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公开(公告)号：US20120202776A1
公开(公告)日：2012-08-09
申请号：US12736910
申请日：2009-05-21
申请人： Yihan Wang , Wei-Sheng Huang , Shuangying Liu , William C. Shakespeare , R. Mathew Thomas , Jiwei Qi , Feng Li , Xiaotian Zhu , Anna Kohlmann , David C. Dalgarno , Jan Antoinette C. Romero , Dong Zou
发明人： Yihan Wang , Wei-Sheng Huang , Shuangying Liu , William C. Shakespeare , R. Mathew Thomas , Jiwei Qi , Feng Li , Xiaotian Zhu , Anna Kohlmann , David C. Dalgarno , Jan Antoinette C. Romero , Dong Zou
IPC分类号： A61K31/675 , C07F9/6512 , C07F9/6561 , A61P35/00 , C07F9/6509 , C07F9/6521 , C07F9/58 , C07F9/6558 , C07F9/6584
CPC分类号： C07F9/6533 , C07D239/48 , C07F9/58 , C07F9/650905 , C07F9/6512 , C07F9/6521 , C07F9/65218 , C07F9/65583 , C07F9/65586 , C07F9/6561 , C07F9/65616 , C07F9/65685 , C07F9/657172 , C07F9/65846
摘要： The invention features compounds of the general formula (I) in which the variable groups are as defined herein, and to their preparation and use.
摘要翻译： 本发明的特征在于其中可变基团如本文所定义的通式（I）的化合物及其制备和用途。
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公开(公告)号：US09012462B2
公开(公告)日：2015-04-21
申请号：US12736910
申请日：2009-05-21
申请人： Yihan Wang , Wei-Sheng Huang , Shuangying Liu , William C. Shakespeare , R. Mathew Thomas , Jiwei Qi , Feng Li , Xiaotian Zhu , Anna Kohlman , David C. Dalgarno , Jan Antoinette C. Romero , Dong Zou
发明人： Yihan Wang , Wei-Sheng Huang , Shuangying Liu , William C. Shakespeare , R. Mathew Thomas , Jiwei Qi , Feng Li , Xiaotian Zhu , Anna Kohlman , David C. Dalgarno , Jan Antoinette C. Romero , Dong Zou
IPC分类号： A61K31/506 , C07F9/30 , C07D239/48 , C07F9/6509 , C07F9/6512 , C07F9/6521 , C07F9/6558 , C07F9/6561 , C07F9/6568 , C07F9/6571
CPC分类号： C07F9/6533 , C07D239/48 , C07F9/58 , C07F9/650905 , C07F9/6512 , C07F9/6521 , C07F9/65218 , C07F9/65583 , C07F9/65586 , C07F9/6561 , C07F9/65616 , C07F9/65685 , C07F9/657172 , C07F9/65846
摘要： The invention features compounds of the general formula (I) in which the variable groups are as defined herein, and to their preparation and use.
摘要翻译： 本发明的特征在于其中可变基团如本文所定义的通式（I）的化合物及其制备和用途。
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公开(公告)号：US20090156596A1
公开(公告)日：2009-06-18
申请号：US11990299
申请日：2006-08-11
申请人： Yihan Wang , Wei-Sheng Huang , Rajeswari Sundaramoorthi , Xiaotian Zhu , R. Mathew Thomas , William C. Shakespeare , David C. Dalgarno , Tomi K. Sawyer
发明人： Yihan Wang , Wei-Sheng Huang , Rajeswari Sundaramoorthi , Xiaotian Zhu , R. Mathew Thomas , William C. Shakespeare , David C. Dalgarno , Tomi K. Sawyer
IPC分类号： A61K31/5355 , C07D473/00 , C07D413/14 , A61P35/00 , A61K31/52
CPC分类号： C07F9/65616
摘要： This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
摘要翻译： 本发明涉及以下通式的化合物：其中可变基团如本文所定义，及其制备和用途。
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公开(公告)号：US08586566B2
公开(公告)日：2013-11-19
申请号：US13311106
申请日：2011-12-05
申请人： Yihan Wang , Wei-Sheng Huang , Rajeswari Sundaramoorthi , Xiaotian Zhu , R. Mathew Thomas , William C. Shakespeare , David C. Dalgarno , Tomi K. Sawyer
发明人： Yihan Wang , Wei-Sheng Huang , Rajeswari Sundaramoorthi , Xiaotian Zhu , R. Mathew Thomas , William C. Shakespeare , David C. Dalgarno , Tomi K. Sawyer
IPC分类号： A61K31/675 , A61K31/52 , A61P35/00 , C07F9/6561 , C07D473/32
CPC分类号： C07F9/65616
摘要： This invention relates to specific compounds and their pharmaceutically acceptable salts of the general formula: wherein Q is —CR═CR′— and Ring A is an aryl, heteroaryl or heterocyclic ring or ring system. This invention also relates to pharmaceutical compositions comprising such specific compounds or their pharmaceutically acceptable salts and a pharmaceutically acceptable carrier or adjuvant.
摘要翻译： 本发明涉及以下通式的具体化合物及其药学上可接受的盐：其中Q是-CR = CR'-，环A是芳基，杂芳基或杂环或环系。 本发明还涉及包含这些特定化合物或其药学上可接受的盐和药学上可接受的载体或佐剂的药物组合物。
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公开(公告)号：US20120178716A1
公开(公告)日：2012-07-12
申请号：US13311106
申请日：2011-12-05
申请人： Yihan Wang , Wei-Sheng Huang , Rajeswari Sundaramoorthi , Xiaotian Zhu , R. Mathew Thomas , William C. Shakespeare , David C. Dalgarno , Tomi K. Sawyer
发明人： Yihan Wang , Wei-Sheng Huang , Rajeswari Sundaramoorthi , Xiaotian Zhu , R. Mathew Thomas , William C. Shakespeare , David C. Dalgarno , Tomi K. Sawyer
IPC分类号： A61K31/675 , A61P35/00 , C07F9/6561 , A61K31/52 , C07D473/32
CPC分类号： C07F9/65616
摘要： This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
摘要翻译： 本发明涉及以下通式的化合物：其中可变基团如本文所定义，以及其制备和用途。
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公开(公告)号：US08071609B2
公开(公告)日：2011-12-06
申请号：US11990299
申请日：2006-08-11
申请人： Yihan Wang , Wei-Sheng Huang , Rajeswari Sundaramoorthi , Xiaotian Zhu , R. Mathew Thomas , William C. Shakespeare , David C. Dalgarno , Tomi K. Sawyer
发明人： Yihan Wang , Wei-Sheng Huang , Rajeswari Sundaramoorthi , Xiaotian Zhu , R. Mathew Thomas , William C. Shakespeare , David C. Dalgarno , Tomi K. Sawyer
IPC分类号： C07D473/16 , C07D473/34 , A61K31/52 , C07F9/6561 , C07D473/40 , A61P35/00
CPC分类号： C07F9/65616
摘要： This invention relates to compounds of the general formula: in which Q is an ethynyl or ethenyl moiety; Ring A is an aryl, heteroaryl or heterocyclic ring or ring system; and the remaining variable groups are as defined herein, and to their preparation and use.
摘要翻译： 本发明涉及下列通式的化合物：其中Q是乙炔基或乙烯基部分; 环A是芳基，杂芳基或杂环或环系; 并且其余的可变基团如本文所定义，以及其制备和使用。
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公开(公告)号：US07115589B2
公开(公告)日：2006-10-03
申请号：US09740393
申请日：2000-12-18
申请人： Manfred Weigele , Tomi K. Sawyer , Regine Bohacek , William C. Shakespeare , Rajeswari Sundaramoorthi , Yihan Wang , David C. Dalgarno , Chester A. Metcalf, III
发明人： Manfred Weigele , Tomi K. Sawyer , Regine Bohacek , William C. Shakespeare , Rajeswari Sundaramoorthi , Yihan Wang , David C. Dalgarno , Chester A. Metcalf, III
IPC分类号： C07F9/6561 , A61K31/675 , A61P19/10 , A61P19/08 , A61P35/00
CPC分类号： C07D471/04 , A61K47/548 , C07D487/04 , C07F9/4012 , C07F9/405 , C07F9/58 , C07F9/65583 , C07F9/6561 , C07F9/65616
摘要： This invention relates to compounds of the general formula: in which RA, RB, RC and RD are as defined herein, and to their preparation and use. In these compounds, RB is an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety which comprises one or more phosphorus-containing moieties.
摘要翻译： 本发明涉及以下通式的化合物：其中R A，R B，R C和R D D均为 >如本文所定义，以及其制备和使用。 在这些化合物中，R B是包含一个或多个含磷部分的脂族，杂脂族，芳基或杂芳基部分。
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公开(公告)号：US08912330B2
公开(公告)日：2014-12-16
申请号：US12998873
申请日：2009-12-11
申请人： Jiwei Qi , Yihan Wang , Feng Li , William C. Shakespeare , Anna Kohlmann , David C. Dalgarno , Xiaotian Zhu
发明人： Jiwei Qi , Yihan Wang , Feng Li , William C. Shakespeare , Anna Kohlmann , David C. Dalgarno , Xiaotian Zhu
IPC分类号： C07D471/04 , C07D401/14 , A61K31/437 , A61K31/44 , A61P35/00
CPC分类号： A61K31/44 , C07D471/04
摘要： This invention relates to compounds of the general formula (I) in which the variable groups are as defined herein, and to their preparation and use.
摘要翻译： 本发明涉及其中可变基团如本文所定义的通式（I）的化合物及其制备和用途。
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公开(公告)号：US20110294806A1
公开(公告)日：2011-12-01
申请号：US12998873
申请日：2009-12-11
申请人： Jiwei Qi , Yihan Wang , Feng Li , William C. Shakespeare , Anna Kohlmann , David C. Dalgarno , Xiaotian Zhu
发明人： Jiwei Qi , Yihan Wang , Feng Li , William C. Shakespeare , Anna Kohlmann , David C. Dalgarno , Xiaotian Zhu
IPC分类号： A61K31/437 , A61P35/00 , A61K31/506 , C07D471/04 , A61K31/5377
CPC分类号： A61K31/44 , C07D471/04
摘要： This invention relates to compounds of the general formula (I) in which the variable groups are as defined herein, and to their preparation and use.
摘要翻译： 本发明涉及其中可变基团如本文所定义的通式（I）的化合物及其制备和用途。
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公开(公告)号：US09834518B2
公开(公告)日：2017-12-05
申请号：US13464921
申请日：2012-05-04
IPC分类号： C07D239/46 , C07D239/50 , C07D401/12 , C07D403/12 , C07D413/12 , A61K31/4025 , A61K31/444 , A61K31/4523 , A61K31/506 , A61K31/505 , A61K31/538 , A61K31/553 , A61P35/00 , C07D239/48 , C07D405/12
CPC分类号： C07D239/48 , A61K31/4025 , A61K31/444 , A61K31/4523 , A61K31/505 , A61K31/506 , A61K31/538 , A61K31/553 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要： The invention features compounds, pharmaceutical compositions and methods for treating patients who have an EGFR-driven cancer of formula I: wherein the variables are as defined herein.
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