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    Preparation of 5-hydroxy-4-methyl-2(5H)-furanone
    13.
    发明授权
    Preparation of 5-hydroxy-4-methyl-2(5H)-furanone 失效
    制备5-羟基-4-甲基-2（5H） - 呋喃酮

    公开(公告)号：US5654444A

    公开(公告)日：1997-08-05

    申请号：US621035

    申请日：1996-03-22

    申请人： Michael John ,  Walter Dobler ,  Joachim Paust

    发明人： Michael John ,  Walter Dobler ,  Joachim Paust

    IPC分类号： C07D307/60

    CPC分类号： C07D307/60

    摘要： 5-Hydroxy-4-methyl-2(5H)-furanone is prepared by cyclization of alkyl .beta.-formylcrotonates by heating with dilute aqueous hydrochloric acid or, advantageously, in the presence of dilute aqueous hydrochloric acid and catalytic amounts of methanol as solubilizer, subsequent workup of the reaction mixture by distillation and, where appropriate, isomerization of the 5-methoxy- or 5-ethoxy-4-methyl-2(5H)-furanone, which is formed as byproduct, by heating with dilute hydrochloric acid.

    摘要翻译： 5-羟基-4-甲基-2（5H） - 呋喃酮是通过用稀盐酸水溶液加热或有利地在稀盐酸水溶液和催化量的甲醇作为增溶剂的存在下，通过环化β-甲酰基巴豆酸烷基酯来制备的， 随后通过蒸馏和通过用稀盐酸加热作为副产物形成的5-甲氧基 - 或5-乙氧基-4-甲基-2（5H） - 呋喃酮的异构化反应混合物进行后处理。

    Continuous epimerization of sugars, in particular D-arabinose to D-ribose
    15.
    发明授权
    Continuous epimerization of sugars, in particular D-arabinose to D-ribose 失效
    糖，特别是D-阿拉伯糖到D-核糖的连续差向异构化

    公开(公告)号：US5015296A

    公开(公告)日：1991-05-14

    申请号：US184805

    申请日：1988-04-22

    申请人： Walter Dobler ,  Joachim Paust

    发明人： Walter Dobler ,  Joachim Paust

    IPC分类号： C07B61/00 ,  C07H3/02

    CPC分类号： C07H3/02

    摘要： Pentoses and hexoses are continuously epimerized by heating a sugar in solution in a solvent in the presence of a basic anion exchanger charged with a molybedenum(VI) compound by preparing a D- or L-sugar having cis-disposed OH groups in the 2- and 3-positions of the sugar by continuously passing a homogeneous solution of the corresponding sugar having transdisposed OH groups in the 2- and 3-positions of the sugar in a mixture of water and methanol or ethanol at from 70.degree. to 100.degree. C., preferably at from 73.degree. and 80.degree. C., through a reaction tube which contains the basic anion exchanger charged with the molybdenum(VI) compound, this method being suitable in particular for epimerizing D-arabinose to prepare D-ribose required for the production of riboflavin.

    摘要翻译： 戊二酸和己糖通过在带有钼（VI）化合物的碱性阴离子交换剂存在下，在溶剂中加热溶液而连续差向异构化，通过制备在2-位上具有顺式设置的OH基团的D-或L-糖， 和糖的3-位，通过在70至100℃的水和甲醇或乙醇的混合物中连续通过糖的2-位和3-位的具有反式OH基团的相应糖的均匀溶液。 ，优选在73℃和80℃，通过含有装载有（VI）化合物的碱性阴离子交换剂的反应管，该方法特别适合于差向异构化D-阿拉伯糖以制备D-阿拉伯糖所需的D-核糖 生产核黄素。

    Purification of salts of riboflavin 5'-phosphate, in particular of monosodium riboflavin 5'-phosphate
    16.
    发明授权
    Purification of salts of riboflavin 5'-phosphate, in particular of monosodium riboflavin 5'-phosphate 失效
    核黄素5'-磷酸盐，特别是核黄素5'-磷酸一钠的盐的纯化

    公开(公告)号：US4987229A

    公开(公告)日：1991-01-22

    申请号：US323795

    申请日：1989-03-15

    申请人： Walter Dobler ,  Manfred Eggersdorfer ,  Joachim Paust

    发明人： Walter Dobler ,  Manfred Eggersdorfer ,  Joachim Paust

    IPC分类号： C07D475/14 ,  C07F9/6561

    CPC分类号： C07F9/65618

    摘要： Salts of riboflavin 5'-phosphate which are obtained by phosphorylation of riboflavin and reaction of the resulting riboflavin 5'-phosphate (5'-FMN), contaminated with unconverted riboflavin and isomeric riboflavin monophosphates and diphosphates, with an alkali metal hydroxide or a nitrogen base are purified by a process in which(a) a roughly 1-15% strength by weight homogeneous, clear, aqueous 5'-FMN salt solution having a pH of from 4 to 7 is prepared from the crude 5'-FMN obtained in the phosphorylation, water and the alkali metal hydroxide or the nitrogen base, preferably sodium hydroxide solution, if necessary with heating at from 30.degree. to 100.degree. C.,(b) the resulting solution is treated with a suitable polymeric adsorber resin and(c) the 5'-FMN salt substantially freed from unconverted riboflavin is isolated from the resulting solution and, if desired, the solution is fed to a subsequent fine purification.Treatment with the suitable polymeric adsorber resin is advantageously carried out in a column filled with adsorber resin. The subsequent fine purification can be effected by evaporative crystallization or by chromatographing a 5'-FMN solution, containing from 1 to 15% by weight of dry substance, in water or in a mixture of water and a lower aliphatic alcohol, having a pH of from 4 to 7, in a minimum amount of from 5 to 50% of the bed volume of the column over RP silica gel derivatized with alkyl groups, using water, or a mixture of water and a lower aliphatic alcohol, as the eluant. Preparative chromatography of 5'-FMN salts over derivatized RP silica gel using water, or a mixture of water and a lower aliphatic alcohol, as the solvent and eluant is also claimed independently of pretreatment with the suitable adsorber resin.

    摘要翻译： 通过核黄素磷酸化获得的核黄素5'-磷酸盐的盐和由未转化的核黄素和异构核黄素单磷酸酯和二磷酸酯污染的所得核黄素5'-磷酸（5'-FMN）与碱金属氢氧化物或氮 碱通过以下方法纯化，其中（a）从所得粗制5'-FMN制备了具有约1-15％重量的均匀，透明的pH5-4的5-FMN盐水溶液， 磷酸化，水和碱金属氢氧化物或氮碱，优选氢氧化钠溶液，如果需要，在30℃至100℃下加热，（b）所得溶液用合适的聚合物吸附树脂处理，（c ）从所得溶液中分离出基本上未转化的核黄素的5'-FMN盐，并且如果需要，将溶液加入到随后的精细纯化中。 用合适的聚合物吸附树脂处理有利地在填充有吸附树脂的柱中进行。 随后的精细纯化可以通过蒸发结晶或通过色谱法将含有1至15重量％干物质的5-FMN溶液在水或水和低级脂族醇的混合物中进行，其pH为 作为洗脱剂，使用水或水和低级脂族醇的混合物，用烷基衍生的RP硅胶的柱体积的最小量为5至50％。 独立于合适的吸附剂树脂的预处理，也要求使用水，或水和低级脂族醇的混合物作为溶剂和洗脱剂的衍生化RP硅胶的5-FMN盐的制备色谱法。

    Graft copolymers having improved phase binding between the graft base and the grafted-on polymer phase
    19.
    发明授权
    Graft copolymers having improved phase binding between the graft base and the grafted-on polymer phase 失效
    具有改善接枝基质和接枝聚合物相之间的相结合的接枝共聚物

    公开(公告)号：US5384381A

    公开(公告)日：1995-01-24

    申请号：US152740

    申请日：1993-11-15

    申请人： Klaus Kohlhammer ,  Hermann Petersen ,  Walter Dobler

    发明人： Klaus Kohlhammer ,  Hermann Petersen ,  Walter Dobler

    IPC分类号： C08F291/00 ,  C07C409/38 ,  C08F4/34 ,  C08F261/06 ,  C08F293/00 ,  C08F218/04

    CPC分类号： C08F261/06 ,  C08F293/00

    摘要： Graft copolymers having improved phase binding between the graft base and the grafted-on polymer, are prepared from:a) a grafted-on polymer phase containing one or more monomers from the group consisting of (meth)acrylates of alcohols having 1 to 10 carbon atoms, vinyl esters of saturated aliphatic carboxylic acids having 2 to 10 carbon atoms, olefins, vinyl halides, styrene and styrene derivatives, andb) a peroxy group-containing copolymer phase containing from 0.01 to 20% by weight of an olefinically unsaturated peroxy compound of the general formula I or II ##STR1## where R.sup.1 is a chemical bond or a linear or branched alkyl chain having 1 to 10 carbon atoms or a cycloalkyl group having 3 to 10 carbon atoms, R.sup.2 and R.sup.3 are an alkyl group having 1 to 4 carbon atoms, R.sup.4 is an alkyl group or an alkyl-substituted phenyl group having 3 to 12 carbon atoms, and R.sup.5 is a cycloalkyl group having 3 to 12 carbon atoms, and from 80 to 99.9% by weight of one or more comonomers from the group consisting of the (meth)acrylates of alcohols having 1 to 10 carbon atoms, vinyl esters of saturated aliphatic carboxylic acids having 2 to 10 carbon atoms, olefins, vinylaromatic compounds, vinyl halides and/or vinyl ethers.The graft copolymers are useful as binders in the textile industry as heat stable binders, as adhesives in plasters and as binders in emulsion paints.

    摘要翻译： 具有改进的接枝基质和接枝聚合物之间的相结合的接枝共聚物由以下物质制备：a）接枝聚合物相，其含有一种或多种由具有1至10个碳的醇的（甲基）丙烯酸酯组成的组中的单体 原子，具有2-10个碳原子的饱和脂族羧酸的乙烯基酯，烯烃，乙烯基卤化物，苯乙烯和苯乙烯衍生物，和b）含有0.01-20重量％的烯属不饱和过氧化合物 其中R 1是化学键或具有1至10个碳原子的直链或支链烷基或具有3至10个碳原子的环烷基，所述通式I或II其中R 1， R2和R3是具有1至4个碳原子的烷基，R4是烷基或具有3-12个碳原子的烷基取代的苯基，R5是具有3-12个碳原子的环烷基，从80到 99.9重量％的一种或多种共聚单体f 由具有1-10个碳原子的（甲基）丙烯酸酯，具有2-10个碳原子的饱和脂族羧酸的乙烯基酯，烯烃，乙烯基芳族化合物，乙烯基卤化物和/或乙烯基醚构成的组中。 接枝共聚物可用作纺织工业中的粘合剂，作为热稳定粘合剂，作为膏药中的粘合剂和乳液涂料中的粘合剂。

    Graft copolymers having improved phase binding between the graft base and the grafted-on polymer phase
    20.
    发明授权
    Graft copolymers having improved phase binding between the graft base and the grafted-on polymer phase 失效
    具有改善接枝基质和接枝聚合物相之间的相结合的接枝共聚物

    公开(公告)号：US5304609A

    公开(公告)日：1994-04-19

    申请号：US967662

    申请日：1993-10-28

    申请人： Klaus Kohlhammer ,  Hermann Petersen ,  Walter Dobler

    发明人： Klaus Kohlhammer ,  Hermann Petersen ,  Walter Dobler

    IPC分类号： C08F291/00 ,  C07C409/38 ,  C08F4/34 ,  C08F261/06 ,  C08F293/00 ,  C08F263/04

    CPC分类号： C08F261/06 ,  C08F293/00

    摘要： Graft copolymers having improved phase binding between the graft base and the grafted-on polymer, are prepared from:a) a grafted-on polymer phase containing one or more monomers from the group consisting of (meth)acrylates of alcohols having 1 to 10 carbon atoms, vinyl esters of saturated aliphatic carboxylic acids having 2 to 10 carbon atoms, olefins, vinyl halides, styrene and styrene derivatives, andb) a peroxy group-containing copolymer phase containing from 0.01 to 20% by weight of an olefinically unsaturated peroxy compound of the general formula I or II ##STR1## where R.sup.1 is a chemical bond or a linear or branched alkyl chain having 1 to 10 carbon atoms or a cycloalkyl group having 3 to 10 carbon atoms, R.sup.2 and R.sup.3 are an alkyl group having 1 to 4 carbon atoms, R.sup.4 is an alkyl group or an alkyl-substituted phenyl group having 3 to 12 carbon atoms, and R.sup.5 is a cycloalkyl group having 3 to 12 carbon atoms, and from 80 to 99.9% by weight of one or more comonomers from the group consisting of the (meth)acrylates of alcohols having 1 to 10 carbon atoms, vinyl esters of saturated aliphatic carboxylic acids having 2 to 10 carbon atoms, olefins, vinylaromatic compounds, vinyl halides and/or vinyl ethers.The graft copolymers are useful as binders in the textile industry as heat stable binders, as adhesives in plasters and as binders in emulsion paints.

    摘要翻译： 具有改进的接枝基质和接枝聚合物之间的相结合的接枝共聚物由以下物质制备：a）接枝聚合物相，其含有一种或多种由具有1至10个碳的醇的（甲基）丙烯酸酯组成的组中的单体 原子，具有2-10个碳原子的饱和脂族羧酸的乙烯基酯，烯烃，乙烯基卤化物，苯乙烯和苯乙烯衍生物，和b）含有0.01-20重量％的烯属不饱和过氧化合物 通式I或II（*化学结构*）（I）或（*化学结构*）（II）其中R1是化学键或具有1-10个碳原子的直链或支链烷基链或具有 3〜10个碳原子，R2和R3为碳原子数1〜4的烷基，R4为碳原子数3〜12的烷基或烷基取代苯基，R5为碳原子数为3〜12的环烷基 原子，从80到99.9％ 一种或多种由具有1-10个碳原子的醇的（甲基）丙烯酸酯组成的组中的一种或多种共聚单体的重量，具有2-10个碳原子的饱和脂族羧酸的乙烯基酯，烯烃，乙烯基芳族化合物，乙烯基卤化物和/或乙烯基 醚类。 接枝共聚物可用作纺织工业中的粘合剂，作为热稳定粘合剂，作为膏药中的粘合剂和乳液涂料中的粘合剂。