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公开(公告)号：US20060020000A1
公开(公告)日：2006-01-26
申请号：US10530840
申请日：2003-11-04
申请人： James Doherty , Meng-Hsin Chen , Luping Liu , Swaminathan Natarajan , Dong Ming Shen , Robert Tynebor
发明人： James Doherty , Meng-Hsin Chen , Luping Liu , Swaminathan Natarajan , Dong Ming Shen , Robert Tynebor
IPC分类号： A61K31/427 , A61K31/416 , C07D417/02 , C07D231/04
CPC分类号： C07D417/14 , C07D231/56 , C07D401/06 , C07D403/06 , C07D417/12
摘要： This invention relates to potent potassium channel blocker compounds of Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraocular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.
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公开(公告)号：US20070129418A1
公开(公告)日：2007-06-07
申请号：US11641212
申请日：2006-12-19
IPC分类号： A61K31/416 , C07D231/56
CPC分类号： C07F9/65038 , C07D231/56
摘要： This invention relates to potent potassium channel blocker compounds of Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.
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公开(公告)号：US20060154897A1
公开(公告)日：2006-07-13
申请号：US10528982
申请日：2003-11-04
IPC分类号： A61K31/675 , A61K31/4439 , A61K31/416 , C07D403/02 , C07D231/56 , C07F9/6503
CPC分类号： C07D401/06 , C07D231/56
摘要： This invention relates to potent potassium channel blocker compounds of Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.
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公开(公告)号：US07528163B2
公开(公告)日：2009-05-05
申请号：US10530840
申请日：2003-11-04
申请人： James B. Doherty , Meng-Hsin Chen , Luping Liu , Swaminathan R. Natarajan , Dong-Ming Shen , Robert M. Tynebor
发明人： James B. Doherty , Meng-Hsin Chen , Luping Liu , Swaminathan R. Natarajan , Dong-Ming Shen , Robert M. Tynebor
IPC分类号： A61K31/415 , C07D231/56
CPC分类号： C07D417/14 , C07D231/56 , C07D401/06 , C07D403/06 , C07D417/12
摘要： This invention relates to potent potassium channel blocker compounds of Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraocular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.
摘要翻译： 本发明涉及式I的有效钾通道阻断剂化合物或其制剂用于治疗青光眼和导致患者眼睛眼内压升高的其它病症。 本发明还涉及这些化合物对哺乳动物物种尤其是人的眼睛的神经保护作用的用途。
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公开(公告)号：US20070129372A1
公开(公告)日：2007-06-07
申请号：US11602782
申请日：2006-11-21
申请人： Meng-Hsin Chen , James Doherty , Robert Tynebor
发明人： Meng-Hsin Chen , James Doherty , Robert Tynebor
IPC分类号： A61K31/503 , C07D487/04
CPC分类号： C07D455/02 , C07D471/04
摘要： Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.
摘要翻译： 由化学式（I）或其药学上可接受的盐描述的化合物是p38的抑制剂，可用于治疗炎症，例如治疗类风湿性关节炎，类风湿性脊椎炎，骨关节炎，痛风性关节炎和其他关节炎病症; 发炎关节，湿疹，牛皮癣或其他炎症皮肤病如晒伤; 炎症性眼病，包括结膜炎; 皮肤炎，疼痛等与炎症有关的病症。
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公开(公告)号：US07547720B2
公开(公告)日：2009-06-16
申请号：US11641212
申请日：2006-12-19
IPC分类号： A61K31/416 , C07D231/56
CPC分类号： C07F9/65038 , C07D231/56
摘要： This invention relates to potent potassium channel blocker compounds of Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraocular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.
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公开(公告)号：US07196082B2
公开(公告)日：2007-03-27
申请号：US10684990
申请日：2003-10-14
IPC分类号： A61K31/5375 , A61K31/44 , A61K31/416 , C07D231/56 , C07D413/06
CPC分类号： C07F9/65038 , C07D231/56
摘要： This invention relates to potent potassium channel blocker compounds of Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.
摘要翻译： 本发明涉及式I的有效钾通道阻断剂化合物或其制剂用于治疗青光眼和导致患者眼睛中眼内压升高的其它病症。 本发明还涉及这些化合物对哺乳动物物种尤其是人的眼睛的神经保护作用的用途。
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8.发明授权(Halo-benzo carbonyl)heterocyclo fused phenyl p38 kinase inhibiting agents 失效（卤 - 苯并羰基）杂环稠合苯基p38激酶抑制剂公开(公告)号：US06809199B2
公开(公告)日：2004-10-26
申请号：US10023231
申请日：2001-12-17
申请人： James B. Doherty , John E. Stelmach , Meng-Hsin Chen , Luping Liu , Julianne A. Hunt , Rowena D. Ruzck , Joung L. Goulet , David D. Wisnoski , Swaminathan Ravi Natarajan , Kathleen M. Rupprecht , Jianming Bao , Shouwu Miao , Xingfang Hong , Peter J. Sinclair , Florida Kallashi
发明人： James B. Doherty , John E. Stelmach , Meng-Hsin Chen , Luping Liu , Julianne A. Hunt , Rowena D. Ruzck , Joung L. Goulet , David D. Wisnoski , Swaminathan Ravi Natarajan , Kathleen M. Rupprecht , Jianming Bao , Shouwu Miao , Xingfang Hong , Peter J. Sinclair , Florida Kallashi
IPC分类号： C07D23972
CPC分类号： C07D215/227 , C07D221/06 , C07D231/12 , C07D233/56 , C07D239/80 , C07D249/08 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/04 , C07D409/14 , C07D417/12 , C07D451/02 , C07D471/04 , C07D487/08
摘要： Compounds described by the chemical formula (I) or a pharmaceutically acceptable salt thereof: are inhibitors of p38 useful in the treatment of inflammatory diseases such as arthritis.
摘要翻译： 由化学式（I）表示的化合物或其药学上可接受的盐是可用于治疗炎性疾病如关节炎的p38的抑制剂。
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公开(公告)号：US07879875B2
公开(公告)日：2011-02-01
申请号：US11990050
申请日：2006-08-08
申请人： Meng-Hsin Chen , James B. Doherty , Robert Tynebor , Swaminathan R. Natarajan , Zhen Li , Soumya P. Sahoo
发明人： Meng-Hsin Chen , James B. Doherty , Robert Tynebor , Swaminathan R. Natarajan , Zhen Li , Soumya P. Sahoo
IPC分类号： A61K31/4375 , C07D455/02
CPC分类号： C07D471/04
摘要： Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: (I) are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.
摘要翻译： 由化学式（I）或其药学上可接受的盐描述的化合物：（I）是p38的抑制剂，可用于治疗炎症，例如治疗类风湿性关节炎，类风湿性脊椎炎，骨关节炎，痛风性关节炎和其他关节炎病症 ; 发炎关节，湿疹，牛皮癣或其他炎症皮肤病如晒伤; 炎症性眼病，包括结膜炎; 皮肤炎，疼痛等与炎症有关的病症。
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公开(公告)号：US20090088436A1
公开(公告)日：2009-04-02
申请号：US12085419
申请日：2006-12-01
申请人： Meng-Hsin Chen , James B. Doherty , Robert Tynebor
发明人： Meng-Hsin Chen , James B. Doherty , Robert Tynebor
IPC分类号： A61K31/502 , C07D237/26 , A61P35/00
CPC分类号： C07D455/02 , C07D471/04
摘要： Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.
摘要翻译： 由化学式（I）或其药学上可接受的盐描述的化合物是p38的抑制剂，可用于治疗炎症，例如治疗类风湿性关节炎，类风湿性脊椎炎，骨关节炎，痛风性关节炎和其他关节炎病症; 发炎关节，湿疹，牛皮癣或其他炎症皮肤病如晒伤; 炎症性眼病，包括结膜炎; 皮肤炎，疼痛等与炎症有关的病症。
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