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    INHIBITION OF PLATELET ACTIVATION, AGGREGATION AND/OR ADHESION BY HYPOTHERMIA
    2.
    发明申请
    INHIBITION OF PLATELET ACTIVATION, AGGREGATION AND/OR ADHESION BY HYPOTHERMIA 审中-公开
    抑制血小板活化，聚集和/或粘附

    公开(公告)号：US20130304166A1

    公开(公告)日：2013-11-14

    申请号：US13868764

    申请日：2013-04-23

    Applicant: ZOLL CIRCULATION INC.

    Inventor： Michael W. Dae ,  Timothy R. Machold ,  Wade A. Keller

    IPC: A61F7/12

    CPC classification number: A61F7/12 ,  A61F7/123 ,  A61F2007/126

    Abstract: A method for treating acute coronary syndromes (i.e., unstable angina or non-Q-wave MI) or transient ischemic attacks in a human or animal patient by placing a heat exchange apparatus in the patient's vasculature and using that heat exchange apparatus to cool the patient to a temperature (e.g. 30-36 degrees C.) at which platelet inhibition (i.e., inhibition of platelet activation and/or aggregation and/or adhesion) occurs. Anti-shivering drugs or anesthesia may be administered to patients whose body temperature is cooled below that patient's shivering threshold (typically approximately 35.5 degrees C.). If it is determined that platelet inhibition is no longer desirable, such as when the patient is about to undergo a surgical or interventional procedure wherein bleeding could be problematic, the hypothermia-induced platelet inhibition may be rapidly reversed by using the intravascular heat exchange apparatus to re-warm the patient's body to normothermia or near normothermia.

    Abstract translation: 一种通过将热交换装置放置在患者的脉管系统中并使用该热交换装置来冷却患者来治疗人或动物患者的急性冠状动脉综合征（即不稳定型心绞痛或非Q波MI）或短暂性脑缺血发作的方法 达到血小板抑制（即，抑制血小板活化和/或聚集和/或粘附）的温度（例如30-36℃）。 可以将抗发抖药物或麻醉剂施用于体温低于该患者发抖阈值（通常约35.5摄氏度）的患者。 如果确定不再期望血小板抑制，例如当患者即将进行其中出血可能成问题的手术或介入手术时，通过使用血管内热交换装置可以快速逆转低温诱导的血小板抑制 将患者的身体重温为正常体温或接近正常体温。

    Intra-aortic balloon counterpulsation with concurrent hypothermia
    3.
    发明授权
    Intra-aortic balloon counterpulsation with concurrent hypothermia 有权
    主动脉内气囊反搏与并发低温

    公开(公告)号：US09533086B2

    公开(公告)日：2017-01-03

    申请号：US14936507

    申请日：2015-11-09

    Applicant: ZOLL Circulation, Inc.

    Inventor： Michael W. Dae ,  Timothy R. Machold

    IPC: A61B7/00 ,  A61M1/10 ,  A61F7/12 ,  A61F7/10 ,  A61F7/00 ,  A61M19/00

    CPC classification number: A61M1/1086 ,  A61F7/10 ,  A61F7/123 ,  A61F2007/0056 ,  A61F2007/0095 ,  A61F2007/126 ,  A61M1/106 ,  A61M1/107 ,  A61M1/1072 ,  A61M1/1074 ,  A61M1/125 ,  A61M19/00 ,  A61M2205/3606 ,  A61M2230/04

    Abstract: Devices, systems and methods for treating disorders characterized by low cardiac output. The devices, systems and methods use intra-aortic balloon counterpulsation in combination with hypothermia of all or a portion of a human or veterinary patient's body to improve coronary perfusion and cardiac output. To effect the hypothermia, a heat exchange catheter may be positioned in the a patient's vasculature separately from the intra-aortic balloon counterpulsation catheter. Alternatively, a combination Intra-aortic balloon counterpulsation/heat exchange catheter may be utilized. Such combination catheter comprises a) a catheter sized for insertion into the aorta, b) a counterpulsation balloon and c) a heat exchanger. A drive/control system receives temperature and electrocardiograph signals and drives the inflation/deflation of the counterpulsation balloon as well as the heating/cooling of the heat exchanger.

    Abstract translation: 用于治疗以低心输出量为特征的疾病的装置，系统和方法。 装置，系统和方法使用主动脉内气囊反搏与人或兽医患者身体的全部或一部分的低体温结合以改善冠状动脉灌注和心输出量。 为了降低体温，可以将热交换导管与主动脉内气囊反搏导管分开设置在患者的脉管系统中。 或者，可以使用主动脉内球囊反搏/热交换导管的组合。 这种组合导管包括a）尺寸适于插入主动脉的导管，b）反力气囊和c）热交换器。 驱动/控制系统接收温度和心电图仪信号并驱动反力气囊的充气/放气以及热交换器的加热/冷却。

    Devices and Methods for Using Endovascular Cooling to Treat Septic Shock and Other Disorders
    4.
    发明申请
    Devices and Methods for Using Endovascular Cooling to Treat Septic Shock and Other Disorders 审中-公开
    使用血管内冷却治疗脓毒性休克和其他疾病的装置和方法

    公开(公告)号：US20140148882A1

    公开(公告)日：2014-05-29

    申请号：US13932743

    申请日：2013-07-01

    Applicant: ZOLL Circulation, Inc.

    Inventor： Michael W. Dae

    IPC: A61F7/00

    CPC classification number: A61F7/0085 ,  A61F7/12 ,  A61F2007/0054 ,  A61F2007/0093 ,  A61F2007/126

    Abstract: Apparatus, systems and methods for cooling or warming the temperature of all or a portion of the body of a human or animal subject to treat disorders including but not limited to sepsis, septic shock or other inflammatory or infectious conditions which can result in shock, hypoxia, ischemia and/or multiple organ failure in human or animal subjects.

    Abstract translation: 用于冷却或升温患有人或动物身体的全部或一部分体温的装置，系统和方法，其治疗包括但不限于脓毒症，败血性休克或可导致休克，缺氧的其它炎性或感染性疾病的病症 ，人或动物受试者的缺血和/或多器官衰竭。

    Method for Reducing Myocardial Infarct by Application of Intravascular Hypothermia
    5.
    发明申请
    Method for Reducing Myocardial Infarct by Application of Intravascular Hypothermia 审中-公开
    通过应用血管内低温降低心肌梗塞的方法

    公开(公告)号：US20140121735A1

    公开(公告)日：2014-05-01

    申请号：US14065208

    申请日：2013-10-28

    Applicant: ZOLL Circulation, Inc.

    Inventor： Michael W. Dae ,  Wade A. Keller ,  Timothy R. Machold

    IPC: A61F7/12

    CPC classification number: A61F7/12 ,  A61F7/123 ,  A61F2007/0056 ,  A61F2007/0076 ,  A61F2007/126 ,  A61M25/1002

    Abstract: Methods and apparatus for preventing myocardial infarction, or lessening the size/severity of an evolving myocardial infarction, by cooling at least the affected area of the myocardium using an intravascular heat exchange catheter. The heat exchange catheter may be inserted into the vasculature (e.g., a vein) and advanced to a position wherein a heat exchanger on the catheter is located in or near the heart (e.g., within the vena cava near the patient's heart). Thereafter, the heat exchange catheter is used to cool the myocardium (or the entire body of the patient) to a temperature that effectively lessens the metabolic rate and/or oxygen consumption of the ischemic myocardial cells or otherwise protects the ischemic myocardium from undergoing irreversible damage or infarction.

    Abstract translation: 通过使用血管内热交换导管至少冷却至少心肌的受影响区域来预防心肌梗死或减轻心肌梗死的大小/严重程度的方法和装置。 热交换导管可以插入脉管系统（例如静脉）中并且前进到导管上的热交换器位于心脏中或附近（例如在患者心脏附近的腔静脉内）的位置。 此后，热交换导管用于将心肌（或患者的整个身体）冷却到有效降低缺血心肌细胞的代谢率和/或氧消耗的温度，或以其它方式保护缺血心肌免受不可逆损伤 或梗死。

    Inhibition of platelet activation, aggregation and/or adhesion by hypothermia
    6.
    发明授权
    Inhibition of platelet activation, aggregation and/or adhesion by hypothermia 有权

    公开(公告)号：US10369044B2

    公开(公告)日：2019-08-06

    申请号：US15174690

    申请日：2016-06-06

    Applicant: ZOLL Circulation Inc.

    Inventor： Michael W. Dae ,  Timothy R. Machold ,  Wade A. Keller

    IPC: A61F7/12

    Abstract: A method for treating acute coronary syndromes (i.e., unstable angina or non-Q-wave MI) or transient ischemic attacks in a human or animal patient by placing a heat exchange apparatus in the patient=s vasculature and using that heat exchange apparatus to cool the patient to a temperature (e.g. 30-36 degrees C.) at which platelet inhibition (i.e., inhibition of platelet activation and/or aggregation and/or adhesion) occurs. Anti-shivering drugs or anesthesia may be administered to patients whose body temperature is cooled below that patient=s shivering threshold (typically approximately 35.5 degrees C.). If it is determined that platelet inhibition is no longer desirable, such as when the patient is about to undergo a surgical or interventional procedure wherein bleeding could be problematic, the hypothermia-induced platelet inhibition may be rapidly reversed by using the intravascular heat exchange apparatus to re-warm the patient=s body to normothermia or near normothermia.

    Intra-aortic balloon counterpulsation with concurrent hypothermia
    7.
    发明授权
    Intra-aortic balloon counterpulsation with concurrent hypothermia 有权
    主动脉内气囊反搏与并发低温

    公开(公告)号：US09180236B2

    公开(公告)日：2015-11-10

    申请号：US13872984

    申请日：2013-04-29

    Applicant: ZOLL Circulation, Inc.

    Inventor： Michael W. Dae ,  Timothy R. Machold

    IPC: A61F7/00 ,  A61M1/10 ,  A61F7/12 ,  A61F7/10 ,  A61M19/00

    CPC classification number: A61M1/1086 ,  A61F7/10 ,  A61F7/123 ,  A61F2007/0056 ,  A61F2007/0095 ,  A61F2007/126 ,  A61M1/106 ,  A61M1/107 ,  A61M1/1072 ,  A61M1/1074 ,  A61M1/125 ,  A61M19/00 ,  A61M2205/3606 ,  A61M2230/04

    Abstract: Devices, systems and methods for treating disorders characterized by low cardiac output. The devices, systems and methods use intra-aortic balloon counterpulsation in combination with hypothermia of all or a portion of a human or veterinary patient's body to improve coronary perfusion and cardiac output. To effect the hypothermia, a heat exchange catheter may be positioned in the a patient's vasculature separately from the intra-aortic balloon counterpulsation catheter. Alternatively, a combination Intra-aortic balloon counterpulsation/heat exchange catheter may be utilized. Such combination catheter comprises a) a catheter sized for insertion into the aorta, b) a counterpulsation balloon and c) a heat exchanger. A drive/control system receives temperature and electrocardiograph signals and drives the inflation/deflation of the counterpulsation balloon as well as the heating/cooling of the heat exchanger.

    Abstract translation: 用于治疗以低心输出量为特征的疾病的装置，系统和方法。 装置，系统和方法使用主动脉内气囊反搏与人或兽医患者身体的全部或一部分的低体温结合以改善冠状动脉灌注和心输出量。 为了降低体温，可以将热交换导管与主动脉内气囊反搏导管分开设置在患者的脉管系统中。 或者，可以使用主动脉内球囊反搏/热交换导管的组合。 这种组合导管包括a）尺寸适于插入主动脉的导管，b）反力气囊和c）热交换器。 驱动/控制系统接收温度和心电图仪信号并驱动反力气囊的充气/放气以及热交换器的加热/冷却。

    Inhibition of platelet activation, aggregation and/or adhesion by hypothermia
    9.
    发明授权
    Inhibition of platelet activation, aggregation and/or adhesion by hypothermia 有权
    通过低温抑制血小板活化，聚集和/或粘附

    公开(公告)号：US09358153B2

    公开(公告)日：2016-06-07

    申请号：US13868764

    申请日：2013-04-23

    Applicant: ZOLL Circulation Inc.

    Inventor： Michael W. Dae ,  Timothy R. Machold ,  Wade A. Keller

    IPC: A61F7/12

    CPC classification number: A61F7/12 ,  A61F7/123 ,  A61F2007/126

    Abstract: A method for treating acute coronary syndromes (i.e., unstable angina or non-Q-wave MI) or transient ischemic attacks in a human or animal patient by placing a heat exchange apparatus in the patient's vasculature and using that heat exchange apparatus to cool the patient to a temperature (e.g. 30-36 degrees C.) at which platelet inhibition (i.e., inhibition of platelet activation and/or aggregation and/or adhesion) occurs. Anti-shivering drugs or anesthesia may be administered to patients whose body temperature is cooled below that patient's shivering threshold (typically approximately 35.5 degrees C.). If it is determined that platelet inhibition is no longer desirable, such as when the patient is about to undergo a surgical or interventional procedure wherein bleeding could be problematic, the hypothermia-induced platelet inhibition may be rapidly reversed by using the intravascular heat exchange apparatus to re-warm the patient's body to normothermia or near normothermia.

    Abstract translation: 一种通过将热交换装置放置在患者的脉管系统中并使用该热交换装置来冷却患者来治疗人或动物患者的急性冠状动脉综合征（即不稳定型心绞痛或非Q波MI）或短暂性脑缺血发作的方法 达到血小板抑制（即，抑制血小板活化和/或聚集和/或粘附）的温度（例如30-36℃）。 可以将抗发抖药物或麻醉剂施用于体温低于该患者发抖阈值（通常约35.5摄氏度）的患者。 如果确定不再需要血小板抑制，例如当患者即将进行其中出血可能有问题的手术或介入手术时，通过使用血管内热交换装置可以快速逆转低体温诱导的血小板抑制 将患者的身体重温为正常体温或接近正常体温。

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