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公开(公告)号：US20090149471A1
公开(公告)日：2009-06-11
申请号：US12227130
申请日：2007-05-08
申请人： William C. Shakespeare , Wei-Sheng Huang , David C. Dalgarno , Xiaotian Zhu , R. Matthew Thomas , Yihan Wang , Jiwei Qi , Rajeswari Sundaramoorthi , Dong Zou , Chester A. Metcalf, III , Tomi k. Sawyer , Jan Antoinette C. Romero
发明人： William C. Shakespeare , Wei-Sheng Huang , David C. Dalgarno , Xiaotian Zhu , R. Matthew Thomas , Yihan Wang , Jiwei Qi , Rajeswari Sundaramoorthi , Dong Zou , Chester A. Metcalf, III , Tomi k. Sawyer , Jan Antoinette C. Romero
IPC分类号： A61K31/4178 , C07D403/12 , C07D417/12 , A61K31/427 , A61K31/4439 , A61K31/506 , A61P35/00 , A61K31/496
CPC分类号： C07D231/12 , C07D233/64 , C07D233/90 , C07D277/40 , C07D403/12 , C07D403/14 , C07D417/12 , C07D417/14
摘要： This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
摘要翻译： 本发明涉及以下通式的化合物：其中可变基团如本文所定义，以及其制备和用途。
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公开(公告)号：US20070191376A1
公开(公告)日：2007-08-16
申请号：US11644849
申请日：2006-12-22
申请人： Dong Zou , Wei-Sheng Huang , R. Thomas , Jan Romero , Jiwei Qi , Yihan Wang , Xiaotian Zhu , William Shakespeare , Rajeswari Sundaramoorthi , Chester Metcalf, , David Dalgarno , Tomi Sawyer
发明人： Dong Zou , Wei-Sheng Huang , R. Thomas , Jan Romero , Jiwei Qi , Yihan Wang , Xiaotian Zhu , William Shakespeare , Rajeswari Sundaramoorthi , Chester Metcalf, , David Dalgarno , Tomi Sawyer
IPC分类号： A61K31/53 , A61K31/519 , A61K31/496 , A61K31/503 , A61K31/498 , A61K31/4745 , C07D487/04
CPC分类号： C07D471/04 , C07D473/34 , C07D487/04
摘要： This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
摘要翻译： 本发明涉及以下通式的化合物：其中可变基团如本文所定义，及其制备和用途。
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公开(公告)号：US06576766B1
公开(公告)日：2003-06-10
申请号：US09554230
申请日：2000-08-17
申请人： Manfred Weigele , Regine Bohacek , Virginia A. Jacobsen , Karina Macek , Michael G. Yang , Noriyuki H. Kawahata , Rajeswari Sundaramoorthi , Yihan Wang , Craig S. Takeuchi , George P. Luke , Chester A. Metcalf, III , William C. Shakespeare , Tomi K. Sawyer
发明人： Manfred Weigele , Regine Bohacek , Virginia A. Jacobsen , Karina Macek , Michael G. Yang , Noriyuki H. Kawahata , Rajeswari Sundaramoorthi , Yihan Wang , Craig S. Takeuchi , George P. Luke , Chester A. Metcalf, III , William C. Shakespeare , Tomi K. Sawyer
IPC分类号： C07D30789
CPC分类号： C07D307/92 , A61K38/00 , C07C237/22 , C07C2601/14 , C07F9/12 , C07F9/3834 , C07F9/3869 , C07F9/3873 , C07F9/3882 , C07F9/65527 , C07K5/06191
摘要： This invention concerns compounds for inhibiting intracellular signal transduction, especially intracellular signal transduction mediate by one or more molecular interactions involving a phosphotyrosine-containing protein. This invention also relates to pharmaceutic compositions containing the compounds and prophylactic and therapeutic methods involving pharmaceutical and veterinary administration of the compounds. The compounds are of formula (1) as defined herein.
摘要翻译： 本发明涉及用于抑制细胞内信号转导的化合物，特别是通过涉及含磷酸酪氨酸的蛋白质的一种或多种分子相互作用介导的细胞内信号转导。 本发明还涉及包含化合物的药物组合物和涉及化合物的药物和兽药施用的预防和治疗方法。 化合物是如本文所定义的式（1）。
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4.发明授权Bicyclic signal transduction inhibitors, compositions containing them & uses thereof 有权双环信号转导抑制剂，含有它们的组合物及其用途公开(公告)号：US06482852B2
公开(公告)日：2002-11-19
申请号：US09854027
申请日：2001-05-11
申请人： William C. Shakespeare , Michael G. Yang , Rajeswari Sundaramoorthi , Regine Bohacek , Charles Joseph Eyermann , Tomi K. Sawyer
发明人： William C. Shakespeare , Michael G. Yang , Rajeswari Sundaramoorthi , Regine Bohacek , Charles Joseph Eyermann , Tomi K. Sawyer
IPC分类号： A61K3121
CPC分类号： C07F9/65527 , C07C237/48 , C07C2601/14 , C07C2602/12 , C07D313/08 , C07F9/12 , C07F9/3834 , C07F9/3873 , C07F9/3882 , C07F9/4021
摘要： This invention concerns compounds for inhibiting intracellular signal transduction, especially intracellular signal transduction mediated by one or more molecular interactions involving a phosphotyrosine-containing protein. This invention also relates to pharmaceutical compositions containing the compounds and prophylactic and therapeutic methods involving pharmaceutical and veterinary administration of the compounds. The compounds are of the formula as defined herein.
摘要翻译： 本发明涉及用于抑制细胞内信号转导的化合物，特别是通过涉及含磷酸酪氨酸的蛋白质的一种或多种分子相互作用介导的细胞内信号转导。 本发明还涉及包含化合物的药物组合物和涉及化合物的药物和兽药施用的预防和治疗方法。 这些化合物是本文定义的式。
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公开(公告)号：US08461167B2
公开(公告)日：2013-06-11
申请号：US12227002
申请日：2007-05-08
申请人： Yihan Wang , Xiaotian Zhu , Rajeswari Sundaramoorthi , Wei-Sheng Huang , Dong Zou , R. Mathew Thomas , Jiwei Qi , Jan Antoinette C. Romero , David C. Dalgarno , William C. Shakespeare , Tomi K. Sawyer , Chester A. Metcalf, III
发明人： Yihan Wang , Xiaotian Zhu , Rajeswari Sundaramoorthi , Wei-Sheng Huang , Dong Zou , R. Mathew Thomas , Jiwei Qi , Jan Antoinette C. Romero , David C. Dalgarno , William C. Shakespeare , Tomi K. Sawyer , Chester A. Metcalf, III
IPC分类号： A01N43/54 , A61K31/505 , C07D239/02
CPC分类号： C07D213/56 , C07D213/73 , C07D213/75 , C07D213/78 , C07D217/14 , C07D217/22 , C07D237/20 , C07D237/28 , C07D239/26 , C07D241/12 , C07D241/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D413/12 , C07D417/12 , C07D471/04
摘要： This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
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公开(公告)号：US20130005738A1
公开(公告)日：2013-01-03
申请号：US13612067
申请日：2012-09-12
申请人： William C. Shakespeare , Wei-Sheng Huang , David C. Dalgarno , Xiaotian Zhu , R. Mathew Thomas , Yihan Wang , Jiwei Qi , Rajeswari Sundaramoorthi , Dong Zou , Chester A. Metcalf, III , Tomi K. Sawyer , Jan Antoinette C. Romero
发明人： William C. Shakespeare , Wei-Sheng Huang , David C. Dalgarno , Xiaotian Zhu , R. Mathew Thomas , Yihan Wang , Jiwei Qi , Rajeswari Sundaramoorthi , Dong Zou , Chester A. Metcalf, III , Tomi K. Sawyer , Jan Antoinette C. Romero
IPC分类号： C07D403/12 , A61P35/00 , C07D417/12 , A61K31/427 , A61K31/496 , A61K31/4178
CPC分类号： C07D231/12 , C07D233/64 , C07D233/90 , C07D277/40 , C07D403/12 , C07D403/14 , C07D417/12 , C07D417/14
摘要： This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
摘要翻译： 本发明涉及以下通式的化合物：其中可变基团如本文所定义，及其制备和用途。
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![Substituted acetylenic imidazo[1,2-B]pyridazine compounds as kinase inhibitors](/abs-image/US/2012/02/14/US08114874B2/abs.jpg.150x150.jpg)
7.发明授权Substituted acetylenic imidazo[1,2-B]pyridazine compounds as kinase inhibitors 有权取代的炔属咪唑并[1,2-B]哒嗪化合物作为激酶抑制剂公开(公告)号：US08114874B2
公开(公告)日：2012-02-14
申请号：US11644849
申请日：2006-12-22
申请人： Dong Zou , Wei-Sheng Huang , R. Mathew Thomas , Jan Antionette C. Romero , Jiwei Qi , Yihan Wang , Xiaotian Zhu , William C. Shakespeare , Rajeswari Sundaramoorthi , Chester A. Metcalf, III , David C. Dalgarno , Tomi K. Sawyer
发明人： Dong Zou , Wei-Sheng Huang , R. Mathew Thomas , Jan Antionette C. Romero , Jiwei Qi , Yihan Wang , Xiaotian Zhu , William C. Shakespeare , Rajeswari Sundaramoorthi , Chester A. Metcalf, III , David C. Dalgarno , Tomi K. Sawyer
IPC分类号： A61K31/495
CPC分类号： C07D471/04 , C07D473/34 , C07D487/04
摘要： This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use. In particular, the compounds include embodiments in which Ring T is an imidazo[1,2-b]pyridazine ring system, Rings A and B are each aryl and L1 is —C(O)NR1— or —NR1C(O)—. Uses for the compounds and for compositions containing them include treatment of cancer and other diseases mediated by protein kinases.
摘要翻译： 本发明涉及以下通式的化合物：其中可变基团如本文所定义，及其制备和用途。 特别地，化合物包括其中环T是咪唑并[1,2-b]哒嗪环体系的实施方案，环A和B各自为芳基且L 1为-C（O）NR 1 - 或-NR 1 C（O） - 。 用于化合物和含有它们的组合物的用途包括治疗由蛋白激酶介导的癌症和其它疾病。
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公开(公告)号：US20120135986A1
公开(公告)日：2012-05-31
申请号：US13357745
申请日：2012-01-25
申请人： Dong Zou , Wei-Sheng Huang , R. Mathew Thomas , Jan Antionette C. Romero , Jiwei Qi , Yihan Wang , Xiaotian Zhu , William C. Shakespeare , Rajeswari Sundaramoorthi , Chester A. Metcalf, III , David C. Dalgarno , Tomi K. Sawyer
发明人： Dong Zou , Wei-Sheng Huang , R. Mathew Thomas , Jan Antionette C. Romero , Jiwei Qi , Yihan Wang , Xiaotian Zhu , William C. Shakespeare , Rajeswari Sundaramoorthi , Chester A. Metcalf, III , David C. Dalgarno , Tomi K. Sawyer
IPC分类号： A61K31/5377 , A61K31/4985 , C07D471/04 , A61K31/437 , A61P35/00 , A61K31/5025 , A61K31/53 , A61K31/519 , C07D473/34 , A61K31/52 , C07D487/04 , A61K31/496
CPC分类号： C07D471/04 , C07D473/34 , C07D487/04
摘要： This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
摘要翻译： 本发明涉及以下通式的化合物：其中可变基团如本文所定义，以及其制备和用途。
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公开(公告)号：US20090176781A1
公开(公告)日：2009-07-09
申请号：US12227002
申请日：2007-05-08
申请人： Yihan Wang , Xiaotian Zhu , Rajeswari Sundaramoorthi , Wei-Sheng Huang , Dong Zhu , R. Mathew Thomas , Jiwei Qi , Jan Antoinette C. Romero , David C. Dalgarno , William C. Shakespeare , Tomi K. Sawyer , Chester A. Metcalf, III
发明人： Yihan Wang , Xiaotian Zhu , Rajeswari Sundaramoorthi , Wei-Sheng Huang , Dong Zhu , R. Mathew Thomas , Jiwei Qi , Jan Antoinette C. Romero , David C. Dalgarno , William C. Shakespeare , Tomi K. Sawyer , Chester A. Metcalf, III
IPC分类号： A61K31/5377 , C07D401/14 , A61K31/4439 , A61K31/506 , C07D403/12 , C07D413/12 , A61P35/00
CPC分类号： C07D213/56 , C07D213/73 , C07D213/75 , C07D213/78 , C07D217/14 , C07D217/22 , C07D237/20 , C07D237/28 , C07D239/26 , C07D241/12 , C07D241/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D413/12 , C07D417/12 , C07D471/04
摘要： This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
摘要翻译： 本发明涉及以下通式的化合物：其中可变基团如本文所定义，及其制备和用途。
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公开(公告)号：US07132427B2
公开(公告)日：2006-11-07
申请号：US10177595
申请日：2002-06-21
申请人： Yihan Wang , Chester A. Metcalf, III , William C. Shakespeare , Tomi K. Sawyer , Regine Bohacek , Rajeswari Sundaramoorthi
发明人： Yihan Wang , Chester A. Metcalf, III , William C. Shakespeare , Tomi K. Sawyer , Regine Bohacek , Rajeswari Sundaramoorthi
IPC分类号： A61K31/70 , A61K31/517 , C07F9/02 , C07D401/00 , C07D403/00 , C07D413/00 , C07D417/00 , C07D419/00 , A01N43/04 , A61P19/10 , C08B3/00 , C07H11/04
CPC分类号： C07D239/94 , C07F9/65128 , C07F9/65583
摘要： This invention relates to compounds of the general formula: in which RA, RB, RC and RD are as defined herein, and to their preparation and use.
摘要翻译： 本发明涉及以下通式的化合物：其中R A，R B，R C和R D D均为 >如本文所定义，以及其制备和使用。
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