-
11.发明授权26,26,26,27,27,27-Hexafluoro-1.alpha.,25-dihydroxycholecalciferol and process for preparing same 失效26,26,26,27,27,27-六氟-1α，25-二羟基胆钙化甾醇及其制备方法
公开(公告)号：US4358406A
公开(公告)日：1982-11-09
申请号：US286790
申请日：1981-07-27
IPC分类号： C07J1/00 , A61K31/59 , A61P3/02 , C07C67/00 , C07C401/00 , C07J9/00 , C07J71/00 , C07J17/00 , C07C35/21 , C07C69/013
CPC分类号： C07J9/00 , C07J71/001
摘要： This invention provides a new derivative of vitamin D, 26,26,26,27,27,27-hexafluoro-1.alpha.,25-dihydroxycholecalciferol, a process for preparing the same, and novel intermediate compounds.The compound is characterized by vitamin D-like activity substantially greater than that exhibited by 1.alpha.,25-dihydroxycholecalciferol which is considered to be the active hormonal form of vitamin D. The compound would find ready application as a substitute for vitamin D and in the treatment of or prophylaxis for disease states evincing metabolic calcium and phosphorous deficiences or imbalances.
摘要翻译： 本发明提供维生素D的新衍生物，26,26,26,27,27,27-六氟-1α，25-二羟基胆钙化甾醇，其制备方法和新型中间体化合物。 该化合物的特征在于维生素D样活性显着大于被认为是维生素D的活性激素形式的1α，25-二羟基胆钙化醇所表现的活性。该化合物可以作为维生素D的替代物，并且在 治疗或预防代谢钙和磷缺乏或不平衡的疾病状态。
-
公开(公告)号：US5210237A
公开(公告)日：1993-05-11
申请号：US750307
申请日：1991-08-27
IPC分类号： A61K31/59 , A61P35/00 , C07C401/00 , C07F7/18
CPC分类号： C07C401/00 , C07F7/1856 , Y02P20/55
摘要： Vitamin D.sub.3 analogues of the formula: ##STR1## wherein R.sup.1 is hydrogen atom and R.sup.2 is hydroxy, or R.sup.1 is hydroxy and R.sup.2 is hydrogen atom, X is hydrogen atom, hydroxy or a hydroxy protected by a hydroxy-protecting group, and R.sup.3 is hydrogen atom or a hydroxy-protecting group, which have vitamin D.sub.3 -like activities such as activity of controlling calcium metabolism and tumor cell differentiation-inducing activity.
-
13.发明授权Process for producing subculturable lymphokine-producing human T cell hybridomas 失效用于产生亚培养的产生淋巴因子的人类T细胞杂交瘤的方法
公开(公告)号：US4675295A
公开(公告)日：1987-06-23
申请号：US574213
申请日：1984-01-26
CPC分类号： C07K14/525 , C07K14/52 , C12N5/163 , C12N2510/02
摘要： A process for preparing human T cell hybridomas which are subculturable and produce lymphokines comprising the steps of: (1) treating a human acute leukemia cell with a protein and/or RNA synthesis inhibitor; (2) independently activating a human T cell with a mitogen or antigen; (3) fusing the thus-treated human acute leukemia cell with the thus-activated human T cell in the presence of a fusion accelerator; and (4) isolating the thus-formed hybridoma. An in vivo process for producing lymphokines using the hybridomas is also described.
摘要翻译： 一种制备可亚培养并产生淋巴因子的人T细胞杂交瘤的方法，包括以下步骤：（1）用蛋白质和/或RNA合成抑制剂处理人急性白血病细胞; （2）用丝裂原或抗原独立活化人T细胞; （3）在融合加速器的存在下将如此治疗的人急性白血病细胞与如此活化的人T细胞融合; 和（4）分离由此形成的杂交瘤。 还描述了使用杂交瘤产生淋巴因子的体内方法。
-
14.发明授权
公开(公告)号：US4283344A
公开(公告)日：1981-08-11
申请号：US128190
申请日：1980-03-07
IPC分类号： C07D307/87 , C07D307/78
CPC分类号： C07D307/87
摘要： 1,1,3,3-Tetrafluoro-1,3-dihydro-isobenzofuran is produced easily in good yield and high purity by allowing .alpha.,.alpha.,.alpha.-trichloro-o-toluic chloride to react with anhydrous hydrogen fluoride at an amount ratio of 4 moles or slight excess of the latter to 1 mole of the former. The final product may be used as an intermediate in the preparation of a fungicidal compound.
摘要翻译： 1,1,3,3-四氟-1,3-二氢异苯并呋喃通过使α，α，α-三氯邻甲苯氯与无水氟化氢以一定量的比例反应而容易地以良好的产率和高纯度产生 4摩尔或略过剩的1摩尔前者。 最终产物可用作制备杀真菌化合物的中间体。
-
公开(公告)号：US4201881A
公开(公告)日：1980-05-06
申请号：US24848
申请日：1979-03-28
CPC分类号： C07C401/00 , C07C35/52 , C07C2101/14 , C07C2102/24
摘要： The invention provides new derivatives of vitamin D, 24,24-difluoro-1.alpha.,25-dihydroxycholecalciferol and 24,24-difluoro-1.alpha.,25-dihydroxy-5,6-trans-cholecalciferol and processes for preparing the same.The compounds are characterized by vitamin D-like activity essentially equivalent to the vitamin D-like activity of 1.alpha.,25-dihydrocholecalciferol which is considered to be the hormonal form and most active derivative of vitamin D. The compounds of this invention are characterized by their ability to increase intestinal calcium transport, increase serum calcium and to prevent the development of rickets. These compounds would find ready application as a substitute for vitamin D and in the treatment of disease states evincing metabolic calcium and phosphorus deficiencies.
摘要翻译： 本发明提供维生素D，24,24-二氟-1α，25-二羟基胆钙化甾醇和24,24-二氟-1α，25-二羟基-5,6-反式胆钙化甾醇的新衍生物及其制备方法。 该化合物的特征在于维生素D样活性，其基本上等同于被认为是维生素D的激素形式和最活泼的衍生物的1α，25-二氢胆钙化醇的维生素D样活性。本发明的化合物的特征在于 增加肠钙运输能力，增加血清钙，防止r the病的发展。 这些化合物可以作为维生素D的替代物和治疗代谢钙和磷缺乏症的疾病状态得到准备。
-
公开(公告)号：US5319915A
公开(公告)日：1994-06-14
申请号：US4630
申请日：1993-01-14
CPC分类号： D07B1/0646 , B60C9/0007 , B60C9/0057 , D07B3/04 , D07B3/10 , D07B7/025 , D07B2201/2007 , D07B2201/2022 , D07B2201/2024 , D07B2201/2025 , D07B2201/2039 , D07B2201/204 , D07B2207/204 , D07B2501/2046 , Y10S57/902
摘要： A steel cord comprising a number (between 3 and 27) of element steel wires tightly twisted at a regular pitch P between 5 and 20 mm in the same direction. Each wire has a diameter d between 0.1 and 0.4 mm. At least one of the wires includes a spiral portion having a spiral pitch P1 between 0.1P and 0.7P and a spiral diameter d1 between d+2/100 mm and d+2/10 mm. At least one other wire includes a straight portion. At any cross section of the cord, 1/4 through 2/3 of the wires is/are spiral and the other wire/s is/are straight. The stretch of the cord under a load of 5 kg is between 0.10 and 0.40%. A method of producing a steel cord comprises supplying a number of element steel wires, forming at least part of at least one of the wires to be spiral, and tightly twisting the wires. An apparatus for producing a steel cord comprises feeders supported by a frame, each feeding an element steel wire along an axis, a tension device for applying a tension to the wire from at least one of the feeders, a spiral device having pins which extend across and are spaced along an axis, so that at least one of the wires from the tension device turns alternately over and under the pins, a strand device rotatable on the axis, so that the wires are twisted to form a strand, and a take-up device to take up the strand.
摘要翻译： 一种钢帘线，包括以相同方向以5至20mm之间的规则间距P紧密地扭曲的多个（3至27个）元素钢丝。 每根线的直径d在0.1和0.4mm之间。 至少一根电线包括具有0.1P和0.7P之间的螺旋间距P1和d + 2 / 100mm和d + 2 / 10mm之间的螺旋直径d1的螺旋部分。 至少另一根线包括直线部分。 在电线的任何横截面处，1/4至2/3的电线是螺旋形的，另一根电线是/是直的。 在5kg载荷下，绳索的伸长率在0.10至0.40％之间。 一种生产钢帘线的方法包括：供给若干元素钢线，形成要被螺旋形的至少一根电线的至少一部分，并且紧紧地扭曲线。 一种用于生产钢帘线的装置，包括由框架支撑的馈送器，每个馈送器沿着轴线馈送元件钢丝;张紧装置，用于从至少一个馈送器向线材施加张力;螺旋装置， 并且沿着轴线间隔开，使得来自张力装置的至少一根电线交替地在销上方和下方转动，可在轴线上旋转的绞线装置，使得电线被扭曲以形成绞线， 收起装置来收起绳子。
-
公开(公告)号：US4305880A
公开(公告)日：1981-12-15
申请号：US189513
申请日：1980-09-22
IPC分类号： C07J9/00
摘要： The invention provides a new derivative of vitamin D.sub.3, 24-fluoro-25-hydroxycholecalciferol.The compound is characterized by vitamin D-like activity in its ability to increase intestinal calcium transport, increase serum calcium and inorganic phosphorous concentration and to prevent the development of rickets. It would find ready application as a substitute for vitamin D.sub.3 and in the treatment of disease states evincing calcium-phosphorous imbalance and which are nonresponsive to vitamin D.sub.3 therapy.
摘要翻译： 本发明提供维生素D3，24-氟-25-羟基胆钙化甾醇的新衍生物。 该化合物的特征在于维生素D样活性增加肠钙运输能力，增加血清钙和无机磷浓度，并防止r the病的发展。 它可以作为维生素D3的替代品和治疗表现出钙磷不平衡的疾病状态，并且对维生素D3治疗无反应。
-
18.发明授权
公开(公告)号：US5278155A
公开(公告)日：1994-01-11
申请号：US710394
申请日：1991-06-05
申请人： Nobuo Ikekawa , Yoshiro Kobayashi , Yoko Tanaka , Tadashi Eguchi
发明人： Nobuo Ikekawa , Yoshiro Kobayashi , Yoko Tanaka , Tadashi Eguchi
CPC分类号： C07C401/00 , C07J31/006 , C07J9/00 , Y02P20/55
摘要： Fluorine-containing vitamin D.sub.3 analogues of the formula [I]: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are independently hydrogen atom, a chemically inactive hydroxy-protecting group, an acyl having 2 to 8 carbon atoms or an alkyl having 1 to 8 carbon atoms, and n is an integer of 4 to 6, which have excellent pharmacological activities, particularly anti-tumor activity owing to differentiation-inducing activity and are useful for the prophylaxis and treatment of various tumors and intermediates therefore.
摘要翻译： 具有式[I]的含氟维生素D3类似物：其中R1，R2和R3独立地是氢原子，化学惰性的羟基保护基，具有2-8个碳原子的酰基或具有 1〜8个碳原子，n为4〜6的整数，由于分化诱导活性，具有优异的药理活性，特别是抗肿瘤活性，因此可用于预防和治疗各种肿瘤及中间体。
-
19.发明授权26,26,26,27,27-pentafluoro-1.alpha.-hydroxy-27-methoxyvitamin D.sub.3 失效26,26,26,27,27-五氟-1α-羟基-27-甲氧基维生素D3
公开(公告)号：US4619920A
公开(公告)日：1986-10-28
申请号：US776342
申请日：1985-09-16
IPC分类号： C07J1/00 , C07C67/00 , C07C401/00 , C07J9/00
CPC分类号： C07C401/00 , C07J9/00
摘要： The invention provides a new derivative of vitamin D.sub.3, 26,26,26,27,27-pentafluoro-1.alpha.-hydroxy-27-methoxy-cholecalciferol and a process for preparing the same.The compound is characterized by some vitamin D-like activity except that it exhibits negligible activity in mobilizing bone. This characteristic indicates that the compound would find ready application in the treatment of disease or physiological states which evince loss of bone mass and application in other situations where metabolic calcium imbalances are found.
摘要翻译： 本发明提供维生素D3,26,26,26,27,27-五氟-1α-羟基-27-甲氧基胆钙化甾醇的新衍生物及其制备方法。 该化合物的特征在于一些维生素D样活性，除了它在动员骨中显示出可忽略的活性。 该特征表明该化合物可用于治疗疾病或生理状态，这些疾病或生理状态证明骨质量的损失和在发现代谢钙不平衡的其他情况下的应用。
-
公开(公告)号：US4594192A
公开(公告)日：1986-06-10
申请号：US713941
申请日：1985-03-20
IPC分类号： C07C401/00 , C07J9/00
CPC分类号： C07J9/00 , C07C401/00
摘要： The invention provides new derivatives of vitamin D.sub.3, 2.alpha.-fluorovitamin D.sub.3 and the acylates thereof.The compounds are characterized by vitamin D-like activity in their ability to increase intestinal calcium transport and serum calcium indicating their ready application as substitutes for vitamin D.
摘要翻译： 本发明提供维生素D3,2α-氟维生素D3及其酰化物的新衍生物。 这些化合物的特征在于维生素D样活性能够增加肠钙运输和血清钙，表明它们作为维生素D替代品的适用。
-
-
-
-
-
-
-
-
-
搜索结果
31 条记录 (耗时 0.02 秒)
