公开(公告)号：US11627874B2

公开(公告)日：2023-04-18

申请号：US17248850

申请日：2021-02-10

Applicant: ACUCELA INC.

Inventor： Lukas Scheibler ,  Matthias Pfister ,  Urban Schnell ,  Stefan Troller ,  Ryo Kubota

IPC: A61B3/10 ,  A61B3/00 ,  A61B3/12 ,  A61B5/00 ,  G01B9/02

Abstract: Improved optical coherence tomography systems and methods to measure thickness of the retina are presented. The systems may be compact, handheld, provide in-home monitoring, allow the patient to measure himself or herself, and be robust enough to be dropped while still measuring the retina reliably.

公开(公告)号：US20230110912A1

公开(公告)日：2023-04-13

申请号：US18064422

申请日：2022-12-12

Applicant: ACUCELA INC.

Inventor： Christian OGGENFUSS ,  Karim HAROUD ,  Lukas SCHEIBLER ,  Matthias PFISTER ,  Urban SCHNELL ,  Stefan TROLLER ,  Ryo KUBOTA ,  Philip BUSCEMI

IPC: A61B3/10 ,  A61B3/00 ,  A61B3/13

Abstract: Improved optical coherence tomography systems and methods to measure thickness of the retina are presented. The systems may be compact, handheld, provide in-home monitoring, allow the patient to measure himself or herself, and be robust enough to be dropped while still measuring the retina reliably.

公开(公告)号：US20230089006A1

公开(公告)日：2023-03-23

申请号：US18051804

申请日：2022-11-01

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA ,  Gordon Frederick MACCABEE ,  Ferry WIDJAJA ,  Amitava GUPTA

IPC: G02C11/00 ,  G02C7/04

Abstract: A contact lens may include a body of contact lens material extending between a first surface and a second surface. An electromechanical component may be supported in the contact lens material between the first surface and the second surface. A support comprising a plurality of pillars may be formed of the contact lens material and may extend from at least one of the first surface and the second surface to the electromechanical component.

公开(公告)号：US20230026753A1

公开(公告)日：2023-01-26

申请号：US17936263

申请日：2022-09-28

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA ,  Philip M. BUSCEMI ,  Matthias PFISTER ,  Stephan WYDER ,  Amitava GUPTA

IPC: A61B3/10 ,  G01B9/02091

Abstract: An OCT axial length measurement device is configured to measure an area of the retina within a range from about 0.05 mm to about 2.0 mm. The area can be measured with a scanned measurement beam or plurality of substantially fixed measurement beams. The OCT measurement device may comprise a plurality of reference optical path lengths, in which a first optical path length corresponds to a first position of a cornea, and a second optical path length corresponds to a second position of the retina, in which the axial length is determined based on a difference between the first position and the second position. An axial length map can be generated to determine alignment of the eye with the measurement device and improve accuracy and repeatability of the measurements. In some embodiments, the OCT measurement device comprises a swept source vertical cavity surface emitting laser (“VCSEL”).

公开(公告)号：US20230020468A1

公开(公告)日：2023-01-19

申请号：US17757748

申请日：2020-09-02

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA ,  Philip M. BUSCEMI

IPC: A61B3/10 ,  A61B3/00 ,  A61B3/12

Abstract: Improved optical coherence tomography systems and methods to measure retinal data are presented. The systems may be compact, provide in-home monitoring, and have automation to allow the patient to measure himself or herself.

公开(公告)号：US20220404638A1

公开(公告)日：2022-12-22

申请号：US17820738

申请日：2022-08-18

Applicant: ACUCELA INC.

Inventor： Philip M. BUSCEMI ,  Ryo KUBOTA

IPC: G02C7/04 ,  G02B27/01 ,  G02C7/14

Abstract: Systems, devices, apparatuses and methods for an active projection system that may be incorporated into spectacles, contact lenses or provided as an add-on layer to existing spectacles or lenses. The active projection system operates to generate a stimulus or stimuli for viewing by a person's eye. The stimulus or stimuli creates an image that is defocused in front of the person's retina and can assist in slowing or stopping the progression of myopia or other refractive errors in the person.

公开(公告)号：US11467428B2

公开(公告)日：2022-10-11

申请号：US17657036

申请日：2022-03-29

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Amitava Gupta

IPC: G02C7/08 ,  G02F1/29

Abstract: An apparatus to treat refractive error of an eye comprises an electroactive component configured to switch between a light scattering or optical power providing configuration to treat refractive error of the eye and a substantially transparent configuration to allow normal viewing. The electroactive component can be located on the lens away from a central axis of the lens to provide light to a peripheral region of the retina to decrease the progression of myopia. The electroactive component can be located on the lens away from the central axis of the lens in order for the wearer to view objects through an optical zone while the electroactive component scatters light. The electroactive component can be configured to switch to the substantially transparent configuration to allow light to pass through the electroactive component and to allow the lens to refract light to correct vision and allow normal viewing through the lens.

公开(公告)号：US20220304573A1

公开(公告)日：2022-09-29

申请号：US17647585

申请日：2022-01-10

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA ,  Philip M. BUSCEMI ,  Matthias PFISTER ,  Stephan WYDER ,  Amitava GUPTA

IPC: A61B3/10 ,  G01B9/02091

Abstract: An OCT axial length measurement device is configured to measure an area of the retina within a range from about 0.05 mm to about 2.0 mm. The area can be measured with a scanned measurement beam or plurality of substantially fixed measurement beams. The OCT measurement device may comprise a plurality of reference optical path lengths, in which a first optical path length corresponds to a first position of a cornea, and a second optical path length corresponds to a second position of the retina, in which the axial length is determined based on a difference between the first position and the second position. An axial length map can be generated to determine alignment of the eye with the measurement device and improve accuracy and repeatability of the measurements. In some embodiments, the OCT measurement device comprises a swept source vertical cavity surface emitting laser (“VCSEL”).

公开(公告)号：US11446261B2

公开(公告)日：2022-09-20

申请号：US16865195

申请日：2020-05-01

Applicant: Acucela Inc.

Inventor： Ian L. Scott ,  Vladimir A. Kuksa ,  Mark W. Orme ,  Thomas L. Little, Jr. ,  Anna Gall ,  Feng Hong

IPC: A61K31/137 ,  C07C217/60 ,  C07C217/62 ,  C07C217/64 ,  C07C217/72 ,  C07C225/16 ,  C07C229/38 ,  C07C233/18 ,  C07C235/08 ,  C07C251/86 ,  C07C279/08 ,  C07C317/28 ,  C07C323/25 ,  C07D277/24 ,  C07D309/06 ,  C07C217/20 ,  C07C215/20 ,  C07C309/06 ,  C07C217/84 ,  C07C323/33 ,  A61K31/165 ,  A61K31/222

Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

公开(公告)号：US20220214564A1

公开(公告)日：2022-07-07

申请号：US17655496

申请日：2022-03-18

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA ,  Philip M. BUSCEMI ,  Amitava GUPTA ,  Stefan BAUER ,  Benjamin CROOK ,  Julien SAUVET

IPC: G02C7/08 ,  G02C7/06 ,  G02C7/14 ,  G02C7/10 ,  G02C7/02

Abstract: An apparatus to treat refractive error of an eye comprises an optic comprising an optical zone and a peripheral defocus optical structure to form images of a plurality of stimuli anterior or posterior to a peripheral portion of a retina of the eye. In some embodiments, the peripheral defocus optical structure located outside the optical zone. In some embodiments, the peripheral defocus optical structure comprises optical power to focus light to a different depth of the eye than the optical zone. In some embodiments, the optic comprises one or more of a lens, an optically transparent substrate, a beam splitter, a prism, or an optically transmissive support.