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公开(公告)号：US20110079423A1
公开(公告)日：2011-04-07
申请号：US12889189
申请日：2010-09-23
Applicant: Yong D. Zhao , Rolf Hill , Ingmar Viohl , Martin Cholette
Inventor： Yong D. Zhao , Rolf Hill , Ingmar Viohl , Martin Cholette
Abstract: An implantable lead is provided that includes a lead body configured to be implanted in a patient. The lead body has a distal end and a proximal end, and a lumen extending between the distal and proximal ends and includes a connector assembly provided at the proximal end of the lead body. The connector assembly is configured to connect to an implantable medical device and includes an electrode provided proximate to the distal end of the lead body with the electrode configured to at least one of deliver stimulating pulses and sense electrical activity. A multi-layer coil is located within the lumen and extends at least partially along a length of the lead body. The coil includes a first winding formed with multiple winding turns, the winding turns being segmented in an alternating pattern of insulated segments and non-insulated segments along the length of the lead body. The multi-layer coil further includes a winding turn connective layer extending along and interconnecting the winding turns within at least one of the non-insulated segments. The multi-layer coil further includes a first winding formed with multiple winding turns, the winding turns being segmented into an alternating pattern of insulated segments and non-insulated segments along a length of the winding with a winding turn connective layer extending along and interconnecting the winding turns within at least one of the non-insulated segments.
Abstract translation: 提供了可植入引线，其包括构造成植入患者体内的引线主体。 引线体具有远端和近端，以及在远端和近端之间延伸的内腔，并且包括设置在引线本体的近端处的连接器组件。 所述连接器组件被配置成连接到可植入医疗装置，并且包括靠近所述引线本体的远端设置的电极，所述电极被配置为递送刺激脉冲和感测电活动中的至少一个。 多层线圈位于内腔内并且至少部分地沿着引线体的长度延伸。 线圈包括形成有多个绕组匝的第一绕组，绕组匝沿着引线主体的长度以绝缘段和非绝缘段的交替模式分段。 多层线圈还包括沿至少一个非绝缘段延伸并互连绕组匝的绕组匝连接层。 多层线圈还包括形成有多个绕组匝的第一绕组，绕组匝被分割成沿着绕组的长度的绝缘段和非绝缘段的交替图案，其中绕组匝连接层沿着并联连接 匝内至少一个非绝缘段。
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公开(公告)号：US20100036466A1
公开(公告)日：2010-02-11
申请号：US12189555
申请日：2008-08-11
Applicant: Xiaoyi Min , Yong D. Zhao , Pedro Medrano
Inventor： Xiaoyi Min , Yong D. Zhao , Pedro Medrano
IPC: A61N1/00
Abstract: A lead construction includes a lead body, an electrically conductive element disposed therein, and a shield layer disposed over the conductive element formed from a composite material comprising a polymer material and a non-ferrous particulate material. The non-ferrous material can include gold, platinum, iridium, nickel, cobalt, chromium, molybdenum, carbon/graphite powders, and alloys thereof. The composite material has a non-ferrous particulate content of from about 40 to 90 volume percent, and the shield layer has a thickness of from about 0.1 to 1 mm. The composite material forms an electrically conductive layer when exposed to RF having a frequency of greater than about 64 MHz. A layer of insulating material may be interposed between the shield layer and the conductive element. The shield layer can be part of the lead body, can be an intermediate layer within the lead body, or can be an outer surface of the lead body.
Abstract translation: 引线结构包括引线体，设置在其中的导电元件和设置在由包含聚合物材料和有色金属颗粒材料的复合材料形成的导电元件上的屏蔽层。 有色金属材料可以包括金，铂，铱，镍，钴，铬，钼，碳/石墨粉及其合金。 复合材料具有约40至90体积％的有色金属颗粒含量，并且屏蔽层具有约0.1至1mm的厚度。 当暴露于频率大于约64MHz的RF时，复合材料形成导电层。 可以在屏蔽层和导电元件之间插入一层绝缘材料。 屏蔽层可以是引线体的一部分，可以是引线体内的中间层，也可以是引线体的外表面。
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公开(公告)号：US09399129B2
公开(公告)日：2016-07-26
申请号：US12262083
申请日：2008-10-30
Applicant: Yong D. Zhao , Xiaoyi Min , Virote Indravudh
Inventor： Yong D. Zhao , Xiaoyi Min , Virote Indravudh
Abstract: An implantable medical lead is disclosed herein. The lead may include a body and an electrical pathway. The body may include a distal portion with an electrode and a proximal portion with a lead connector end. The electrical pathway may extend between the electrode and lead connector end and may include a coiled inductor including first and second electrically conductive filar cores. The first and second filar cores may be physically joined into a unified single piece proximal terminal on a proximal end of the coiled inductor. The first and second cores may be physically joined into a unified single piece distal terminal on a distal end of the coiled inductor. The first and second filar cores may be helically wound into a coiled portion between the proximal and distal terminals, the filar cores being electrically isolated from each other in the coiled portion. The proximal terminal may be electrically coupled to a portion of the electrical pathway extending to the lead connector end, and the distal terminal may be electrically coupled to a portion of the electrical pathway extending to the electrode.
Abstract translation: 本文公开了可植入医疗引线。 引线可以包括主体和电路径。 主体可以包括具有电极的远端部分和具有引线连接器端部的近端部分。 电路可以在电极和引线连接器端之间延伸并且可以包括包括第一和第二导电丝芯的线圈电感器。 第一和第二丝状芯可以物理地连接到线圈电感器的近端上的统一的单件式近端端子。 第一和第二芯可以物理地连接到线圈电感器的远端上的统一的单件式远端终端。 第一和第二丝芯可以螺旋地缠绕在近端和远端之间的线圈部分中，丝芯在线圈部分中彼此电隔离。 近端端子可以电连接到延伸到引线连接器端的电路径的一部分，并且远端端子可电耦合到延伸到电极的电路径的一部分。
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公开(公告)号：US08127618B1
公开(公告)日：2012-03-06
申请号：US11750575
申请日：2007-05-18
Applicant: Yong D. Zhao , Apratim Dixit
Inventor： Yong D. Zhao , Apratim Dixit
CPC classification number: A61B5/0215 , A61B5/686 , A61B5/6869 , A61B2562/0247 , A61B2562/0271 , A61B2562/028 , A61N1/056 , A61N1/3702 , G01L9/0073 , G01L27/002
Abstract: The disclosure relates in some aspects to an implantable pressure sensor and a method of measuring pressure. In some embodiments pressure may be measured through the use of an implantable lead incorporating one or more pressure sensors. In some aspects a pressure sensor is implemented in a micro-electromechanical system (“MEMS”) that employs direct mechanical sensing. A biocompatible material is attached to one or more portions of the MEMS sensor to facilitate implant in a body of a patient. The MEMS sensor may thus be incorporated into an implantable lead for measuring blood pressure in, for example, one or more chambers of the patient's heart.
Abstract translation: 本公开在一些方面涉及可植入压力传感器和测量压力的方法。 在一些实施例中，可以通过使用结合有一个或多个压力传感器的可植入引线来测量压力。 在一些方面，在采用直接机械感测的微机电系统（“MEMS”）中实现压力传感器。 生物相容性材料附接到MEMS传感器的一个或多个部分以便于植入患者体内。 因此，MEMS传感器可以被结合到可植入引线中，用于测量例如患者心脏的一个或多个腔室中的血压。
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15.发明授权Implantable medical lead configured for improved MRI safety and heating reduction performance 有权可植入的医用导线，用于改善MRI安全性和加热减少性能公开(公告)号：US08099171B2
公开(公告)日：2012-01-17
申请号：US12495612
申请日：2009-06-30
Applicant: Virote Indravudh , Yong D. Zhao , Kevin L. Morgan , Dion F. Davis , Grace Jang
Inventor： Virote Indravudh , Yong D. Zhao , Kevin L. Morgan , Dion F. Davis , Grace Jang
IPC: A61N1/00
Abstract: An implantable medical lead configured for improved MRI safety and heating reduction performance is disclosed herein. In one embodiment, the lead includes a tubular body having a proximal end and a distal end with a lead connector near the proximal end. In this embodiment the lead further includes a conductor extending longitudinally within the tubular body and having a proximal end that is electrically coupled to the connector and a distal end electrically coupled to a contact pin. The lead in this embodiment further includes a filter element electrically coupled to a distal end of the contact pin and a flange electrically coupled between a proximal end of the filter element and a proximal portion of an electrode. In this embodiment the flange and the proximal portion of the electrode form at least a first part of a hermetic chamber enclosing the filter element.
Abstract translation: 本文公开了一种被配置用于改善MRI安全性和加热降低性能的可植入医疗引线。 在一个实施例中，引线包括具有近端和远端的管状体，其具有靠近近端的引线连接器。 在该实施例中，引线还包括在管状体内纵向延伸的导体，并且具有电连接到连接器的近端和电耦合到接触销的远端。 该实施例中的引线还包括电耦合到接触针的远端的过滤元件和电耦合在过滤元件的近端和电极的近端部分之间的凸缘。 在该实施例中，电极的凸缘和近端部分形成封闭过滤元件的密封室的至少第一部分。
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Patent Agency Ranking
公开(公告)号：US20100204767A1
公开(公告)日：2010-08-12
申请号：US12370461
申请日：2009-02-12
Applicant: Yong D. Zhao
Inventor： Yong D. Zhao
Abstract: Implantable medical leads have reduced diameter while providing for optimized mechanical and electrical properties, by reducing the diameters of the conducting cables used within the leads for sensing and delivery of therapeutic electrical stimulation. In an embodiment, conducting filaments within a cable have oval cross-sectional areas. Suitably orienting the oval filaments increases the contact surface between adjacent filaments, broadly distributing the pressure between filaments and reducing fretting fatigue, while the oval cross-sectional area also increases conductivity. In an embodiment, non-conducting coatings around filaments within a cable, or around groups of filaments organized into cable-layers, reduce fretting fatigue. In an embodiment, the cross-sectional area of filaments decreases as the filaments are positioned at increasing radial distances from the center of the cable. In an embodiment, the relative composition of various filament metals and/or alloys is varied in filaments at different radial distances from the center of the cable.
Abstract translation: 可植入的医疗引线通过减小引线内使用的导电电缆的直径来获得最佳的机械和电学性能，减小了直径，用于传感和传递治疗性电刺激。 在一个实施例中，电缆内的导电细丝具有椭圆形横截面。 适当地定向椭圆形长丝增加相邻细丝之间的接触表面，广泛地分布长丝之间的压力并减少微动疲劳，而椭圆形横截面积也增加导电性。 在一个实施例中，电缆周围的细丝周围的非导电涂层或组织成电缆层的细丝组周围的非导电涂层减少了微动疲劳。 在一个实施例中，长丝的横截面积随着电缆的距离中心距离增加的径向距离而减小。 在一个实施例中，各种细丝金属和/或合金的相对组成在长丝中在与电缆中心不同的径向距离处变化。
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公开(公告)号：US20100114277A1
公开(公告)日：2010-05-06
申请号：US12262083
申请日：2008-10-30
Applicant: Yong D. Zhao , Xiaoyi Min , Virote Indravudh
Inventor： Yong D. Zhao , Xiaoyi Min , Virote Indravudh
IPC: A61N1/05
Abstract: An implantable medical lead is disclosed herein. The lead may include a body and an electrical pathway. The body may include a distal portion with an electrode and a proximal portion with a lead connector end. The electrical pathway may extend between the electrode and lead connector end and may include a coiled inductor including first and second electrically conductive filar cores. The first and second filar cores may be physically joined into a unified single piece proximal terminal on a proximal end of the coiled inductor. The first and second cores may be physically joined into a unified single piece distal terminal on a distal end of the coiled inductor. The first and second filar cores may be helically wound into a coiled portion between the proximal and distal terminals, the filar cores being electrically isolated from each other in the coiled portion. The proximal terminal may be electrically coupled to a portion of the electrical pathway extending to the lead connector end, and the distal terminal may be electrically coupled to a portion of the electrical pathway extending to the electrode.
Abstract translation: 本文公开了可植入医疗引线。 引线可以包括主体和电路径。 主体可以包括具有电极的远端部分和具有引线连接器端部的近端部分。 电路可以在电极和引线连接器端之间延伸并且可以包括包括第一和第二导电丝芯的线圈电感器。 第一和第二丝状芯可以物理地连接到线圈电感器的近端上的统一的单件式近端端子。 第一和第二芯可以物理地连接到线圈电感器的远端上的统一的单件式远端终端。 第一和第二丝芯可以螺旋地缠绕在近端和远端之间的线圈部分中，丝芯在线圈部分中彼此电隔离。 近端端子可以电连接到延伸到引线连接器端的电路径的一部分，并且远端端子可电耦合到延伸到电极的电路径的一部分。
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公开(公告)号：US20100049290A1
公开(公告)日：2010-02-25
申请号：US12197957
申请日：2008-08-25
Applicant: Xiaoyi Min , J. Christopher Moulder , Yong D. Zhao , Kevin L. Morgan , Martin Cholette , Phong D. Doan
Inventor： Xiaoyi Min , J. Christopher Moulder , Yong D. Zhao , Kevin L. Morgan , Martin Cholette , Phong D. Doan
IPC: A61N1/05
CPC classification number: A61N1/0563 , A61N1/086
Abstract: Disclosed herein is an implantable medical lead. In one embodiment, the lead includes a ring electrode, a tip electrode, first and second helically wound coaxial conductor coils, and a distal coil transition. The coils extend between the proximal and distal ends of the lead. The distal coil transition is proximal to the ring electrode and near the distal end and is where the first coil transitions from being outside the second coil proximal of the distal coil transition to being inside the second coil distal of the distal coil transition.
Abstract translation: 本文公开了可植入医疗引线。 在一个实施例中，引线包括环形电极，尖端电极，第一和第二螺旋缠绕的同轴导体线圈和远端线圈转变。 线圈在引线的近端和远端之间延伸。 远侧线圈转变靠近环形电极并且靠近远端，并且是第一线圈从远端线圈过渡处的第二线圈的外侧转变到远端线圈转变远端的第二线圈内部的位置。
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公开(公告)号：US08244375B2
公开(公告)日：2012-08-14
申请号：US12197957
申请日：2008-08-25
Applicant: Xiaoyi Min , J. Christopher Moulder , Yong D. Zhao , Kevin L. Morgan , Martin Cholette , Phong D. Doan
Inventor： Xiaoyi Min , J. Christopher Moulder , Yong D. Zhao , Kevin L. Morgan , Martin Cholette , Phong D. Doan
IPC: A61N1/05
CPC classification number: A61N1/0563 , A61N1/086
Abstract: Disclosed herein is an implantable medical lead. In one embodiment, the lead includes a ring electrode, a tip electrode, first and second helically wound coaxial conductor coils, and a distal coil transition. The coils extend between the proximal and distal ends of the lead. The distal coil transition is proximal to the ring electrode and near the distal end and is where the first coil transitions from being outside the second coil proximal of the distal coil transition to being inside the second coil distal of the distal coil transition.
Abstract translation: 本文公开了可植入医疗引线。 在一个实施例中，引线包括环形电极，尖端电极，第一和第二螺旋缠绕的同轴导体线圈和远端线圈转变。 线圈在引线的近端和远端之间延伸。 远侧线圈转变靠近环形电极并且靠近远端，并且是第一线圈从远端线圈过渡处的第二线圈的外侧转变到远端线圈转变远端的第二线圈内部的位置。
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公开(公告)号：US08219212B2
公开(公告)日：2012-07-10
申请号：US10923926
申请日：2004-08-23
Applicant: Ryan T. Bauer , Yong D. Zhao
Inventor： Ryan T. Bauer , Yong D. Zhao
IPC: A61N1/372
CPC classification number: A61N1/057 , A61N1/0568 , A61N2001/0585
Abstract: A medical electrical lead includes a canted lead body distal portion extending from an approximately straight lead body proximal portion; the canted distal portion includes an approximately straight segment and a hump-like segment extending from a first end, in proximity to the approximately straight segment, to a second end. The lead further includes a first electrode coupled to the approximately straight segment of the distal portion and a second electrode coupled to the distal portion in proximity to a second end of the hump-like segment.
Abstract translation: 医疗用电线包括：从大致直的铅体近端部延伸的倾斜的铅体远端部; 倾斜的远侧部分包括大致直的部分和从第一端部延伸到大致直线部分的隆起状部分到第二端部。 引线还包括耦合到远端部分的大致直线部分的第一电极和耦合到靠近隆起状部分的第二端的远端部分的第二电极。
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