公开(公告)号：US07521473B2

公开(公告)日：2009-04-21

申请号：US11063475

申请日：2005-02-23

Applicant: Jinbo Lee ,  Zhao-Kui Wan ,  Douglas P. Wilson ,  Bruce C. Follows ,  Steven J. Kirincich ,  Michael J. Smith ,  Jun-Jun Wu ,  Kenneth W. Foreman ,  David V. Erbe ,  Yan-Ling Zhang ,  Weixin Xu ,  Steve Y. Tam

Inventor： Jinbo Lee ,  Zhao-Kui Wan ,  Douglas P. Wilson ,  Bruce C. Follows ,  Steven J. Kirincich ,  Michael J. Smith ,  Jun-Jun Wu ,  Kenneth W. Foreman ,  David V. Erbe ,  Yan-Ling Zhang ,  Weixin Xu ,  Steve Y. Tam

IPC: A61K31/381 ,  C07D333/38

CPC classification number: C07D333/38 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D413/12 ,  C07D451/02

Abstract: Protein tyrosine phosphatases (PTPases) such as PTP1B can play a role in regulating a wide variety of cellular responses such as insulin signaling. Substituted thiophene compounds such as, for example, 2-carboxyl, 3-carboxymethoxy, 5-aryl substituted thiophenes, can inhibit PTP1B and thereby induce greater insulin sensitivity. Accordingly, PTP1B inhibition can provide an alternate treatment for PTPase-mediated disorders such as diabetes.

Abstract translation: 蛋白酪氨酸磷酸酶（PTPases）如PTP1B可以在调节各种细胞反应（如胰岛素信号）中发挥作用。 取代的噻吩化合物例如2-羧基，3-羧基甲氧基，5-芳基取代的噻吩可以抑制PTP1B，从而诱导更大的胰岛素敏感性。 因此，PTP1B抑制可以为PTPase介导的病症例如糖尿病提供替代治疗。

公开(公告)号：US07674822B2

公开(公告)日：2010-03-09

申请号：US11285223

申请日：2005-11-22

Applicant: Jinbo Lee ,  Michael J. Smith ,  Alessandro Fabio Moretto ,  Zhao-Kui Wan ,  Eva Deanna Binnun ,  Weixin Xu ,  Kenneth W. Foreman ,  Diane M. Joseph-McCarthy ,  David V. Erbe ,  Steve Y. Tam

Inventor： Jinbo Lee ,  Michael J. Smith ,  Alessandro Fabio Moretto ,  Zhao-Kui Wan ,  Eva Deanna Binnun ,  Weixin Xu ,  Kenneth W. Foreman ,  Diane M. Joseph-McCarthy ,  David V. Erbe ,  Steve Y. Tam

IPC: A61K31/381 ,  C07D495/04

CPC classification number: C07D495/04 ,  C07D333/70 ,  C07D333/74

Abstract: This invention relates to modulating (e.g., inhibiting) protein tyrosine phosphatase 1B (PTP1B).

Abstract translation: 本发明涉及调节（例如抑制）蛋白质酪氨酸磷酸酶1B（PTP1B）。

公开(公告)号：US20090073172A1

公开(公告)日：2009-03-19

申请号：US12212588

申请日：2008-09-17

Applicant: Chang Jie Guo ,  Tie Jun Ou ,  Yi Hui ,  Wei Sun ,  Weixin Xu

Inventor： Chang Jie Guo ,  Tie Jun Ou ,  Yi Hui ,  Wei Sun ,  Weixin Xu

IPC: G06T11/20

CPC classification number: G06Q10/06

Abstract: A method, apparatus, computer program product for displaying the operation path of a process. According to the invention, at least two virtual instance views are generated, and the at least two virtual instance views and the relationships therebetween together exhibit the complete operation path containing possible dynamic operations, wherein a virtual instance view corresponds to a virtual instance and a virtual instance is a part of the entire operation path of the process. In each virtual instance view generated, the operation path of the corresponding virtual instance is presented, i.e. its starting node, terminating node and operation paths therebetween. The generated virtual instance views can be displayed in a temporal order and the operation paths between these virtual instances are visually displayed between the adjacent virtual instance views.

Abstract translation: 一种用于显示处理的操作路径的方法，装置，计算机程序产品。 根据本发明，生成至少两个虚拟实例视图，并且所述至少两个虚拟实例视图及其之间的关系表现出包含可能的动态操作的完整操作路径，其中虚拟实例视图对应于虚拟实例和虚拟实例视图 实例是整个过程的整个操作路径的一部分。 在生成的每个虚拟实例视图中，呈现相应虚拟实例的操作路径，即其起始节点，终止节点及其间的操作路径。 所生成的虚拟实例视图可以以时间顺序显示，并且在相邻虚拟实例视图之间可视地显示这些虚拟实例之间的操作路径。

公开(公告)号：US20090048286A1

公开(公告)日：2009-02-19

申请号：US12236121

申请日：2008-09-23

Applicant: Jinbo Lee ,  Steven J. Kirincich ,  Michael J. Smith ,  Douglas P. Wilson ,  Bruce C. Follows ,  Zhao-Kui Wan ,  Diane M. Joseph-McCarthy ,  David V. Erbe ,  Yan-Ling Zhang ,  Weixin Xu ,  Steve Y. Tam

Inventor： Jinbo Lee ,  Steven J. Kirincich ,  Michael J. Smith ,  Douglas P. Wilson ,  Bruce C. Follows ,  Zhao-Kui Wan ,  Diane M. Joseph-McCarthy ,  David V. Erbe ,  Yan-Ling Zhang ,  Weixin Xu ,  Steve Y. Tam

IPC: A61K31/4365 ,  C07D495/04 ,  A61K31/381 ,  C07D333/70 ,  C12N9/99

CPC classification number: C07D495/04 ,  C07D333/70

Abstract: Protein tyrosine phosphatases (PTPases) such as PTP1B can play a role in regulating a wide variety of cellular responses such as insulin signaling. Substituted bicyclic fused-thiophene compounds can inhibit PTP1B and thereby induce greater insulin sensitivity. Accordingly, PTP1B inhibition can provide an alternate treatment for PTPase-mediated disorders such as diabetes.

Abstract translation: 蛋白酪氨酸磷酸酶（PTPases）如PTP1B可以在调节各种细胞反应（如胰岛素信号）中发挥作用。 取代的双环稠合噻吩化合物可以抑制PTP1B，从而诱导更大的胰岛素敏感性。 因此，PTP1B抑制可以为PTPase介导的病症例如糖尿病提供替代治疗。

公开(公告)号：US20050203081A1

公开(公告)日：2005-09-15

申请号：US11064390

申请日：2005-02-23

Applicant: Jinbo Lee ,  Steve Kirincich ,  Michael Smith ,  Douglas Wilson ,  Bruce Follows ,  Zhao-Kui Wan ,  Diane Joseph-McCarthy ,  David Erbe ,  Yan-Ling Zhang ,  Weixin Xu ,  Steve Tam

Inventor： Jinbo Lee ,  Steve Kirincich ,  Michael Smith ,  Douglas Wilson ,  Bruce Follows ,  Zhao-Kui Wan ,  Diane Joseph-McCarthy ,  David Erbe ,  Yan-Ling Zhang ,  Weixin Xu ,  Steve Tam

IPC: A61K31/381 ,  A61K31/407 ,  A61K31/4743 ,  A61K31/55 ,  C07D333/70 ,  C07D495/04 ,  C07D498/02

CPC classification number: C07D495/04 ,  C07D333/70

Abstract: Protein tyrosine phosphatases (PTPases) such as PTP1B can play a role in regulating a wide variety of cellular responses such as insulin signaling. Substituted bicyclic fused-thiophene compounds can inhibit PTP1B and thereby induce greater insulin sensitivity. Accordingly, PTP1B inhibition can provide an alternate treatment for PTPase-mediated disorders such as diabetes.

Abstract translation: 蛋白酪氨酸磷酸酶（PTPases）如PTP1B可以在调节各种细胞反应（如胰岛素信号）中发挥作用。 取代的双环稠合噻吩化合物可以抑制PTP1B，从而诱导更大的胰岛素敏感性。 因此，PTP1B抑制可以为PTPase介导的病症例如糖尿病提供替代治疗。