公开(公告)号：US20070010491A1

公开(公告)日：2007-01-11

申请号：US10569921

申请日：2004-08-31

申请人： Meng Hsin Chen ,  James Doherty ,  Luping Liu ,  Swaminathan Natarajan ,  Robert Tynebor

发明人： Meng Hsin Chen ,  James Doherty ,  Luping Liu ,  Swaminathan Natarajan ,  Robert Tynebor

IPC分类号： A61K31/4439 ,  A61K31/675

CPC分类号： C07D401/06 ,  C07F9/65038 ,  C07F9/65583

摘要： This invention relates to potent potassium channel blocker compounds of Formula (I) or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans, or a pharmaceutically acceptable salt, in vivo hydrolysable ester, enantiomer, diastereomer or mixture thereof: formula (II) represents C6-10 aryl or C3-10 heterocyclyl, said aryl or heterocyclyl optionally substituted with 1-3 groups selected from Ra; Z represents (CH2)nPO(OR)(OR*).

摘要翻译： 本发明涉及式（I）的有效钾通道阻断剂化合物或其制剂用于治疗青光眼和导致患者眼睛中眼内压升高的其它病症。 本发明还涉及这些化合物对哺乳动物物种，特别是人类或其药学上可接受的盐，体内可水解的酯，对映异构体，非对映体或其混合物的眼睛的神经保护作用的用途：式（II） 所述芳基或杂环基任选被1-3个选自R a，R b，R 3，R 3，R 3， Z表示（CH 2）n PO（OR）（OR *）。

公开(公告)号：US20060020000A1

公开(公告)日：2006-01-26

申请号：US10530840

申请日：2003-11-04

申请人： James Doherty ,  Meng-Hsin Chen ,  Luping Liu ,  Swaminathan Natarajan ,  Dong Ming Shen ,  Robert Tynebor

发明人： James Doherty ,  Meng-Hsin Chen ,  Luping Liu ,  Swaminathan Natarajan ,  Dong Ming Shen ,  Robert Tynebor

IPC分类号： A61K31/427 ,  A61K31/416 ,  C07D417/02 ,  C07D231/04

CPC分类号： C07D417/14 ,  C07D231/56 ,  C07D401/06 ,  C07D403/06 ,  C07D417/12

摘要： This invention relates to potent potassium channel blocker compounds of Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraocular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.

公开(公告)号：US07528163B2

公开(公告)日：2009-05-05

申请号：US10530840

申请日：2003-11-04

申请人： James B. Doherty ,  Meng-Hsin Chen ,  Luping Liu ,  Swaminathan R. Natarajan ,  Dong-Ming Shen ,  Robert M. Tynebor

发明人： James B. Doherty ,  Meng-Hsin Chen ,  Luping Liu ,  Swaminathan R. Natarajan ,  Dong-Ming Shen ,  Robert M. Tynebor

IPC分类号： A61K31/415 ,  C07D231/56

CPC分类号： C07D417/14 ,  C07D231/56 ,  C07D401/06 ,  C07D403/06 ,  C07D417/12

摘要： This invention relates to potent potassium channel blocker compounds of Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraocular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.

摘要翻译： 本发明涉及式I的有效钾通道阻断剂化合物或其制剂用于治疗青光眼和导致患者眼睛眼内压升高的其它病症。 本发明还涉及这些化合物对哺乳动物物种尤其是人的眼睛的神经保护作用的用途。

公开(公告)号：US20060154897A1

公开(公告)日：2006-07-13

申请号：US10528982

申请日：2003-11-04

申请人： James Doherty ,  Meng-Hsin Chen ,  Luping Liu ,  Swaminathan Natarajan ,  Robert Tynebor

发明人： James Doherty ,  Meng-Hsin Chen ,  Luping Liu ,  Swaminathan Natarajan ,  Robert Tynebor

IPC分类号： A61K31/675 ,  A61K31/4439 ,  A61K31/416 ,  C07D403/02 ,  C07D231/56 ,  C07F9/6503

CPC分类号： C07D401/06 ,  C07D231/56

摘要： This invention relates to potent potassium channel blocker compounds of Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.

公开(公告)号：US06809199B2

公开(公告)日：2004-10-26

申请号：US10023231

申请日：2001-12-17

申请人： James B. Doherty ,  John E. Stelmach ,  Meng-Hsin Chen ,  Luping Liu ,  Julianne A. Hunt ,  Rowena D. Ruzck ,  Joung L. Goulet ,  David D. Wisnoski ,  Swaminathan Ravi Natarajan ,  Kathleen M. Rupprecht ,  Jianming Bao ,  Shouwu Miao ,  Xingfang Hong ,  Peter J. Sinclair ,  Florida Kallashi

发明人： James B. Doherty ,  John E. Stelmach ,  Meng-Hsin Chen ,  Luping Liu ,  Julianne A. Hunt ,  Rowena D. Ruzck ,  Joung L. Goulet ,  David D. Wisnoski ,  Swaminathan Ravi Natarajan ,  Kathleen M. Rupprecht ,  Jianming Bao ,  Shouwu Miao ,  Xingfang Hong ,  Peter J. Sinclair ,  Florida Kallashi

IPC分类号： C07D23972

CPC分类号： C07D215/227 ,  C07D221/06 ,  C07D231/12 ,  C07D233/56 ,  C07D239/80 ,  C07D249/08 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D405/04 ,  C07D409/14 ,  C07D417/12 ,  C07D451/02 ,  C07D471/04 ,  C07D487/08

摘要： Compounds described by the chemical formula (I) or a pharmaceutically acceptable salt thereof: are inhibitors of p38 useful in the treatment of inflammatory diseases such as arthritis.

摘要翻译： 由化学式（I）表示的化合物或其药学上可接受的盐是可用于治疗炎性疾病如关节炎的p38的抑制剂。