公开(公告)号：US5536623A

公开(公告)日：1996-07-16

申请号：US011457

申请日：1993-01-29

申请人： Yoshihiro Ohmachi ,  Yoshihiko Tsugawa ,  Akihiro Nagai

发明人： Yoshihiro Ohmachi ,  Yoshihiko Tsugawa ,  Akihiro Nagai

IPC分类号： A61K47/48 ,  C08B37/16

CPC分类号： B82Y5/00 ,  A61K47/48969

摘要： The present invention provides 1) a method of producing a complex of a fumagillol derivative of the formula: ##STR1## wherein R.sup.1 is hydrogen; R.sup.2 is halogen, N(O)mR.sup.5 R.sup.6, N+R.sup.5 R.sup.6 R.sup.7.X-- or S(O)nR.sup.5, wherein R.sup.5, R.sup.6 and R.sup.7 are independently an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; X-- is a counter anion; m is 0 or 1; n is an integer of 0 to 2; and R.sup.5 and R.sup.6 together with the adjacent nitrogen or sulfur atom may form an optionally substituted nitrogen- or sulfur-containing heterocyclic group which may form a condensed ring; or R.sup.1 and R.sup.2 are combined to represent a chemical bond; R.sup.3 is 2-methyl-1-propenyl group or isobutyl group; A is oxygen or NR.sup.8, wherein R.sup.8 is hydrogen or an optionally substituted lower alkyl or aryl group; and R.sup.4 is hydrogen, an optionally substituted hydrocarbon group or an optionally substituted acyl group; or a physiologically acceptable salt thereof, with a highly water-soluble cyclodextrin derivative, which comprises mixing the fumagillol derivative or a physiologically acceptable salt thereof with the highly water-soluble cyclodextrin derivative into an aqueous solution, the concentration of the highly water-soluble cyclodextrin derivative being at about 100 mg/ml or more, and 2) the complex of the fumaggillol derivative (I) or physiologically acceptable salt thereof with the highly water-soluble cyclodextrin derivative obtained by the production method 1).The complex of the fumagillol derivative (I) or physiologically acceptable salt thereof with the highly water-soluble cyclodextrin derivative is highly soluble in water, highly stable in storage and can be used as a preparation for injection.

摘要翻译： 本发明提供1）制备下式的烟曲霉醇衍生物的复合物的方法：其中R 1是氢; R2是卤素，N（O）mR5R6，N + R5R6R7.X-或S（O）nR5，其中R5，R6和R7独立地是任选取代的烃基或任选取代的杂环基; X-是抗衡阴离子; m为0或1; n为0〜2的整数， 并且R 5和R 6与相邻的氮或硫原子一起可以形成可以形成稠环的任选取代的含氮或含硫杂环基; 或R1和R2组合以表示化学键; R3是2-甲基-1-丙烯基或异丁基; A是氧或NR8，其中R8是氢或任选取代的低级烷基或芳基; 且R 4为氢，任选取代的烃基或任选取代的酰基; 或其生理上可接受的盐与高度水溶性的环糊精衍生物组合，其包括将烟曲霉醇衍生物或其生理学上可接受的盐与高度水溶性环糊精衍生物混合到水溶液中，高度水溶性环糊精的浓度 衍生物为约100mg / ml以上，以及2）烟曲霉衍生物（I）或其生理学上可接受的盐与通过制备方法1）获得的高度水溶性环糊精衍生物的络合物。 烟曲霉醇衍生物（I）或其生理学上可接受的盐与高度水溶性环糊精衍生物的络合物高度可溶于水，储存高度稳定，可用作注射剂。

公开(公告)号：US5359946A

公开(公告)日：1994-11-01

申请号：US73076

申请日：1993-06-08

申请人： Keisuke Asoh ,  Akihiro Nagai

发明人： Keisuke Asoh ,  Akihiro Nagai

IPC分类号： B01D53/68 ,  F23J15/02 ,  F23J15/00

CPC分类号： F23J15/02 ,  B01D53/68 ,  F23G2203/401

摘要： A method of purifying combustion gases by removing acid gases therefrom, wherein a stream of combustion gases is caused to flow in contact with a surface of an acid gas remover formed from a mixture including a calcium compound for neutralizing said acid gases, and a binder for holding together particles of the calcium compound. Also disclosed is an incinerator incorporating the acid gas remover.

摘要翻译： 通过从其中除去酸性气体来净化燃烧气体的方法，其中使燃烧气体流与由包含用于中和所述酸性气体的钙化合物的混合物形成的酸性气体去除剂的表面接触，以及用于 将钙化合物的颗粒保持在一起。 还公开了掺入酸性气体去除剂的焚化炉。

公开(公告)号：US5220437A

公开(公告)日：1993-06-15

申请号：US618558

申请日：1990-11-27

申请人： Hiroshi Saegusa ,  Masanori Kamata ,  Yasushi Nakajima ,  Akihito Mochizuki ,  Akihiro Nagai

发明人： Hiroshi Saegusa ,  Masanori Kamata ,  Yasushi Nakajima ,  Akihito Mochizuki ,  Akihiro Nagai

IPC分类号： H04N1/04 ,  H04N1/047 ,  H04N1/17 ,  H04N1/32

CPC分类号： H04N1/32368 ,  H04N1/0473 ,  H04N1/32363 ,  H04N1/32379 ,  H04N1/32448 ,  H04N2201/04755 ,  H04N2201/3298

摘要： A scanning control system for use in a transmission or reception system of a facsimile equipment for controlling the secondary scanning speed of an image reader or recorder provided therein. In the transmission system, the scanning control system is coupled to an image memory for storing image information inputted from the image reader and supplying the image information to a coder, and responsive to the input signal and output signal of the image memory so as to detect the remaining capacity of the image memory. The scanning control system controls the secondary scanning speed in accordance with the detection results of the remaining capacity of the image memory. The secondary scanning speed is continuously increased under a condition of limiting it to a predetermined maximum speed when the remaining capacity is in a first range, maintained as it is when being in a second range, continuously decreased under a condition of limiting it to a predetermined intermediate speed when being in a third range, and the secondary scanning is stopped when being in a fourth range. In re-start after the stopping, the secondary scanning speed is set to a predetermined minimum speed.

摘要翻译： 一种用于传真设备的发送或接收系统中用于控制其中提供的图像读取器或记录器的次扫描速度的扫描控制系统。 在传输系统中，扫描控制系统耦合到图像存储器，用于存储从图像读取器输入的图像信息，并将图像信息提供给编码器，并且响应于图像存储器的输入信号和输出信号，以便检测 图像存储器的剩余容量。 扫描控制系统根据图像存储器的剩余容量的检测结果来控制二次扫描速度。 当剩余容量处于第一范围时，在将其维持在第二范围内时，二次扫描速度在将其限制在预定最大速度的条件下连续增加，在将其限制在预定的条件下 处于第三范围时的中间速度，并且当处于第四范围时二次扫描停止。 在停止后重新开始，将二次扫描速度设定为预定的最小速度。