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公开(公告)号：US12144871B2
公开(公告)日：2024-11-19
申请号：US16936909
申请日：2020-07-23
Applicant: Translate Bio, Inc.
Inventor： Shrirang Karve , Frank DeRosa , Michael Heartlein , Natalia Vargas Montoya , Priyal Patel , Ashish Sarode
Abstract: The present invention provides an improved compositions and processes for preparing mRNA-loaded lipid nanoparticles (mRNA-LNPs). In some embodiments, the present invention provides mRNA-LNPs with exceptional stability and is particularly useful in cases where LNPs comprising low or no PEG-modified lipids are desired.
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公开(公告)号：US20220287966A1
公开(公告)日：2022-09-15
申请号：US17534956
申请日：2021-11-24
Applicant: Translate Bio, Inc.
Inventor： Shrirang Karve , Ashish Sarode , Natalia Vargas Montoya , Priyal Patel , Frank DeRosa
Abstract: The present invention provides, among other things, a liquid lipid nanoparticle (LNP) formulation encapsulating mRNA encoding a peptide or polypeptide, that is resistant to aggregation and to mRNA degradation following multiple rounds of freezing at −20° C. and rethawing.
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公开(公告)号：US11357726B2
公开(公告)日：2022-06-14
申请号：US16553747
申请日：2019-08-28
Applicant: Translate Bio, Inc.
Inventor： Shrirang Karve , Zarna Patel , Yi Zhang , Ashish Sarode , Rebecca L. Goldman , Frank DeRosa , Michael Heartlein
IPC: A61K9/12 , A61K9/127 , A61K9/14 , A61K9/51 , A61K31/7105
Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of mixing a solution of pre-formed lipid nanoparticles and mRNA at a low concentration.
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公开(公告)号：US20210186890A1
公开(公告)日：2021-06-24
申请号：US17129666
申请日：2020-12-21
Applicant: Translate Bio, Inc.
Inventor： Shrirang Karve , Frank DeRosa , Ashish Sarode , Natalia Vargas Montoya , Priyal Patel
IPC: A61K9/51 , A61K31/7105 , B82Y5/00 , B82Y40/00
Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of combining a solution of preformed lipid nanoparticles with lipid nanoparticles encapsulating mRNA, resulting in a composition of increased potency of mRNA encoded protein expression in vivo.
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公开(公告)号：US20210046192A1
公开(公告)日：2021-02-18
申请号：US16936909
申请日：2020-07-23
Applicant: Translate Bio, Inc.
Inventor： Shrirang Karve , Frank DeRosa , Michael Heartlein , Natalia Vargas Montoya , Priyal Patel , Ashish Sarode
Abstract: The present invention provides an improved compositions and processes for preparing mRNA-loaded lipid nanoparticles (mRNA-LNPs). In some embodiments, the present invention provides mRNA-LNPs with exceptional stability and is particularly useful in cases where LNPs comprising low or no PEG-modified lipids are desired.
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Patent Agency Ranking
公开(公告)号：US20250025430A1
公开(公告)日：2025-01-23
申请号：US18753746
申请日：2024-06-25
Applicant: TRANSLATE BIO, INC.
Inventor： Shrirang Karve , Frank DeRosa , Ashish Sarode , Natalia Vargas Montoya , Priyal Patel
IPC: A61K9/51 , A61K31/7105 , B82Y5/00 , B82Y40/00
Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of combining a solution of preformed lipid nanoparticles with lipid nanoparticles encapsulating mRNA, resulting in a composition of increased potency of mRNA encoded protein expression in vivo.
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公开(公告)号：US12064515B2
公开(公告)日：2024-08-20
申请号：US17737712
申请日：2022-05-05
Applicant: Translate Bio, Inc.
Inventor： Shrirang Karve , Zarna Patel , Yi Zhang , Ashish Sarode , Rebecca L. Goldman , Frank DeRosa , Michael Heartlein
IPC: A61K9/51 , A61K9/127 , A61K9/14 , A61K31/7105
CPC classification number: A61K9/1277 , A61K9/141 , A61K9/51 , A61K31/7105
Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of mixing a solution of pre-formed lipid nanoparticles and mRNA at a low concentration.
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公开(公告)号：US12053551B2
公开(公告)日：2024-08-06
申请号：US17129666
申请日：2020-12-21
Applicant: Translate Bio, Inc.
Inventor： Shrirang Karve , Frank DeRosa , Ashish Sarode , Natalia Vargas Montoya , Priyal Patel
IPC: A61K9/51 , A61K31/7105 , B82Y5/00 , B82Y40/00
CPC classification number: A61K9/5192 , A61K31/7105 , B82Y5/00 , B82Y40/00
Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of combining a solution of preformed lipid nanoparticles with lipid nanoparticles encapsulating mRNA, resulting in a composition of increased potency of mRNA encoded protein expression in vivo.
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公开(公告)号：US20230181483A1
公开(公告)日：2023-06-15
申请号：US17625507
申请日：2020-07-08
Applicant: Translate Bio, Inc.
Inventor： Shrirang Karve , Ashish Sarode , Frank DeRosa
CPC classification number: A61K9/5192 , A61K47/544 , A61K47/6929 , A61K9/0019 , A61K9/1272 , A61K9/5123 , A61K38/00
Abstract: The present invention provides an improved lipid nanoparticle formulation encapsulating mRNA comprising DEPE as a helper lipid.
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公开(公告)号：US20230051811A1
公开(公告)日：2023-02-16
申请号：US17786971
申请日：2020-12-18
Applicant: Translate Bio, Inc
Inventor： Shrirang Karve , Frank DeRosa , Ashish Sarode
Abstract: The present invention provides, among other things, effective methods and compositions for delivering messenger RNA (mRNA) via rectal delivery. The present invention is, in part, based on unexpected observation that mRNA may be effectively delivered to the circulation, liver, kidney, colon and/or rectum via rectal delivery despite the barriers such as RNase and mucus layer.
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