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    Cardiac rhythm management system with staggered pulses for coordination therapy
    13.
    发明申请
    Cardiac rhythm management system with staggered pulses for coordination therapy 审中-公开
    用于协调治疗的具有交错脉冲的心律管理系统

    公开(公告)号：US20080046017A1

    公开(公告)日：2008-02-21

    申请号：US11891896

    申请日：2007-08-14

    申请人： Jeffrey Stahmann ,  Andrew Kramer ,  Julio Spinelli

    发明人： Jeffrey Stahmann ,  Andrew Kramer ,  Julio Spinelli

    IPC分类号： A61N1/362

    CPC分类号： A61N1/3627 ,  A61N1/3622 ,  A61N1/368 ,  A61N1/3684 ,  A61N1/3716

    摘要： A cardiac rhythm management system for coordination therapy includes a pulse generator to generate pacing and discharging of recharge pulses. A pulse delivery controller coupled to the pulse generator, times the delivery of the pacing and discharging of recharge pulses in a desired sequence. A therapy circuit coupled to the pulse delivery controller, receives the timed pulses from the pulse delivery controller and delivers the timed pulses to one or more electrodes disposed in or around a heart to communicate the timed pacing and discharging of recharge pulses to different sites of a heart, to avoid any interactions resulting from the electric fields surrounding the electrodes during a multiple site pacing required by the coordination therapy.

    摘要翻译： 用于协调治疗的心律管理系统包括产生起搏和再充电脉冲放电的脉冲发生器。 耦合到脉冲发生器的脉冲传送控制器以期望的顺序对起搏的递送和再充电脉冲的放电进行倍增。 耦合到脉冲传送控制器的治疗电路接收来自脉冲传送控制器的定时脉冲，并将定时脉冲传送到设置在心脏中或周围的一个或多个电极，以将定时起搏和再充电脉冲的放电传达到不同部位 心脏，以避免由协调治疗所需的多个位置起搏期间由电极周围的电场引起的任何相互作用。

    Method and apparatus for device controlled gene expression for cardiac protection
    14.
    发明申请
    Method and apparatus for device controlled gene expression for cardiac protection 有权
    心脏保护装置控制基因表达的方法和装置

    公开(公告)号：US20070054871A1

    公开(公告)日：2007-03-08

    申请号：US11220397

    申请日：2005-09-06

    申请人： Joseph Pastore ,  Jeffrey Ross ,  Tamara Baynham ,  Rodney Salo ,  Andrew Kramer ,  Julio Spinelli

    发明人： Joseph Pastore ,  Jeffrey Ross ,  Tamara Baynham ,  Rodney Salo ,  Andrew Kramer ,  Julio Spinelli

    IPC分类号： A61K48/00 ,  A61N1/00

    CPC分类号： A61N1/3627 ,  A61K48/0083 ,  A61N1/36514

    摘要： A gene regulatory system detects ischemia events and is capable of delivering a biologic therapy in response to the detection of an ischemic event or the reception of a command. The biologic therapy protects the heart from ischemic damage by regulating the expression of an exogenously introduced gene product. In one embodiment, the gene regulatory system includes an implantable system that emits at least one gene regulatory signal in response to the detection of the ischemic event or the reception of the command. The gene regulatory signal directly or indirectly regulates gene expression of the gene product.

    摘要翻译： 基因调控系统检测缺血事件，并且能够响应于缺血事件的检测或命令的接收而递送生物疗法。 生物治疗通过调节外源基因产物的表达来保护心脏免于缺血性损伤。 在一个实施方案中，基因调控系统包括可植入系统，其可以响应于缺血事件的检测或命令的接收而发射至少一个基因调节信号。 基因调控信号直接或间接调控基因产物的基因表达。

    REDUCTION OF INTERACTION WITH TACHYARRHYTHMIA DETECTION BY NEGATIVE OFFSET PACING
    16.
    发明申请
    REDUCTION OF INTERACTION WITH TACHYARRHYTHMIA DETECTION BY NEGATIVE OFFSET PACING 有权
    减少与负面偏差相关的TACHYARRHYTHMIA检测

    公开(公告)号：US20060116728A1

    公开(公告)日：2006-06-01

    申请号：US11276031

    申请日：2006-02-10

    申请人： Jeffrey Stahmann ,  Andrew Kramer ,  Julio Spinelli

    发明人： Jeffrey Stahmann ,  Andrew Kramer ,  Julio Spinelli

    IPC分类号： A61N1/36

    CPC分类号： A61N1/3622

    摘要： A device and method is disclosed for improving tachyarrhythmia detection when the ventricles are resynchronized by delivering paces to both ventricles separated by a specified negative offset interval. Timing of escape intervals and tachyarrhythmia detection is based upon senses from one of the ventricles designated as a rate ventricle. Techniques are presented for preventing tachyarrhythmia detection from being compromised when the rate ventricle is paced after the other ventricle.

    摘要翻译： 公开了一种用于改善心律失常检测的装置和方法，当通过将指定的负偏移间隔分开的两个心室递送步调来再同步时，心律失常检测。 逃避间隔和快速性心律失常检测的时间是基于指定为速率心室的心室之一的感觉。 提出技术用于在速率心室在另一脑室之后起搏时预防快速性心律失常检测受到损害。

    Cardiac rhythm management system with arrhythmia classification and electrode selection
    17.
    发明申请
    Cardiac rhythm management system with arrhythmia classification and electrode selection 失效
    具有心律失常分类和电极选择的心律管理系统

    公开(公告)号：US20050203581A1

    公开(公告)日：2005-09-15

    申请号：US11125501

    申请日：2005-05-10

    申请人： Julio Spinelli ,  Qingsheng Zhu ,  Jeffrey Stahmann ,  Andrew Kramer

    发明人： Julio Spinelli ,  Qingsheng Zhu ,  Jeffrey Stahmann ,  Andrew Kramer

    IPC分类号： A61N1/362 ,  A61N1/368

    CPC分类号： A61N1/3622 ,  A61N1/3684

    摘要： A system, method, or device classifies an arrhythmia according to the temporal order in which a depolarization wave associated with a particular heart contraction is received at a plurality of electrodes. One or more antiarrhythmia therapies is mapped to each arrhythmia classification. When a particularly classified arrhythmia is detected, the correspondingly mapped therapy list is selected and an appropriate antiarrhythmia therapy delivered. In one example, the particular therapy delivered in response to an arrhythmia depends at least in part on its historical success in treating arrhythmias of that classification.

    摘要翻译： 系统，方法或装置根据在多个电极处接收与特定心脏收缩相关联的去极化波的时间顺序对心律失常进行分类。 一种或多种抗心律失常疗法被映射到每种心律失常分类。 当检测到特别分类的心律失常时，选择相应地映射的治疗列表并进行适当的抗心律失常治疗。 在一个示例中，响应于心律失常递送的特定治疗至少部分地取决于其在治疗该分类的心律失常方面的历史成功。