公开(公告)号：US06359145B1

公开(公告)日：2002-03-19

申请号：US09764995

申请日：2001-03-09

申请人： Tadashi Terasaka ,  Katsuya Nakamura ,  Nobuo Seki ,  Masako Kuno ,  Susumu Tsujimoto ,  Akihiro Sato ,  Isao Nakanishi ,  Takayoshi Kinoshita ,  Nobuya Nishio ,  Hiroyuki Okumura ,  Kiyoshi Tsuji

发明人： Tadashi Terasaka ,  Katsuya Nakamura ,  Nobuo Seki ,  Masako Kuno ,  Susumu Tsujimoto ,  Akihiro Sato ,  Isao Nakanishi ,  Takayoshi Kinoshita ,  Nobuya Nishio ,  Hiroyuki Okumura ,  Kiyoshi Tsuji

IPC分类号： C07D23366

CPC分类号： C07D403/04 ,  C07D233/90 ,  C07D405/06 ,  C07F7/1804

摘要： Imidazole compounds having adenosine deaminase inhibitory activity represented by formula (I) wherein R1 is hydrogen, hydroxy, protected hydroxy, or aryl optionally substituted with suitable substituent(s); R2 is hydrogen or lower alkyl; R3 is hydroxy or protected hydroxy; R4 is cyano, (hydroxy)iminoamino(lower)alkyl, carboxy, protected carboxy, heterocyclic group optionally substituted with amino, or carbamoyl optionally substituted with suitable substituent(s); and —A— is —Q— or —O—Q—, wherein Q is single bond or lower alkylene, provided that when R2 is lower alkyl, then R1 is hydroxy, protected hydroxy, or aryl optionally substituted with suitable substituent(s), its prodrug, or their salt. The compounds are useful for treating and/or preventing diseases for which adenosine is effective.

摘要翻译： 式（I）表示的具有腺苷脱氨酶抑制活性的咪唑化合物，其中R 1为氢，羟基，保护的羟基或任选被合适的取代基取代的芳基; R2是氢或低级烷基; R3是羟基或被保护的羟基; R4是氰基，（羟基）亚氨基氨基（低级）烷基，羧基，受保护的羧基，任选被氨基取代的杂环基或任选被合适的取代基取代的氨基甲酰基; 并且-A-是-Q-或-OQ-，其中Q是单键或低级亚烷基，条件是当R 2是低级烷基时，则R 1是羟基，保护的羟基或任选地被合适的取代基取代的芳基，其 前药或其盐。 该化合物可用于治疗和/或预防腺苷有效的疾病。

公开(公告)号：US5229317A

公开(公告)日：1993-07-20

申请号：US942290

申请日：1992-09-09

申请人： Nobuya Nishio

发明人： Nobuya Nishio

IPC分类号： H01L21/76 ,  H01L21/762

CPC分类号： H01L21/76232 ,  H01L21/76221 ,  Y10S148/05 ,  Y10S148/117

摘要： According to this invention, an isolation trench is formed in a semiconductor substrate. A first insulating film is formed on a surface of the semiconductor substrate and an inner surface of the trench. A silicon oxide film containing phosphorus and boron is buried in the trench in which the first insulating film is formed. A second insulating film pattern having a width larger than that of the trench is formed on the trench and a peripheral portion of the trench. The second insulating film pattern prevents out-diffusion phosphorus and boron in the silicon oxide film. The first insulating film which is not covered with the second insulating film pattern is removed to form a first insulating film pattern. The surface of the semiconductor substrate which is not covered with the first and second insulating film patterns is thermally oxidized.

公开(公告)号：US20050214858A1

公开(公告)日：2005-09-29

申请号：US10511270

申请日：2003-04-28

申请人： Hidenori Nakajima ,  Mitsuru Ohkubo ,  Seiji Yoshimura ,  Nobuya Nishio ,  Kaori Nishio

发明人： Hidenori Nakajima ,  Mitsuru Ohkubo ,  Seiji Yoshimura ,  Nobuya Nishio ,  Kaori Nishio

IPC分类号： C07K14/47 ,  C12N9/88 ,  C12N15/12 ,  G01N33/53 ,  C07H21/04 ,  C12N9/24 ,  C12N15/09

CPC分类号： C12N9/88 ,  C07K14/4702 ,  G01N2500/00

摘要： It is intended to provide a protein participating in the regulation of sugar production, a polynucleotide encoding the same, a method of screening a compound participating in the regulation of sugar production and a drug for treating or preventing diabetes which contains the compound participating in the regulation of sugar production. A polynucleotide encoding a protein specifically binding to a substance WF00144 is found out from rat liver cells and thus a protein participating in the regulation of sugar production and a polynucleotide encoding the same are provided. Moreover, a method and a substance relating to a method of treating and preventing diabetes are found out and thus a method of treating diabetes relating to the regulation of sugar production relating to the method of treating and preventing diabetes is provided.

摘要翻译： 目的在于提供参与糖生产调节的蛋白质，编码糖蛋白的多核苷酸，筛选参与糖生产调节的化合物的方法和用于治疗或预防糖尿病的药物，其含有参与调节的化合物 的糖生产。 从大鼠肝细胞中发现编码与物质WF00144特异性结合的蛋白质的多核苷酸，因此提供了参与糖产​​生调节的蛋白质和编码该多核苷酸的多核苷酸。 此外，发现了与治疗和预防糖尿病的方法有关的方法和物质，因此提供了治疗和预防糖尿病的方法中关于糖生产调节的糖尿病的治疗方法。

公开(公告)号：US06525548B1

公开(公告)日：2003-02-25

申请号：US09710597

申请日：2000-11-10

申请人： Nobuya Nishio

发明人： Nobuya Nishio

IPC分类号： G01R2708

CPC分类号： H01L22/34 ,  H01L2924/0002 ,  H01L2924/00

摘要： The present invention provides a check pattern for evaluating the result of via openings during fabrication of a semiconductor device. The check pattern uses a Wheatstone bridge circuit so as to eliminate any influence of variation of wiring resistance and/or contact resistance. In the bridge circuit, four terminals are provided, namely first, second, third and fourth terminals. Each of four sides of the bridge circuit is defined by connecting an upper conductor layer including one terminal, a sub-group of via openings belonging to one group, a lower conductor layer, the other sub-group of via openings belonging to the same group, and an upper conductor layer including another terminal.

摘要翻译： 本发明提供了一种用于在制造半导体器件期间评估通孔开口结果的检查图案。 检查图案使用惠斯通电桥电路，以消除布线电阻和/或接触电阻变化的任何影响。 在桥式电路中，设置有四个端子，即第一，第二，第三和第四端子。 通过连接包括一个端子，属于一个组的通路开口的子组，下部导体层，属于同一组的通孔的另一个子组的上部导体层来限定桥接电路的四个侧面 ，以及包括另一个端子的上导体层。

公开(公告)号：US07371842B2

公开(公告)日：2008-05-13

申请号：US10511270

申请日：2003-04-28

申请人： Hidenori Nakajima ,  Mitsuru Ohkubo ,  Seiji Yoshimura ,  Nobuya Nishio ,  Kaori Nishio

发明人： Hidenori Nakajima ,  Mitsuru Ohkubo ,  Seiji Yoshimura ,  Nobuya Nishio ,  Kaori Nishio

IPC分类号： C07H21/04 ,  C12P21/06 ,  C12N15/00 ,  C07K14/00

CPC分类号： C12N9/88 ,  C07K14/4702 ,  G01N2500/00

摘要： It is intended to provide a protein participating in the regulation of sugar production, a polynucleotide encoding the same, a method of screening a compound participating in the regulation of sugar production and a drug for treating or preventing diabetes which contains the compound participating in the regulation of sugar production. A polynucleotide encoding a protein specifically binding to a substance WF00144 is found out from rat liver cells and thus a protein participating in the regulation of sugar production and a polynucleotide encoding the same are provided. Moreover, a method and a substance relating to a method of treating and preventing diabetes are found out and thus a method of treating diabetes relating to the regulation of sugar production relating to the method of treating and preventing diabetes is provided.

摘要翻译： 目的在于提供参与糖生产调节的蛋白质，编码糖蛋白的多核苷酸，筛选参与糖生产调节的化合物的方法和用于治疗或预防糖尿病的药物，其含有参与调节的化合物 的糖生产。 从大鼠肝细胞中发现编码与物质WF00144特异性结合的蛋白质的多核苷酸，因此提供了参与糖产​​生调节的蛋白质和编码该多核苷酸的多核苷酸。 此外，发现了与治疗和预防糖尿病的方法有关的方法和物质，因此提供了治疗和预防糖尿病的方法中关于糖生产调节的糖尿病的治疗方法。