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公开(公告)号：US20060020000A1
公开(公告)日：2006-01-26
申请号：US10530840
申请日：2003-11-04
申请人： James Doherty , Meng-Hsin Chen , Luping Liu , Swaminathan Natarajan , Dong Ming Shen , Robert Tynebor
发明人： James Doherty , Meng-Hsin Chen , Luping Liu , Swaminathan Natarajan , Dong Ming Shen , Robert Tynebor
IPC分类号： A61K31/427 , A61K31/416 , C07D417/02 , C07D231/04
CPC分类号： C07D417/14 , C07D231/56 , C07D401/06 , C07D403/06 , C07D417/12
摘要： This invention relates to potent potassium channel blocker compounds of Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraocular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.
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公开(公告)号：US20060148805A1
公开(公告)日：2006-07-06
申请号：US10561571
申请日：2004-06-25
申请人： Meng Hsin Chen , James Doherty , Luping Liu , Swaminathan Natarajan , Dong-Ming Shen , Min Shu
发明人： Meng Hsin Chen , James Doherty , Luping Liu , Swaminathan Natarajan , Dong-Ming Shen , Min Shu
IPC分类号： A61K31/522 , A61K31/503 , A61K31/498 , A61K31/4184 , C07D473/10 , C07D471/02 , C07D487/02
CPC分类号： C07D235/12 , C07D235/08 , C07D235/16 , C07D405/04 , C07D471/04
摘要： This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.
摘要翻译： 本发明涉及有效的钾通道阻滞剂或其制剂在治疗青光眼和导致患者眼睛中眼内压升高的其它病症中的用途。 本发明还涉及这些化合物对哺乳动物物种尤其是人的眼睛的神经保护作用的用途。
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公开(公告)号：US20070129418A1
公开(公告)日：2007-06-07
申请号：US11641212
申请日：2006-12-19
IPC分类号： A61K31/416 , C07D231/56
CPC分类号： C07F9/65038 , C07D231/56
摘要： This invention relates to potent potassium channel blocker compounds of Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.
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公开(公告)号：US20060154897A1
公开(公告)日：2006-07-13
申请号：US10528982
申请日：2003-11-04
IPC分类号： A61K31/675 , A61K31/4439 , A61K31/416 , C07D403/02 , C07D231/56 , C07F9/6503
CPC分类号： C07D401/06 , C07D231/56
摘要： This invention relates to potent potassium channel blocker compounds of Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.
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公开(公告)号：US20070010491A1
公开(公告)日：2007-01-11
申请号：US10569921
申请日：2004-08-31
IPC分类号： A61K31/4439 , A61K31/675
CPC分类号： C07D401/06 , C07F9/65038 , C07F9/65583
摘要： This invention relates to potent potassium channel blocker compounds of Formula (I) or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans, or a pharmaceutically acceptable salt, in vivo hydrolysable ester, enantiomer, diastereomer or mixture thereof: formula (II) represents C6-10 aryl or C3-10 heterocyclyl, said aryl or heterocyclyl optionally substituted with 1-3 groups selected from Ra; Z represents (CH2)nPO(OR)(OR*).
摘要翻译： 本发明涉及式（I）的有效钾通道阻断剂化合物或其制剂用于治疗青光眼和导致患者眼睛中眼内压升高的其它病症。 本发明还涉及这些化合物对哺乳动物物种，特别是人类或其药学上可接受的盐，体内可水解的酯，对映异构体，非对映体或其混合物的眼睛的神经保护作用的用途：式（II） 所述芳基或杂环基任选被1-3个选自R a，R b，R 3，R 3，R 3， Z表示（CH 2）n PO（OR）（OR *）。
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公开(公告)号：US20070027188A1
公开(公告)日：2007-02-01
申请号：US10570231
申请日：2004-08-31
申请人： Meng Chen , James Doherty , Luping Liu , Swaminathan Natarajan , Robert Tynebor
发明人： Meng Chen , James Doherty , Luping Liu , Swaminathan Natarajan , Robert Tynebor
IPC分类号： A61K31/4439 , C07D403/02
CPC分类号： C07D401/06
摘要： This invention relates to potent potassium channel blocker compounds of structural Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.
摘要翻译： 本发明涉及结构式I的有效钾通道阻断剂化合物或其用于治疗青光眼的其它制剂及导致患者眼睛中眼内压升高的其它病症本发明还涉及这些化合物在使用中提供 对哺乳动物物种，特别是人类的眼睛的神经保护作用。
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公开(公告)号：US07410992B2
公开(公告)日：2008-08-12
申请号：US10569921
申请日：2004-08-31
IPC分类号： A61K31/416 , C07D231/54
CPC分类号： C07D401/06 , C07F9/65038 , C07F9/65583
摘要： This invention relates to potent potassium channel blocker compounds of Formula (I) or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans, or a pharmaceutically acceptable salt, in vivo hydrolysable ester, enantiomer, diastereomer or mixture thereof: formula (II) represents C6-10 aryl or C3-10 heterocyclyl, said aryl or heterocyclyl optionally substituted with 1-3 groups selected from Ra; Z represents (CH2)nPO(OR)(OR*).
摘要翻译： 本发明涉及式（I）的有效钾通道阻断剂化合物或其制剂用于治疗青光眼和导致患者眼睛中眼内压升高的其它病症。 本发明还涉及这些化合物对哺乳动物物种，特别是人类或其药学上可接受的盐，体内可水解的酯，对映异构体，非对映体或其混合物的眼睛的神经保护作用的用途：式（II） 所述芳基或杂环基任选被1-3个选自R a，R b，R 3，R 3，R 3， Z表示（CH 2）n PO（OR）（OR *）。
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公开(公告)号：US07494983B2
公开(公告)日：2009-02-24
申请号：US10570231
申请日：2004-08-31
IPC分类号： A61K31/675 , A61K31/4439 , C07F9/06
CPC分类号： C07D401/06
摘要： This invention relates to potent potassium channel blocker compounds of structural Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.
摘要翻译： 本发明涉及结构式I的有效钾通道阻断剂化合物或其制剂用于治疗青光眼和导致患者眼睛中眼内压升高的其它病症。 本发明还涉及这些化合物对哺乳动物物种尤其是人的眼睛的神经保护作用的用途。
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公开(公告)号：US20050176723A1
公开(公告)日：2005-08-11
申请号：US10517754
申请日：2003-06-06
IPC分类号： A61K31/519 , A61K31/5377 , A61P1/04 , A61P9/10 , A61P11/00 , A61P17/02 , A61P17/04 , A61P17/06 , A61P19/02 , A61P19/06 , A61P19/08 , A61P19/10 , A61P21/00 , A61P27/02 , A61P29/00 , A61P31/04 , A61P31/12 , A61P31/18 , A61P33/06 , A61P37/06 , A61P39/02 , A61P43/00 , C07D471/04 , C07D487/02 , C07D519/00
CPC分类号： C07D471/04
摘要： Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: (I) are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.
摘要翻译： 由化学式（I）或其药学上可接受的盐描述的化合物：（I）是p38的抑制剂，可用于治疗炎症，例如治疗类风湿性关节炎，类风湿性脊椎炎，骨关节炎，痛风性关节炎和其他关节炎病症 ; 发炎关节，湿疹，牛皮癣或其他炎症皮肤病如晒伤; 炎症性眼病，包括结膜炎; 皮肤炎，疼痛等与炎症有关的病症。
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公开(公告)号：US20120259877A1
公开(公告)日：2012-10-11
申请号：US13111411
申请日：2011-05-19
IPC分类号： G06F17/30
CPC分类号： G06F21/6254
摘要： Systems, methods, and computer-readable media for anonymizing data include: intercepting a communication; identifying sensitive data in the communication; transmitting the sensitive data to an anonymization engine; receiving masked data from the anonymization engine; and transmitting the masked data.
摘要翻译： 用于匿名数据的系统，方法和计算机可读介质包括：拦截通信; 识别通信中的敏感数据; 将敏感数据传输到匿名引擎; 从匿名引擎接收蒙版数据; 并发送掩蔽的数据。
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