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公开(公告)号：US07371849B2
公开(公告)日：2008-05-13
申请号：US10489477
申请日：2002-09-13
CPC分类号： C07K16/40 , C07K16/00 , C07K16/005 , C07K2317/22 , C07K2317/52 , C07K2317/569
摘要： The present invention provides camel antibody libraries that maintain in vivo diversity of camelid antibody variable region genes. The in vivo diversity of antibody variable region genes can be accomplished by, for example, mixing genes derived from a plurality of animals or modifying gene amplification conditions. Conventional methods yield only VHHs with limited repertoire diversity. However, the present invention provides libraries comprising genes encoding functional VHHs with sufficient repertoire size. According to the present invention, libraries that enable to freely obtain VHHs against arbitrary antigens are provided. VHHs have excellent solubility and stability, and show a reactivity that usually cannot be expected from tetrameric IgGs.
摘要翻译： 本发明提供了保持骆驼抗体可变区基因的体内多样性的骆驼抗体文库。 抗体可变区基因的体内多样性可以通过例如混合衍生自多种动物的基因或修饰基因扩增条件来实现。 常规方法仅产生具有有限谱库多样性的VHH。 然而，本发明提供了包含编码具有足够谱库大小的功能性VHH的基因的文库。 根据本发明，提供能够自由获得针对任意抗原的VHH的文库。 VHH具有优异的溶解度和稳定性，并显示通常不能从四聚体IgGs预期的反应性。
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公开(公告)号：US20050037421A1
公开(公告)日：2005-02-17
申请号：US10489477
申请日：2002-09-13
CPC分类号： C07K16/40 , C07K16/00 , C07K16/005 , C07K2317/22 , C07K2317/52 , C07K2317/569
摘要： The present invention provides camel antibody libraries that maintain in vivo diversity of camelid antibody variable region genes. The in vivo diversity of antibody variable region genes can be accomplished by, for example, mixing genes derived from a plurality of animals or modifying gene amplification conditions. Conventional methods yield only VHHs with limited repertoire diversity. However, the present invention provides libraries comprising genes encoding functional VHHs with sufficient repertoire size. According to the present invention, libraries that enable to freely obtain VHHs against arbitrary antigens are provided. VHHs have excellent solubility and stability, and show a reactivity that usually cannot be expected from tetrameric IgGs.
摘要翻译： 本发明提供了保持骆驼抗体可变区基因的体内多样性的骆驼抗体文库。 抗体可变区基因的体内多样性可以通过例如混合衍生自多种动物的基因或修饰基因扩增条件来实现。 常规方法仅产生具有有限谱库多样性的VHH。 然而，本发明提供了包含编码具有足够谱库大小的功能性VHH的基因的文库。 根据本发明，提供能够自由获得针对任意抗原的VHH的文库。 VHH具有优异的溶解度和稳定性，并显示通常不能从四聚体IgGs预期的反应性。
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公开(公告)号：US5475100A
公开(公告)日：1995-12-12
申请号：US109106
申请日：1993-08-19
申请人： Kimikazu Hashino , Fusao Kimizuka , Ikunoshin Kato , Yoshikazu Kurosawa , Koiti Titani , Kiyotoshi Sekiguchi
发明人： Kimikazu Hashino , Fusao Kimizuka , Ikunoshin Kato , Yoshikazu Kurosawa , Koiti Titani , Kiyotoshi Sekiguchi
IPC分类号： A61K39/395 , A61K38/00 , A61P37/00 , C07K14/00 , C07K16/00 , C07K16/46 , C07K19/00 , C12N5/10 , C12N15/09 , C12N15/13 , C12P21/02 , C12P21/08 , C12R1/91 , C07H21/00
CPC分类号： C07K16/00 , A61K38/00 , C07K2317/77
摘要： This invention provides an antibody having antigen binding activity and which has a heavy chain constant region into which has been introduced an RGDS amino acid sequence giving the antibody affinity for cells, including macrophages. The antibody exhibits artificial cell adhesive activity which is the newly expressed activity that results from insertion of the RGDS amino acid sequence. This antibody having artificial cell adhesive activity can accelerate the phagocytosis of macrophages, and can activate other effector cells. Therefore, this antibody contributes to the self-defense mechanism.
摘要翻译： 本发明提供具有抗原结合活性的抗体，其具有重链恒定区，其中已引入RGDS氨基酸序列，其给予对包括巨噬细胞的细胞的抗体亲和力。 抗体表现出人工细胞粘附活性，其是由RGDS氨基酸序列的插入引起的新表达的活性。 具有人造细胞粘附活性的该抗体可以加速巨噬细胞的吞噬作用，并可以激活其他效应细胞。 因此，该抗体有助于自卫机制。
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