利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

18 条记录 (耗时 0.023 秒)

    Inhibition of platelet activation, aggregation and/or adhesion by hypothermia
    1.
    发明授权
    Inhibition of platelet activation, aggregation and/or adhesion by hypothermia 有权

    公开(公告)号：US10369044B2

    公开(公告)日：2019-08-06

    申请号：US15174690

    申请日：2016-06-06

    申请人： ZOLL Circulation Inc.

    发明人： Michael W. Dae ,  Timothy R. Machold ,  Wade A. Keller

    IPC分类号： A61F7/12

    摘要： A method for treating acute coronary syndromes (i.e., unstable angina or non-Q-wave MI) or transient ischemic attacks in a human or animal patient by placing a heat exchange apparatus in the patient=s vasculature and using that heat exchange apparatus to cool the patient to a temperature (e.g. 30-36 degrees C.) at which platelet inhibition (i.e., inhibition of platelet activation and/or aggregation and/or adhesion) occurs. Anti-shivering drugs or anesthesia may be administered to patients whose body temperature is cooled below that patient=s shivering threshold (typically approximately 35.5 degrees C.). If it is determined that platelet inhibition is no longer desirable, such as when the patient is about to undergo a surgical or interventional procedure wherein bleeding could be problematic, the hypothermia-induced platelet inhibition may be rapidly reversed by using the intravascular heat exchange apparatus to re-warm the patient=s body to normothermia or near normothermia.

    Intra-aortic balloon counterpulsation with concurrent hypothermia
    2.
    发明授权
    Intra-aortic balloon counterpulsation with concurrent hypothermia 有权
    主动脉内气囊反搏与并发低温

    公开(公告)号：US09180236B2

    公开(公告)日：2015-11-10

    申请号：US13872984

    申请日：2013-04-29

    申请人： ZOLL Circulation, Inc.

    发明人： Michael W. Dae ,  Timothy R. Machold

    IPC分类号： A61F7/00 ,  A61M1/10 ,  A61F7/12 ,  A61F7/10 ,  A61M19/00

    CPC分类号： A61M1/1086 ,  A61F7/10 ,  A61F7/123 ,  A61F2007/0056 ,  A61F2007/0095 ,  A61F2007/126 ,  A61M1/106 ,  A61M1/107 ,  A61M1/1072 ,  A61M1/1074 ,  A61M1/125 ,  A61M19/00 ,  A61M2205/3606 ,  A61M2230/04

    摘要： Devices, systems and methods for treating disorders characterized by low cardiac output. The devices, systems and methods use intra-aortic balloon counterpulsation in combination with hypothermia of all or a portion of a human or veterinary patient's body to improve coronary perfusion and cardiac output. To effect the hypothermia, a heat exchange catheter may be positioned in the a patient's vasculature separately from the intra-aortic balloon counterpulsation catheter. Alternatively, a combination Intra-aortic balloon counterpulsation/heat exchange catheter may be utilized. Such combination catheter comprises a) a catheter sized for insertion into the aorta, b) a counterpulsation balloon and c) a heat exchanger. A drive/control system receives temperature and electrocardiograph signals and drives the inflation/deflation of the counterpulsation balloon as well as the heating/cooling of the heat exchanger.

    摘要翻译： 用于治疗以低心输出量为特征的疾病的装置，系统和方法。 装置，系统和方法使用主动脉内气囊反搏与人或兽医患者身体的全部或一部分的低体温结合以改善冠状动脉灌注和心输出量。 为了降低体温，可以将热交换导管与主动脉内气囊反搏导管分开设置在患者的脉管系统中。 或者，可以使用主动脉内球囊反搏/热交换导管的组合。 这种组合导管包括a）尺寸适于插入主动脉的导管，b）反力气囊和c）热交换器。 驱动/控制系统接收温度和心电图仪信号并驱动反力气囊的充气/放气以及热交换器的加热/冷却。

    METHOD AND SYSTEM FOR CONTROL OF A PATIENT'S BODY TEMPERATURE BY WAY OF A TRANSLUMINALLY INSERTABLE HEAT EXCHANGE CATHETER
    5.
    发明申请
    METHOD AND SYSTEM FOR CONTROL OF A PATIENT'S BODY TEMPERATURE BY WAY OF A TRANSLUMINALLY INSERTABLE HEAT EXCHANGE CATHETER 审中-公开
    方法和系统通过一个透明的热交换导管的方式控制患者身体温度

    公开(公告)号：US20130150929A1

    公开(公告)日：2013-06-13

    申请号：US13758793

    申请日：2013-02-04

    申请人： ZOLL CIRCULATION, INC.

    发明人： Timothy R. Machold ,  Wade A. Keller ,  Alex T. Roth ,  Nicole Denise Bloom

    IPC分类号： A61F7/00

    CPC分类号： A61F7/0085 ,  A61B2017/00092 ,  A61B2017/00119 ,  A61B2017/00123 ,  A61B2017/00199 ,  A61B2017/22051 ,  A61F7/0097 ,  A61F7/10 ,  A61F7/123 ,  A61F2007/0054 ,  A61F2007/0096 ,  A61F2007/126 ,  A61M25/10 ,  A61M25/1011 ,  A61M2025/1072 ,  A61M2025/1086 ,  A61M2205/12 ,  A61M2205/127

    摘要： Methods and apparatuses for temperature modification of a patient, or selected regions thereof, including an induced state of hypothermia. The temperature modification is accomplished using an in-dwelling heat exchange catheter within which a fluid heat exchange medium circulates. A heat exchange cassette of any one of several disclosed variations is attached to the circulatory conduits of the catheter, the heat exchange cassette being sized to engage a cavity within one of various described re-usable control units. The control units include a heater/cooler device, a user input device, and a processor connected to receive input from various sensors around the body and the system. The heater/cooler device may be thermoelectric to enable both heating and 15″ cooling based on polarity. A temperature control scheme for ramping the body temperature up or down without overshoot is provided. The disposable heat exchange cassettes may include an integral pump head that engages with a pump drive mechanism within the re-usable control unit. More than one control unit may be provided to receive the same heat exchange cassette so that, for example, a large capacity control unit can be used initially, and a smaller, battery-powered unit can be substituted once the patient reaches the desired target temperature.

    摘要翻译： 包括诱导低温的状态的患者的温度改变方法和装置，或其选定的区域。 使用在其中流体热交换介质循环的内部热交换导管来实现温度改变。 几个公开的变型中的任何一个的热交换盒附接到导管的循环导管，热交换盒的尺寸适于接合各种所描述的可重复使用的控制单元之一内的空腔。 控制单元包括加热器/冷却器装置，用户输入装置和连接以接收来自身体和系统周围的各种传感器的输入的处理器。 加热器/冷却器装置可以是热电，以使得能够基于极性进行加热和15“冷却。 提供了一种用于使体温上升或下降而没有过冲的温度控制方案。 一次性热交换盒可以包括与可再使用的控制单元内的泵驱动机构接合的整体泵头。 可以提供多于一个控制单元以接收相同的热交换盒，使得例如最初可以使用大容量控制单元，并且一旦患者达到期望的目标温度，可以取代较小的电池供电的单元 。

    Intra-aortic balloon counterpulsation with concurrent hypothermia
    6.
    发明授权
    Intra-aortic balloon counterpulsation with concurrent hypothermia 有权
    主动脉内气囊反搏与并发低温

    公开(公告)号：US09533086B2

    公开(公告)日：2017-01-03

    申请号：US14936507

    申请日：2015-11-09

    申请人： ZOLL Circulation, Inc.

    发明人： Michael W. Dae ,  Timothy R. Machold

    IPC分类号： A61B7/00 ,  A61M1/10 ,  A61F7/12 ,  A61F7/10 ,  A61F7/00 ,  A61M19/00

    CPC分类号： A61M1/1086 ,  A61F7/10 ,  A61F7/123 ,  A61F2007/0056 ,  A61F2007/0095 ,  A61F2007/126 ,  A61M1/106 ,  A61M1/107 ,  A61M1/1072 ,  A61M1/1074 ,  A61M1/125 ,  A61M19/00 ,  A61M2205/3606 ,  A61M2230/04

    摘要： Devices, systems and methods for treating disorders characterized by low cardiac output. The devices, systems and methods use intra-aortic balloon counterpulsation in combination with hypothermia of all or a portion of a human or veterinary patient's body to improve coronary perfusion and cardiac output. To effect the hypothermia, a heat exchange catheter may be positioned in the a patient's vasculature separately from the intra-aortic balloon counterpulsation catheter. Alternatively, a combination Intra-aortic balloon counterpulsation/heat exchange catheter may be utilized. Such combination catheter comprises a) a catheter sized for insertion into the aorta, b) a counterpulsation balloon and c) a heat exchanger. A drive/control system receives temperature and electrocardiograph signals and drives the inflation/deflation of the counterpulsation balloon as well as the heating/cooling of the heat exchanger.

    摘要翻译： 用于治疗以低心输出量为特征的疾病的装置，系统和方法。 装置，系统和方法使用主动脉内气囊反搏与人或兽医患者身体的全部或一部分的低体温结合以改善冠状动脉灌注和心输出量。 为了降低体温，可以将热交换导管与主动脉内气囊反搏导管分开设置在患者的脉管系统中。 或者，可以使用主动脉内球囊反搏/热交换导管的组合。 这种组合导管包括a）尺寸适于插入主动脉的导管，b）反力气囊和c）热交换器。 驱动/控制系统接收温度和心电图仪信号并驱动反力气囊的充气/放气以及热交换器的加热/冷却。

    Method for Reducing Myocardial Infarct by Application of Intravascular Hypothermia
    9.
    发明申请
    Method for Reducing Myocardial Infarct by Application of Intravascular Hypothermia 审中-公开
    通过应用血管内低温降低心肌梗塞的方法

    公开(公告)号：US20140121735A1

    公开(公告)日：2014-05-01

    申请号：US14065208

    申请日：2013-10-28

    申请人： ZOLL Circulation, Inc.

    发明人： Michael W. Dae ,  Wade A. Keller ,  Timothy R. Machold

    IPC分类号： A61F7/12

    CPC分类号： A61F7/12 ,  A61F7/123 ,  A61F2007/0056 ,  A61F2007/0076 ,  A61F2007/126 ,  A61M25/1002

    摘要： Methods and apparatus for preventing myocardial infarction, or lessening the size/severity of an evolving myocardial infarction, by cooling at least the affected area of the myocardium using an intravascular heat exchange catheter. The heat exchange catheter may be inserted into the vasculature (e.g., a vein) and advanced to a position wherein a heat exchanger on the catheter is located in or near the heart (e.g., within the vena cava near the patient's heart). Thereafter, the heat exchange catheter is used to cool the myocardium (or the entire body of the patient) to a temperature that effectively lessens the metabolic rate and/or oxygen consumption of the ischemic myocardial cells or otherwise protects the ischemic myocardium from undergoing irreversible damage or infarction.

    摘要翻译： 通过使用血管内热交换导管至少冷却至少心肌的受影响区域来预防心肌梗死或减轻心肌梗死的大小/严重程度的方法和装置。 热交换导管可以插入脉管系统（例如静脉）中并且前进到导管上的热交换器位于心脏中或附近（例如在患者心脏附近的腔静脉内）的位置。 此后，热交换导管用于将心肌（或患者的整个身体）冷却到有效降低缺血心肌细胞的代谢率和/或氧消耗的温度，或以其它方式保护缺血心肌免受不可逆损伤 或梗死。

    METHOD AND SYSTEM FOR CONTROL OF A PATIENT'S BODY TEMPERATURE BY WAY OF A TRASLUMINALLY INSERTABLE HEAT EXCHANGE CATHETER
    10.
    发明申请
    METHOD AND SYSTEM FOR CONTROL OF A PATIENT'S BODY TEMPERATURE BY WAY OF A TRASLUMINALLY INSERTABLE HEAT EXCHANGE CATHETER 审中-公开

    公开(公告)号：US20190083300A1

    公开(公告)日：2019-03-21

    申请号：US16124601

    申请日：2018-09-07

    申请人： Zoll Circulation, Inc.

    发明人： Timothy R. Machold ,  Wade A. Keller ,  Alex T. Roth ,  Nicole Denise Bloom

    IPC分类号： A61F7/00 ,  A61M25/10 ,  A61F7/12 ,  A61B17/00 ,  A61F7/10 ,  A61B17/22

    摘要： Methods and apparatuses for temperature modification of a patient, or selected regions thereof, including an induced state of hypothermia. The temperature modification is accomplished using an in-dwelling heat exchange catheter within which a fluid heat exchange medium circulates. A heat exchange cassette of any one of several disclosed variations is attached to the circulatory conduits of the catheter, the heat exchange cassette being sized to engage a cavity within one of various described re-usable control units. The control units include a heater/cooler device, a user input device, and a processor connected to receive input from various sensors around the body and the system. The heater/cooler device may be thermoelectric to enable both heating and 15″ cooling based on polarity. A temperature control scheme for ramping the body temperature up or down without overshoot is provided. The disposable heat exchange cassettes may include an integral pump head that engages with a pump drive mechanism within the re-usable control unit. More than one control unit may be provided to receive the same heat exchange cassette so that, for example, a large capacity control unit can be used initially, and a smaller, battery-powered unit can be substituted once the patient reaches the desired target temperature.