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    Compounds useful in therapy
    11.
    发明申请
    Compounds useful in therapy 失效
    化合物可用于治疗

    公开(公告)号：US20070105909A1

    公开(公告)日：2007-05-10

    申请号：US11592574

    申请日：2006-11-03

    申请人： Paul Bradley ,  Kevin Dack ,  Patrick Johnson ,  Sarah Skerratt

    发明人： Paul Bradley ,  Kevin Dack ,  Patrick Johnson ,  Sarah Skerratt

    IPC分类号： A61K31/4439 ,  A61K31/4152 ,  C07D403/02 ,  C07D231/12

    CPC分类号： C07D231/18 ,  C07D401/12

    摘要： Compounds of formula (I), or a pharmaceutically acceptable derivative thereof, wherein R1 and R3 independently represent H, C1-6alkyl, C3-8cycloalkyl, or halogen; R2 represents C1-6alkyl, CF3 or aryl; a represents 1 or 2; R4, R5, R7 and R8 independently represent H, C1-6alkyl, C1-6alkyloxy, CN or halogen, or R4 and R5, or R7 and R8, together with the ring to which they are attached form an aryl or heterocyclic fused ring system; X represents C or N; Y represents CH2 or O; R6 represents H, CN or halo provided that, when X represents N, R6 is absent. The compounds are useful for treating endometriosis, uterine fibroids (leiomyomata), menorrhagia, adenomyosis, primary and secondary dysmenorrhoea (including symptoms of dyspareunia, dyschexia and chronic pelvic pain), or chronic pelvic pain syndrome.

    摘要翻译： 式（I）化合物或其药学上可接受的衍生物，其中R 1和R 3独立代表H，C 1-6烷基 C 3-8环烷基或卤素; R 2表示C 1-6烷基，CF 3或芳基; a代表1或2; R 4，R 5，R 7和R 8独立地表示H，C 1-6 C 1-6烷基，C 1-6烷氧基，CN或卤素，或R 4和R 5或R 7 和它们所连接的环连接形成芳基或杂环稠环体系; X表示C或N; Y表示CH 2或O; R 6表示H，CN或卤素，条件是当X表示N时，R 6不存在。 这些化合物可用于治疗子宫内膜异位症，子宫肌瘤（平滑肌瘤），月经过多，子宫腺肌症，原发性和继发性痛经（包括性交疼痛，dyschexia和慢性盆腔疼痛症状）或慢性盆腔疼痛综合征。

    Compounds useful in therapy
    13.
    发明申请
    Compounds useful in therapy 失效
    化合物可用于治疗

    公开(公告)号：US20060241125A1

    公开(公告)日：2006-10-26

    申请号：US11408286

    申请日：2006-04-18

    申请人： Paul Bradley ,  Kevin Dack ,  Ian Marsh

    发明人： Paul Bradley ,  Kevin Dack ,  Ian Marsh

    IPC分类号： A61K31/506 ,  A61K31/4152 ,  C07D403/02

    CPC分类号： C07D231/28 ,  C07D231/18 ,  C07D401/04 ,  C07D401/06 ,  C07D403/04 ,  C07D403/06 ,  C07D413/06 ,  C07D417/06

    摘要： Compounds of formula (I), or pharmaceutically acceptable derivatives thereof, wherein: R1 represents H, C1-6-alkyl, C1-6alkyloxy, C3-8cycloalkyl, or halo; R2 represents H, C1-6alkyl (optionally substituted by R3), phenyl (optionally substituted by CN), or Het; R3 represents OH, CN, Het, —R4—C1-6alkyl, or CONR5R6; R4 represents —CO2—, or —O—; R5 and R6 independently represent H, C1-6alkyl (optionally substituted by OR7) or C3-8cycloalkyl; R7 represents H or C1-6alkyl; Het represents a five or six membered aromatic heterocyclic group containing (i) from one to four nitrogen heteroatom(s) or (ii) one or two nitrogen heteroatom(s) and one oxygen or one sulphur heteroatom or (iii) one or two oxygen or sulphur heteroatom(s), said heterocyclic group being optionally substituted by one or more groups selected from CN and C1-6 alkyl; R8 represents C1-6alkyl, C1-6alkyloxy, C3-8cycloalkyl, or halo; R9 and R10 independently represent H, C1-6alkyl, C1-6alkyloxy, CN, CF3 or halo; may be useful for treating endometriosis, uterine fibroids (leiomyomata), menorrhagia, adenomyosis, primary and secondary dysmenorrhoea (including symptoms of dyspareunia, dyschexia and chronic pelvic pain), or chronic pelvic pain syndrome.

    摘要翻译： 式（I）化合物或其药学上可接受的衍生物，其中：R 1表示H，C 1-6烷基，C 1-6烷基， 烷氧基，C 3-8环烷基或卤素; R 2表示H，C 1-6烷基（任选被R 3 O 3取代），苯基（任选被CN取代）或Het; R 3表示OH，CN，Het，-R 4 -C 1-6烷基或CONR 5 R 6; R 4表示-CO 2 - 或-O-; R 5和R 6独立地表示H，C 1-6烷基（任选被OR 7取代）或 C 3-8环烷基; R 7表示H或C 1-6烷基; Het表示含有（i）1-4个氮杂原子或（ii）一个或两个氮杂原子和一个氧或一个硫杂原子的五元或六元芳族杂环基，或（iii）一个或两个氧 或硫杂原子，所述杂环基团任选被一个或多个选自CN和C 1-6烷基的基团取代; R 8表示C 1-6烷基，C 1-6烷氧基，C 3-8环烷基，或 光环; R 9和R 10独立地代表H，C 1-6烷基，C 1-6烷氧基，CN CF 3或卤素; 可能有助于治疗子宫内膜异位症，子宫肌瘤（平滑肌瘤），月经过多，子宫腺肌症，原发性和继发性痛经（包括性交疼痛，dyschexia和慢性盆腔疼痛症状）或慢性盆腔疼痛综合征。

    Acoustically coupled resonators and method of making the same
    14.
    发明申请
    Acoustically coupled resonators and method of making the same 有权
    声耦合谐振器及其制作方法

    公开(公告)号：US20060232361A1

    公开(公告)日：2006-10-19

    申请号：US11109596

    申请日：2005-04-18

    申请人： Kun Wang ,  Paul Bradley ,  Richard Ruby

    发明人： Kun Wang ,  Paul Bradley ,  Richard Ruby

    IPC分类号： H03H9/72 ,  H03H9/56

    CPC分类号： H03H9/587 ,  H03H3/02 ,  H03H7/1708 ,  H03H9/0095 ,  H03H9/0571 ,  H03H9/583 ,  H03H9/584 ,  H03H9/706 ,  H03H2003/0428 ,  Y10T29/49002

    摘要： An apparatus includes a substrate with a cavity and a two-stage resonator filter fabricated over the cavity. The two-stage resonator filter includes a first stage and a second stage. The first stage includes a first resonator and a second resonator, the second resonator acoustically coupled to the first resonator. The second stage includes a third resonator and a fourth resonator, the fourth resonator acoustically coupled to the third resonator. The second resonator and the third resonators are electrically coupled. A decoupling layer couples the first resonator and the second resonator. The decoupling layer extends between the third resonator and the fourth resonator. The first resonator and the fourth resonator are above the substrate. The decoupling layer is above the first resonator and the fourth resonator. The second resonator and the third resonators are above the decoupling layer.

    摘要翻译： 一种装置包括具有空腔的衬底和在空腔上制造的两级谐振器滤波器。 两级谐振滤波器包括第一级和第二级。 第一级包括第一谐振器和第二谐振器，第二谐振器声耦合到第一谐振器。 第二级包括第三谐振器和第四谐振器，第四谐振器声耦合到第三谐振器。 第二谐振器和第三谐振器电耦合。 去耦层耦合第一谐振器和第二谐振器。 解耦层在第三谐振器和第四谐振器之间延伸。 第一谐振器和第四谐振器在衬底之上。 去耦层位于第一谐振器和第四谐振器之上。 第二谐振器和第三谐振器在去耦层之上。