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19 条记录 (耗时 0.034 秒)

    2-pyridyloxy-3-ester-4-nitrile orexin receptor antagonists
    15.
    发明授权
    2-pyridyloxy-3-ester-4-nitrile orexin receptor antagonists 有权
    2-吡啶氧基-3-酯-4-腈食欲素受体拮抗剂

    公开(公告)号：US09586950B2

    公开(公告)日：2017-03-07

    申请号：US14436380

    申请日：2013-10-14

    申请人： MERCK SHARP & DOHME CORP. ,  Scott D. Kuduk ,  Jason W. Skudlarek

    发明人： Scott D. Kuduk ,  Jason W. Skudlarek

    IPC分类号： C07D401/14 ,  A61K31/4545 ,  C07D413/14 ,  C07D401/12

    CPC分类号： C07D413/14 ,  C07D401/12 ,  C07D401/14

    摘要： The present invention is directed to 2-pyridyloxy-3-ester-4-nitrile compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the 2-pyridyloxy-3-ester-4-nitrile compounds described herein in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

    摘要翻译： 本发明涉及作为食欲肽受体拮抗剂的2-吡啶氧基-3-酯-4-腈化合物。 本发明还涉及本文所述的2-吡啶氧基-3-酯-4-腈化合物在治疗或预防涉及食欲肽受体的神经和精神病症和疾病中的用途。 本发明还涉及包含这些化合物的药物组合物。 本发明还涉及这些药物组合物在预防或治疗涉及食欲素受体的疾病中的用途。

    Heterocyclic fused phenanthrolinone M1 receptor positive allosteric modulators
    16.
    发明授权
    Heterocyclic fused phenanthrolinone M1 receptor positive allosteric modulators 有权
    杂环稠合菲咯啉酮M1受体阳性变构调节剂

    公开(公告)号：US08557992B2

    公开(公告)日：2013-10-15

    申请号：US13703983

    申请日：2011-06-10

    申请人： Scott D. Kuduk ,  Jason W. Skudlarek

    发明人： Scott D. Kuduk ,  Jason W. Skudlarek

    IPC分类号： A61K31/44 ,  C07D221/22

    CPC分类号： A61K31/4745 ,  C07D471/04

    摘要： The present invention is directed to heterocyclic fused phenanthrolinone compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.

    摘要翻译： 本发明涉及式（I）的杂环稠合菲咯啉酮化合物，其为M1受体阳性变构调节剂，可用于治疗涉及M1受体的疾病，例如阿尔茨海默病，精神分裂症，疼痛或睡眠障碍 。 本发明还涉及包含该化合物的药物组合物，以及该化合物和组合物在治疗由M1受体介导的疾病中的用途。

    HETEROCYCLIC FUSED PHENANTHROLINONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS
    17.
    发明申请
    HETEROCYCLIC FUSED PHENANTHROLINONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS 有权
    异源融合的菲咯啉酮M1受体阳性调节因子

    公开(公告)号：US20130116272A1

    公开(公告)日：2013-05-09

    申请号：US13703983

    申请日：2011-06-10

    申请人： Scott D. Kuduk ,  Jason W. Skudlarek

    发明人： Scott D. Kuduk ,  Jason W. Skudlarek

    IPC分类号： A61K31/4745 ,  C07D471/04

    CPC分类号： A61K31/4745 ,  C07D471/04

    摘要： The present invention is directed to heterocyclic fused phenanthrolinone compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.

    摘要翻译： 本发明涉及式（I）的杂环稠合菲咯啉酮化合物，其为M1受体阳性变构调节剂，可用于治疗涉及M1受体的疾病，例如阿尔茨海默病，精神分裂症，疼痛或睡眠障碍 。 本发明还涉及包含该化合物的药物组合物，以及该化合物和组合物在治疗由M1受体介导的疾病中的用途。

    2-PYRIDYLOXY-3-ESTER-4-NITRILE OREXIN RECEPTOR ANTAGONISTS
    19.
    发明申请
    2-PYRIDYLOXY-3-ESTER-4-NITRILE OREXIN RECEPTOR ANTAGONISTS 有权
    2-吡啶并[3-ESTER-4-NITRILE OREXIN受体拮抗剂]

    公开(公告)号：US20150252033A1

    公开(公告)日：2015-09-10

    申请号：US14436380

    申请日：2013-10-14

    申请人： Scott D. KUDUK ,  Jason W. SKUDLAREK ,  MERCK SHARP & DOHME CORP.

    发明人： Scott D. Kuduk ,  Jason W. Skudlarek

    IPC分类号： C07D413/14 ,  C07D401/12 ,  C07D401/14

    CPC分类号： C07D413/14 ,  C07D401/12 ,  C07D401/14

    摘要： The present invention is directed to 2-pyridyloxy-3-ester-4-nitrile compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the 2-pyridyloxy-3-ester-4-nitrile compounds described herein in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

    摘要翻译： 本发明涉及作为食欲肽受体拮抗剂的2-吡啶氧基-3-酯-4-腈化合物。 本发明还涉及本文所述的2-吡啶氧基-3-酯-4-腈化合物在治疗或预防涉及食欲肽受体的神经和精神病症和疾病中的用途。 本发明还涉及包含这些化合物的药物组合物。 本发明还涉及这些药物组合物在预防或治疗涉及食欲素受体的疾病中的用途。