Monocyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them
    12.
    发明授权
    Monocyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them 失效
    单环化合物及其在药物中的应用:其制备方法和含有它们的药物组合物

    公开(公告)号:US06369067B1

    公开(公告)日:2002-04-09

    申请号:US09507371

    申请日:2000-02-18

    IPC分类号: A01N4354

    摘要: The present invention relates to novel antiobesity and hypocholesterolemic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. More particularly, the present invention relates to novel &bgr;-aryl-&agr;-oxysubstituted alkylcarboxylic acids of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. The present invention also relates to a process for the preparation of the above said novel compounds, their analogs, their derivatives, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutical compositions containing them. The present invention also relates to novel intermediates, processes for their preparation and their use in the preparation of compounds of formula (I).

    摘要翻译: 本发明涉及新型抗肥胖和低胆固醇血症化合物,其衍生物,其类似物,其互变异构形式,其立体异构体,其多晶型物,其药学上可接受的盐,其药学上可接受的溶剂合物和含有它们的药学上可接受的组合物。 更具体地,本发明涉及通式(I)的新型β-芳基-α-氧代取代的烷基羧酸,其衍生物,它们的类似物,其互变异构形式,它们的立体异构体,它们的多晶型物,其药学上可接受的盐,它们的药学上可接受的 溶剂合物和含有它们的药学上可接受的组合物。 本发明还涉及制备上述新化合物,其类似物,其衍生物,其互变异构形式,其立体异构体,其多晶型物,其药学上可接受的盐,药学上可接受的溶剂化物和含有它们的药物组合物的方法。 本发明还涉及新型中间体,其制备方法及其在制备式(I)化合物中的用途。

    Intermediates of benzoxazinone derivatives and preparation thereof
    13.
    发明授权
    Intermediates of benzoxazinone derivatives and preparation thereof 失效
    苯并恶嗪酮衍生物的中间体及其制备方法

    公开(公告)号:US06331627B1

    公开(公告)日:2001-12-18

    申请号:US09610623

    申请日:2000-07-05

    IPC分类号: C07D27916

    摘要: The present invention relates to novel antiobesity and hypocholesterolemic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. More particularly, the present invention relates to novel &bgr;-aryl-&agr;-oxysubstituted alkylcarboxylic acids of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereo-somers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. The present invention also relates to a process for the preparation of the above said novel compounds, their analogs, their derivatives, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, novel intermediates and pharmaceutical compositions containing them.

    摘要翻译: 本发明涉及新型抗肥胖和低胆固醇血症化合物,其衍生物,其类似物,其互变异构形式,其立体异构体,其多晶型物,其药学上可接受的盐,其药学上可接受的溶剂合物和含有它们的药学上可接受的组合物。 更具体地,本发明涉及通式(I)的新型β-芳基-α-氧代取代的烷基羧酸,其衍生物,它们的类似物,它们的互变异构形式,它们的立体异构体,它们的多晶型物,其药学上可接受的盐,它们的 药学上可接受的溶剂合物和含有它们的药学上可接受的组合物。本发明还涉及制备上述新化合物,其类似物,其衍生物,其互变异构形式,其立体异构体,其多晶型物,其药学上可接受的盐,药学上可接受的盐 可接受的溶剂合物,新型中间体和含有它们的药物组合物。

    Monocyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them
    16.
    发明授权
    Monocyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them 失效
    单环化合物及其在药物中的应用:其制备方法和含有它们的药物组合物

    公开(公告)号:US07157581B2

    公开(公告)日:2007-01-02

    申请号:US11296749

    申请日:2005-12-07

    IPC分类号: C07D239/02

    摘要: The present invention relates to novel antiobesity and hypocholesterolemic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. More particularly, the present invention relates to novel β-aryl-α-oxysubstituted alkylcarboxylic acids of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. The present invention also relates to a process for the preparation of the above said novel compounds, their analogs, their derivatives, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutical compositions containing them. The present invention also relates to novel intermediates, processes for their preparation and their use in the preparation of compounds of formula (I).

    摘要翻译: 本发明涉及新型抗肥胖和低胆固醇血症化合物,其衍生物,其类似物,其互变异构形式,其立体异构体,其多晶型物,其药学上可接受的盐,其药学上可接受的溶剂合物和含有它们的药学上可接受的组合物。 更具体地,本发明涉及通式(I)的新型β-芳基-α-氧代取代的烷基羧酸,其衍生物,它们的类似物,其互变异构形式,它们的立体异构体,它们的多晶型物,其药学上可接受的盐,它们的药学上可接受的 溶剂合物和含有它们的药学上可接受的组合物。 本发明还涉及制备上述新化合物,其类似物,其衍生物,其互变异构形式,其立体异构体,其多晶型物,其药学上可接受的盐,药学上可接受的溶剂化物和含有它们的药物组合物的方法。 本发明还涉及新型中间体,其制备方法及其在制备式(I)化合物中的用途。

    Heterocyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them
    17.
    发明授权
    Heterocyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them 失效
    杂环化合物及其在医药中的应用 其制备方法和含有它们的药物组合物

    公开(公告)号:US06664411B2

    公开(公告)日:2003-12-16

    申请号:US09818339

    申请日:2001-03-27

    IPC分类号: C07C6976

    摘要: The present invention relates to novel antiobesity and hypocholesterolemic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. More particularly, the present invention relates to novel &bgr;-aryl-&agr;-oxysubstituted alkylcarboxylic acids of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereosomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. The present invention also relates to a process for the preparation of the above said novel compounds, their analogs, their derivatives, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, novel intermediates and pharmaceutical compositions containing them.

    摘要翻译: 本发明涉及新型抗肥胖和低胆固醇血症化合物,其衍生物,其类似物,其互变异构形式,其立体异构体,其多晶型物,其药学上可接受的盐,其药学上可接受的溶剂合物和含有它们的药学上可接受的组合物。 更具体地,本发明涉及通式(I)的新型β-芳基-α-氧代取代的烷基羧酸,其衍生物,其类似物,其互变异构形式,其立体异构体,其多晶型物,其药学上可接受的盐,其药学上可接受的盐 本发明还涉及制备上述新化合物,其类似物,其衍生物,其互变异构形式,其立体异构体,其多晶型物,其药学上可接受的盐,药学上可接受的溶剂合物的方法 ,新颖的中间体和含有它们的药物组合物。