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241 条记录 (耗时 0.049 秒)

    Methods of treatment using thymus-derived compositions
    16.
    发明授权
    Methods of treatment using thymus-derived compositions 有权

    公开(公告)号：US08609824B2

    公开(公告)日：2013-12-17

    申请号：US12829829

    申请日：2010-07-02

    申请人： Richard N. Ushijima

    发明人： Richard N. Ushijima

    IPC分类号： C07K1/00

    CPC分类号： A61K35/26 ,  A61K36/78 ,  G01N33/0098 ,  G01N2500/00

    摘要： Embodiments of the present invention provide processes for preparing thymus extracts and plant or fungal extracts, and more particularly provide compositions (Thyex-1-6A and -6B) produced in accordance with said processes, and methods for treatment of various conditions comprising administration of said compositions including but not limited to impaired physical vigor or aptitude, and aging and/or age-related conditions (arthritis, mobility deficits, loss of appetite, etc.). Additional aspects provide methods for building muscle mass, for reducing exercise recovery period, or for sustaining exercise intensity. Particular aspects relate to preparation of Houttuynia cordata extracts and the use of those extracts as an anti-emetic and/or anti-nausea treatment for a subject in need thereof.

    IMMUNOSUPPRESSIVE DRUG COMBINATION FOR A STABLE AND LONG TERM ENGRAFTMENT
    17.
    发明申请
    IMMUNOSUPPRESSIVE DRUG COMBINATION FOR A STABLE AND LONG TERM ENGRAFTMENT 审中-公开
    免疫抑制药物组合用于稳定和长期的植入

    公开(公告)号：US20130183322A1

    公开(公告)日：2013-07-18

    申请号：US13821269

    申请日：2011-09-08

    申请人： Yair Reisner ,  Esther Bachar-Lustig ,  Dalit Tchorsh-Yutsis

    发明人： Yair Reisner ,  Esther Bachar-Lustig ,  Dalit Tchorsh-Yutsis

    IPC分类号： A61K39/395 ,  A61K35/26 ,  A61K35/28

    CPC分类号： A61K39/3955 ,  A61K35/26 ,  A61K35/28 ,  A61K38/1774 ,  A61K2035/122 ,  A61K2300/00

    摘要： A method of treating a subject in need of a cell or tissue transplant is disclosed. The method comprising (a) transplanting a non-syngeneic cell or tissue transplant into the subject, wherein the transplant comprises bone marrow or lymphoid cells; and (b) administering to the subject a therapeutically effective amount of an immunosuppressive regimen comprising a Sphingosine 1-Phosphate Receptor Agonist, a B7 molecule inhibitor and a CD2/CD58 pathway inhibitor, thereby treating the subject.

    摘要翻译： 公开了一种治疗需要细胞或组织移植的受试者的方法。 所述方法包括（a）将非同基因细胞或组织移植移植到所述受试者中，其中所述移植物包含骨髓或淋巴样细胞; 和（b）向受试者施用治疗有效量的包含1-鞘氨醇鞘氨醇受体激动剂，B7分子抑制剂和CD2 / CD58途径抑制剂的免疫抑制方案，从而治疗受试者。

    REGULATORY IMMUNE CELLS WITH ENHANCED TARGETED CELL DEATH EFFECT
    18.
    发明申请
    REGULATORY IMMUNE CELLS WITH ENHANCED TARGETED CELL DEATH EFFECT 有权
    具有增强的靶向细胞死亡效应的调节性免疫细胞

    公开(公告)号：US20130129771A1

    公开(公告)日：2013-05-23

    申请号：US13811374

    申请日：2011-07-21

    申请人： Shai Yarkoni ,  Nadir Askenasy

    发明人： Shai Yarkoni ,  Nadir Askenasy

    IPC分类号： C12N5/0783 ,  A61K35/14

    CPC分类号： C12N5/0637 ,  A61K35/16 ,  A61K35/17 ,  A61K35/26 ,  A61K39/0008 ,  A61K39/001 ,  A61K2039/5158 ,  C12N5/0006 ,  C12N2501/48

    摘要： An isolated immune regulatory cell having an exogenous cell death-inducing moiety attached to a surface thereof is disclosed herein. Additionally, a molecule comprising a cell death-inducing moiety heterologously attached to an immune regulatory cell-specific binding moiety is disclosed herein. Methods of generating and using same as well as pharmaceutical compositions comprising same are also disclosed.

    摘要翻译： 本文公开了具有连接到其表面的外源性细胞死亡诱导部分的分离的免疫调节细胞。 此外，本文公开了包含异源连接到免疫调节细胞特异性结合部分的细胞死亡诱导部分的分子。 还公开了产生和使用它们的方法以及包含其的药物组合物。

    Proliferated cell lines and uses thereof
    19.
    发明授权
    Proliferated cell lines and uses thereof 有权
    增殖细胞系及其用途

    公开(公告)号：US08137662B2

    公开(公告)日：2012-03-20

    申请号：US11981945

    申请日：2007-10-31

    申请人： Thomas B. Freeman ,  Pablo Caviedes ,  Raul Caviedes

    发明人： Thomas B. Freeman ,  Pablo Caviedes ,  Raul Caviedes

    IPC分类号： A61K35/12

    CPC分类号： A61K35/26 ,  C12N5/0018 ,  C12N2500/84 ,  C12N2502/078 ,  C12N2502/30 ,  C12N2503/02

    摘要： The subject invention pertains to tumor cell lines useful for increasing the proliferation potential of any human or animal cell in culture, thereby providing immortalized or continuous cell lines and cultures. The invention also concerns proliferation factors, and compositions containing the factors, which are capable of increasing the proliferation potential of any human or other animal cell in culture. The subject invention further pertains to a method for proliferating cells in culture by containing cells with the proliferation factors. The proliferated cells can range in plasticity and can include, for example, blast cells, fertilized ova, non-fertilized gametes, embryonic stem cells, adult stem cells, precursor or progenitor cells, and highly specialized cells. Optionally, the cells can be induced to cease proliferation. The proliferated cells of the subject invention are useful for cell therapy, cell/gene therapy, biological production of molecules, and as in vitro models for research, toxicity testing, and drug development.

    摘要翻译： 本发明涉及可用于增加培养物中任何人或动物细胞的增殖潜力的肿瘤细胞系，从而提供永生化或连续的细胞系和培养物。 本发明还涉及增殖因子和含有因子的组合物，其能够增加培养物中任何人或其他动物细胞的增殖潜力。 本发明还涉及通过含有增殖因子的细胞来增殖培养细胞的方法。 增殖的细胞可以在可塑性范围内，并且可以包括例如胚细胞，受精卵，非受精配子，胚胎干细胞，成体干细胞，前体或祖细胞和高度专门的细胞。 任选地，可诱导细胞停止增殖。 本发明的增殖细胞可用于细胞治疗，细胞/基因治疗，分子的生物制备，以及用于研究，毒性测试和药物开发的体外模型。

    Method of isolating regulatory T cells from human samples
    20.
    发明授权
    Method of isolating regulatory T cells from human samples 有权
    从人类样品中分离调节性T细胞的方法

    公开(公告)号：US07968300B2

    公开(公告)日：2011-06-28

    申请号：US11943682

    申请日：2007-11-21

    申请人： Li-Te Chin ,  Shu-Ching Hsu

    发明人： Li-Te Chin ,  Shu-Ching Hsu

    IPC分类号： G01N33/53

    CPC分类号： A61K35/26 ,  A61K38/17 ,  C07K16/2818 ,  C07K2317/34 ,  C07K2317/92 ,  G01N33/505

    摘要： The present invention provides a CTLA-4 non-blocking agent of a complete human antibody nature, thus is non-immunogenic in a human. The immunoassay method using such a non-blocking agent measures the CTLA-4 content in a sample of a human subject. The present invention further provides a novel method for isolating human regulatory T cells. The resultant enriched and depleted cellular populations are useful in treating or ameliorating of human diseases.

    摘要翻译： 本发明提供了完全人抗体性质的CTLA-4非阻断剂，因此在人体中是非免疫原性的。 使用这种非阻断剂的免疫测定方法测量人受试者样品中的CTLA-4含量。 本发明还提供了一种分离人类调节性T细胞的新方法。 所产生的富含和贫化的细胞群可用于治疗或改善人类疾病。