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1.3,4,4a,10b-Tetrahydro-1H-thiopyrano-[44,3-c] isoquinoline derivatives 有权
标题翻译: 3,4,4a,10b-四氢-1H-噻喃并[4,3-c]异喹啉衍生物公开(公告)号:US09018175B2
公开(公告)日:2015-04-28
申请号:US13515214
申请日:2010-12-15
申请人: Dieter Flockerzi , Thomas Stengel , Alexander Mann , Harald Ohmer , Ulrich Kautz , Steffen Weinbrenner , Stefan Fischer , Christof Zitt , Armin Hatzelmann , Torsten Dunkern , Christian Hesslinger , Thomas Maier , Hermann Tenor , Clemens Braun , Raimund Külzer , Degenhard Marx
发明人: Dieter Flockerzi , Thomas Stengel , Alexander Mann , Harald Ohmer , Ulrich Kautz , Steffen Weinbrenner , Stefan Fischer , Christof Zitt , Armin Hatzelmann , Torsten Dunkern , Christian Hesslinger , Thomas Maier , Hermann Tenor , Clemens Braun , Raimund Külzer , Degenhard Marx
IPC分类号: A61K31/56 , A61K31/519 , A61K31/5585 , C07D495/04 , C07D519/00
CPC分类号: C07D519/00
摘要: The compounds of Formula (1), in which A, R1, R2, R3 and R5 have the meanings as given in the description, are novel effective inhibitors of type 4 and 5 phosphodiesterase.
摘要翻译: 其中A,R1,R2,R3和R5具有如说明书中给出的含义的式(1)化合物是4型和5型磷酸二酯酶的新型有效抑制剂。
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2.3,4,4A,10B-TETRAHYDRO-1H-THIOPYRANO-[4,3-c] ISOQUINOLINE DERIVATIVES 有权
标题翻译: 3,4,4A,10B-TETRAHYDRO-1H-噻吩并[4,3-c]异喹啉衍生物公开(公告)号:US20120289474A1
公开(公告)日:2012-11-15
申请号:US13515214
申请日:2010-12-15
申请人: Dieter Flockerzi , Thomas Stengel , Alexander Mann , Harald Ohmer , Ulrich Kautz , Steffen Weinbrenner , Stefan Fischer , Christof Zitt , Armin Hatzelmann , Torsten Dunkern , Christian Hesslinger , Thomas Maier , Hermann Tenor , Clemens Braun , Raimund Külzer , Degenhard Marx
发明人: Dieter Flockerzi , Thomas Stengel , Alexander Mann , Harald Ohmer , Ulrich Kautz , Steffen Weinbrenner , Stefan Fischer , Christof Zitt , Armin Hatzelmann , Torsten Dunkern , Christian Hesslinger , Thomas Maier , Hermann Tenor , Clemens Braun , Raimund Külzer , Degenhard Marx
IPC分类号: A61K31/519 , A61K31/56 , A61K31/5585 , A61K31/59 , A61K31/7048 , A61P9/12 , A61P31/00 , A61P7/02 , A61P7/10 , A61P11/00 , A61P11/06 , A61P11/08 , C07D495/04 , A61P37/06
CPC分类号: C07D519/00
摘要: The compounds of Formula (1), in which A, R1, R2, R3 and R5 have the meanings as given in the description, are novel effective inhibitors of type 4 and 5 phosphodiesterase.
摘要翻译: 其中A,R1,R2,R3和R5具有如说明书中给出的含义的式(1)化合物是4型和5型磷酸二酯酶的新型有效抑制剂。
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3.NOVEL 3,4,4A,10B-TETRAHYDRO-1H-THIOPYRANO[4,3-C] ISOQUINOLINE COMPOUNDS 审中-公开
标题翻译: 新的3,4,4A,10B-四氢-1H-苯并[4,3-C]异喹啉化合物公开(公告)号:US20140113877A1
公开(公告)日:2014-04-24
申请号:US14124446
申请日:2012-06-12
申请人: Dieter Flockerzi , Alexander Mann , Thomas Stengel , Harald Ohmer , Ulrich Kautz , Steffen Weinbrenner , Stefan Fischer , Hermann Tenor , Christof Zitt , Armin Hatzelmann , Torsten Dunkern , Christian Hesslinger , Clemens Braun , Ewald Benediktus , Andreas Pahl , Raimund Kuelzer , Degenhard Marx
发明人: Dieter Flockerzi , Alexander Mann , Thomas Stengel , Harald Ohmer , Ulrich Kautz , Steffen Weinbrenner , Stefan Fischer , Hermann Tenor , Christof Zitt , Armin Hatzelmann , Torsten Dunkern , Christian Hesslinger , Clemens Braun , Ewald Benediktus , Andreas Pahl , Raimund Kuelzer , Degenhard Marx
IPC分类号: C07D519/00 , A61K45/06 , A61K31/519
CPC分类号: C07D519/00 , A61K31/519 , A61K45/06 , C07D495/04
摘要: The compounds of formula (1) in which A, X, R1, R2, R3 and R7 have the meanings as given in the description, are novel effective inhibitors of type 4 and type 5 phosphodiesterase.
摘要翻译: 其中A,X,R1,R2,R3和R7具有说明书中给出的含义的式(1)化合物是4型和5型磷酸二酯酶的新型有效抑制剂。
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4.
公开(公告)号:US20110218201A1
公开(公告)日:2011-09-08
申请号:US13128051
申请日:2009-11-12
申请人: Imre Schlemminger , Beate Schmidt , Dieter Flockerzi , Hermann Tenor , Christof Zitt , Armin Hatzelmann , Degenhard Marx , Clemens Braun , Raimund Külzer , Anke Heuser , Hans-Peter Kley , Geert Jan Sterk
发明人: Imre Schlemminger , Beate Schmidt , Dieter Flockerzi , Hermann Tenor , Christof Zitt , Armin Hatzelmann , Degenhard Marx , Clemens Braun , Raimund Külzer , Anke Heuser , Hans-Peter Kley , Geert Jan Sterk
IPC分类号: A61K31/454 , C07D401/04 , C07D405/14 , A61K31/4709 , C07D401/14 , A61K31/4545 , C07D471/04 , A61K31/498 , C07D413/14 , A61K31/5377 , A61P29/00 , A61P11/00
CPC分类号: C07D401/04 , C07D401/14 , C07D405/14 , C07D471/04
摘要: The compounds of Formula (I), are novel effective inhibitors of the type 4 phosphodiesterase.
摘要翻译: 式(I)的化合物是4型磷酸二酯酶的新型有效抑制剂。
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公开(公告)号:US08609848B2
公开(公告)日:2013-12-17
申请号:US13128051
申请日:2009-11-12
申请人: Imre Schlemminger , Beate Schmidt , Dieter Flockerzi , Hermann Tenor , Christof Zitt , Armin Hatzelmann , Degenhard Marx , Clemens Braun , Raimund Külzer , Anke Heuser , Hans-Peter Kley , Geert Jan Sterk
发明人: Imre Schlemminger , Beate Schmidt , Dieter Flockerzi , Hermann Tenor , Christof Zitt , Armin Hatzelmann , Degenhard Marx , Clemens Braun , Raimund Külzer , Anke Heuser , Hans-Peter Kley , Geert Jan Sterk
IPC分类号: C07D401/00 , A61K31/445
CPC分类号: C07D401/04 , C07D401/14 , C07D405/14 , C07D471/04
摘要: The compounds of Formula (I), are novel effective inhibitors of the type 4 phosphodiesterase.
摘要翻译: 式(I)的化合物是4型磷酸二酯酶的新型有效抑制剂。
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6.
公开(公告)号:US20080221111A1
公开(公告)日:2008-09-11
申请号:US11919742
申请日:2006-05-08
IPC分类号: A61K31/4985 , A61K31/44 , A61P11/00 , A61P21/00
CPC分类号: A61K31/41 , A61K31/505 , A61K2300/00
摘要: The invention describes the use of a PDE4 inhibitor in combination with BH4 or a BH4 derivative for the prevention and/or treatment of respiratory diseases.
摘要翻译: 本发明描述了PDE4抑制剂与BH4或BH4衍生物联合用于预防和/或治疗呼吸系统疾病的用途。
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公开(公告)号:US5133431A
公开(公告)日:1992-07-28
申请号:US662705
申请日:1991-03-01
申请人: Clemens Braun
发明人: Clemens Braun
IPC分类号: F16D66/02
CPC分类号: F16D66/024
摘要: A brake lining wear indicating device is inserted into an aperture (7) of a brake lining carrier (8) of a drum or disc brake from the side facing away from the brake lining (1) and secured in the aperture. The indicating device includes a slotted (16) sleeve shaped holder (2) and a contact member (3) inserted into and axially secured to the holder and has an electrical conductor (4) therein. In order that the indicating device can be fitted into brake lining carriers of different thickness, holder (2) has on its side facing away from the brake lining (1) a frustonconical section (13) having an outwardly narrowing inner frustoconical area (14) and several axially extending slots (16). When contact member (3) is inserted into holder (2), frustoconical part (13) of the holder is forcibly radially expanded and wedged into aperture (7) of brake lining carrier (8).
摘要翻译: 制动衬片磨损指示装置从背离制动衬片(1)的一侧插入到鼓或盘式制动器的制动衬片载体(8)的孔(7)中并固定在孔中。 指示装置包括插槽(16)套筒形保持器(2)和插入并轴向固定到保持器的接触构件(3),并且在其中具有电导体(4)。 为了使指示装置能够装配到不同厚度的制动衬片载体中,保持器(2)的侧面背向制动衬片(1)具有向外变窄的内截头圆锥形区域(14)的截头圆锥体部分(13) 和多个轴向延伸的槽(16)。 当接触构件(3)插入到保持器(2)中时,保持器的截头圆锥形部分(13)被强制地径向膨胀并楔入制动衬片载体(8)的孔(7)中。
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