公开(公告)号：US11658021B2

公开(公告)日：2023-05-23

申请号：US17762081

申请日：2020-08-26

申请人： Zeteo Tech, Inc.

发明人： Wayne A. Bryden ,  Charles J. Call ,  Michael McLoughlin ,  Dapeng Chen ,  Scott Ecelberger ,  Nathaniel K. Jones ,  Steven Strohl ,  Gary Anderson

IPC分类号： H01J49/16 ,  H01J49/04 ,  H01J49/40 ,  G01N15/10 ,  G01N35/04 ,  G01N1/22 ,  G01N27/626 ,  G01N35/10 ,  G01N15/00

CPC分类号： H01J49/164 ,  G01N1/2273 ,  G01N15/10 ,  G01N27/628 ,  G01N35/04 ,  H01J49/0418 ,  H01J49/40 ,  G01N2015/0038 ,  G01N2015/0046 ,  G01N2035/0475 ,  G01N2035/1034

摘要： Disclosed are systems and methods to provide rapid and autonomous detection of analyte particles in gas and liquid samples. Disclosed are methods and devices for identifying biological aerosol analytes using MALDI-MS and chemical aerosol analytes using LDI and MALDI-MS using time-of-flight mass spectrometry (TOFMS).

公开(公告)号：US20220323045A1

公开(公告)日：2022-10-13

申请号：US17827708

申请日：2022-05-29

申请人： Zeteo Tech, Inc.

发明人： Dapeng Chen ,  Wayne A. Bryden ,  Michael McLoughlin

IPC分类号： A61B10/00 ,  A61B5/083 ,  A61B5/097 ,  A61M16/08 ,  G01N33/68

摘要： Methods and devices to capture and analyze aerosolized particles such as protein biomarkers and their truncated proteoforms characteristic of a disease, including a respiratory disease, in exhaled breath to enable rapid detection of diseases are disclosed. The disclosed methods and systems selectively capture aerosolized particles using a packed bed column. The captured particles are then eluted using one or more solvents and analyzed using devices including mass spectrometry.