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11.发明授权Methods of treating glomerulonephritis associated with IGA nephropathy for TACI-immunoglobulin fusion proteins 有权治疗IGA肾病与TACI-免疫球蛋白融合蛋白相关的肾小球肾炎的方法公开(公告)号：US09346878B2
公开(公告)日：2016-05-24
申请号：US14331567
申请日：2014-07-15
申请人： Zymogenetics, Inc.
发明人： Mark W. Rixon , Jane A. Gross
IPC分类号： A61K39/00 , A61K45/00 , C12P21/08 , C07K16/24 , C07K14/705 , A61K39/395 , A61K45/06 , A61K38/00
CPC分类号： C07K16/241 , A61K38/00 , A61K39/3955 , A61K45/06 , C07K14/70578 , C07K2319/00 , C07K2319/30
摘要： Molecules that interfere with the binding of a tumor necrosis factor receptor with its ligand, such as a soluble receptor, have proven usefulness in both basic research and as therapeutics. The present invention provides improved soluble transmembrane activator and calcium modulator and cyclophilin ligand-interactor (TACI) receptors.
摘要翻译： 干扰肿瘤坏死因子受体与其配体如可溶性受体的结合的分子已被证明在基础研究和治疗中都是有用的。 本发明提供改进的可溶性跨膜激活剂和钙调节剂和亲环蛋白配体相互作用（TACI）受体。
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公开(公告)号：US20140328844A1
公开(公告)日：2014-11-06
申请号：US14331567
申请日：2014-07-15
申请人： Zymogenetics, Inc.
发明人： Mark W. Rixon , Jane A. Gross
IPC分类号： C07K16/24 , A61K39/395 , A61K45/06
CPC分类号： C07K16/241 , A61K38/00 , A61K39/3955 , A61K45/06 , C07K14/70578 , C07K2319/00 , C07K2319/30
摘要： Molecules that interfere with the binding of a tumor necrosis factor receptor with its ligand, such as a soluble receptor, have proven usefulness in both basic research and as therapeutics. The present invention provides improved soluble transmembrane activator and calcium modulator and cyclophilin ligand-interactor (TACI) receptors.
摘要翻译： 干扰肿瘤坏死因子受体与其配体如可溶性受体的结合的分子已被证明在基础研究和治疗中都是有用的。 本发明提供改进的可溶性跨膜激活剂和钙调节剂和亲环蛋白配体相互作用（TACI）受体。
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13.发明申请LEVELS OF BCMA PROTEIN EXPRESSION ON B CELLS AND USE IN DIAGNOSTIC METHODS 审中-公开B细胞中BCMA蛋白表达水平和诊断方法中的应用公开(公告)号：US20140220014A1
公开(公告)日：2014-08-07
申请号：US14192911
申请日：2014-02-28
发明人： Stacey R. Dillon , Jane A. Gross , Keith B. Elkon
IPC分类号： C07K16/24 , G01N33/564 , C07K14/705
CPC分类号： C07K16/24 , C07K14/70578 , G01N33/5091 , G01N33/564 , G01N2333/70575 , G01N2800/042 , G01N2800/065 , G01N2800/101 , G01N2800/102 , G01N2800/104 , G01N2800/24 , G01N2800/285 , G01N2800/347
摘要： The present invention provides a method of measuring the levels of BCMA in a biological sample, specifically upon the B cell surface. The diagnostic assays are useful in predicting an individual's likelihood of developing or currently suffering from an autoimmune disease, such as SLE, and for methods for treating an individual clinically diagnosed with an autoimmune disease. This diagnostic test serves to predict a patient's likelihood to respond to a specific drug treatment, in particular treatment with BLyS antagonists, either singly or in combination with other immune suppressive drugs
摘要翻译： 本发明提供了一种测量生物样品中的BCMA水平，特别是B细胞表面的方法。 诊断测定法可用于预测个体发展或目前患有自身免疫性疾病如SLE的可能性，以及用于治疗临床诊断患有自身免疫性疾病的个体的方法。 该诊断测试用于预测患者对特定药物治疗的反应的可能性，特别是用BLyS拮抗剂单独或与其它免疫抑制药物组合
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公开(公告)号：US20130143265A1
公开(公告)日：2013-06-06
申请号：US13741036
申请日：2013-01-14
申请人： ZymoGenetics, Inc.
发明人： Cindy A. Sprecher , Joseph L. Kuijper , Maria M. Dasovich , Francis J. Grant , Theodore E. Whitmore , Anglea K. Hammond , Julia E. Novak , Jane A. Gross , Stacey R. Dillon
IPC分类号： C07K14/715
CPC分类号： C07K16/2866 , A01K2217/05 , A61K38/00 , C07K14/52 , C07K14/715 , C07K2317/24 , C07K2317/76
摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.
摘要翻译： 公开了新型多肽组合，编码多肽的多核苷酸以及相关组合物和方法，用于含有Zcytor17的多聚体或异二聚体细胞因子受体，其可用作新的细胞因子拮抗剂，并且用于检测刺激造血细胞增殖和/或发育的配体的方法 ，淋巴和骨髓细胞体外和体内。 本发明还包括用于产生多聚体或异二聚体细胞因子受体的方法，其用途及其抗体。
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15.发明申请公开(公告)号：US20190040125A1
公开(公告)日：2019-02-07
申请号：US16164883
申请日：2018-10-19
IPC分类号： C07K16/24 , G01N33/68 , G01N33/50 , C07K14/52 , A61K49/00 , C07K16/28 , A61K39/395 , A61K39/00
摘要： The present invention relates to methods of treating patients suffering from itching and puritis mediated by cutaneous lymphocyte antigen positive T cell. In particular, diseases or disorders including contact dermatitis, drug induced delayed type cutaneous allergic reactions, toxic epidermal necrolysis, cutaneous T cell lymphoma, bullous pemphigoid, alopecia aereata, vitiligo, acne rosacea, prurigo nodularis, and herpes simplex virus, or combination thereof will benefit from the administration of an IL-31 antagonist. The invention also includes methods of predicting a therapeutically responsive patient population.
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公开(公告)号：US09605062B2
公开(公告)日：2017-03-28
申请号：US14296488
申请日：2014-06-05
申请人： ZymoGenetics, Inc.
发明人： Cindy A. Sprecher , Joseph L. Kuijper , Maria M. Dasovich , Francis J. Grant , Jane A. Gross , Angela K. Hammond
CPC分类号： C07K16/24 , A01K2217/05 , A61K38/00 , C07K14/47 , C07K14/52 , C07K2317/24
摘要： The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for stimulating the immune system, and proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
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17.发明申请公开(公告)号：US20160024201A1
公开(公告)日：2016-01-28
申请号：US14879550
申请日：2015-10-09
申请人： ZymoGenetics, Inc.
IPC分类号： C07K16/24
CPC分类号： C07K16/244 , A61K39/3955 , A61K49/0008 , A61K49/006 , A61K2039/505 , A61K2039/545 , C07K14/52 , C07K16/2803 , C07K2317/76 , G01N33/505 , G01N33/6869 , G01N33/6881
摘要： The present invention relates to methods of treating patients suffering from itching and puritis mediated by cutaneous lymphocyte antigen positive T cell. In particular, diseases or disorders including contact dermatitis, drug induced delayed type cutaneous allergic reactions, toxic epidermal necrolysis, cutaneous T cell lymphoma, bullous pemphigoid, alopecia aereata, vitiligo, acne rosacea, prurigo nodularis, and herpes simplex virus, or combination thereof will benefit from the administration of an IL-31 antagonist. The invention also includes methods of predicting a therapeutically responsive patient population.
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公开(公告)号：US20210139577A1
公开(公告)日：2021-05-13
申请号：US17115326
申请日：2020-12-08
发明人： Stacey R. Dillon , Jane A. Gross
IPC分类号： C07K16/24 , C07K14/705 , G01N33/50 , G01N33/564
摘要： The present invention provides a method of measuring the levels of BCMA in a biological sample, specifically upon the B cell surface. The diagnostic assays are useful in predicting an individual's likelihood of developing or currently suffering from an autoimmune disease, such as SLE, and for methods for treating an individual clinically diagnosed with an autoimmune disease. This diagnostic test serves to predict a patient's likelihood to respond to a specific drug treatment, in particular treatment with BLyS antagonists, either singly or in combination with other immune suppressive drugs
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公开(公告)号：US20190338020A1
公开(公告)日：2019-11-07
申请号：US16144289
申请日：2018-09-27
申请人： ZymoGenetics, Inc.
发明人： Cindy A. Sprecher , Joseph L. Kuijper , Maria M. Dasovich , Francis J. Grant , Jane A. Gross , Angela K. Hammond
摘要： The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for stimulating the immune system, and proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
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公开(公告)号：US20160060323A1
公开(公告)日：2016-03-03
申请号：US14937919
申请日：2015-11-11
申请人： ZymoGenetics, Inc.
发明人： Cindy A. Sprecher , Joseph L. Kuijper , Maria M. Dasovich , Francis J. Grant , Theodore E. Whitmore , Angela K. Hammond , Julia E. Novak , Jane A. Gross , Stacey R. Dillon
IPC分类号： C07K14/715
CPC分类号： C07K14/715 , A01K2217/05 , A61K38/00 , C07K14/52 , C07K16/2866 , C07K2317/24 , C07K2317/76
摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.
摘要翻译： 公开了新型多肽组合，编码多肽的多核苷酸以及相关组合物和方法，用于含有Zcytor17的多聚体或异二聚体细胞因子受体，其可用作新的细胞因子拮抗剂，并且用于检测刺激造血细胞增殖和/或发育的配体的方法 ，淋巴和骨髓细胞体外和体内。 本发明还包括用于产生多聚体或异二聚体细胞因子受体的方法，其用途及其抗体。
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