Stem cell differentiation using novel light-responsive hydrogels
    13.
    发明授权
    Stem cell differentiation using novel light-responsive hydrogels 有权
    使用新的光响应水凝胶的干细胞分化

    公开(公告)号:US09234171B2

    公开(公告)日:2016-01-12

    申请号:US13314891

    申请日:2011-12-08

    摘要: This application discloses a light-responsive hydrogel-based platform that can modulate multiple microenvironmental signals to direct the differentiation of human induced pluripotent stem cell-derived neural progenitor cells (hiPSC-NPCs) into neuronal cells. The invention provides novel methods for directing differentiation of neural stem cells into neurons useful for treatment of degenerative diseases or disorders, including but not limited to Alzheimer's, Parkinson's, or spinal cord injury (SCI).

    摘要翻译: 该申请公开了一种光反应性水凝胶基平台,其可以调节多种微环境信号以将人诱导的多能干细胞衍生的神经祖细胞(hiPSC-NPC)分化为神经元细胞。 本发明提供了用于将神经干细胞分化为用于治疗退行性疾病或病症(包括但不限于阿尔茨海默病,帕金森病或脊髓损伤(SCI))的神经元的新颖方法。

    STEM CELL DIFFERENTIATION USING NOVEL LIGHT-RESPONSIVE HYDROGELS
    15.
    发明申请
    STEM CELL DIFFERENTIATION USING NOVEL LIGHT-RESPONSIVE HYDROGELS 有权
    使用新型反应性水凝胶的干细胞分化

    公开(公告)号:US20120149781A1

    公开(公告)日:2012-06-14

    申请号:US13314891

    申请日:2011-12-08

    IPC分类号: A61K47/42 C12N5/0797

    摘要: This application discloses a light-responsive hydrogel-based platform that can modulate multiple microenvironmental signals to direct the differentiation of human induced pluripotent stem cell-derived neural progenitor cells (hiPSC-NPCs) into neuronal cells. The invention provides novel methods for directing differentiation of neural stem cells into neurons useful for treatment of degenerative diseases or disorders, including but not limited to Alzheimer's, Parkinson's, or spinal cord injury (SCI).

    摘要翻译: 该申请公开了一种光反应性水凝胶基平台,其可以调节多种微环境信号以将人诱导的多能干细胞衍生的神经祖细胞(hiPSC-NPC)分化为神经元细胞。 本发明提供了用于将神经干细胞分化为用于治疗退行性疾病或病症(包括但不限于阿尔茨海默病,帕金森病或脊髓损伤(SCI))的神经元的新颖方法。