公开(公告)号：US10689420B2

公开(公告)日：2020-06-23

申请号：US16019636

申请日：2018-06-27

Applicant: University of Massachusetts

Inventor： Guangping Gao ,  Terence Flotte ,  Jun Xie

IPC: C12N15/00 ,  C12N7/00 ,  A61K39/23 ,  C07K14/005 ,  C12N15/86 ,  A61K31/7088 ,  A61K35/76 ,  A61K48/00

Abstract: The invention in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the invention relates to gene transfer methods using the recombinant adeno-associate viruses. In some aspects, the invention relates to isolated AAV capsid proteins and isolated nucleic acids encoding the same.

公开(公告)号：US20180362592A1

公开(公告)日：2018-12-20

申请号：US16019636

申请日：2018-06-27

Applicant: University of Massachusetts

Inventor： Guangping Gao ,  Terence Flotte ,  Jun Xie

IPC: C07K14/005 ,  C12N15/86 ,  C12N7/00 ,  A61K31/7088 ,  A61K35/76

Abstract: The invention in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the invention relates to gene transfer methods using the recombinant adeno-associate viruses. In some aspects, the invention relates to isolated AAV capsid proteins and isolated nucleic acids encoding the same.

公开(公告)号：US09885057B2

公开(公告)日：2018-02-06

申请号：US14952217

申请日：2015-11-25

Applicant: University of Massachusetts

Inventor： Terence Flotte ,  Christian Mueller ,  Phillip D. Zamore

IPC: C07H21/02 ,  C07H21/04 ,  A61K48/00 ,  A61K35/00 ,  C12N15/86 ,  C12N7/00 ,  C12N15/113 ,  A61K35/12

CPC classification number: C12N15/86 ,  A61K31/713 ,  A61K35/12 ,  A61K38/57 ,  A61K48/005 ,  A61K48/0058 ,  C07K14/8125 ,  C12N7/00 ,  C12N15/111 ,  C12N15/113 ,  C12N15/67 ,  C12N2310/141 ,  C12N2310/3519 ,  C12N2320/31 ,  C12N2750/14121 ,  C12N2750/14132 ,  C12N2750/14143

Abstract: The invention relates to isolated nucleic acids and rAAV-based compositions, methods and kits useful for treating genetic diseases (e.g., alpha-1 antitrypsin deficiency).

公开(公告)号：US09284357B2

公开(公告)日：2016-03-15

申请号：US14246560

申请日：2014-04-07

Applicant: University of Massachusetts

Inventor： Guangping Gao ,  Terence Flotte ,  Jun Xie

IPC: A61K39/23 ,  A61K39/235 ,  C12N15/00 ,  C12P21/06 ,  C07K14/005 ,  C12N15/86

CPC classification number: C07K14/005 ,  A61K31/7088 ,  A61K35/76 ,  A61K48/00 ,  C12N7/00 ,  C12N15/86 ,  C12N2750/14122 ,  C12N2750/14143 ,  C12N2750/14145

Abstract: The invention in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the invention relates to gene transfer methods using the recombinant adeno-associate viruses. In some aspects, the invention relates to isolated AAV capsid proteins and isolated nucleic acids encoding the same.

Abstract translation: 本发明在某些方面涉及具有不同组织靶向能力的重组腺相关病毒。 在一些方面，本发明涉及使用重组腺相关病毒的基因转移方法。 在一些方面，本发明涉及分离的AAV衣壳蛋白和编码其的分离的核酸。

公开(公告)号：US11920133B2

公开(公告)日：2024-03-05

申请号：US17576130

申请日：2022-01-14

Applicant: University of Massachusetts

Inventor： Terence Flotte ,  Christian Mueller ,  Phillip D. Zamore

IPC: C07H21/04 ,  A61K31/713 ,  A61K35/12 ,  A61K38/57 ,  A61K48/00 ,  C07K14/81 ,  C12N7/00 ,  C12N15/113 ,  C12N15/67 ,  C12N15/86 ,  C12N15/11

CPC classification number: C12N15/113 ,  A61K31/713 ,  A61K35/12 ,  A61K38/57 ,  A61K48/005 ,  A61K48/0058 ,  C07K14/8125 ,  C12N7/00 ,  C12N15/67 ,  C12N15/86 ,  C12N15/111 ,  C12N2310/141 ,  C12N2310/3519 ,  C12N2320/31 ,  C12N2750/14121 ,  C12N2750/14132 ,  C12N2750/14143

Abstract: The invention relates to isolated nucleic acids and rAAV-based compositions, methods and kits useful for treating genetic diseases (e.g., alpha-1 antitrypsin deficiency).

公开(公告)号：US11834474B2

公开(公告)日：2023-12-05

申请号：US16870816

申请日：2020-05-08

Applicant: University of Massachusetts

Inventor： Guangping Gao ,  Terence Flotte ,  Jun Xie

IPC: C12N7/00 ,  C07K14/005 ,  C12N15/86 ,  A61K31/7088 ,  A61K35/76 ,  A61K48/00

CPC classification number: C07K14/005 ,  A61K31/7088 ,  A61K35/76 ,  C12N7/00 ,  C12N15/86 ,  A61K48/00 ,  C12N2750/14122 ,  C12N2750/14143 ,  C12N2750/14145

Abstract: The invention in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the invention relates to gene transfer methods using the recombinant adeno-associate viruses. In some aspects, the invention relates to isolated AAV capsid proteins and isolated nucleic acids encoding the same.

公开(公告)号：US20200377554A1

公开(公告)日：2020-12-03

申请号：US16870816

申请日：2020-05-08

Applicant: University of Massachusetts

Inventor： Guangping Gao ,  Terence Flotte ,  Jun Xie

IPC: C07K14/005 ,  C12N15/86 ,  A61K31/7088 ,  A61K35/76 ,  C12N7/00

Abstract: The invention in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the invention relates to gene transfer methods using the recombinant adeno-associate viruses. In some aspects, the invention relates to isolated AAV capsid proteins and isolated nucleic acids encoding the same.

公开(公告)号：US10597656B2

公开(公告)日：2020-03-24

申请号：US16059121

申请日：2018-08-09

Applicant: University of Massachusetts

Inventor： Terence Flotte ,  Christian Mueller ,  Phillip D. Zamore

IPC: C07H21/02 ,  C07H21/04 ,  A61K35/00 ,  C12N15/113 ,  C12N15/67 ,  A61K48/00 ,  A61K35/12 ,  C12N7/00 ,  C12N15/86 ,  A61K31/713 ,  A61K38/57 ,  C07K14/81 ,  C12N15/11

Abstract: The invention relates to isolated nucleic acids and rAAV-based compositions, methods and kits useful for treating genetic diseases (e.g., alpha-1 antitrypsin deficiency).

公开(公告)号：US10480011B2

公开(公告)日：2019-11-19

申请号：US15520977

申请日：2015-10-21

Applicant: University of Massachusetts

Inventor： Guangping Gao ,  Jun Xie ,  Terence Flotte

IPC: C12N15/86 ,  C07K14/005 ,  A01K67/027 ,  A61K48/00 ,  C12N7/00 ,  C12N15/113 ,  C12N15/85 ,  A61K35/00

Abstract: The disclosure in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the disclosure relates to gene transfer methods using the recombinant adeno-associated viruses. In some aspects, the disclosure relates to isolated AAV capsid proteins and isolated nucleic acids encoding the same.

公开(公告)号：US20160326524A1

公开(公告)日：2016-11-10

申请号：US15098833

申请日：2016-04-14

Applicant: University of Massachusetts

Inventor： Terence Flotte ,  Christian Mueller

IPC: C12N15/113 ,  A61K31/713 ,  A61K48/00 ,  A61K38/57 ,  C12N7/00 ,  C07K14/81

CPC classification number: C12N15/86 ,  A61K31/713 ,  A61K35/12 ,  A61K38/57 ,  A61K48/005 ,  A61K48/0058 ,  C07K14/8125 ,  C12N7/00 ,  C12N15/111 ,  C12N15/113 ,  C12N15/67 ,  C12N2310/141 ,  C12N2310/3519 ,  C12N2320/31 ,  C12N2750/14121 ,  C12N2750/14132 ,  C12N2750/14143

Abstract: The invention relates to isolated nucleic acids and rAAV-based compositions, methods and kits useful for treating genetic diseases (e.g., alpha-1 antitrypsin deficiency).

Abstract translation: 本发明涉及分离的核酸和基于rAAV的组合物，用于治疗遗传疾病（例如α-1抗胰蛋白酶缺乏症）的方法和试剂盒。