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公开(公告)号：US07432277B2
公开(公告)日：2008-10-07
申请号：US11429582
申请日：2006-05-05
Applicant: Chester A. Metcalf, III , Leonard W. Rozamus , Yihan Wang , R. Mathew Thomas , Dong Zou , David L. Berstein
Inventor： Chester A. Metcalf, III , Leonard W. Rozamus , Yihan Wang , R. Mathew Thomas , Dong Zou , David L. Berstein
IPC: C07D491/06 , A61K31/395
CPC classification number: C07F9/6561 , A61K31/407 , A61K31/4745 , A61K31/675 , C07F9/6527
Abstract: This invention concerns a new family of phosphorus-containing macrocycles containing various phosphonate- and phosphonate-containing moieties.
Abstract translation: 本发明涉及含有各种含膦酸盐和膦酸盐的部分的含磷大环的新家族。
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公开(公告)号：US08461167B2
公开(公告)日：2013-06-11
申请号：US12227002
申请日：2007-05-08
Applicant: Yihan Wang , Xiaotian Zhu , Rajeswari Sundaramoorthi , Wei-Sheng Huang , Dong Zou , R. Mathew Thomas , Jiwei Qi , Jan Antoinette C. Romero , David C. Dalgarno , William C. Shakespeare , Tomi K. Sawyer , Chester A. Metcalf, III
Inventor： Yihan Wang , Xiaotian Zhu , Rajeswari Sundaramoorthi , Wei-Sheng Huang , Dong Zou , R. Mathew Thomas , Jiwei Qi , Jan Antoinette C. Romero , David C. Dalgarno , William C. Shakespeare , Tomi K. Sawyer , Chester A. Metcalf, III
IPC: A01N43/54 , A61K31/505 , C07D239/02
CPC classification number: C07D213/56 , C07D213/73 , C07D213/75 , C07D213/78 , C07D217/14 , C07D217/22 , C07D237/20 , C07D237/28 , C07D239/26 , C07D241/12 , C07D241/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D413/12 , C07D417/12 , C07D471/04
Abstract: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
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公开(公告)号：US20130005738A1
公开(公告)日：2013-01-03
申请号：US13612067
申请日：2012-09-12
Applicant: William C. Shakespeare , Wei-Sheng Huang , David C. Dalgarno , Xiaotian Zhu , R. Mathew Thomas , Yihan Wang , Jiwei Qi , Rajeswari Sundaramoorthi , Dong Zou , Chester A. Metcalf, III , Tomi K. Sawyer , Jan Antoinette C. Romero
Inventor： William C. Shakespeare , Wei-Sheng Huang , David C. Dalgarno , Xiaotian Zhu , R. Mathew Thomas , Yihan Wang , Jiwei Qi , Rajeswari Sundaramoorthi , Dong Zou , Chester A. Metcalf, III , Tomi K. Sawyer , Jan Antoinette C. Romero
IPC: C07D403/12 , A61P35/00 , C07D417/12 , A61K31/427 , A61K31/496 , A61K31/4178
CPC classification number: C07D231/12 , C07D233/64 , C07D233/90 , C07D277/40 , C07D403/12 , C07D403/14 , C07D417/12 , C07D417/14
Abstract: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
Abstract translation: 本发明涉及以下通式的化合物：其中可变基团如本文所定义，及其制备和用途。
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公开(公告)号：US20120202776A1
公开(公告)日：2012-08-09
申请号：US12736910
申请日：2009-05-21
Applicant: Yihan Wang , Wei-Sheng Huang , Shuangying Liu , William C. Shakespeare , R. Mathew Thomas , Jiwei Qi , Feng Li , Xiaotian Zhu , Anna Kohlmann , David C. Dalgarno , Jan Antoinette C. Romero , Dong Zou
Inventor： Yihan Wang , Wei-Sheng Huang , Shuangying Liu , William C. Shakespeare , R. Mathew Thomas , Jiwei Qi , Feng Li , Xiaotian Zhu , Anna Kohlmann , David C. Dalgarno , Jan Antoinette C. Romero , Dong Zou
IPC: A61K31/675 , C07F9/6512 , C07F9/6561 , A61P35/00 , C07F9/6509 , C07F9/6521 , C07F9/58 , C07F9/6558 , C07F9/6584
CPC classification number: C07F9/6533 , C07D239/48 , C07F9/58 , C07F9/650905 , C07F9/6512 , C07F9/6521 , C07F9/65218 , C07F9/65583 , C07F9/65586 , C07F9/6561 , C07F9/65616 , C07F9/65685 , C07F9/657172 , C07F9/65846
Abstract: The invention features compounds of the general formula (I) in which the variable groups are as defined herein, and to their preparation and use.
Abstract translation: 本发明的特征在于其中可变基团如本文所定义的通式（I）的化合物及其制备和用途。
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![Substituted acetylenic imidazo[1,2-B]pyridazine compounds as kinase inhibitors](/abs-image/US/2012/02/14/US08114874B2/abs.jpg.150x150.jpg)
5.发明授权Substituted acetylenic imidazo[1,2-B]pyridazine compounds as kinase inhibitors 有权取代的炔属咪唑并[1,2-B]哒嗪化合物作为激酶抑制剂公开(公告)号：US08114874B2
公开(公告)日：2012-02-14
申请号：US11644849
申请日：2006-12-22
Applicant: Dong Zou , Wei-Sheng Huang , R. Mathew Thomas , Jan Antionette C. Romero , Jiwei Qi , Yihan Wang , Xiaotian Zhu , William C. Shakespeare , Rajeswari Sundaramoorthi , Chester A. Metcalf, III , David C. Dalgarno , Tomi K. Sawyer
Inventor： Dong Zou , Wei-Sheng Huang , R. Mathew Thomas , Jan Antionette C. Romero , Jiwei Qi , Yihan Wang , Xiaotian Zhu , William C. Shakespeare , Rajeswari Sundaramoorthi , Chester A. Metcalf, III , David C. Dalgarno , Tomi K. Sawyer
IPC: A61K31/495
CPC classification number: C07D471/04 , C07D473/34 , C07D487/04
Abstract: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use. In particular, the compounds include embodiments in which Ring T is an imidazo[1,2-b]pyridazine ring system, Rings A and B are each aryl and L1 is —C(O)NR1— or —NR1C(O)—. Uses for the compounds and for compositions containing them include treatment of cancer and other diseases mediated by protein kinases.
Abstract translation: 本发明涉及以下通式的化合物：其中可变基团如本文所定义，及其制备和用途。 特别地，化合物包括其中环T是咪唑并[1,2-b]哒嗪环体系的实施方案，环A和B各自为芳基且L 1为-C（O）NR 1 - 或-NR 1 C（O） - 。 用于化合物和含有它们的组合物的用途包括治疗由蛋白激酶介导的癌症和其它疾病。
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Patent Agency Ranking
公开(公告)号：US20110288078A1
公开(公告)日：2011-11-24
申请号：US12998634
申请日：2009-11-12
Applicant: Wei-Sheng Huang , R. Mathew Thomas
Inventor： Wei-Sheng Huang , R. Mathew Thomas
IPC: C07D487/04 , A61P35/04 , A61K31/5377 , A61K31/551 , A61K31/541 , C07D471/04
CPC classification number: C07D487/04 , A61K9/0019 , A61K9/008 , A61K9/2018 , A61K9/2866 , A61K9/4858 , A61K47/10 , C07D471/04
Abstract: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
Abstract translation: 本发明涉及以下通式的化合物：其中可变基团如本文所定义，及其制备和用途。
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公开(公告)号：US09090561B2
公开(公告)日：2015-07-28
申请号：US13614838
申请日：2012-09-13
Applicant: Yihan Wang , Xiaotian Zhu , Rajeswari Sundaramoorthi , Wei-Sheng Huang , Dong Zou , R. Mathew Thomas , Jiwei Qi , Jan Antoinette C. Romero , David C. Dalgarno , William C. Shakespeare , Tomi K. Sawyer , Chester A. Metcalf, III
Inventor： Yihan Wang , Xiaotian Zhu , Rajeswari Sundaramoorthi , Wei-Sheng Huang , Dong Zou , R. Mathew Thomas , Jiwei Qi , Jan Antoinette C. Romero , David C. Dalgarno , William C. Shakespeare , Tomi K. Sawyer , Chester A. Metcalf, III
IPC: C07D471/04 , A61K31/4375 , C07D213/56 , C07D213/73 , C07D213/75 , C07D213/78 , C07D217/14 , C07D217/22 , C07D237/20 , C07D237/28 , C07D239/26 , C07D241/12 , C07D241/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D413/12 , C07D417/12
CPC classification number: C07D213/56 , C07D213/73 , C07D213/75 , C07D213/78 , C07D217/14 , C07D217/22 , C07D237/20 , C07D237/28 , C07D239/26 , C07D241/12 , C07D241/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D413/12 , C07D417/12 , C07D471/04
Abstract: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
Abstract translation: 本发明涉及以下通式的化合物：其中可变基团如本文所定义，及其制备和用途。
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公开(公告)号：US08846664B2
公开(公告)日：2014-09-30
申请号：US12998634
申请日：2009-11-12
Applicant: Wei-Sheng Huang , R. Mathew Thomas
Inventor： Wei-Sheng Huang , R. Mathew Thomas
IPC: A01N43/62 , A61K31/55 , A61K31/497 , C07D491/00 , C07D513/00 , C07D515/00 , C07D471/00 , C07D487/00 , C07D495/00 , C07D497/00 , A61K9/48 , C07D471/04 , A61K9/28 , A61K47/10 , A61K9/20 , A61K9/00 , C07D487/04
CPC classification number: C07D487/04 , A61K9/0019 , A61K9/008 , A61K9/2018 , A61K9/2866 , A61K9/4858 , A61K47/10 , C07D471/04
Abstract: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
Abstract translation: 本发明涉及以下通式的化合物：其中可变基团如本文所定义，及其制备和用途。
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公开(公告)号：US20130018046A1
公开(公告)日：2013-01-17
申请号：US13614838
申请日：2012-09-13
Applicant: Yihan Wang , Xiaotian Zhu , Rajeswari Sundaramoorthi , Wei-Sheng Huang , Dong Zou , R. Mathew Thomas , Jiwei Qi , Jan Antoinette C. Romero , David C. Dalgarno , William C. Shakespeare , Tomi K. Sawyer , Chester A. Metcalf, III
Inventor： Yihan Wang , Xiaotian Zhu , Rajeswari Sundaramoorthi , Wei-Sheng Huang , Dong Zou , R. Mathew Thomas , Jiwei Qi , Jan Antoinette C. Romero , David C. Dalgarno , William C. Shakespeare , Tomi K. Sawyer , Chester A. Metcalf, III
IPC: A61K31/4439 , C07D403/12 , A61K31/506 , C07D401/12 , A61K31/496 , C07D471/04 , A61K31/4375 , C07D413/12 , A61K31/4725 , A61K31/502 , A61K31/497 , C07D498/04 , A61K31/5383 , A61K31/551 , A61K31/5377 , A61K31/53 , A61P35/00 , C07D401/14
CPC classification number: C07D213/56 , C07D213/73 , C07D213/75 , C07D213/78 , C07D217/14 , C07D217/22 , C07D237/20 , C07D237/28 , C07D239/26 , C07D241/12 , C07D241/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D413/12 , C07D417/12 , C07D471/04
Abstract: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
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公开(公告)号：US08278307B2
公开(公告)日：2012-10-02
申请号：US12227130
申请日：2007-05-08
Applicant: William C. Shakespeare , Wei-Sheng Huang , David C. Dalgarno , Xiaotian Zhu , R. Mathew Thomas , Yihan Wang , Jiwei Qi , Rajeswari Sundaramoorthi , Dong Zou , Chester A. Metcalf, III , Tomi K. Sawyer , Jan Antoinette C. Romero
Inventor： William C. Shakespeare , Wei-Sheng Huang , David C. Dalgarno , Xiaotian Zhu , R. Mathew Thomas , Yihan Wang , Jiwei Qi , Rajeswari Sundaramoorthi , Dong Zou , Chester A. Metcalf, III , Tomi K. Sawyer , Jan Antoinette C. Romero
IPC: A61K31/496 , A61K31/4178 , C07D403/12
CPC classification number: C07D231/12 , C07D233/64 , C07D233/90 , C07D277/40 , C07D403/12 , C07D403/14 , C07D417/12 , C07D417/14
Abstract: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
Abstract translation: 本发明涉及以下通式的化合物：其中可变基团如本文所定义，以及其制备和用途。
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