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公开(公告)号：US12162871B2
公开(公告)日：2024-12-10
申请号：US18201715
申请日：2023-05-24
Applicant: Acucela Inc.
Inventor： Mark W. Orme , Edison S. Zuniga , Vladimir A. Kuksa , Russell Stuart Craft , Eduardo Moreno Saveedra , Johannes Wilhelm Georg Meissner , Jacobus Antonius Joseph den Hartog , Albert Cornelis Dros
IPC: C07D413/12 , C07D235/08 , C07D249/18 , C07D261/20 , C07D263/56 , C07D263/58 , C07D277/64 , C07D277/82 , C07D413/04 , C07D491/107
Abstract: Provided herein are compounds and methods of use thereof for the modulation of VAP-1 activity.
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公开(公告)号：US12029708B2
公开(公告)日：2024-07-09
申请号：US17817927
申请日：2022-08-05
Applicant: Acucela Inc.
Inventor： Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas L Little, Jr. , Anna Gall , Feng Hong
IPC: A61K31/137 , A61K31/165 , A61K31/222 , C07C215/20 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C217/84 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C309/06 , C07C317/28 , C07C323/25 , C07C323/33 , C07D277/24 , C07D309/06
CPC classification number: A61K31/137 , A61K31/165 , A61K31/222 , C07C215/20 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C217/84 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C309/06 , C07C317/28 , C07C323/25 , C07C323/33 , C07D277/24 , C07D309/06 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42
Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
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公开(公告)号：US10730825B2
公开(公告)日：2020-08-04
申请号：US15967080
申请日：2018-04-30
Applicant: Acucela Inc.
Inventor： Claes Olof Bavik , Susan Hayes Henry , Ryo Kubota , Vladimir A. Kuksa
IPC: A61K31/138 , A61K45/06 , A61K31/137 , A61K31/35 , A61K31/765 , C07C215/08 , C07C211/27 , C07C217/20 , C07C323/32 , C07D309/06
Abstract: Methods are provided herein for the treatment of ophthalmic diseases or conditions such as an ophthalmic disease or disorder associated with diabetes in a patient. Also provided herein are methods of treating retinopathy of prematurity in a patient. Further, provided herein are methods for treating wet age-related macular degeneration in a patient. The methods comprise administration of compounds disclosed herein to a patient in need thereof that inhibit or slow one or more signs or symptoms of such conditions.
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公开(公告)号：US09458088B2
公开(公告)日：2016-10-04
申请号：US14631763
申请日：2015-02-25
Applicant: Acucela Inc.
Inventor： Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas L. Little, Jr. , Anna Gall , Feng Hong
IPC: C09B11/02 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C317/28 , C07C323/25 , C07D277/24 , C07D309/06 , C07C215/20 , C07C309/06 , C07C217/84 , C07C323/33
CPC classification number: A61K31/137 , A61K31/165 , A61K31/222 , C07C215/20 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C217/84 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C309/06 , C07C317/28 , C07C323/25 , C07C323/33 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07D277/24 , C07D309/06
Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
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5.发明授权公开(公告)号：US09056849B2
公开(公告)日：2015-06-16
申请号：US14226665
申请日：2014-03-26
Applicant: Acucela Inc.
Inventor： Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Feng Hong , Thomas L. Little , Ryo Kubota
IPC: C07C213/00 , C07D335/02 , C07C211/27 , C07C215/28 , C07C215/30 , C07C215/42 , C07C217/16 , C07C217/48 , C07C217/54 , C07C217/72 , C07C219/22 , C07C225/16 , C07C225/18 , C07C233/18 , C07C235/34 , C07C235/54 , C07C237/20 , C07C237/38 , C07C237/40 , C07C257/14 , C07C279/08 , C07C317/28 , C07C323/25 , C07C323/29 , C07D213/30 , C07D309/06 , C07D333/16 , C07D333/20 , C07C215/20 , C07C217/74 , C07D213/38
CPC classification number: A61K31/382 , A61K31/138 , A61K31/165 , A61K31/351 , C07C211/27 , C07C213/00 , C07C215/20 , C07C215/28 , C07C215/30 , C07C215/42 , C07C217/16 , C07C217/48 , C07C217/54 , C07C217/72 , C07C217/74 , C07C219/22 , C07C225/16 , C07C225/18 , C07C233/18 , C07C235/34 , C07C235/54 , C07C237/20 , C07C237/38 , C07C237/40 , C07C257/14 , C07C279/08 , C07C317/28 , C07C323/25 , C07C323/29 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D213/30 , C07D213/38 , C07D309/06 , C07D333/16 , C07D333/20 , C07D335/02
Abstract: Provided are amine derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.
Abstract translation: 提供的是胺衍生物化合物，其药物组合物，以及使用所述化合物和组合物治疗眼科疾病和失调症的方法，例如年龄相关性黄斑变性和Stargardt氏病。
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Patent Agency Ranking
公开(公告)号：US11446261B2
公开(公告)日：2022-09-20
申请号：US16865195
申请日：2020-05-01
Applicant: Acucela Inc.
Inventor： Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas L. Little, Jr. , Anna Gall , Feng Hong
IPC: A61K31/137 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C317/28 , C07C323/25 , C07D277/24 , C07D309/06 , C07C217/20 , C07C215/20 , C07C309/06 , C07C217/84 , C07C323/33 , A61K31/165 , A61K31/222
Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
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公开(公告)号：US20170049722A1
公开(公告)日：2017-02-23
申请号：US15260127
申请日：2016-09-08
Applicant: Acucela Inc.
Inventor： Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas L. Little, JR. , Anna Gall , Feng Hong
IPC: A61K31/137 , A61K31/222 , A61K31/165
CPC classification number: A61K31/137 , A61K31/165 , A61K31/222 , C07C215/20 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C217/84 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C309/06 , C07C317/28 , C07C323/25 , C07C323/33 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07D277/24 , C07D309/06
Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
Abstract translation: 本发明一般涉及用于治疗神经变性疾病和病症，特别是眼科疾病和病症的组合物和方法。 本文提供的是烷氧基衍生物化合物和包含这些化合物的药物组合物。 主题组合物可用于治疗和预防眼科疾病和病症，包括年龄相关性黄斑变性（AMD）和斯塔尔加氏病。
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8.发明申请公开(公告)号：US20160229831A1
公开(公告)日：2016-08-11
申请号：US14849859
申请日：2015-09-10
Applicant: Acucela Inc.
Inventor： Vladimir A. Kuksa , Mark W. Orme , Feng Hong , Ryo Kubota
IPC: C07D335/02 , C07D213/38 , C07D211/26 , C07D307/81 , C07D307/14 , C07D211/60 , C07D233/96 , C07D311/04 , C07D207/09 , C07D211/76 , C07D333/12 , C07D207/26 , C07D279/02 , C07D211/96 , C07D209/08 , C07D233/64 , C07D309/06
CPC classification number: C07D335/02 , A61K31/341 , A61K31/343 , A61K31/351 , A61K31/382 , A61K31/44 , A61K31/4406 , A61K31/4409 , A61K31/445 , A61K31/4465 , A61K31/505 , C07D207/08 , C07D207/09 , C07D207/26 , C07D209/08 , C07D209/14 , C07D211/22 , C07D211/26 , C07D211/60 , C07D211/76 , C07D211/96 , C07D213/30 , C07D213/38 , C07D233/64 , C07D233/96 , C07D239/26 , C07D279/02 , C07D307/12 , C07D307/14 , C07D307/80 , C07D307/81 , C07D309/04 , C07D309/06 , C07D311/04 , C07D311/58 , C07D333/12 , C07D333/16 , C07D333/20
Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are substituted 3-phenylpropylamine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
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公开(公告)号：US20150239836A1
公开(公告)日：2015-08-27
申请号：US14631779
申请日：2015-02-25
Applicant: Acucela Inc.
Inventor： Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas L. Little, JR. , Anna Gall , Feng Hong
IPC: C07C323/33 , C07C217/84 , C07C217/62
CPC classification number: A61K31/137 , A61K31/165 , A61K31/222 , C07C215/20 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C217/84 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C309/06 , C07C317/28 , C07C323/25 , C07C323/33 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07D277/24 , C07D309/06
Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
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公开(公告)号：US20180177746A1
公开(公告)日：2018-06-28
申请号：US15672031
申请日：2017-08-08
Applicant: Acucela Inc.
Inventor： Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas L. Little, Jr. , Anna Gall , Feng Hong
IPC: A61K31/137 , C07C309/06 , A61K31/222 , A61K31/165 , C07C323/33 , C07C215/20 , C07D309/06 , C07D277/24 , C07C323/25 , C07C317/28 , C07C279/08 , C07C251/86 , C07C235/08 , C07C233/18 , C07C229/38 , C07C225/16 , C07C217/72 , C07C217/64 , C07C217/62 , C07C217/60 , C07C217/20 , C07C217/84
CPC classification number: A61K31/137 , A61K31/165 , A61K31/222 , C07C215/20 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C217/84 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C309/06 , C07C317/28 , C07C323/25 , C07C323/33 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07D277/24 , C07D309/06
Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
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