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公开(公告)号：US09464033B2
公开(公告)日：2016-10-11
申请号：US14807436
申请日：2015-07-23
申请人： Acucela Inc.
发明人： Ian Leslie Scott , Vladimir Aleksandrovich Kuksa , Mark W. Orme , Thomas Little , Anna Gall , Jennifer Gage , Feng Hong
IPC分类号： C07C321/00 , C07C215/68 , C07D309/06 , C07D333/16 , C07C211/27 , C07C211/30 , C07C215/30 , C07C215/42 , C07C217/14 , C07C217/48 , C07C217/62 , C07C217/72 , C07C235/34 , C07C237/20 , C07C251/40 , C07C255/58 , C07C323/29 , C07C323/36 , C07D209/32 , C07D213/14 , C07D309/10 , C07D333/06 , C07D335/02 , C07C217/64 , C07D213/38 , C07D309/12 , C07C215/28 , C07C317/28 , C07C323/25
CPC分类号： C07C215/68 , C07C211/27 , C07C211/30 , C07C215/28 , C07C215/30 , C07C215/42 , C07C217/14 , C07C217/48 , C07C217/62 , C07C217/64 , C07C217/72 , C07C235/34 , C07C237/20 , C07C251/40 , C07C255/58 , C07C317/28 , C07C323/25 , C07C323/29 , C07C323/36 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D209/32 , C07D213/14 , C07D213/38 , C07D309/06 , C07D309/10 , C07D309/12 , C07D333/06 , C07D333/16 , C07D335/02
摘要： Provided are alkynyl phenyl derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.
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公开(公告)号：US09452153B2
公开(公告)日：2016-09-27
申请号：US14720705
申请日：2015-05-22
申请人： Acucela, Inc.
发明人： Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Feng Hong , Thomas L. Little, Jr. , Ryo Kubota
IPC分类号： C07C213/00 , A61K31/382 , A61K31/138 , A61K31/351 , A61K31/165
CPC分类号： A61K31/382 , A61K31/138 , A61K31/165 , A61K31/351 , C07C211/27 , C07C213/00 , C07C215/20 , C07C215/28 , C07C215/30 , C07C215/42 , C07C217/16 , C07C217/48 , C07C217/54 , C07C217/72 , C07C217/74 , C07C219/22 , C07C225/16 , C07C225/18 , C07C233/18 , C07C235/34 , C07C235/54 , C07C237/20 , C07C237/38 , C07C237/40 , C07C257/14 , C07C279/08 , C07C317/28 , C07C323/25 , C07C323/29 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D213/30 , C07D213/38 , C07D309/06 , C07D333/16 , C07D333/20 , C07D335/02
摘要： Provided are amine derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.
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3.发明申请公开(公告)号：US20160193181A1
公开(公告)日：2016-07-07
申请号：US14720705
申请日：2015-05-22
申请人： Acucela, Inc.
发明人： Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Feng Hong , Thomas L. Little, JR. , Ryo Kubota
IPC分类号： A61K31/382 , A61K31/351 , A61K31/165 , A61K31/138
CPC分类号： A61K31/382 , A61K31/138 , A61K31/165 , A61K31/351 , C07C211/27 , C07C213/00 , C07C215/20 , C07C215/28 , C07C215/30 , C07C215/42 , C07C217/16 , C07C217/48 , C07C217/54 , C07C217/72 , C07C217/74 , C07C219/22 , C07C225/16 , C07C225/18 , C07C233/18 , C07C235/34 , C07C235/54 , C07C237/20 , C07C237/38 , C07C237/40 , C07C257/14 , C07C279/08 , C07C317/28 , C07C323/25 , C07C323/29 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D213/30 , C07D213/38 , C07D309/06 , C07D333/16 , C07D333/20 , C07D335/02
摘要： Provided are amine derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.
摘要翻译： 提供的是胺衍生物化合物，其药物组合物，以及使用所述化合物和组合物治疗眼科疾病和失调症的方法，例如年龄相关性黄斑变性和Stargardt氏病。
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公开(公告)号：US20150239825A1
公开(公告)日：2015-08-27
申请号：US14631763
申请日：2015-02-25
申请人： Acucela Inc.
发明人： Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas L. Little, JR. , Anna Gall , Feng Hong
IPC分类号： C07C217/20
CPC分类号： A61K31/137 , A61K31/165 , A61K31/222 , C07C215/20 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C217/84 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C309/06 , C07C317/28 , C07C323/25 , C07C323/33 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07D277/24 , C07D309/06
摘要： The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
摘要翻译： 本发明一般涉及用于治疗神经变性疾病和病症，特别是眼科疾病和病症的组合物和方法。 本文提供的是烷氧基衍生物化合物和包含这些化合物的药物组合物。 主题组合物可用于治疗和预防眼科疾病和病症，包括年龄相关性黄斑变性（AMD）和斯塔尔加氏病。
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5.发明申请SUBSTITUTED 3-PHENYLPROPYLAMINE DERIVATIVES FOR THE TREATMENT OF OPHTHALMIC DISEASES AND DISORDERS 有权用于治疗眼科疾病和疾病的替代3-苯丙氨酸衍生物公开(公告)号：US20140275043A1
公开(公告)日：2014-09-18
申请号：US14205117
申请日：2014-03-11
申请人： Acucela Inc.
发明人： Vladimir A. Kuksa , Mark W. Orme , Feng Hong , Ryo Kubota
IPC分类号： C07D309/06 , C07D335/02 , C07D211/26 , C07D307/81 , C07D307/14 , C07D279/02 , C07D311/58 , C07D207/09 , C07D211/76 , C07D333/20 , C07D209/14 , C07D213/38 , C07D239/26
CPC分类号： C07D335/02 , A61K31/341 , A61K31/343 , A61K31/351 , A61K31/382 , A61K31/44 , A61K31/4406 , A61K31/4409 , A61K31/445 , A61K31/4465 , A61K31/505 , C07D207/08 , C07D207/09 , C07D207/26 , C07D209/08 , C07D209/14 , C07D211/22 , C07D211/26 , C07D211/60 , C07D211/76 , C07D211/96 , C07D213/30 , C07D213/38 , C07D233/64 , C07D233/96 , C07D239/26 , C07D279/02 , C07D307/12 , C07D307/14 , C07D307/80 , C07D307/81 , C07D309/04 , C07D309/06 , C07D311/04 , C07D311/58 , C07D333/12 , C07D333/16 , C07D333/20
摘要： The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are substituted 3-phenylpropylamine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
摘要翻译： 本发明一般涉及用于治疗神经变性疾病和病症，特别是眼科疾病和病症的组合物和方法。 本文提供了取代的3-苯基丙胺衍生物化合物和包含所述化合物的药物组合物。 主题组合物可用于治疗和预防眼科疾病和病症，包括年龄相关性黄斑变性（AMD）和斯塔尔加氏病。
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公开(公告)号：US10188615B2
公开(公告)日：2019-01-29
申请号：US15672031
申请日：2017-08-08
申请人： Acucela Inc.
发明人： Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas L. Little, Jr. , Anna Gall , Feng Hong
IPC分类号： C09B11/02 , A61K31/137 , A61K31/222 , A61K31/165 , C07C323/33 , C07C215/20 , C07D309/06 , C07D277/24 , C07C323/25 , C07C317/28 , C07C279/08 , C07C251/86 , C07C235/08 , C07C233/18 , C07C229/38 , C07C225/16 , C07C217/72 , C07C217/64 , C07C217/62 , C07C217/60 , C07C217/20 , C07C217/84 , C07C309/06
摘要： The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
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7.发明申请SUBSTITUTED 3-PHENYLPROPYLAMINE DERIVATIVES FOR THE TREATMENT OF OPHTHALMIC DISEASES AND DISORDERS 审中-公开用于治疗眼科疾病和疾病的替代3-苯丙氨酸衍生物公开(公告)号：US20170022180A1
公开(公告)日：2017-01-26
申请号：US14849857
申请日：2015-09-10
申请人： Acucela Inc.
发明人： Vladimir A. Kuksa , Mark W. Orme , Feng Hong , Ryo Kubota
IPC分类号： C07D335/02 , C07D213/30 , C07D211/22 , C07D307/80 , C07D307/12 , C07D239/26 , C07D311/58 , C07D207/08 , C07D309/04 , C07D211/76 , C07D333/16 , C07D279/02 , C07D209/08 , C07D211/96 , C07D233/64 , C07D309/06
CPC分类号： C07D335/02 , A61K31/341 , A61K31/343 , A61K31/351 , A61K31/382 , A61K31/44 , A61K31/4406 , A61K31/4409 , A61K31/445 , A61K31/4465 , A61K31/505 , C07D207/08 , C07D207/09 , C07D207/26 , C07D209/08 , C07D209/14 , C07D211/22 , C07D211/26 , C07D211/60 , C07D211/76 , C07D211/96 , C07D213/30 , C07D213/38 , C07D233/64 , C07D233/96 , C07D239/26 , C07D279/02 , C07D307/12 , C07D307/14 , C07D307/80 , C07D307/81 , C07D309/04 , C07D309/06 , C07D311/04 , C07D311/58 , C07D333/12 , C07D333/16 , C07D333/20
摘要： The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are substituted 3-phenylpropylamine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
摘要翻译： 本发明一般涉及用于治疗神经变性疾病和病症，特别是眼科疾病和病症的组合物和方法。 本文提供了取代的3-苯基丙胺衍生物化合物和包含所述化合物的药物组合物。 主题组合物可用于治疗和预防眼科疾病和病症，包括年龄相关性黄斑变性（AMD）和斯塔尔加氏病。
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公开(公告)号：US09447078B2
公开(公告)日：2016-09-20
申请号：US13745675
申请日：2013-01-18
申请人： Acucela Inc.
发明人： Vladimir A. Kuksa , Mark W. Orme , Feng Hong , Ryo Kubota
IPC分类号： C07D213/36 , C07D213/42 , C07D405/12 , C07D207/36 , C07D213/38 , C07D213/64 , C07D213/71 , C07D239/34 , C07D249/04 , C07D277/28 , C07D307/52 , C07D307/58 , C07D307/66 , C07D333/20 , C07D333/32 , C07D333/36 , C07D401/12 , C07D213/74 , C07D333/16 , C07D333/34 , C07D213/30 , C07D213/65 , C07D213/68 , C07D213/70 , C07D307/42
CPC分类号： C07D405/12 , C07D207/36 , C07D213/30 , C07D213/38 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/70 , C07D213/71 , C07D213/74 , C07D239/34 , C07D249/04 , C07D277/28 , C07D307/42 , C07D307/52 , C07D307/58 , C07D307/66 , C07D333/16 , C07D333/20 , C07D333/32 , C07D333/34 , C07D333/36 , C07D401/12
摘要： The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are substituted heterocyclic amine derivative compound and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
摘要翻译： 本发明一般涉及用于治疗神经变性疾病和病症，特别是眼科疾病和病症的组合物和方法。 本文提供了取代的杂环胺衍生物化合物和包含这些化合物的药物组合物。 主题组合物可用于治疗和预防眼科疾病和病症，包括年龄相关性黄斑变性（AMD）和斯塔尔加氏病。
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公开(公告)号：US09193669B2
公开(公告)日：2015-11-24
申请号：US14175959
申请日：2014-02-07
申请人： Acucela Inc.
发明人： Ian L. Scott , Vladimir A. Kuksa , Feng Hong , Ryo Kubota , Jennifer Gage
IPC分类号： C07C215/00 , C07C211/49 , A61K31/167 , A61K31/18 , C07B59/00 , C07C211/52 , C07C215/14 , C07C215/42 , C07C215/68 , C07C217/08 , C07C217/10 , C07C217/58 , C07C225/22 , C07C233/36 , C07C233/43 , C07C233/62 , C07C275/40 , C07C311/08 , C07C311/10 , C07C311/14 , C07C311/21 , C07C311/24 , C07C335/18 , C07D277/28 , C07C215/08 , C07C225/06 , C07C233/25
CPC分类号： C07C233/25 , A61K31/167 , A61K31/18 , C07B59/001 , C07B2200/05 , C07C211/49 , C07C211/52 , C07C215/08 , C07C215/14 , C07C215/42 , C07C215/68 , C07C217/08 , C07C217/10 , C07C217/58 , C07C225/06 , C07C225/22 , C07C233/36 , C07C233/43 , C07C233/62 , C07C275/40 , C07C311/08 , C07C311/10 , C07C311/14 , C07C311/21 , C07C311/24 , C07C335/18 , C07C2601/08 , C07C2601/14 , C07D277/28
摘要： Provided are compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.
摘要翻译： 提供了化合物，其药物组合物，以及使用所述化合物和组合物治疗眼科疾病和病症如老年性黄斑变性和Stargardt氏病的方法。
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公开(公告)号：US20140228443A1
公开(公告)日：2014-08-14
申请号：US14175959
申请日：2014-02-07
申请人： Acucela Inc.
发明人： Ian L. Scott , Vladimir A. Kuksa , Feng Hong , Ryo Kubota , Jennifer Gage
IPC分类号： C07C211/49 , C07C233/25 , C07C225/06 , C07C233/62 , C07C215/08
CPC分类号： C07C233/25 , A61K31/167 , A61K31/18 , C07B59/001 , C07B2200/05 , C07C211/49 , C07C211/52 , C07C215/08 , C07C215/14 , C07C215/42 , C07C215/68 , C07C217/08 , C07C217/10 , C07C217/58 , C07C225/06 , C07C225/22 , C07C233/36 , C07C233/43 , C07C233/62 , C07C275/40 , C07C311/08 , C07C311/10 , C07C311/14 , C07C311/21 , C07C311/24 , C07C335/18 , C07C2601/08 , C07C2601/14 , C07D277/28
摘要： Provided are compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.
摘要翻译： 提供了化合物，其药物组合物，以及使用所述化合物和组合物治疗眼科疾病和病症如老年性黄斑变性和Stargardt氏病的方法。
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