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公开(公告)号：US2877161A
公开(公告)日：1959-03-10
申请号：US61039956
申请日：1956-09-17
Applicant: UPJOHN CO
Inventor： SEBEK OLDRICH K , MICHAELS RHODA M
IPC: C12P33/00
CPC classification number: C12P33/00 , Y10S435/843 , Y10S435/947
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公开(公告)号：US3920522A
公开(公告)日：1975-11-18
申请号：US42446273
申请日：1973-12-13
Applicant: UPJOHN CO
Inventor： ARGOUDELIS ALEXANDER D , COATS JOHN H , SEBEK OLDRICH K
CPC classification number: C07G11/00 , C07H15/16 , Y10S435/803 , Y10S435/886
Abstract: A new antibiotic 7-0-demethylcelesticetin (IV) is produced by the controlled fermentation of the new microorganism Streptomyces caelestis strain 22227a in an aqueous nutrient medium. 7-0Demethylcelesticetin is antibacterially active and also can be converted to various antibacterially active analogues.
Abstract translation: 通过在水性营养培养基中新型微生物链霉菌链霉菌22227a菌株的受控发酵产生新的抗生素7-0-去甲基肉豆蔻酸（Ⅳ）。 7-0-甲基酪氨酸是具有抗菌活性的，也可转化为各种抗菌活性类似物。
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公开(公告)号：US3671628A
公开(公告)日：1972-06-20
申请号：US3671628D
申请日：1969-09-08
Applicant: UPJOHN CO
Inventor： SEBEK OLDRICH K , MEYER CURTIS E
IPC: A61K21/00
CPC classification number: C12P1/06 , Y10S435/886
Abstract: Antibiotic tirandamycin producible by culturing Streptomyces tirandis var. tirandis in an aqueous nutrient medium. Tirandamycin is active against Bacillus subtiles and can be used to minimize or prevent odor in fish and fish crates caused by this organism.
Abstract translation: 通过培养链霉菌Streptomyces tirandis var。 在营养培养基中培养。 蒂拉达霉素对枯草芽孢杆菌具有活性，可用于最小化或防止由该生物体引起的鱼和鱼条的气味。
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Patent Agency Ranking
公开(公告)号：US3629402A
公开(公告)日：1971-12-21
申请号：US3629402D
申请日：1969-04-28
Applicant: UPJOHN CO
Inventor： SEBEK OLDRICH K , WHALEY HOWARD A
CPC classification number: C07G11/00 , Y10S435/886 , Y10S435/94
Abstract: THE LIPOXAMYCIN MIXTURE OF THE SUBJECT INVENTION IS PRODUCIBLE BY CULTURING STREPTOMYCES VIRGINIAE VAR. LIPOXAE VAR. NOVA IN AN AQUEOUS NUTRIENT MEDIUM. LIPOXAMYCIN IS THE MAJOR COMPONENT OF SAID MIXTURE. THE LIPOXAMYCIN MIXTURE AND LIPOXAMYCIN INHIBIT THE GROWTH OF STAPHYLOCOCCUS AUREUS AND OTHER MICROORGANISMS, AND CAN BE USED TO INHIBIT SUCH MICROORGANISMS IN VARIOUS ENVIRONMENTS.
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公开(公告)号：US3579426A
公开(公告)日：1971-05-18
申请号：US3579426D
申请日：1968-10-21
Applicant: UPJOHN CO
Inventor： ARGOUDELIS ALEXANDER D , COATS JOHN H , MASON DONALD J , SEBEK OLDRICH K
CPC classification number: C07H15/16 , Y10S435/886 , Y10S435/906
Abstract: A MICROBIOLOGICAL PROCESS FOR THE 1''-DEMETHYLATION OF 7HALO-7-DEXOYLINCOMYYCINS TO OBTAIN THE CORRESPONDING 7HALO-7-DEOXY-1-DEMETHYLLINCOMYCINS, WHICH ARE KNOWN ACTIVE ANTIBACTERIAL AGENT WITH BROADER SCOPE OF ACTIVITY THAN THE PRESENT COMPOUNDS.
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16.发明授权9alpha-hydroxylation of delta4-3-keto pregnane series steroids by fungi of the cunninghamella and helicostylum genera 失效菊苣和螺旋体属真菌对δ4-3-酮孕烷系列甾族化合物的9α-羟化作用
公开(公告)号：US3038913A
公开(公告)日：1962-06-12
申请号：US77384458
申请日：1958-11-14
Applicant: UPJOHN CO
Inventor： HANZE ARTHUR R , MURRAY HERBERT C , SEBEK OLDRICH K
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公开(公告)号：US2864838A
公开(公告)日：1958-12-16
申请号：US71603758
申请日：1958-02-19
Applicant: UPJOHN CO
Inventor： LINCOLN FRANK H , SCHNEIDER WILLIAM P , SEBEK OLDRICH K , SPERO GEORGE B
CPC classification number: C12P33/00 , C07J7/00 , C07J75/00 , Y10S435/886
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公开(公告)号：US2838547A
公开(公告)日：1958-06-10
申请号：US71601558
申请日：1958-02-19
Applicant: UPJOHN CO
Inventor： MAGERLEIN BARNEY J , SCHNEIDER WILLIAM P , SEBEK OLDRICH K , SPERO GEORGE B
CPC classification number: C07J5/00 , C07J75/00 , Y10S435/886
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