-
公开(公告)号:US09073913B2
公开(公告)日:2015-07-07
申请号:US12934228
申请日:2009-03-23
申请人: Volker Gekeler , Thomas Maier , Astrid Zimmermann , Hans-Peter Hofmann , Sanjeev A. Kulkarni , Anil P. Jagtap , Ganesh S. Chaure
发明人: Volker Gekeler , Thomas Maier , Astrid Zimmermann , Hans-Peter Hofmann , Sanjeev A. Kulkarni , Anil P. Jagtap , Ganesh S. Chaure
IPC分类号: A61K31/44 , C07D471/04
CPC分类号: C07D471/04 , A61K31/4745 , C07D453/04 , Y02A50/409 , Y02A50/414
摘要: Imidazoquinolines of formula I that contain substituted amine or amide functionality at 1-position and that are effective as Toll like Receptor 7 activators are disclosed. These compounds are useful as anticancer agents.
摘要翻译: 公开了在1-位含有取代的胺或酰胺官能团并且作为Toll样受体7激活剂有效的式I的咪唑并喹啉。 这些化合物可用作抗癌剂。
-
公开(公告)号:US20100104659A1
公开(公告)日:2010-04-29
申请号:US12373433
申请日:2007-07-12
申请人: Matthias Vennemann , Thomas Bär , Thomas Maier , Andreas Lindenmaier , Jürgen Braunger , Markus Boehm , Astrid Zimmermann , Volker Gekeler
发明人: Matthias Vennemann , Thomas Bär , Thomas Maier , Andreas Lindenmaier , Jürgen Braunger , Markus Boehm , Astrid Zimmermann , Volker Gekeler
IPC分类号: A61K31/4162 , C07D491/04 , C07D471/02 , C07D401/14 , C07D403/14 , A61K31/4738 , A61K31/454 , A61K31/496 , A61K33/24 , A61P35/00 , A61K31/397
CPC分类号: C07D491/04
摘要: Compounds of a certain formula I, in which Ra, Rb and Rc have the meanings indicated in the description, are effective compounds with anti-proliferative and/or apoptosis inducing activity.
摘要翻译: 其中Ra,Rb和Rc具有说明书中所示含义的某种式I化合物是具有抗增殖和/或凋亡诱导活性的有效化合物。
-
公开(公告)号:US20110245289A1
公开(公告)日:2011-10-06
申请号:US12934228
申请日:2009-03-23
申请人: Volker Gekeler , Thomas Maier , Astrid Zimmermann , Hans-Peter Hofmann , Sanjeev Kulkarni , Anil Jagtap , Ganesh Chaure
发明人: Volker Gekeler , Thomas Maier , Astrid Zimmermann , Hans-Peter Hofmann , Sanjeev Kulkarni , Anil Jagtap , Ganesh Chaure
IPC分类号: A61K31/4745 , C07D471/04 , A61P31/12 , A61P35/00
CPC分类号: C07D471/04 , A61K31/4745 , C07D453/04 , Y02A50/409 , Y02A50/414
摘要: Imidazoquinolines of formula I that contain substituted amine or amide functionality at 1-position and that are effective as Toll like Receptor 7 activators are disclosed. These compounds are useful as anticancer agents.
摘要翻译: 公开了在1-位含有取代的胺或酰胺官能团并且作为Toll样受体7激活剂有效的式I的咪唑并喹啉。 这些化合物可用作抗癌剂。
-
公开(公告)号:US07842820B2
公开(公告)日:2010-11-30
申请号:US10591477
申请日:2005-03-10
申请人: Thomas Maier , Thomas Beckers , Thomas Baer , Petra Gimmnich , Frank Dullweber , Matthias Vennemann
发明人: Thomas Maier , Thomas Beckers , Thomas Baer , Petra Gimmnich , Frank Dullweber , Matthias Vennemann
IPC分类号: C07D207/46 , A61K31/40
CPC分类号: A61K31/40 , C07D207/48 , C07D401/12 , C07D403/12 , C07D409/12 , C07D409/14 , C07D413/12
摘要: Compounds of the formula I in which the substitutents have the definitions provided in the specification, are novel, effective HDAC inhibitors.
摘要翻译: 其中取代基具有说明书中提供的定义的式I化合物是新的有效的HDAC抑制剂。
-
公开(公告)号:US20100261761A1
公开(公告)日:2010-10-14
申请号:US12822606
申请日:2010-06-24
申请人: Thomas Maier , Thomas Beckers , Thomas Baer , Petra Gimmnich , Frank Dullweber , Matthias Vennemann
发明人: Thomas Maier , Thomas Beckers , Thomas Baer , Petra Gimmnich , Frank Dullweber , Matthias Vennemann
IPC分类号: A61K31/415 , A61K31/4025 , A61K31/44
CPC分类号: A61K31/40 , C07D207/48 , C07D401/12 , C07D403/12 , C07D409/12 , C07D409/14 , C07D413/12
摘要: Compounds of a certain formula (I), in which R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in the description, are novel effective HDAC inhibitors.
摘要翻译: 其中R 1,R 2,R 3,R 4,R 5,R 6和R 7具有说明书中所示含义的某种式(I)的化合物是新的有效的HDAC抑制剂。
-
公开(公告)号:US08067615B2
公开(公告)日:2011-11-29
申请号:US12822641
申请日:2010-06-24
申请人: Thomas Maier , Thomas Beckers , Thomas Baer , Petra Gimmnich , Frank Dullweber , Matthias Vennemann
发明人: Thomas Maier , Thomas Beckers , Thomas Baer , Petra Gimmnich , Frank Dullweber , Matthias Vennemann
IPC分类号: C07D231/10
CPC分类号: A61K31/40 , C07D207/48 , C07D401/12 , C07D403/12 , C07D409/12 , C07D409/14 , C07D413/12
摘要: Compounds of a certain formula (I), in which R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in the description, are novel effective HDAC inhibitors.
摘要翻译: 其中R 1,R 2,R 3,R 4,R 5,R 6和R 7具有说明书中所示含义的某种式(I)的化合物是新的有效的HDAC抑制剂。
-
公开(公告)号:US08399505B2
公开(公告)日:2013-03-19
申请号:US12822606
申请日:2010-06-24
申请人: Thomas Maier , Thomas Beckers , Thomas Baer , Petra Gimmnich , Frank Dullweber , Matthias Vennemann
发明人: Thomas Maier , Thomas Beckers , Thomas Baer , Petra Gimmnich , Frank Dullweber , Matthias Vennemann
IPC分类号: A61K31/40 , C07D207/34
CPC分类号: A61K31/40 , C07D207/48 , C07D401/12 , C07D403/12 , C07D409/12 , C07D409/14 , C07D413/12
摘要: Compounds of a certain formula (I), in which R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in the description, are novel effective HDAC inhibitors.
-
公开(公告)号:US20070184979A1
公开(公告)日:2007-08-09
申请号:US10591477
申请日:2005-03-10
申请人: Thomas Maier , Thomas Beckers , Thomas Baer , Petra Gimmnich , Frank Dullweber , Matthias Vennemann
发明人: Thomas Maier , Thomas Beckers , Thomas Baer , Petra Gimmnich , Frank Dullweber , Matthias Vennemann
IPC分类号: A01N25/32
CPC分类号: A61K31/40 , C07D207/48 , C07D401/12 , C07D403/12 , C07D409/12 , C07D409/14 , C07D413/12
摘要: Compounds of the formula I in which the substitutents have the definitions provided in the specification, are novel, effective HDAC inhibitors.
摘要翻译: 其中取代基具有说明书中提供的定义的式I化合物是新的有效的HDAC抑制剂。
-
19.3,4,4A,10B-TETRAHYDRO-1H-THIOPYRANO-[4,3-c] ISOQUINOLINE DERIVATIVES 有权
标题翻译: 3,4,4A,10B-TETRAHYDRO-1H-噻吩并[4,3-c]异喹啉衍生物公开(公告)号:US20120289474A1
公开(公告)日:2012-11-15
申请号:US13515214
申请日:2010-12-15
申请人: Dieter Flockerzi , Thomas Stengel , Alexander Mann , Harald Ohmer , Ulrich Kautz , Steffen Weinbrenner , Stefan Fischer , Christof Zitt , Armin Hatzelmann , Torsten Dunkern , Christian Hesslinger , Thomas Maier , Hermann Tenor , Clemens Braun , Raimund Külzer , Degenhard Marx
发明人: Dieter Flockerzi , Thomas Stengel , Alexander Mann , Harald Ohmer , Ulrich Kautz , Steffen Weinbrenner , Stefan Fischer , Christof Zitt , Armin Hatzelmann , Torsten Dunkern , Christian Hesslinger , Thomas Maier , Hermann Tenor , Clemens Braun , Raimund Külzer , Degenhard Marx
IPC分类号: A61K31/519 , A61K31/56 , A61K31/5585 , A61K31/59 , A61K31/7048 , A61P9/12 , A61P31/00 , A61P7/02 , A61P7/10 , A61P11/00 , A61P11/06 , A61P11/08 , C07D495/04 , A61P37/06
CPC分类号: C07D519/00
摘要: The compounds of Formula (1), in which A, R1, R2, R3 and R5 have the meanings as given in the description, are novel effective inhibitors of type 4 and 5 phosphodiesterase.
摘要翻译: 其中A,R1,R2,R3和R5具有如说明书中给出的含义的式(1)化合物是4型和5型磷酸二酯酶的新型有效抑制剂。
-
20.3,4,4a,10b-Tetrahydro-1H-thiopyrano-[44,3-c] isoquinoline derivatives 有权
标题翻译: 3,4,4a,10b-四氢-1H-噻喃并[4,3-c]异喹啉衍生物公开(公告)号:US09018175B2
公开(公告)日:2015-04-28
申请号:US13515214
申请日:2010-12-15
申请人: Dieter Flockerzi , Thomas Stengel , Alexander Mann , Harald Ohmer , Ulrich Kautz , Steffen Weinbrenner , Stefan Fischer , Christof Zitt , Armin Hatzelmann , Torsten Dunkern , Christian Hesslinger , Thomas Maier , Hermann Tenor , Clemens Braun , Raimund Külzer , Degenhard Marx
发明人: Dieter Flockerzi , Thomas Stengel , Alexander Mann , Harald Ohmer , Ulrich Kautz , Steffen Weinbrenner , Stefan Fischer , Christof Zitt , Armin Hatzelmann , Torsten Dunkern , Christian Hesslinger , Thomas Maier , Hermann Tenor , Clemens Braun , Raimund Külzer , Degenhard Marx
IPC分类号: A61K31/56 , A61K31/519 , A61K31/5585 , C07D495/04 , C07D519/00
CPC分类号: C07D519/00
摘要: The compounds of Formula (1), in which A, R1, R2, R3 and R5 have the meanings as given in the description, are novel effective inhibitors of type 4 and 5 phosphodiesterase.
摘要翻译: 其中A,R1,R2,R3和R5具有如说明书中给出的含义的式(1)化合物是4型和5型磷酸二酯酶的新型有效抑制剂。
-
-
-
-
-
-
-
-
-