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    INHIBITION OF PLATELET ACTIVATION, AGGREGATION AND/OR ADHESION BY HYPOTHERMIA
    12.
    发明申请
    INHIBITION OF PLATELET ACTIVATION, AGGREGATION AND/OR ADHESION BY HYPOTHERMIA 审中-公开
    抑制血小板活化，聚集和/或粘附

    公开(公告)号：US20160354236A1

    公开(公告)日：2016-12-08

    申请号：US15174690

    申请日：2016-06-06

    Applicant: ZOLL Circulation Inc.

    Inventor： Michael W. Dae ,  Timothy R. Machold ,  Wade A. Keller

    IPC: A61F7/12

    CPC classification number: A61F7/12 ,  A61F7/123 ,  A61F2007/126

    Abstract: A method for treating acute coronary syndromes (i.e., unstable angina or non-Q-wave MI) or transient ischemic attacks in a human or animal patient by placing a heat exchange apparatus in the patient=s vasculature and using that heat exchange apparatus to cool the patient to a temperature (e.g. 30-36 degrees C.) at which platelet inhibition (i.e., inhibition of platelet activation and/or aggregation and/or adhesion) occurs. Anti-shivering drugs or anesthesia may be administered to patients whose body temperature is cooled below that patient=s shivering threshold (typically approximately 35.5 degrees C.). If it is determined that platelet inhibition is no longer desirable, such as when the patient is about to undergo a surgical or interventional procedure wherein bleeding could be problematic, the hypothermia-induced platelet inhibition may be rapidly reversed by using the intravascular heat exchange apparatus to re-warm the patient=s body to normothermia or near normothermia.

    Abstract translation: 一种通过在患者脉管系统中放置热交换装置并使用该热交换装置冷却来治疗人或动物患者的急性冠状动脉综合征（即不稳定心绞痛或非Q波MI）或短暂性脑缺血发作的方法 患者达到出现血小板抑制（即，抑制血小板活化和/或凝集和/或粘附）的温度（例如30-36摄氏度）。 可将抗发抖药物或麻醉剂施用于体温低于该患者发抖阈值（通常约35.5摄氏度）的患者。 如果确定不再需要血小板抑制，例如当患者即将进行其中出血可能有问题的手术或介入手术时，通过使用血管内热交换装置可以快速逆转低体温诱导的血小板抑制 将患者身体重新加热至正常体温或接近正常体温。

    Vascular sheath with temperature monitoring probe
    13.
    发明授权
    Vascular sheath with temperature monitoring probe 有权
    血管鞘带温度监测探头

    公开(公告)号：US09357967B2

    公开(公告)日：2016-06-07

    申请号：US14445892

    申请日：2014-07-29

    Applicant: ZOLL Circulation, Inc.

    Inventor： Jeffrey P. Callister ,  Michael W. Dae ,  Amy L. Hammack

    IPC: A61B5/00 ,  A61F7/12 ,  A61B5/01 ,  A61B17/00 ,  A61M25/06

    CPC classification number: A61B5/6852 ,  A61B5/0008 ,  A61B5/01 ,  A61B2017/00084 ,  A61F7/12 ,  A61F2007/126 ,  A61M25/0662

    Abstract: An introducer sheath/temperature probe assembly that is insertable into a blood vessel of a human or veterinary patent to measure the temperature of blood flowing through that blood vessel. The introducer sheath/temperature probe assembly may be used in conjunction with an indwelling heat exchange catheter system to warm or cool all or a portion of the patient's body to a desired target temperature and to maintain such target temperature for a desired period of time.

    Abstract translation: 导引鞘/温度探针组件，其可插入人或兽医专利的血管中，以测量流过该血管的血液的温度。 导引鞘/温度探针组件可以与留置的热交换导管系统一起使用，以将患者身体的全部或一部分加热或冷却到期望的目标温度，并将该目标温度保持在期望的时间段内。

    INTRA-AORTIC BALLOON COUNTERPULSATION WITH CONCURRENT HYPOTHERMIA
    16.
    发明申请
    INTRA-AORTIC BALLOON COUNTERPULSATION WITH CONCURRENT HYPOTHERMIA 审中-公开
    具有同时性的血压的内在气球反应

    公开(公告)号：US20130310632A1

    公开(公告)日：2013-11-21

    申请号：US13872984

    申请日：2013-04-29

    Applicant: ZOLL Circulation, Inc.

    Inventor： Michael W. Dae ,  Timmothy R. Machold

    IPC: A61M1/10

    CPC classification number: A61M1/1086 ,  A61F7/10 ,  A61F7/123 ,  A61F2007/0056 ,  A61F2007/0095 ,  A61F2007/126 ,  A61M1/106 ,  A61M1/107 ,  A61M1/1072 ,  A61M1/1074 ,  A61M1/125 ,  A61M19/00 ,  A61M2205/3606 ,  A61M2230/04

    Abstract: Devices, systems and methods for treating disorders characterized by low cardiac output. The devices, systems and methods use intra-aortic balloon counterpulsation in combination with hypothermia of all or a portion of a human or veterinary patient's body to improve coronary perfusion and cardiac output. To effect the hypothermia, a heat exchange catheter may be positioned in the a patient's vasculature separately from the intra-aortic balloon counterpulsation catheter. Alternatively, a combination Intra-aortic balloon counterpulsation/heat exchange catheter may be utilized. Such combination catheter comprises a) a catheter sized for insertion into the aorta, b) a counterpulsation balloon and c) a heat exchanger. A drive/control system receives temperature and electrocardiograph signals and drives the inflation/deflation of the counterpulsation balloon as well as the heating/cooling of the heat exchanger.

    Abstract translation: 用于治疗以低心输出量为特征的疾病的装置，系统和方法。 装置，系统和方法使用主动脉内气囊反搏与人或兽医患者身体的全部或一部分的低体温结合以改善冠状动脉灌注和心输出量。 为了降低体温，可以将热交换导管与主动脉内气囊反搏导管分开设置在患者的脉管系统中。 或者，可以使用主动脉内球囊反搏/热交换导管的组合。 这种组合导管包括a）尺寸适于插入主动脉的导管，b）反力气囊和c）热交换器。 驱动/控制系统接收温度和心电图仪信号并驱动反力气囊的充气/放气以及热交换器的加热/冷却。

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