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公开(公告)号：US20140214113A1
公开(公告)日：2014-07-31
申请号：US13796314
申请日：2013-03-12
Applicant: Valencia Technologies Corporation
Inventor： Jeffrey H. Greiner , David K. L. Peterson , Chuladatta Thenuwara , Stacy O. Greiner
CPC classification number: A61H39/002 , A61N1/36067 , A61N1/36096 , A61N1/36107 , A61N1/36114 , A61N1/36117 , A61N1/36125 , A61N1/36175 , A61N1/37205 , A61N1/3756 , A61N1/3758 , A61N1/3782 , H01L2224/48091 , Y10T29/49002 , H01L2924/00014
Abstract: An implantable electroacupuncture device (IEAD) treats a medical condition of a patient through application of electroacupuncture (EA) stimulation pulses applied at a target tissue location, such as an acupoint. The IEAD comprises an implantable, coin-sized, self-contained, leadless electroacupuncture device having at least two electrodes attached to an outside surface of its housing. The device generates EA stimulation pulses in accordance with a specified stimulation regimen. Power management circuitry within the device allows a primary battery, having a high internal impedance, to be used to power the device. The stimulation regimen generates stimulation pulses during a stimulation session of duration T3 minutes applied every T4 minutes. The duty cycle, or ratio T3/T4, is very low, no greater than 0.05. The low duty cycle and careful power management allow the IEAD to perform its intended function for several years.
Abstract translation: 可植入电针装置（IEAD）通过施加在目标组织位置（例如穴位）上施加的电针（EA）刺激脉冲来治疗患者的医疗状况。 IEAD包括可植入的硬币大小的独立的无引线电针装置，其具有附接到其外壳的外表面的至少两个电极。 该设备根据指定的刺激方案产生EA刺激脉冲。 设备内的电源管理电路允许使用具有高内部阻抗的一次电池为设备供电。 刺激方案在每T4分钟施用持续时间T3分钟的刺激期间产生刺激脉冲。 占空比或比例T3 / T4非常低，不大于0.05。 低占空比和仔细的电源管理允许IEAD执行其预期功能几年。
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12.发明申请公开(公告)号：US20190290541A1
公开(公告)日：2019-09-26
申请号：US16392378
申请日：2019-04-23
Applicant: Valencia Technologies Corporation
Inventor： Jeffrey H. Greiner , David K. L. Peterson , Chuladatta Thenuwara , Stacy O. Greiner
Abstract: A method of treating a mental disorder of a patient includes generating, by an implantable stimulator configured to be implanted beneath a skin surface of the patient, stimulation sessions at a duty cycle that is less than 0.05 and applying, by the implantable stimulator in accordance with the duty cycle, the stimulation sessions to a tissue location associated with the mental disorder. The duty cycle is a ratio of T3 to T4. Each stimulation session included in the stimulation sessions has a duration of T3 minutes and occurs at a rate of once every T4 minutes. The implantable stimulator is powered by a primary battery located within the implantable stimulator and having an internal impedance greater than 5 ohms.
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公开(公告)号：US09327134B2
公开(公告)日：2016-05-03
申请号：US13796314
申请日：2013-03-12
Applicant: Valencia Technologies Corporation
Inventor： Jeffrey H. Greiner , David K. L. Peterson , Chuladatta Thenuwara , Stacy O. Greiner
CPC classification number: A61H39/002 , A61N1/36067 , A61N1/36096 , A61N1/36107 , A61N1/36114 , A61N1/36117 , A61N1/36125 , A61N1/36175 , A61N1/37205 , A61N1/3756 , A61N1/3758 , A61N1/3782 , H01L2224/48091 , Y10T29/49002 , H01L2924/00014
Abstract: An implantable electroacupuncture device (IEAD) treats a medical condition of a patient through application of electroacupuncture (EA) stimulation pulses applied at a target tissue location, such as an acupoint. The IEAD comprises an implantable, coin-sized, self-contained, leadless electroacupuncture device having at least two electrodes attached to an outside surface of its housing. The device generates EA stimulation pulses in accordance with a specified stimulation regimen. Power management circuitry within the device allows a primary battery, having a high internal impedance, to be used to power the device. The stimulation regimen generates stimulation pulses during a stimulation session of duration T3 minutes applied every T4 minutes. The duty cycle, or ratio T3/T4, is very low, no greater than 0.05. The low duty cycle and careful power management allow the IEAD to perform its intended function for several years.
Abstract translation: 可植入电针装置（IEAD）通过施加在目标组织位置（例如穴位）上施加的电针（EA）刺激脉冲来治疗患者的医疗状况。 IEAD包括可植入的硬币大小的独立的无引线电针装置，其具有附接到其外壳的外表面的至少两个电极。 该设备根据指定的刺激方案产生EA刺激脉冲。 设备内的电源管理电路允许使用具有高内部阻抗的一次电池为设备供电。 刺激方案在每T4分钟施用持续时间T3分钟的刺激期间产生刺激脉冲。 占空比或比例T3 / T4非常低，不大于0.05。 低占空比和仔细的电源管理允许IEAD执行其预期功能几年。
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14.发明授权Implantable electroacupuncture device and method for treating depression, bipolar disorder and anxiety 有权可植入式电针装置及治疗抑郁症，双相情感障碍和焦虑症的方法公开(公告)号：US09198828B2
公开(公告)日：2015-12-01
申请号：US13630322
申请日：2012-09-28
Applicant: Valencia Technologies Corporation
Inventor： Jeffrey H. Greiner , David K. L. Peterson , Chuladatta Thenuwara , Stacy O. Greiner
CPC classification number: A61H39/002 , A61N1/36096 , A61N1/36117 , A61N1/36125 , A61N1/36175 , A61N1/37205 , A61N1/3756 , A61N1/3782 , Y10T29/49002
Abstract: An implantable electroacupuncture device (IEAD) treats depression, bipolar disorder or Anxiety through application of stimulation pulses applied at acupoints GV20 and/or EXHN3. The IEAD comprises an implantable, coin-sized, self-contained, leadless electroacupuncture device having at least two electrodes attached to an outside surface of its housing. The device generates stimulation pulses in accordance with a specified stimulation regimen. Power management circuitry within the device allows a primary battery, having a high internal impedance, to be used to power the device. The stimulation regimen generates stimulation pulses during a stimulation session of duration T3 minutes applied every T4 minutes. The duty cycle, or ratio T3/T4, is very low, no greater than 0.05. The low duty cycle and careful power management allow the IEAD to perform its intended function for several years.
Abstract translation: 可植入电针装置（IEAD）通过施加在穴位GV20和/或EXHN3处施加的刺激脉冲来治疗抑郁症，双相情感障碍或焦虑症。 IEAD包括可植入的硬币大小的独立的无引线电针装置，其具有附接到其外壳的外表面的至少两个电极。 该设备根据指定的刺激方案产生刺激脉冲。 设备内的电源管理电路允许使用具有高内部阻抗的一次电池为设备供电。 刺激方案在每T4分钟施用持续时间T3分钟的刺激期间产生刺激脉冲。 占空比或比例T3 / T4非常低，不大于0.05。 低占空比和仔细的电源管理允许IEAD执行其预期功能几年。
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15.发明申请公开(公告)号：US20140214127A1
公开(公告)日：2014-07-31
申请号：US13736041
申请日：2013-01-07
Applicant: Valencia Technologies Corporation
Inventor： Jeffrey H. Greiner , David K. L. Peterson , Chuladatta Thenuwara , Stacy O. Greiner
IPC: A61H39/00
CPC classification number: A61H39/002 , A61H2201/5035 , A61H2201/5038 , A61H2201/5097 , A61N1/3606 , A61N1/36085 , A61N1/36125 , A61N1/36153 , A61N1/36157 , A61N1/36175 , A61N1/37205 , A61N1/3756 , A61N1/3758 , A61N1/3782 , Y10T29/49117
Abstract: An Implantable ElectroAcupuncture Device (IEAD) treats dyslipidemia conditions of a patient through application of stimulation pulses applied at acupoint ST40, or its underlying nerves saphenous and peroneal. The IEAD comprises an implantable, coin-sized, self-contained, leadless electroacupuncture device having at least two electrodes attached to an outside surface of its housing. The device generates stimulation pulses in accordance with a specified stimulation regimen. Power management circuitry within the device allows a primary battery, having a high internal impedance, to be used to power the device. The stimulation regimen generates stimulation pulses during a stimulation session of duration T3 minutes applied every T4 minutes. The duty cycle, or ratio T3/T4, is very low, no greater than 0.05. The low duty cycle and careful power management allow the IEAD to perform its intended function for several years.
Abstract translation: 可植入电针装置（IEAD）通过施加在穴位ST40施加的刺激脉冲或其潜伏的神经隐匿和腓骨来治疗患者的血脂异常状况。 IEAD包括可植入的硬币大小的独立的无引线电针装置，其具有附接到其外壳的外表面的至少两个电极。 该设备根据指定的刺激方案产生刺激脉冲。 设备内的电源管理电路允许使用具有高内部阻抗的一次电池为设备供电。 刺激方案在每T4分钟施用持续时间T3分钟的刺激期间产生刺激脉冲。 占空比或比例T3 / T4非常低，不大于0.05。 低占空比和仔细的电源管理允许IEAD执行其预期功能几年。
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Patent Agency Ranking
16.发明申请Implantable Electroacupuncture System and Method for Treating Dyslipidemia and Obesity 有权植入式电针系统及治疗脂血症和肥胖的方法公开(公告)号：US20140214125A1
公开(公告)日：2014-07-31
申请号：US13736033
申请日：2013-01-07
Applicant: Valencia Technologies Corporation
Inventor： Jeffrey H. Greiner , David K. L. Peterson , Chuladatta Thenuwara , Stacy O. Greiner
IPC: A61H39/00
CPC classification number: A61H39/002 , A61F5/0026 , A61H2201/50 , A61H2201/5005 , A61H2201/5038 , A61H2201/5097 , A61N1/36085 , A61N1/36117 , A61N1/36125 , A61N1/36153 , A61N1/36157 , A61N1/36175 , A61N1/37205 , A61N1/375 , A61N1/3756 , A61N1/3758 , A61N1/3782 , Y10T29/49117
Abstract: An Implantable ElectroAcupuncture System (IEAS) treats dyslipidemia or obesity through application of stimulation pulses applied at at least one of acupoints ST36, SP4, ST37, ST40, SP6, SP9, K16, or LR8, or underlying nerves saphenous or peroneal. The IEAS includes an hermetically-sealed implantable electroacupuncture (EA) device having at least two electrodes located outside of its housing. The housing contains a primary power source, pulse generation circuitry, and a sensor that wirelessly senses externally-generated operating commands. The pulse generation circuitry generates stimulation pulses as controlled, at least in part, by the operating commands sensed through the sensor. The stimulation pulses are applied to the specified acupoint or nerve through the electrodes in accordance with a specified stimulation regimen. Such stimulation regimen requires that the stimulation session be applied at a very low duty cycle not greater than 0.05.
Abstract translation: 可植入电针刺系统（IEAS）通过施加在穴位ST36，SP4，ST37，ST40，SP6，SP9，K16或LR8中的至少一个或隐匿性或腓神经的下面的神经施加刺激脉冲来治疗血脂异常或肥胖。 IEAS包括密封的可植入电针（EA）装置，其具有位于其壳体外部的至少两个电极。 外壳包含主电源，脉冲发生电路和无线感应外部生成的操作命令的传感器。 脉冲产生电路至少部分地通过通过传感器感测的操作命令来产生刺激脉冲。 刺激脉冲根据指定的刺激方案通过电极施加到指定的穴位或神经。 这种刺激方案要求在非常低的占空比不大于0.05的情况下施用刺激会话。
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17.发明申请Stimulation Paradigm To Improve Blood Pressure Dipping In An Implantable Electroacupuncture Device 有权刺激范式，以改善可植入电针装置中的血压浸渍公开(公告)号：US20140214116A1
公开(公告)日：2014-07-31
申请号：US13786447
申请日：2013-03-05
Applicant: Valencia Technologies Corporation
Inventor： David K. L. Peterson , Stacy O. Greiner
IPC: A61N1/36
CPC classification number: A61N1/36117 , A61H39/002 , A61H2201/5005 , A61H2201/5038 , A61H2201/5041 , A61H2201/5097 , A61N1/3605 , A61N1/36135 , A61N1/36175 , A61N1/37205 , A61N1/3756 , A61N1/3782
Abstract: A coin-sized implantable electroacupuncture (EA) device defines a stimulation paradigm, or stimulation regimen, that controls when EA stimulation pulses are applied to a selected acupoint, or other specified tissue location, to treat hypertension or nondipping. The stimulation regimen is applied when the patient is sleeping in order to minimize or mitigate the occurrence of nondipping or reverse dipping of the patient's blood pressure. In one embodiment, medical personnel, set a timing reference marker at the time of implant that defines how much time should elapse before a nighttime stimulation window opens that allows an EA stimulation session to be applied to the patient. In another embodiment, the patient sets the time when the nighttime stimulation window opens or when the EA stimulation session begins. Typically, an EA stimulation session is applied to the patient at a low duty cycle, e.g., only once a week during the nighttime.
Abstract translation: 硬币大小的可植入电针（EA）装置定义了刺激范例或刺激方案，其控制何时将EA刺激脉冲施加到选定的穴位或其他指定的组织位置以治疗高血压或非浸润。 当患者睡觉时应用刺激方案以便最小化或减轻患者血压的非浸没或反浸渍的发生。 在一个实施例中，医务人员在植入时设置定时参考标记，其定义在夜间刺激窗口打开之前经过多少时间，其允许将EA刺激会话应用于患者。 在另一个实施例中，患者设定夜间刺激窗口打开或EA刺激会话开始时的时间。 通常，EA刺激会话以低工作周期应用于患者，例如在夜间仅每星期一次。
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18.发明申请Implantable Electroacupuncture Device and Method for Treating Erectile Dysfunction 有权植入式电针装置及治疗勃起功能障碍的方法公开(公告)号：US20140214112A1
公开(公告)日：2014-07-31
申请号：US13784573
申请日：2013-03-04
Applicant: Valencia Technologies Corporation
Inventor： Jeffrey H. Greiner , David K. L. Peterson , Chuladatta Thenuwara , Stacy O. Greiner
CPC classification number: A61F5/41 , A61F2005/418 , A61H39/002 , A61H2201/5005 , A61H2201/5038 , A61H2201/5097 , A61H2205/087 , A61N1/18 , A61N1/36107 , A61N1/36125 , A61N1/36153 , A61N1/36157 , A61N1/36175 , A61N1/362 , A61N1/37205 , A61N1/375 , A61N1/3756 , A61N1/3758 , A61N1/3782 , Y10T29/49002
Abstract: An implantable electroacupuncture device (IEAD) treats an erectile dysfunction condition of a patient through application of stimulation pulses applied at a target tissue location underlying, or in the vicinity of, at least one of acupoints BL52, BL23 or GV4. The IEAD comprises an implantable, coin-sized, self-contained, leadless electroacupuncture device having at least two electrodes attached to an outside surface of its housing. The device generates stimulation pulses in accordance with a specified stimulation regimen. Power management circuitry within the device allows a primary battery, having a high internal impedance, to be used to power the device. The stimulation regimen generates stimulation pulses during a stimulation session of duration T3 minutes applied every T4 minutes. The duty cycle, or ratio T3/T4, is very low, no greater than 0.05. The low duty cycle and careful power management allow the IEAD to perform its intended function for several years.
Abstract translation: 可植入电针装置（IEAD）通过施加施加在穴位BL52，BL23或GV4中的至少一个穴位下方或附近的目标组织位置处的刺激脉冲来治疗患者的勃起功能障碍状况。 IEAD包括可植入的硬币大小的独立的无引线电针装置，其具有附接到其外壳的外表面的至少两个电极。 该设备根据指定的刺激方案产生刺激脉冲。 设备内的电源管理电路允许使用具有高内部阻抗的一次电池为设备供电。 刺激方案在每T4分钟施用持续时间T3分钟的刺激期间产生刺激脉冲。 占空比或比例T3 / T4非常低，不大于0.05。 低占空比和仔细的电源管理允许IEAD执行其预期功能几年。
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公开(公告)号：US10792219B2
公开(公告)日：2020-10-06
申请号：US16394932
申请日：2019-04-25
Applicant: Valencia Technologies Corporation
Inventor： Jeffrey H. Greiner , David K. L. Peterson , Chuladatta Thenuwara , Stacy O. Greiner
Abstract: A method comprises generating, by an implantable stimulator, stimulation sessions at a duty cycle that is less than 0.05 and applying, by the implantable stimulator in accordance with the duty cycle, the stimulation sessions to a patient. The duty cycle is a ratio of T3 to T4. Each stimulation session included in the stimulation sessions has a duration of T3 minutes and occurs at a rate of once every T4 minutes. The implantable stimulator is powered by a primary battery located within the implantable stimulator and having an internal impedance greater than 5 ohms.
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公开(公告)号：US10299987B2
公开(公告)日：2019-05-28
申请号：US15918781
申请日：2018-03-12
Applicant: Valencia Technologies Corporation
Inventor： Jeffrey H. Greiner , David K. L. Peterson , Chuladatta Thenuwara , Stacy O. Greiner
Abstract: An exemplary method includes generating, by an electroacupuncture device implanted beneath a skin surface of a patient, stimulation sessions at a duty cycle that is less than 0.05, and applying, by the electroacupuncture device in accordance with the duty cycle, the stimulation sessions to a location within the patient. A primary battery located within the electroacupuncture device and having an internal impedance greater than 5 ohms is configured to provide operating power to pulse generation circuitry within the electroacupuncture device.
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