公开(公告)号：US20090185181A1

公开(公告)日：2009-07-23

申请号：US10575714

申请日：2004-10-12

申请人： Tohru Koike ,  Akihiko Kawasaki ,  Tatsuhiro Kobashi ,  Makoto Takahagi

发明人： Tohru Koike ,  Akihiko Kawasaki ,  Tatsuhiro Kobashi ,  Makoto Takahagi

IPC分类号： G01J3/44 ,  C07D213/36 ,  C07F3/06 ,  G01N21/55

CPC分类号： G01N21/553 ,  C07D213/38 ,  G01J3/44 ,  G01N21/554 ,  G01N21/658 ,  G01N33/54373

摘要： The present invention provides a method for measuring a surface plasmon resonance, the method enabling easy detection of the existence of a phosphorylated peptide (protein) and determination whether a peptide is phosphorylated or not in biological materials. The present invention also provides a noble metal compound having high capability of coordination to a phosphorylated peptide, and being conveniently usable in the method. A first method for measuring surface plasmon resonance of the present invention comprises: placing a noble metal compound on a bottom face of a prism, irradiating a light to the prism to detect a reflected light, wherein, the noble metal compound has substituents of following formula (I) on a side opposite to a side contacting the prism, and a subject sample is added to a side having the substituent groups (I) in the noble metal compound. [wherein, X represents a linker group]

摘要翻译： 本发明提供了一种测定表面等离子体共振的方法，该方法能够容易地检测磷酸化肽（蛋白质）的存在并确定生物材料中肽是否被磷酸化。 本发明还提供了与磷酸化肽具有高配位能力的贵金属化合物，并且在该方法中可以方便地使用。 用于测量本发明的表面等离子体共振的第一种方法包括：将贵金属化合物放置在棱镜的底面上，向棱镜照射光以检测反射光，其中贵金属化合物具有下式的取代基 （I）在与棱镜接触的一侧相反的一侧，并且在贵金属化合物中的具有取代基（I）的一侧加入被检样品。 [其中，X表示连接基团]

公开(公告)号：US07476738B2

公开(公告)日：2009-01-13

申请号：US10547972

申请日：2003-12-24

申请人： Tohru Koike ,  Norio Minami ,  Akihiko Kawasaki

发明人： Tohru Koike ,  Norio Minami ,  Akihiko Kawasaki

IPC分类号： C07F3/06 ,  G01N33/48

CPC分类号： G01N33/6818 ,  G01N2458/15 ,  Y10S436/815 ,  Y10T436/16

摘要： The present invention provides a method for confirming existence of a phosphoric acid monoester compound (peptide, saccharine and the like) and easily identifying the molecular weight thereof even among biological samples including a plurality of compounds, and an additive for a mass spectrometry used for the method. In the method according to the present invention, a complex compound exhibiting extremely high coordination ability to a phosphoric acid monoester group and configured of single kind of zinc isotopes is used to obtain a plurality of mass spectrum data, and then the data are compared.

摘要翻译： 本发明提供了一种用于确认磷酸单酯化合物（肽，糖精等）的存在并且即使在包括多种化合物的生物样品中也容易鉴别其分子量的方法和用于 方法。 在根据本发明的方法中，使用对磷酸单酯基具有极高配位能力并由单种锌同位素构成的配位化合物来获得多个质谱数据，然后比较数据。

公开(公告)号：US4645695A

公开(公告)日：1987-02-24

申请号：US768745

申请日：1985-08-23

申请人： Taichi Negi ,  Akihiko Kawasaki ,  Kyoichiro Ikari

发明人： Taichi Negi ,  Akihiko Kawasaki ,  Kyoichiro Ikari

IPC分类号： C08L23/00 ,  B32B27/30 ,  C08L23/08 ,  C08L23/26 ,  C08L29/04 ,  C08L31/04 ,  C08L33/00 ,  C08L33/02 ,  C08L51/00 ,  C08L51/02 ,  C08L51/06 ,  C08L101/00 ,  B65D1/00

CPC分类号： C08L23/08 ,  B32B27/30 ,  C08L29/04 ,  C08L51/06 ,  Y10S220/917 ,  Y10T428/1352 ,  Y10T428/1379 ,  Y10T428/1397 ,  Y10T428/31909 ,  Y10T428/31928

摘要： A resinous composition which comprises (A) 95 to 50 parts by weight of a saponified product of ethylene-vinyl acetate copolymer and (B) 5 to 50 parts by weight of a product formed by modifying ethylene-vinyl carboxylate ester copolymer or ethylene-acrylate ester copolymer with an .alpha.,.beta.-unsaturated carboxylic acid or anhydride thereof. This resinous composition can be made by melt extrusion into a molded article which is superior in impact resistance to that formed from the component (A) alone. The resinous composition can also be made into an inner layer or interlayer of a laminated container. This container is suitable for bottles of foods and agricultural chemicals because of its outstanding impact resistance, organic solvent resistance, and oxygen barrier properties.

摘要翻译： 一种树脂组合物，其包含（A）95至50重量份的乙烯 - 乙酸乙烯酯共聚物的皂化产物和（B）5至50重量份通过改性乙烯 - 乙烯基羧酸酯共聚物或乙烯 - 丙烯酸酯 酯共聚物与α，β-不饱和羧酸或其酸酐。 该树脂组合物可以通过熔融挤出成型，其耐冲击性优于单独组分（A）形成的成型制品。 树脂组合物也可以制成层压容器的内层或中间层。 该容器由于其优异的耐冲击性，耐溶剂性和阻氧性，因此适用于食品和农药瓶。