公告)号：US20220356158A1
公开(公告)日：2022-11-10
申请号：US17191305
申请日：2021-03-03
Inventor： Boyu ZHONG , Lijun SUN , Heping SHI , Jing LI , Chuo CHEN , Zhijian CHEN
IPC: C07D277/34 , C07D417/14 , A61K31/429 , A61K31/4365 , A61K31/4439 , A61K31/506 , A61K31/519 , A61K31/427 , C07D277/40 , A61K31/437 , A61K31/426 , A61K31/381 , A61K31/433 , A61K31/4709 , A61K39/39 , A61K45/06 , A61K31/454 , A61K31/4725 , A61K31/497 , A61K31/4985 , A61K31/501 , C07D277/36 , C07D403/06 , C07D417/04 , C07D417/06 , C07D417/10 , C07D417/12 , C07D471/04 , C07D495/04 , C07D513/04
Abstract: Disclosed are novel compounds of Formula I that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.
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