利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

16 条记录 (耗时 0.039 秒)

    Imidazole compounds
    11.
    发明授权
    Imidazole compounds 失效
    咪唑化合物

    公开(公告)号：US06359145B1

    公开(公告)日：2002-03-19

    申请号：US09764995

    申请日：2001-03-09

    申请人： Tadashi Terasaka ,  Katsuya Nakamura ,  Nobuo Seki ,  Masako Kuno ,  Susumu Tsujimoto ,  Akihiro Sato ,  Isao Nakanishi ,  Takayoshi Kinoshita ,  Nobuya Nishio ,  Hiroyuki Okumura ,  Kiyoshi Tsuji

    发明人： Tadashi Terasaka ,  Katsuya Nakamura ,  Nobuo Seki ,  Masako Kuno ,  Susumu Tsujimoto ,  Akihiro Sato ,  Isao Nakanishi ,  Takayoshi Kinoshita ,  Nobuya Nishio ,  Hiroyuki Okumura ,  Kiyoshi Tsuji

    IPC分类号： C07D23366

    CPC分类号： C07D403/04 ,  C07D233/90 ,  C07D405/06 ,  C07F7/1804

    摘要： Imidazole compounds having adenosine deaminase inhibitory activity represented by formula (I) wherein R1 is hydrogen, hydroxy, protected hydroxy, or aryl optionally substituted with suitable substituent(s); R2 is hydrogen or lower alkyl; R3 is hydroxy or protected hydroxy; R4 is cyano, (hydroxy)iminoamino(lower)alkyl, carboxy, protected carboxy, heterocyclic group optionally substituted with amino, or carbamoyl optionally substituted with suitable substituent(s); and —A— is —Q— or —O—Q—, wherein Q is single bond or lower alkylene, provided that when R2 is lower alkyl, then R1 is hydroxy, protected hydroxy, or aryl optionally substituted with suitable substituent(s), its prodrug, or their salt. The compounds are useful for treating and/or preventing diseases for which adenosine is effective.

    摘要翻译： 式（I）表示的具有腺苷脱氨酶抑制活性的咪唑化合物，其中R 1为氢，羟基，保护的羟基或任选被合适的取代基取代的芳基; R2是氢或低级烷基; R3是羟基或被保护的羟基; R4是氰基，（羟基）亚氨基氨基（低级）烷基，羧基，受保护的羧基，任选被氨基取代的杂环基或任选被合适的取代基取代的氨基甲酰基; 并且-A-是-Q-或-OQ-，其中Q是单键或低级亚烷基，条件是当R 2是低级烷基时，则R 1是羟基，保护的羟基或任选地被合适的取代基取代的芳基，其 前药或其盐。 该化合物可用于治疗和/或预防腺苷有效的疾病。

    Imidazole derivatives as adenosine deaminase inhibitors
    14.
    发明授权
    Imidazole derivatives as adenosine deaminase inhibitors 失效
    咪唑衍生物作为腺苷脱氨酶抑制剂

    公开(公告)号：US07064144B2

    公开(公告)日：2006-06-20

    申请号：US10483336

    申请日：2002-07-10

    申请人： Tadashi Terasaka ,  Takeshi Kato ,  Kiyoshi Tsuji ,  Katsuya Nakamura

    发明人： Tadashi Terasaka ,  Takeshi Kato ,  Kiyoshi Tsuji ,  Katsuya Nakamura

    IPC分类号： A01N43/36 ,  A61K31/40 ,  C07D233/22 ,  C07D233/64

    CPC分类号： C07D401/12 ,  C07D233/90 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

    摘要： Imidazole compounds having adenosine deaminase inhibitory activity represented by the formula (I) wherein R1 is aryl or heterocyclic group which is optionally substituted with substituent(s); R2 is lower alkyl; R3 is hydroxy or protected hydroxy; -A- is lower alkylene; and —X— is —O— or —S—; provided that when then R1 is aryl which is substituted with substituent(s), or heterocyclic group which is optionally substituted with substituent(s), its prodrug, or their salt. The compounds are useful for treating and/or preventing diseases for which adenosine is effective.

    摘要翻译： 具有由式（I）表示的腺苷脱氨酶抑制活性的咪唑化合物，其中R 1是任选被取代基取代的芳基或杂环基; R 2是低级烷基; R 3是羟基或被保护的羟基; -A-是低级亚烷基; 和-X-是-O-或-S-; 条件是当R 1是被取代基取代的芳基，或任选被取代基取代的杂环基时，其前药或其盐。 该化合物可用于治疗和/或预防腺苷有效的疾病。