公开(公告)号：US20240043393A1

公开(公告)日：2024-02-08

申请号：US18158046

申请日：2023-01-23

Applicant: IMMUNESENSOR THERAPEUTICS, INC. ,  THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Boyu ZHONG ,  Lijun SUN ,  Heping SHI ,  Jing LI ,  Chuo CHEN ,  Zhijian CHEN

IPC: C07D277/34 ,  C07D417/14 ,  A61K31/429 ,  A61K31/4365 ,  A61K31/4439 ,  A61K31/506 ,  A61K31/519 ,  A61K31/427 ,  C07D277/40 ,  A61K31/437 ,  A61K31/426 ,  A61K31/381 ,  A61K31/433 ,  A61K31/4709 ,  A61K39/39 ,  A61K45/06 ,  A61K31/454 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/4985 ,  A61K31/501 ,  C07D277/36 ,  C07D403/06 ,  C07D417/04 ,  C07D417/06 ,  C07D417/10 ,  C07D417/12 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04

CPC classification number: C07D277/34 ,  C07D513/04 ,  A61K31/429 ,  A61K31/4365 ,  A61K31/4439 ,  A61K31/506 ,  A61K31/519 ,  A61K31/427 ,  C07D277/40 ,  A61K31/437 ,  A61K31/426 ,  A61K31/381 ,  A61K31/433 ,  A61K31/4709 ,  A61K39/39 ,  A61K45/06 ,  A61K31/454 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/4985 ,  A61K31/501 ,  C07D277/36 ,  C07D403/06 ,  C07D417/04 ,  C07D417/06 ,  C07D417/10 ,  C07D417/12 ,  C07D471/04 ,  C07D495/04 ,  C07D417/14

Abstract: Disclosed are novel compounds of Formula I that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

公开(公告)号：US20230357158A1

公开(公告)日：2023-11-09

申请号：US18353718

申请日：2023-07-17

Applicant: IMMUNESENSOR THERAPEUTICS, INC. ,  THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Qi WEI ,  Heping SHI ,  Matt TSCHANTZ ,  Jian QIU ,  Youtong WU ,  Huiling TAN ,  Lijun SUN ,  Chuo CHEN ,  Zhijian CHEN

IPC: C07D215/12 ,  C07D417/14 ,  C07D413/14 ,  C07D405/14 ,  C07D401/04 ,  C07D401/14 ,  C07D409/14

CPC classification number: C07D215/12 ,  C07D417/14 ,  C07D413/14 ,  C07D405/14 ,  C07D401/04 ,  C07D401/14 ,  C07D409/14

Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

公开(公告)号：US20180230115A1

公开(公告)日：2018-08-16

申请号：US15953494

申请日：2018-04-15

Applicant: IMMUNE SENSOR, LLC ,  The Board of Regents of the University of Texas System

Inventor： Boyu ZHONG ,  Lijun SUN ,  Heping SHI ,  Jing Li ,  Chuo CHEN ,  Zhijian CHEN

IPC: C07D277/34 ,  C07D417/06 ,  A61K31/4439 ,  C07D417/04 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/506 ,  C07D403/06 ,  A61K31/501 ,  C07D513/04 ,  A61K31/429 ,  C07D277/36 ,  C07D417/12 ,  C07D495/04 ,  A61K31/4365 ,  C07D417/10 ,  A61K31/4985 ,  A61K31/519 ,  C07D417/14 ,  C07D471/04 ,  A61K31/454

CPC classification number: C07D277/34 ,  A61K31/381 ,  A61K31/426 ,  A61K31/427 ,  A61K31/429 ,  A61K31/433 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/506 ,  A61K31/519 ,  A61K39/39 ,  A61K45/06 ,  C07D277/36 ,  C07D277/40 ,  C07D403/06 ,  C07D417/04 ,  C07D417/06 ,  C07D417/10 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04 ,  A61K2300/00

Abstract: Disclosed are novel compounds of Formula I that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

公开(公告)号：US20210380695A1

公开(公告)日：2021-12-09

申请号：US17322827

申请日：2021-05-17

Applicant: ImmuneSensor Therapeutics, Inc. ,  The Board of Regents of the University of Texas System

Inventor： Zhijian CHEN ,  Lijun SUN

IPC: C07K16/28 ,  A61K31/7084 ,  A61K47/68 ,  A61P35/00

Abstract: The disclosure provides, among other things, methods and uses for treating a disease or disorder, particularly a cancer, in a patient, comprising conjointly administering a CTLA4 inhibitor (e.g., an anti-CTLA4 antibody) and a STING agonist to the patient, wherein the CTLA4 inhibitor is administered intratumorally to the patient. The STING agonist can be administered intratumorally, orally or systemically (e.g., intravenously, intramuscularly, or subcutaneously) to the patient.

公开(公告)号：US20210015941A1

公开(公告)日：2021-01-21

申请号：US16933845

申请日：2020-07-20

Applicant: ImmuneSensor Therapeutics, Inc. ,  The Board of Regents of the University of Texas System

Inventor： Zhijian CHEN ,  Heping SHI ,  Qi WEI ,  Chuo CHEN ,  Lijun SUN ,  Jian QIU ,  Youtong WU

IPC: A61K47/68 ,  A61P35/00

Abstract: The present disclosure relates to, among other things, antibody-drug conjugates comprising a STING agonist cyclic di-nucleotide conjugated to an antibody, preparation methods therefor, and uses therefor.

公开(公告)号：US20190060446A1

公开(公告)日：2019-02-28

申请号：US16081911

申请日：2017-03-02

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Jinming GAO ,  Zhijian CHEN ,  Min LUO ,  Zhaohui WANG ,  Hua WANG ,  Haocheng CAI ,  Gang HUANG ,  Yang-Xin FU

IPC: A61K39/39 ,  A61K39/00 ,  A61K9/51 ,  A61K39/145

Abstract: In some aspects, the present disclosure provides vaccine compositions comprising an antigen and a diblock copolymer wherein the diblock copolymer is pH responsive. In some embodiments, these compositions activate the STING and/or the interferon receptor pathways. In some embodiments, the diblock copolymer hits a pKa from about 6 to about 7.5. Also provided herein are methods of treatment using these compositions to treat an infectious disease or cancer.

公开(公告)号：US20220340613A1

公开(公告)日：2022-10-27

申请号：US17697247

申请日：2022-03-17

Applicant: ImmuneSensor Therapeutics, Inc. ,  The Board of Regents of The University of Texas System

Inventor： Boyu ZHONG ,  Heping SHI ,  Yuanwei DAI ,  Qi WEI ,  Chuo CHEN ,  Zhijian CHEN ,  Lijun SUN

IPC: C07H21/02 ,  A61K45/06 ,  C07H21/00 ,  A61K31/7084 ,  C07H21/04

Abstract: Disclosed are cyclic-di-nucleotide cGAMP analogs, methods of synthesizing the compounds, pharmaceutical compositions comprising the compounds thereof, and use of compounds and compositions in medical therapy.

公开(公告)号：US20180230177A1

公开(公告)日：2018-08-16

申请号：US15953492

申请日：2018-04-15

Applicant: IMMUNE SENSOR, LLC ,  The Board of Regents of the University of Texas System

Inventor： Boyu ZHONG ,  Lijun SUN ,  Heping SHI ,  Qi WEI ,  Yuanwei DAI ,  Chuo CHEN ,  Zhijian CHEN

IPC: C07H21/02 ,  A61K31/7084 ,  A61K45/06 ,  C07H21/04

CPC classification number: C07H21/02 ,  A61K31/7084 ,  A61K45/06 ,  C07H21/00 ,  C07H21/04

Abstract: Disclosed are cyclic-di-nucleotide cGAMP analogs, methods of synthesizing the compounds, pharmaceutical compositions comprising the compounds thereof, and use of compounds and compositions in medical therapy.

公开(公告)号：US20240002346A1

公开(公告)日：2024-01-04

申请号：US18177732

申请日：2023-03-02

Applicant: IMMUNESENSOR THERAPEUTICS, INC. ,  THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Qi WEI ,  Heping SHI ,  Matt TSCHANTZ ,  Jian QIU ,  Youtong WU ,  Huiling TAN ,  Lijun SUN ,  Chuo CHEN ,  Zhijian CHEN

IPC: C07D215/12 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D409/14 ,  C07D417/14

CPC classification number: C07D215/12 ,  C07D401/04 ,  C07D401/14 ,  C07D417/14 ,  C07D413/14 ,  C07D409/14 ,  C07D405/14

Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

公开(公告)号：US20230121320A1

公开(公告)日：2023-04-20

申请号：US17814824

申请日：2022-07-25

Applicant: IMMUNESENSOR THERAPEUTICS, INC. ,  THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Zhijian CHEN ,  Lijun SUN ,  Youtong WU ,  Huiling TAN

IPC: A61K38/20 ,  A61K31/7052 ,  A61P35/00

Abstract: The disclosure provides, among other things, methods and uses for treating a disease or disorder, particularly tumors of a cancer patient, comprising conjointly administering effective amounts of a STING agonist, a cytokine, and an optional immune checkpoint inhibitor to the patient, wherein the STING agonist or the cytokine is intratumorally administered to the patient.