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公开(公告)号：US09956274B2
公开(公告)日：2018-05-01
申请号：US14991048
申请日：2016-01-08
Applicant: UCB Biopharma SPRL
Inventor： Terence Seward Baker
IPC: C12N5/07 , A61K39/395 , A61K39/00 , A61K38/12 , C07K16/00 , C07K14/705 , C07K16/28
CPC classification number: A61K39/0005 , A61K2039/545 , A61K2039/6081 , A61K2039/62 , C07K14/705 , C07K16/28 , C07K2317/14 , C07K2317/20 , C07K2317/76
Abstract: The present invention provides a method for generating a functionally modifying antibody to an ion channel comprising immunizing a host with a cyclic peptide comprising at least part of an extracellular sequence of said ion channel.
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公开(公告)号：US20160193309A1
公开(公告)日：2016-07-07
申请号：US14991048
申请日：2016-01-08
Applicant: UCB Biopharma SPRL
Inventor： Terence Seward Baker
CPC classification number: A61K39/0005 , A61K2039/545 , A61K2039/6081 , A61K2039/62 , C07K14/705 , C07K16/28 , C07K2317/14 , C07K2317/20 , C07K2317/76
Abstract: The present invention provides a method for generating a functionally modifying antibody to an ion channel comprising immunizing a host with a cyclic peptide comprising at least part of an extracellular sequence of said ion channel.
Abstract translation: 本发明提供了一种产生功能性改变的离子通道抗体的方法，包括用包含至少部分所述离子通道的细胞外序列的环肽免疫宿主。
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Patent Agency Ranking
公开(公告)号：US20160125124A1
公开(公告)日：2016-05-05
申请号：US14897459
申请日：2014-06-13
Applicant: UCB BIOPHARMA SPRL
Inventor： Jiye Shi , Terence Seward Baker , Alastair David Griffiths Lawson , Xiaofeng Liu
CPC classification number: G16B5/00 , C07K16/244 , C07K2317/55 , C07K2317/76 , G16B15/00 , G16C20/50 , G16C20/90
Abstract: Methods and associated apparatus involving designing a ligand ab initio that will bind to a binding site of a macromolecular target, or of identifying a modification to a ligand for improving the affinity of the ligand to a binding site of a macromolecular target, comprising using information about non-bonding, intra-molecular or inter-molecular atom to atom contacts extracted from a database of biological macromolecules to identify favoured regions adjacent to the binding site for particular atom types and modifying a candidate ligand to increase the intersection between atoms of the candidate ligand and the favoured regions. One or more steps of the methods may be performed by a computer.
Abstract translation: 涉及设计一种将结合大分子靶标的结合位点的配位体或者鉴定对配体的修饰以改善配体对大分子靶标的结合位点的亲和力的方法和相关设备，包括使用关于 从生物大分子数据库中提取的非键合，分子内或分子间或分子间原子与原子接触，以鉴定与特定原子类型的结合位点相邻的有利区域，并修饰候选配体以增加候选配体的原子之间的相交 和优惠地区。 方法的一个或多个步骤可以由计算机执行。
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公开(公告)号：US10287343B2
公开(公告)日：2019-05-14
申请号：US15742087
申请日：2016-07-05
Applicant: UCB BIOPHARMA SPRL
Inventor： David Edward Ormonde Knight , Terence Seward Baker , David James McMillan , Robert Anthony Griffin , Georges Mairet-Coello , Patrick Downey , Jean-Philippe Courade
Abstract: The present invention relates to Tau-binding antibodies and binding fragments thereof.
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公开(公告)号：US20180346561A1
公开(公告)日：2018-12-06
申请号：US15974407
申请日：2018-05-08
Applicant: UCB BIOPHARMA SPRL
Inventor： Ralph Adams , Terence Seward Baker , Alastair David Griffiths Lawson
IPC: C07K16/24
CPC classification number: C07K16/244 , C07K2317/33 , C07K2317/92
Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
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16.发明申请公开(公告)号：US20160222107A1
公开(公告)日：2016-08-04
申请号：US15014145
申请日：2016-02-03
Applicant: UCB Biopharma SPRL
Inventor： Helene Margaret Finney , Terence Seward Baker , Alastair David Griffiths Lawson , Karen Margrete Miller , Marc Roger de Ryck , Christian Gilbert J. Wolff
IPC: C07K16/28 , A61K39/395
CPC classification number: C07K16/28 , A61K39/3955 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76
Abstract: A Nav1.7 binding entity that after binding functionally modifies the activity of the ion channel, in particular an anti-Nav1.7 antibody or binding fragment thereof, pharmaceutical compositions comprising said antibodies, use of the antibodies and compositions comprising the same, in treatment, for example in the treatment/modulation of pain and processes for generating and preparing said antibodies.
Abstract translation: 结合后的Nav1.7结合实体功能性地修饰离子通道的活性，特别是抗Nav1.7抗体或其结合片段，包含所述抗体的药物组合物，使用抗体及其组合物在治疗中 ，例如在疼痛的治疗/调节中以及产生和制备所述抗体的方法。
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公开(公告)号：US20150218271A1
公开(公告)日：2015-08-06
申请号：US14690892
申请日：2015-04-20
Applicant: UCB Biopharma SPRL
Inventor： Ralph Adams , Terence Seward Baker , Alastair David Griffiths Lawson
IPC: C07K16/24
CPC classification number: C07K16/244 , C07K2317/33 , C07K2317/92
Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
Abstract translation: 本发明涉及对IL-17A和IL-17F的抗原决定簇具有特异性的抗体分子，抗体分子的治疗用途和产生所述抗体分子的方法。
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