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公开(公告)号：US20220187208A1
公开(公告)日：2022-06-16
申请号：US17437396
申请日：2020-03-09
发明人： Nicolas DESCHARMES , Raphaël BARBEY
IPC分类号： G01N21/64
摘要： Surface-based measurement substrate including: At least one optical cavity layer; a first optical mirror and a second optical mirror, the first and second optical mirrors enclosing the optical cavity layer and defining an optical cavity, the first optical mirror and the second optical mirror are attached or fixed to the optical cavity layer to sandwich the optical cavity layer between the first and second mirrors; and an interface layer or interface coating provided on the first mirror or the second mirror, the interface layer or coating being configured to receive or hold at least one entity comprising at least one electromagnetic radiation emitting marker.
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公开(公告)号：US20220184386A1
公开(公告)日：2022-06-16
申请号：US17595382
申请日：2020-05-14
发明人： Gregoire Courtine , Aaron Phillips , Jordan Squair
摘要： A system for neuromodulation and/or neurostimulation, for the treatment of a mammal, at least comprising: at least one control unit configured and arranged to provide stimulation data; at least one stimulation unit configured and arranged to provide a stimulation pulse; at least one real-time monitoring unit; at least one signal-processing unit; wherein the system is configured and arranged for control of blood pressure,
wherein the stimulation unit is constructed to comprise a lead, and wherein the lead is capable and configured to provide stimulation to the spinal cord at level T9-L1.-
公开(公告)号：US20220127310A1
公开(公告)日：2022-04-28
申请号：US17082682
申请日：2020-10-28
发明人： Matteo DAL PERARO , Chan CAO
IPC分类号： C07K14/195 , G01N33/487 , G01N27/447
摘要： Aerolysin polypeptides and/or mutant aerolysin monomers include modified amino acid sequences that could have improved substrate analyte, such as (poly)nucleotide and peptide, improved reading properties such as enhanced substrate analyte capture and improved substrate analyte recognition and/or discrimination. Also, aerolysin pores may be derived from the mutant monomers as well as apparatuses and devices may include modified aerolysin polypeptides. Further, methods of using modified aerolysin proteins and pores derive therefrom may be used in characterizing and/or sequencing a polymeric molecule or may be for use as molecular sensors.
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14.发明申请公开(公告)号：US20220122686A1
公开(公告)日：2022-04-21
申请号：US17482594
申请日：2021-09-23
发明人： Andreas Burg , Reza Ghanaatian
摘要： A method of accessing a memory space of a memory device with a decoder, the memory space having faults, including the steps of performing a memory access operation by an electronic device to a access a logical memory space of the memory device, and randomizing the memory access operation with a randomization logic to access data from a physical memory space based on the logical memory space, the randomization logic providing time varying behavior for accessing the physical memory space.
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公开(公告)号：US20220026695A1
公开(公告)日：2022-01-27
申请号：US17413699
申请日：2018-12-17
发明人： Dora MAHECIC , Kyle DOUGLASS , Suliana MANLEY
摘要： A Koehler integrator device (10) comprises a collimating lens (11) being arranged for collimating a light field created by an incoherent or partially coherent light source, a pair of planar first and second micro-lens arrays (12, 13) being arranged for relaying portions of the collimated light field along separate imaging channels, wherein all micro-lenses of the first and second micro-lens arrays (12, 13) have an equal micro-lens focal length and pitch and the micro-lens arrays (12, 13) are arranged with a mutual distance equal to the micro-lens focal length, and a collecting Fourier lens (4) having a Fourier lens diameter and a Fourier lens focal length defining a Fourier lens front focal plane and a Fourier lens back focal plane, wherein the Fourier lens (14) is arranged for superimposing light from all imaging channels in the Fourier lens front focal plane and wherein the second micro-lens array (13) is arranged in the Fourier lens back focal plane, wherein a third micro-lens array (15) is arranged in the Fourier lens front focal plane for creating a wavelength independent array of illumination spots. Furthermore, a confocal microscope apparatus, which comprises the Koehler integrator device, and a method of using the confocal microscope apparatus are described.
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公开(公告)号：US11226232B2
公开(公告)日：2022-01-18
申请号：US16651060
申请日：2018-09-26
摘要： A Multichromatic Calibration (MC) method of at least a spectral sensor which is one of a list comprising at least a spectrometer, a multispectral sensor, a hyperspectral sensor, a spectral camera, a color camera. The method comprises a. generating a plurality of different multichromatic spectra, wherein i. a spectrum from the plurality of different multichromatic spectra contains light intensity measurable by the at least one spectral sensor and by a reference spectral device, and ii. a spectrum from the plurality of different multichromatic spectra contains light centered around at least two different wavelengths and is configured to be integrated during an exposure time of a single measurement from any of the at least one spectral sensor or the reference spectral device; b. measuring each multichromatic spectrum of the plurality of different multichromatic spectra with the reference spectral device and the at least one spectral sensor; and from all data of the measured multichromatic spectra, compute a transfer function which relates a response of the at least one spectral sensor to a corresponding response of the reference spectral device, without measuring the spectral response of the at least one spectral sensor.
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公开(公告)号：US11202911B2
公开(公告)日：2021-12-21
申请号：US16292227
申请日：2019-03-04
发明人： Gregoire Courtine , Nikolaus Wenger , Eduardo Martin Moraud , Silvestro Micera , Marco Bonizzato
IPC分类号： A61N1/36 , A61B5/11 , A61N1/05 , A61B5/04 , A61B5/0476 , A61B5/0488 , A61B5/00 , A61B5/24 , A61B5/369 , A61B5/389
摘要： The present invention provides a closed-loop system for real-time control of epidural and/or subdural electrical stimulation comprising: means for applying to a subject neuromodulation with adjustable stimulation parameters, said means being operatively connected with a real-time monitoring component comprising sensors continuously acquiring feedback signals from said subject, said signals being neural signals and/or signals providing features of motion of said subject, said system being operatively connected with a signal processing device receiving said feedback signals and operating real-time automatic control algorithms, said signal processing device being operatively connected with said means and providing said means with new stimulation parameters, with minimum delay. The system of the invention improves consistency of walking in a subject with a neuromotor impairment. A Real Time Automatic Control Algorithm is used, comprising a feedforward component employing a single input-single output model (SISO), or a multiple input-single output (MISO) model.
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公开(公告)号：US20210369360A1
公开(公告)日：2021-12-02
申请号：US17385824
申请日：2021-07-26
摘要： A novel mechanical system, based on a new cable driven mechanical transmission, able to provide sufficient dexterity, stiffness, speed, precision and payload capacity to actuate multi-DOF micro-manipulators. Besides the possibility of being used in several articulated surgical instruments and robotic systems for surgery or other applications involving remote manipulation, it enables the design of a novel fully mechanical surgical instrument, which offer the advantages of: conventional laparoscopy (low cost, tactile feedback, high payload capacity) combined with the advantages of single port surgery (single incision, starless surgery, navigation through several quadrants of the abdominal cavity) and robotic surgery (greater degrees of freedom, short learning curve, high stiffness, high precision, increased intuition). The unique design of the proposed system provides an intuitive user interface to achieve such enhanced manoeuvrability, allowing each Joint of a teleoperated slave system to be driven by controlling the position of a mechanically connected master unit.
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公开(公告)号：US20210361929A1
公开(公告)日：2021-11-25
申请号：US16767106
申请日：2018-11-23
发明人： Jonathan CHAVANNE , Yoan CIVET , Yves PERRIARD
IPC分类号： A61M60/486 , H01L41/053 , A61M60/161 , A61M60/289
摘要： A spring (3, 3′) comprising a plurality of elements (30), each element (3) comprising a rigid portion (31) and a flexible beam (32), the extremities (320, 321) of the flexible beam being supported by the rigid portion (31), the flexible beam (32) having a single stable position, so that the flexible beam can be deformed when a pressure is exerted between said extremities in the direction of the rigid portion (31), and returns to said single stable position when the pressure is released, and wherein the rigid portion (31) of at least one element (30) is in contact with the flexible beam (32) of the next element between said extremities (320, 321) of the flexible beam (32), so that the spring has a negative stiffness over an operating range. The arrangement ensures a pure radial compression/expansion of the spring.
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20.发明申请公开(公告)号：US20210350846A1
公开(公告)日：2021-11-11
申请号：US16866570
申请日：2020-05-05
发明人： Marco Antonio Rios , William Andrew Simon , Alexandre Sébastien Levisse , Marina Zapater , David Atienza Alonso
IPC分类号： G11C11/419 , G11C11/418
摘要： A random access memory array including a plurality of local memory group ways, each local memory group way including, a plurality of local memory groups, each local memory group including, a memory column including a plurality of memory cells, a pair of local bitlines operatively connected to the plurality of memory cells, and a local group periphery including a local bitline multiplexer operatively connected with the pairs of local bitlines of the corresponding local memory group; and a pair of global read bitlines operatively connected to outputs of the plurality of local group peripheries, a global read bitline multiplexer operatively connected to outputs of the plurality of pairs of the global read bitlines from the local memory group ways, and a bitline operational block operatively connected an output of the global read bitline multiplexer.
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